Identifiers and Description

Gene Model Identifier

TTHERM_01030000

Standard Name

SGS1 (Homolog of budding yeast Sgs1 and fission yeast rqh1)

Aliases

PreTt10830 | 204.m00059

Description

SGS1 ATP-dependent DNA helicase RecQ family protein; ATP-dependent DNA helicase- RecQ family protein; Protein involved in DNA joint molecule resolution dHJ dissolution and crossing over

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• helicase activity (IEA) | GO:0004386
• ATP-dependent 3'-5' DNA helicase activity (IEA) | GO:0043140
• nucleic acid binding (IEA) | GO:0003676
• ATP-dependent helicase activity (IEA) | GO:0008026

Biological Process

• meiosis I (ISA) | GO:0007127 | Ref:18522989
• DNA repair (IEA) | GO:0006281
• DNA replication (IEA) | GO:0006260

Domains

• ( PF01202 ) shikimate kinase
• ( PF00270 ) DEAD/DEAH box helicase
• ( PF08839 ) DNA replication factor CDT1 like
• ( TIGR00643 ) ATP-dependent DNA helicase RecG
• ( TIGR01389 ) ATP-dependent DNA helicase RecQ
• ( TIGR01587 ) CRISPR-associated helicase Cas3
• ( PF06827 ) Zinc finger found in FPG
• ( PF00271 ) Helicase conserved C-terminal domain
• ( PF04851 ) type III restriction enzyme, res
• ( TIGR03158 ) CRISPR-associated helicase, Cyano-type
• ( TIGR00614 ) ATP-dependent DNA helicase, RecQ family

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.4%

TetraMine Data

TTHERM_01030000

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_10497.1	9.997093137033517e-262	ATP-dependent DNA helicase, Re cQ family protein (1193 aa)
Oxytricha	Contig17511.0.g63	1.999149254372995e-126	DEAD/DEAH box helicase
DictyBase	DDB_G0292130	1.9992982665753866e-121	blm on chromosome: 6 position 1240457 to 1244236
SGD	YMR190C	1.0002857351297358e-115	SGS1 Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/cro ssover formation; potential ro le as repressor of a subset of rapamycin responsive genes; r apidly lost in response to rap amycin in Rrd1p-dependent mann er; similar to human BLM and W RN proteins implicated in Bloo m and Werner syndromes
WormBase	WBGene00019334	2.999180586171967e-98	Putative ATP-dependent DNA hel icase Q1 status:Confirmed UniProt:Q9TXJ8 protein_id:CC D61880.1
Stentor Coeruleus	SteCoe_28767	2.572209372642415e-56

General Information

No Data fetched for General Information

Associated Literature

1. Ref:26519827: Lukaszewicz A, Shodhan A, Loidl J (2015) Exo1 and Mre11 execute meiotic DSB end resection in the protist Tetrahymena. DNA repair 35( ):137-43
2. Ref:23935123: Lukaszewicz A, Howard-Till RA, Loidl J (2013) Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex. Nucleic acids research 41(20):9296-309

Sequences

>TTHERM_01030000(coding)
ATGGATGAAATATTGTAGTAATTTATAGATAGCAAAAGATAAGCAAAGAAGATAGAAGAT
TTTGCAGACGCTGTATCATGCAGTGCCACAGAAAGCTTAGAAGATTAGGACTAATCTTTT
GATAGAGGTGCTGATTTCAACGATGGAGAAGTAGATGATGCTTTATTGGATGAACTTATA
GAATATTAAACAAACAGAGAGCGTTAATCAATTACTGAAGAGTAAAATGATCTCATGAAA
ACTGAATTGTAAAAGCCAATAAGCAACAATTTAAATAAAAAATAACCAACTAGCTTGAGC
GGTTTGCAAAAAGGGTTAGGAAACAAAATATCTGGACCTTCTTATGATTTTAGTAACTCT
AATAATATGTAGACATTAAGCGGCATTTATAGTTCAAATTCTAACAATAACTCTTAGAAC
AGCAATGAGAACTTTAATTTCAATAGACAAGGAAATACTACTCTAAAGCCTACGGGTTTT
GATGCTATCAAGCTTAAAAAAAATTAGAATTAAGATTAATAGTAATAATAATAGCAATAG
CAAGTTCTGAAATTTGTAAATTAAAATAGTAATGGAGGGATTTAAGTAGAGGCTTCTTTA
ACAGATAAAAGAAGATAAGTAAATAACTCTAATGATATTGATAGTTTCATGTTGATCAAT
AACGGATAAAAAGAAAAAAAGACAAAAAATTAAAATTCTAAAATAAGTGAGTTGCTTGAG
AAGTACAAAGTGATAGATTCTAATTCAAATACTTAAAATTTCGAGTCTACTTCGCTTAAT
ACTTCTCTCAATACCAAAAATAATAAATTAGAAGTTAAAAATGGGTTTTAAAATTTACCA
CAAAAAACTGAAAAAATAGGGCTTGCAGCCTAAGCTGTAAATCAAAGCTCTAACGTACGT
TCTAATTTTACACCTCCTACAATAGTCAATAGAAATAATTGGACAAATAATTTATCCAAT
GGGCCAGGTAGTGCACTCACTGCATCTTCTACTGCAAAAAAGCAAGCTGACATAAAGGAT
GTTGATTATTCAACCTTAGATTATTTGAATTAACCAGAAAGACCATTTGTTCCTCTTGAA
TCTAAAAATAAAGGAAAACATGTCTCTAAAAGTAACTAATACTACACAGTTGCAGATATT
AATGAATATGCAATAAAACCACATCCTTGGGATCAGAAGGTTAATGATATATTAGCTAAC
GTCTATGGCTATAAAAATTTTAGAAATAATTAAAGAGCAATTATAAATTGTGTCTTGGAG
AATAAAGATGTGTTTGCAATGATGCCCACTGGAGGTGGCAAATCTCTTACATTTTAAATA
CCTGGACTTGTCTAAGATGGAGTTTATATTGTTATTATGCCTCTTATTTCACTTATTTCT
GATTAATACAATCACATGCTTAGGCTCAATATTCCAGTTATCAGAGTTTAAGGAGCTAGG
AAGAACTACTAAAGAGAATTAGATTCAATACTTTATTCAGATAAGAATTAGTCTAAAATT
GTGTTAATCACACCAGAAAAAATATCATCAGATGAAGATTTTAACCAATTTTTAAGCTAA
ATTTATGAAAAAAATAAATTGAGAAGATTTGTTATTGATGAAGCTCACTGTGTTTCTTAA
TGGGGACACGAGTTTAGAAAAGATTATCTTTCTTTAGGATAGTTAAAAATAAAATATCCA
AACATTCCTACACTTGCTCTAACTGCTACAGCTACTGAAAAGTGCAAAATAGATATTATT
TAACTTCTTAATATGAAAGGAACTCTGTATTTTTAATCTTCTTTTAATCGTACAAATCTT
TACTACGATGTAGTAAGGATACCCTAAAAAGTAACAATCGAGCATATGGTTAATTTTATC
AAAGAAAAGTTTAATAAGCAAAGTGGTATTATATATTGCTGCACAAAAAAAGACTCAGAA
GAATTAGCTAGTAAGCTAAATATATAATATAAAATTAATGCAGCATATTATCACGGATCT
ATGAATGACAAAGAAAAAGAATAAGTTCAATAACTTTGGATGTCAAATGATATTTAAGTA
ATATGTGCCACAATAGCTTTTGGTATGGGTATCGACAAGCATGATGTCAGATTTGTCATC
CATTATACTTTTTCTAAATCTATCGAAAATTACTATTAAGAAGCAGGTAGAGCAGGAAGA
GATGGTAAAATATCTCACTGCAGAATTTACTACTCTCCAAAAGATAAAAATTCTTTAGTC
TTTTTGATCACTAATAATGAAGGCAGCAATAAATAGAAAAAAGAAGAATGCATGGCTCAT
TTAAGTAAAATGATAAGATATTGCGAAGATACAATTAATTGTAGAAGGGTTTTGCAATTA
GCACACTTGGGTGAAAAATTTGAACCTAAATTTTGCAATAAAATGTGCGATAACTGCAGA
AATTAAACTTCTAAAAGCAATATAATACAAAAAGATTTTACTTAAGATTGCAAAAATATA
CTATAAGAATATTTGAGTATGTATAATAAAAACATACAGCTGACTTAAAAGCAATTAGTA
GACGTTCTCAGAGGTAAAAAACTACAAAAAAAGGCAGGTTAAAACCTACTTAAAATGATT
GAAAACAGCTCAATCTATAGTCTATTAAAGAATTATGATTAATTAACTGTTGAAAATATT
GTTAAAGAAATGATGTCTTAGGGTTATTTGAGTGAAAAAATTAAAAAGTTTCGTGCTTAT
ACTTAAGTATTTCTTGAAGTAGTTAAGTCTAAGTATAATGAGTTATGTAATCCAAACAAA
ATGACTGACAAAATCATGATCAATTAAGTAGTTTCTCAAAGCTCTAAATCAAAAGTAGAT
AGTCAATTTTTATTTGACAAAGAATTAATTGATGATATTACAGAATCAGATTTACCTAAA
GAGTAAGAATTTTTTGATTAAAATAAAAATCTCATTTTTGATGATGAAGAATCACTATCT
TAAATGTCTGAAGGTGATTTAATAGATTTAATTGATCTTGCAAATAAGAATAAAACTTCT
TGCAACCAAAATGATTCGTCAGATAACATGTAAGAACTAAATAAATAGTATAGCGAAGAT
GATTCAGACTTTTAATTTTAAATACCTTCTGAGAGAAACTAATAAAGTAGAAGTGGGATT
ATTTATGAAGAAAATGATGAATAAAATTAAATTGGTCAAGCATATAGTGAGGATTATAAC
AGTCAAAATAAATAAGCTAATGAAAAACTAAACTAAGAACAGATATAAATTGAAGAGGAT
GATGATGACGATGATGACGACGATGATGATATTTTACAAATAGCAGCTAAAACAAATCTT
TTAGAATAAATAAAAAAATAAAACACGATGAGTGTAGAAAAATAAAATAGTTTGAAAGAA
AATTATCTTTATAAATCTCCTCAAGAATAAGATAATTTCTTTTCTGAATTTAAATTAGGC
AATAATAACAATAAACCTTAAACTTCTTTAGGATAAACAGGTCATAAGCCACCTTAATAA
AACAATTAAAATATGAGCTCATTGAATAATTTTAAATTTTCTACAGGAAACAATAAATTA
AAATAAGACTAAGCTGATCTTTTTTCATTTAACTTTCAAAAACTTGCAAAAAATTGA

>TTHERM_01030000(protein)
MDEILQQFIDSKRQAKKIEDFADAVSCSATESLEDQDQSFDRGADFNDGEVDDALLDELI
EYQTNRERQSITEEQNDLMKTELQKPISNNLNKKQPTSLSGLQKGLGNKISGPSYDFSNS
NNMQTLSGIYSSNSNNNSQNSNENFNFNRQGNTTLKPTGFDAIKLKKNQNQDQQQQQQQQ
QVLKFVNQNSNGGIQVEASLTDKRRQVNNSNDIDSFMLINNGQKEKKTKNQNSKISELLE
KYKVIDSNSNTQNFESTSLNTSLNTKNNKLEVKNGFQNLPQKTEKIGLAAQAVNQSSNVR
SNFTPPTIVNRNNWTNNLSNGPGSALTASSTAKKQADIKDVDYSTLDYLNQPERPFVPLE
SKNKGKHVSKSNQYYTVADINEYAIKPHPWDQKVNDILANVYGYKNFRNNQRAIINCVLE
NKDVFAMMPTGGGKSLTFQIPGLVQDGVYIVIMPLISLISDQYNHMLRLNIPVIRVQGAR
KNYQRELDSILYSDKNQSKIVLITPEKISSDEDFNQFLSQIYEKNKLRRFVIDEAHCVSQ
WGHEFRKDYLSLGQLKIKYPNIPTLALTATATEKCKIDIIQLLNMKGTLYFQSSFNRTNL
YYDVVRIPQKVTIEHMVNFIKEKFNKQSGIIYCCTKKDSEELASKLNIQYKINAAYYHGS
MNDKEKEQVQQLWMSNDIQVICATIAFGMGIDKHDVRFVIHYTFSKSIENYYQEAGRAGR
DGKISHCRIYYSPKDKNSLVFLITNNEGSNKQKKEECMAHLSKMIRYCEDTINCRRVLQL
AHLGEKFEPKFCNKMCDNCRNQTSKSNIIQKDFTQDCKNILQEYLSMYNKNIQLTQKQLV
DVLRGKKLQKKAGQNLLKMIENSSIYSLLKNYDQLTVENIVKEMMSQGYLSEKIKKFRAY
TQVFLEVVKSKYNELCNPNKMTDKIMINQVVSQSSKSKVDSQFLFDKELIDDITESDLPK
EQEFFDQNKNLIFDDEESLSQMSEGDLIDLIDLANKNKTSCNQNDSSDNMQELNKQYSED
DSDFQFQIPSERNQQSRSGIIYEENDEQNQIGQAYSEDYNSQNKQANEKLNQEQIQIEED
DDDDDDDDDDILQIAAKTNLLEQIKKQNTMSVEKQNSLKENYLYKSPQEQDNFFSEFKLG
NNNNKPQTSLGQTGHKPPQQNNQNMSSLNNFKFSTGNNKLKQDQADLFSFNFQKLAKN

>TTHERM_01030000(gene)
ATGGATGAAATATTGTAGTAATTTATAGATAGCAAAAGATAAGCAAAGAAGATAGAAGAT
TTTGCAGACGCTGTATCATGCAGTGCCACAGAAAGCTTAGAAGATTAGGACTAATCTTTT
GATAGAGGTGCTGATTTCAACGATGGAGAAGTAGATGATGCTTTATTGGATGAACTTATA
GAATATTAAACAAACAGAGAGCGTTAATCAATTACTGAAGAGTAAAATGATCTCATGAAA
ACTGAATTGTAAAAGCCAATAAGCAACAATTTAAATAAAAAATAACCAACTAGCTTGAGC
GGTTTGCAAAAAGGGTTAGGAAACAAAATATCTGGACCTTCTTATGATTTTAGTAACTCT
AATAATATGTAGACATTAAGCGGCATTTATAGTTCAAATTCTAACAATAACTCTTAGAAC
AGCAATGAGAACTTTAATGTAAAATATTTTATAAAAATCAAAATTAATTTAAATGCATAA
AAATAAAATAAAAAAGTTCAATAGACAAGGAAATACTACTCTAAAGCCTACGGGTTTTGA
TGCTATCAAGCTTAAAAAAAATTAGAATTAAGATTAATAGTAATAATAATAGCAATAGCA
AGTTCTGAAATTTGTAAATTAAAATAGTAATGGAGGGATTTAAGTAGAGGCTTCTTTAAC
AGATAAAAGAAGATAAGTAAATAACTCTAATGATATTGATAGTTTCATGTTGATCAATAA
CGGATAAAAAGAAAAAAAGACAAAAAATTAAAATTCTAAAATAAGTGAGTTGCTTGAGAA
GTACAAAGTGATAGATTCTAATTCAAATACTTAAAATTTCGAGTCTACTTCGCTTAATAC
TTCTCTCAATACCAAAAATAATAAATTAGAAGTTAAAAATGGGTTTTAAAATTTACCACA
AAAAACTGAAAAAATAGGGCTTGCAGCCTAAGCTGTAAATCAAAGCTCTAACGTACGTTC
TAATTTTACACCTCCTACAATAGTCAATAGAAATAATTGGACAAATAATTTATCCAATGG
GCCAGGTAGTGCACTCACTGCATCTTCTACTGCAAAAAAGCAAGCTGACATAAAGGATGT
TGATTATTCAACCTTAGATTATTTGAATTAACCAGAAAGACCATTTGTTCCTCTTGAATC
TAAAAATAAAGGAAAACATGTCTCTAAAAGTAACTAATACTACACAGTTGCAGATATTAA
TGAATATGTAAAATAATTTATTACAATTTCAGAAAAAAATTAACATTATTCTAATTAATT
CGATGAAGAAATAATTAAATTTATTTATTTTAATATTTTAATATTTTCTTTTTCCTCATC
AAAGAAAATTAAAAATATTTATTGATTAAAATGATTTATTTAATTTTCAAATATAAAAGG
CAATAAAACCACATCCTTGGGATCAGAAGGTTAATGATATATTAGCTAACGTCTATGGCT
ATAAAAATTTTAGAAATAATTAAAGAGCAATTATAAATTGTGTCTTGGAGAATAAAGATG
TGTTTGCAATGATGCCCACTGGAGGTGGCAAATCTCTTACATTTTAAATACCTGGACTTG
TCTAAGATGGAGTTTATATTGTTATTATGCCTCTTATTTCACTTATTTCTGATTAATACA
ATCACATGCTTAGGCTCAATATTCCAGTTATCAGAGTTTAAGGAGCTAGGAAGAACTACT
AAAGAGAATTAGATTCAATACTTTATTCAGATAAGAATTAGTCTAAAATTGTGTTAATCA
CACCAGAAAAAATATCATCAGATGAAGATTTTAACCAATTTTTAAGCTAAATTTATGAAA
AAAATAAATTGAGAAGATTTGTTATTGATGAAGCTCACTGTGTTTCTTAATGGGGACACG
AGTTTAGAAAAGATTATCTTTCTTTAGGATAGTTAAAAATAAAATATCCAAACATTCCTA
CACTTGCTCTAACTGCTACAGCTACTGAAAAGTGCAAAATAGATATTATTTAACTTCTTA
ATATGAAAGGAACTCTGTATTTTTAATCTTCTTTTAATCGTACAAATCTTTACTACGATG
TAGTAAGGATACCCTAAAAAGTAACAATCGAGCATATGGTTAATTTTATCAAAGGTAAAT
AAATCATAATTATTATTTTTCTTTATTTTAGCTAAAAAATTTTACTATTTTACAGAAAAG
TTTAATAAGCAAAGTGGTATTATATATTGCTGCACAAAAAAAGACTCAGAAGAATTAGCT
AGTAAGCTAAATATATAATATAAAATTAATGCAGCATATTATCACGGATCTATGAATGAC
AAAGAAAAAGAATAAGTTCAATAACTTTGGATGTCAAATGATATTTAAGTAATATGTGCC
ACAATAGGTAATAAAATTAGAAATAATTTAATTTGATTATTAAAAATTTTCAAATATATA
TAGCTTTTGGTATGGGTATCGACAAGCATGATGTCAGATTTGTCATCCATTATACTTTTT
CTAAATCTATCGAAAATTACTATTAAGAAGCAGGTAGAGCAGGAAGAGATGGTAAAATAT
CTCACTGCAGAATTTACTACTCTCCAAAAGATAAAAATTCTTTAGTCTTTTTGATCACTA
ATAATGAAGGCAGCAATAAATAGAAAAAAGAAGAATGCATGGCTCATTTAAGTAAAATGA
TAAGGTAAAATCTCTTTTATAACCAAAACCAATATTTATTAAATATTTAAGAATTAATTT
TACATATATATTTATTTTTTAAATTAAAAGTTTAAAATTAAATTTAGTAATTATTAAGTT
TTACAATATATATTGAATATTTATATATAGATATTGCGAAGATACAATTAATTGTAGAAG
GGTTTTGCAATTAGCACACTTGGGTGAAAAATTTGAACCTAAATTTTGCAATAAAATGTG
CGATAACTGCAGAAATTAAACTTCTAAAAGCAATATAATACAAAAAGATTTTACTTAAGA
TTGCAAAAATATACTATAAGAATATTTGAGTATGTATAATAAAAACATACAGCTGACTTA
AAAGCAATTAGTAGACGTTCTCAGAGGTAAAAAACTACAAAAAAAGGCAGGTTAAAACCT
ACTTAAAATGATTGAAAACAGCTCAATCTATAGTCTATTAAAGAATTATGATTAATTAAC
TGTTGAAAATATTGTTAAAGAAATGATGTCTTAGGGTTATTTGAGTGAAAAAATTAAAAA
GTTTCGTGCTTATACTTAAGTATTTCTTGAAGTAGTTAAGTCTAAGTATAATGAGTTATG
TAATCCAAACAAAATGACTGACAAAATCATGATCAATTAAGTAGTTTCTCAAAGCTCTAA
ATCAAAAGTAGATAGTCAATTTTTATTTGACAAAGAATTAATTGATGATATTACAGAATC
AGATTTACCTAAAGAGTAAGAATTTTTTGATTAAAATAAAAATCTCATTTTTGATGATGA
AGAATCACTATCTTAAATGTCTGAAGGTGATTTAATAGATTTAATTGATCTTGCAAATAA
GAATAAAACTTCTTGCAACCAAAATGATTCGTCAGATAACATGTAAGAACTAAATAAATA
GTATAGCGAAGATGATTCAGACTTTTAATTTTAAATACCTTCTGAGAGAAACTAATAAAG
TAGAAGTGGGATTATTTATGAAGAAAATGATGAATAAAATTAAATTGGTCAAGCATATAG
TGAGGATTATAACAGTCAAAATAAATAAGCTAATGAAAAACTAAACTAAGAACAGATATA
AATTGAAGAGGATGATGATGACGATGATGACGACGATGATGATATTTTACAAATAGCAGC
TAAAACAAATCTTTTAGAATAAATAAAAAAATAAAACACGATGAGTGTAGAAAAATAAAA
TAGTTTGAAAGAAAATTATCTTTATAAATCTCCTCAAGAATAAGATAATTTCTTTTCTGA
ATTTAAATTAGGCAATAATAACAATAAACCTTAAACTTCTTTAGGATAAACAGGTCATAA
GCCACCTTAATAAAACAATTAAAATATGAGCTCATTGAATAATTTTAAATTTTCTACAGG
AAACAATAAATTAAAATAAGACTAAGCTGATCTTTTTTCATTTAACTTTCAAAAACTTGC
AAAAAATTGA