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Identifiers and Description
Gene Model Identifier
TTHERM_01030000Standard Name
SGS1 (Homolog of budding yeast Sgs1 and fission yeast rqh1)Aliases
PreTt10830 | 204.m00059Description
ATP-dependent DNA helicase, RecQ family protein Protein involved in DNA joint molecule resolution dHJ dissolution and crossing overGenome Browser (Macronucleus)
Genome Browser (Micronucleus)
Gene Ontology Annotations
Molecular Function
- ATP binding (IEA) | GO:0005524
- helicase activity (IEA) | GO:0004386
- ATP-dependent 3'-5' DNA helicase activity (IEA) | GO:0043140
- nucleic acid binding (IEA) | GO:0003676
- ATP-dependent helicase activity (IEA) | GO:0008026
Biological Process
- DNA replication (IEA) | GO:0006260
- meiosis I (ISA) | GO:0007127 | Ref:18522989
- DNA repair (IEA) | GO:0006281
Domains
- ( PF01202 ) shikimate kinase
- ( PF00270 ) DEAD/DEAH box helicase
- ( PF08839 ) DNA replication factor CDT1 like
- ( TIGR00643 ) ATP-dependent DNA helicase RecG
- ( TIGR01389 ) ATP-dependent DNA helicase RecQ
- ( TIGR01587 ) CRISPR-associated helicase Cas3
- ( PF06827 ) Zinc finger found in FPG
- ( PF00271 ) Helicase conserved C-terminal domain
- ( PF04851 ) type III restriction enzyme, res
- ( TIGR03158 ) CRISPR-associated helicase, Cyano-type
- ( TIGR00614 ) ATP-dependent DNA helicase, RecQ family
Gene Expression Profile
- Tetrahymena Functional Genomics Database:
Change in Gene Expression
TMHMM
TMHMM
Signal Peptide
Signal Peptide Present?: No
Presense Probability: 10.4%
TetraMine Data
TTHERM_01030000
WebApollo
Fullscreen View
Tetrahymena Stock Center
No Data fetched for StockID
Homologs (v.2006 protein sequences)
Source Identifier Score Description Tetrahymena borealis EI9_10497.1 9.997093137033517e-262 ATP-dependent DNA helicase, Re
cQ family protein (1193 aa)
Oxytricha Contig17511.0.g63 1.999149254372995e-126 DEAD/DEAH box helicase
DictyBase DDB_G0292130 1.9992982665753866e-121 blm on chromosome: 6 position
1240457 to 1244236
SGD YMR190C 1.0002857351297358e-115 SGS1 Nucleolar DNA helicase of
the RecQ family; involved in
genome integrity maintenance;
regulates chromosome synapsis
and meiotic joint molecule/cro
ssover formation; potential ro
le as repressor of a subset of
rapamycin responsive genes; r
apidly lost in response to rap
amycin in Rrd1p-dependent mann
er; similar to human BLM and W
RN proteins implicated in Bloo
m and Werner syndromes
WormBase WBGene00019334 2.999180586171967e-98 Putative ATP-dependent DNA hel
icase Q1 status:Confirmed
UniProt:Q9TXJ8 protein_id:CC
D61880.1
Stentor Coeruleus SteCoe_28767 2.572209372642415e-56
General Information
No Data fetched for General Information
Associated Literature
- Ref:26519827: Lukaszewicz A, Shodhan A, Loidl J (2015) Exo1 and Mre11 execute meiotic DSB end resection in the protist Tetrahymena. DNA repair 35( ):137-43
- Ref:23935123: Lukaszewicz A, Howard-Till RA, Loidl J (2013) Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex. Nucleic acids research 41(20):9296-309
Sequences
>TTHERM_01030000(coding)
ATGGATGAAATATTGTAGTAATTTATAGATAGCAAAAGATAAGCAAAGAAGATAGAAGAT
TTTGCAGACGCTGTATCATGCAGTGCCACAGAAAGCTTAGAAGATTAGGACTAATCTTTT
GATAGAGGTGCTGATTTCAACGATGGAGAAGTAGATGATGCTTTATTGGATGAACTTATA
GAATATTAAACAAACAGAGAGCGTTAATCAATTACTGAAGAGTAAAATGATCTCATGAAA
ACTGAATTGTAAAAGCCAATAAGCAACAATTTAAATAAAAAATAACCAACTAGCTTGAGC
GGTTTGCAAAAAGGGTTAGGAAACAAAATATCTGGACCTTCTTATGATTTTAGTAACTCT
AATAATATGTAGACATTAAGCGGCATTTATAGTTCAAATTCTAACAATAACTCTTAGAAC
AGCAATGAGAACTTTAATTTCAATAGACAAGGAAATACTACTCTAAAGCCTACGGGTTTT
GATGCTATCAAGCTTAAAAAAAATTAGAATTAAGATTAATAGTAATAATAATAGCAATAG
CAAGTTCTGAAATTTGTAAATTAAAATAGTAATGGAGGGATTTAAGTAGAGGCTTCTTTA
ACAGATAAAAGAAGATAAGTAAATAACTCTAATGATATTGATAGTTTCATGTTGATCAAT
AACGGATAAAAAGAAAAAAAGACAAAAAATTAAAATTCTAAAATAAGTGAGTTGCTTGAG
AAGTACAAAGTGATAGATTCTAATTCAAATACTTAAAATTTCGAGTCTACTTCGCTTAAT
ACTTCTCTCAATACCAAAAATAATAAATTAGAAGTTAAAAATGGGTTTTAAAATTTACCA
CAAAAAACTGAAAAAATAGGGCTTGCAGCCTAAGCTGTAAATCAAAGCTCTAACGTACGT
TCTAATTTTACACCTCCTACAATAGTCAATAGAAATAATTGGACAAATAATTTATCCAAT
GGGCCAGGTAGTGCACTCACTGCATCTTCTACTGCAAAAAAGCAAGCTGACATAAAGGAT
GTTGATTATTCAACCTTAGATTATTTGAATTAACCAGAAAGACCATTTGTTCCTCTTGAA
TCTAAAAATAAAGGAAAACATGTCTCTAAAAGTAACTAATACTACACAGTTGCAGATATT
AATGAATATGCAATAAAACCACATCCTTGGGATCAGAAGGTTAATGATATATTAGCTAAC
GTCTATGGCTATAAAAATTTTAGAAATAATTAAAGAGCAATTATAAATTGTGTCTTGGAG
AATAAAGATGTGTTTGCAATGATGCCCACTGGAGGTGGCAAATCTCTTACATTTTAAATA
CCTGGACTTGTCTAAGATGGAGTTTATATTGTTATTATGCCTCTTATTTCACTTATTTCT
GATTAATACAATCACATGCTTAGGCTCAATATTCCAGTTATCAGAGTTTAAGGAGCTAGG
AAGAACTACTAAAGAGAATTAGATTCAATACTTTATTCAGATAAGAATTAGTCTAAAATT
GTGTTAATCACACCAGAAAAAATATCATCAGATGAAGATTTTAACCAATTTTTAAGCTAA
ATTTATGAAAAAAATAAATTGAGAAGATTTGTTATTGATGAAGCTCACTGTGTTTCTTAA
TGGGGACACGAGTTTAGAAAAGATTATCTTTCTTTAGGATAGTTAAAAATAAAATATCCA
AACATTCCTACACTTGCTCTAACTGCTACAGCTACTGAAAAGTGCAAAATAGATATTATT
TAACTTCTTAATATGAAAGGAACTCTGTATTTTTAATCTTCTTTTAATCGTACAAATCTT
TACTACGATGTAGTAAGGATACCCTAAAAAGTAACAATCGAGCATATGGTTAATTTTATC
AAAGAAAAGTTTAATAAGCAAAGTGGTATTATATATTGCTGCACAAAAAAAGACTCAGAA
GAATTAGCTAGTAAGCTAAATATATAATATAAAATTAATGCAGCATATTATCACGGATCT
ATGAATGACAAAGAAAAAGAATAAGTTCAATAACTTTGGATGTCAAATGATATTTAAGTA
ATATGTGCCACAATAGCTTTTGGTATGGGTATCGACAAGCATGATGTCAGATTTGTCATC
CATTATACTTTTTCTAAATCTATCGAAAATTACTATTAAGAAGCAGGTAGAGCAGGAAGA
GATGGTAAAATATCTCACTGCAGAATTTACTACTCTCCAAAAGATAAAAATTCTTTAGTC
TTTTTGATCACTAATAATGAAGGCAGCAATAAATAGAAAAAAGAAGAATGCATGGCTCAT
TTAAGTAAAATGATAAGATATTGCGAAGATACAATTAATTGTAGAAGGGTTTTGCAATTA
GCACACTTGGGTGAAAAATTTGAACCTAAATTTTGCAATAAAATGTGCGATAACTGCAGA
AATTAAACTTCTAAAAGCAATATAATACAAAAAGATTTTACTTAAGATTGCAAAAATATA
CTATAAGAATATTTGAGTATGTATAATAAAAACATACAGCTGACTTAAAAGCAATTAGTA
GACGTTCTCAGAGGTAAAAAACTACAAAAAAAGGCAGGTTAAAACCTACTTAAAATGATT
GAAAACAGCTCAATCTATAGTCTATTAAAGAATTATGATTAATTAACTGTTGAAAATATT
GTTAAAGAAATGATGTCTTAGGGTTATTTGAGTGAAAAAATTAAAAAGTTTCGTGCTTAT
ACTTAAGTATTTCTTGAAGTAGTTAAGTCTAAGTATAATGAGTTATGTAATCCAAACAAA
ATGACTGACAAAATCATGATCAATTAAGTAGTTTCTCAAAGCTCTAAATCAAAAGTAGAT
AGTCAATTTTTATTTGACAAAGAATTAATTGATGATATTACAGAATCAGATTTACCTAAA
GAGTAAGAATTTTTTGATTAAAATAAAAATCTCATTTTTGATGATGAAGAATCACTATCT
TAAATGTCTGAAGGTGATTTAATAGATTTAATTGATCTTGCAAATAAGAATAAAACTTCT
TGCAACCAAAATGATTCGTCAGATAACATGTAAGAACTAAATAAATAGTATAGCGAAGAT
GATTCAGACTTTTAATTTTAAATACCTTCTGAGAGAAACTAATAAAGTAGAAGTGGGATT
ATTTATGAAGAAAATGATGAATAAAATTAAATTGGTCAAGCATATAGTGAGGATTATAAC
AGTCAAAATAAATAAGCTAATGAAAAACTAAACTAAGAACAGATATAAATTGAAGAGGAT
GATGATGACGATGATGACGACGATGATGATATTTTACAAATAGCAGCTAAAACAAATCTT
TTAGAATAAATAAAAAAATAAAACACGATGAGTGTAGAAAAATAAAATAGTTTGAAAGAA
AATTATCTTTATAAATCTCCTCAAGAATAAGATAATTTCTTTTCTGAATTTAAATTAGGC
AATAATAACAATAAACCTTAAACTTCTTTAGGATAAACAGGTCATAAGCCACCTTAATAA
AACAATTAAAATATGAGCTCATTGAATAATTTTAAATTTTCTACAGGAAACAATAAATTA
AAATAAGACTAAGCTGATCTTTTTTCATTTAACTTTCAAAAACTTGCAAAAAATTGA>TTHERM_01030000(protein)
MDEILQQFIDSKRQAKKIEDFADAVSCSATESLEDQDQSFDRGADFNDGEVDDALLDELI
EYQTNRERQSITEEQNDLMKTELQKPISNNLNKKQPTSLSGLQKGLGNKISGPSYDFSNS
NNMQTLSGIYSSNSNNNSQNSNENFNFNRQGNTTLKPTGFDAIKLKKNQNQDQQQQQQQQ
QVLKFVNQNSNGGIQVEASLTDKRRQVNNSNDIDSFMLINNGQKEKKTKNQNSKISELLE
KYKVIDSNSNTQNFESTSLNTSLNTKNNKLEVKNGFQNLPQKTEKIGLAAQAVNQSSNVR
SNFTPPTIVNRNNWTNNLSNGPGSALTASSTAKKQADIKDVDYSTLDYLNQPERPFVPLE
SKNKGKHVSKSNQYYTVADINEYAIKPHPWDQKVNDILANVYGYKNFRNNQRAIINCVLE
NKDVFAMMPTGGGKSLTFQIPGLVQDGVYIVIMPLISLISDQYNHMLRLNIPVIRVQGAR
KNYQRELDSILYSDKNQSKIVLITPEKISSDEDFNQFLSQIYEKNKLRRFVIDEAHCVSQ
WGHEFRKDYLSLGQLKIKYPNIPTLALTATATEKCKIDIIQLLNMKGTLYFQSSFNRTNL
YYDVVRIPQKVTIEHMVNFIKEKFNKQSGIIYCCTKKDSEELASKLNIQYKINAAYYHGS
MNDKEKEQVQQLWMSNDIQVICATIAFGMGIDKHDVRFVIHYTFSKSIENYYQEAGRAGR
DGKISHCRIYYSPKDKNSLVFLITNNEGSNKQKKEECMAHLSKMIRYCEDTINCRRVLQL
AHLGEKFEPKFCNKMCDNCRNQTSKSNIIQKDFTQDCKNILQEYLSMYNKNIQLTQKQLV
DVLRGKKLQKKAGQNLLKMIENSSIYSLLKNYDQLTVENIVKEMMSQGYLSEKIKKFRAY
TQVFLEVVKSKYNELCNPNKMTDKIMINQVVSQSSKSKVDSQFLFDKELIDDITESDLPK
EQEFFDQNKNLIFDDEESLSQMSEGDLIDLIDLANKNKTSCNQNDSSDNMQELNKQYSED
DSDFQFQIPSERNQQSRSGIIYEENDEQNQIGQAYSEDYNSQNKQANEKLNQEQIQIEED
DDDDDDDDDDILQIAAKTNLLEQIKKQNTMSVEKQNSLKENYLYKSPQEQDNFFSEFKLG
NNNNKPQTSLGQTGHKPPQQNNQNMSSLNNFKFSTGNNKLKQDQADLFSFNFQKLAKN>TTHERM_01030000(gene)
ATGGATGAAATATTGTAGTAATTTATAGATAGCAAAAGATAAGCAAAGAAGATAGAAGAT
TTTGCAGACGCTGTATCATGCAGTGCCACAGAAAGCTTAGAAGATTAGGACTAATCTTTT
GATAGAGGTGCTGATTTCAACGATGGAGAAGTAGATGATGCTTTATTGGATGAACTTATA
GAATATTAAACAAACAGAGAGCGTTAATCAATTACTGAAGAGTAAAATGATCTCATGAAA
ACTGAATTGTAAAAGCCAATAAGCAACAATTTAAATAAAAAATAACCAACTAGCTTGAGC
GGTTTGCAAAAAGGGTTAGGAAACAAAATATCTGGACCTTCTTATGATTTTAGTAACTCT
AATAATATGTAGACATTAAGCGGCATTTATAGTTCAAATTCTAACAATAACTCTTAGAAC
AGCAATGAGAACTTTAATGTAAAATATTTTATAAAAATCAAAATTAATTTAAATGCATAA
AAATAAAATAAAAAAGTTCAATAGACAAGGAAATACTACTCTAAAGCCTACGGGTTTTGA
TGCTATCAAGCTTAAAAAAAATTAGAATTAAGATTAATAGTAATAATAATAGCAATAGCA
AGTTCTGAAATTTGTAAATTAAAATAGTAATGGAGGGATTTAAGTAGAGGCTTCTTTAAC
AGATAAAAGAAGATAAGTAAATAACTCTAATGATATTGATAGTTTCATGTTGATCAATAA
CGGATAAAAAGAAAAAAAGACAAAAAATTAAAATTCTAAAATAAGTGAGTTGCTTGAGAA
GTACAAAGTGATAGATTCTAATTCAAATACTTAAAATTTCGAGTCTACTTCGCTTAATAC
TTCTCTCAATACCAAAAATAATAAATTAGAAGTTAAAAATGGGTTTTAAAATTTACCACA
AAAAACTGAAAAAATAGGGCTTGCAGCCTAAGCTGTAAATCAAAGCTCTAACGTACGTTC
TAATTTTACACCTCCTACAATAGTCAATAGAAATAATTGGACAAATAATTTATCCAATGG
GCCAGGTAGTGCACTCACTGCATCTTCTACTGCAAAAAAGCAAGCTGACATAAAGGATGT
TGATTATTCAACCTTAGATTATTTGAATTAACCAGAAAGACCATTTGTTCCTCTTGAATC
TAAAAATAAAGGAAAACATGTCTCTAAAAGTAACTAATACTACACAGTTGCAGATATTAA
TGAATATGTAAAATAATTTATTACAATTTCAGAAAAAAATTAACATTATTCTAATTAATT
CGATGAAGAAATAATTAAATTTATTTATTTTAATATTTTAATATTTTCTTTTTCCTCATC
AAAGAAAATTAAAAATATTTATTGATTAAAATGATTTATTTAATTTTCAAATATAAAAGG
CAATAAAACCACATCCTTGGGATCAGAAGGTTAATGATATATTAGCTAACGTCTATGGCT
ATAAAAATTTTAGAAATAATTAAAGAGCAATTATAAATTGTGTCTTGGAGAATAAAGATG
TGTTTGCAATGATGCCCACTGGAGGTGGCAAATCTCTTACATTTTAAATACCTGGACTTG
TCTAAGATGGAGTTTATATTGTTATTATGCCTCTTATTTCACTTATTTCTGATTAATACA
ATCACATGCTTAGGCTCAATATTCCAGTTATCAGAGTTTAAGGAGCTAGGAAGAACTACT
AAAGAGAATTAGATTCAATACTTTATTCAGATAAGAATTAGTCTAAAATTGTGTTAATCA
CACCAGAAAAAATATCATCAGATGAAGATTTTAACCAATTTTTAAGCTAAATTTATGAAA
AAAATAAATTGAGAAGATTTGTTATTGATGAAGCTCACTGTGTTTCTTAATGGGGACACG
AGTTTAGAAAAGATTATCTTTCTTTAGGATAGTTAAAAATAAAATATCCAAACATTCCTA
CACTTGCTCTAACTGCTACAGCTACTGAAAAGTGCAAAATAGATATTATTTAACTTCTTA
ATATGAAAGGAACTCTGTATTTTTAATCTTCTTTTAATCGTACAAATCTTTACTACGATG
TAGTAAGGATACCCTAAAAAGTAACAATCGAGCATATGGTTAATTTTATCAAAGGTAAAT
AAATCATAATTATTATTTTTCTTTATTTTAGCTAAAAAATTTTACTATTTTACAGAAAAG
TTTAATAAGCAAAGTGGTATTATATATTGCTGCACAAAAAAAGACTCAGAAGAATTAGCT
AGTAAGCTAAATATATAATATAAAATTAATGCAGCATATTATCACGGATCTATGAATGAC
AAAGAAAAAGAATAAGTTCAATAACTTTGGATGTCAAATGATATTTAAGTAATATGTGCC
ACAATAGGTAATAAAATTAGAAATAATTTAATTTGATTATTAAAAATTTTCAAATATATA
TAGCTTTTGGTATGGGTATCGACAAGCATGATGTCAGATTTGTCATCCATTATACTTTTT
CTAAATCTATCGAAAATTACTATTAAGAAGCAGGTAGAGCAGGAAGAGATGGTAAAATAT
CTCACTGCAGAATTTACTACTCTCCAAAAGATAAAAATTCTTTAGTCTTTTTGATCACTA
ATAATGAAGGCAGCAATAAATAGAAAAAAGAAGAATGCATGGCTCATTTAAGTAAAATGA
TAAGGTAAAATCTCTTTTATAACCAAAACCAATATTTATTAAATATTTAAGAATTAATTT
TACATATATATTTATTTTTTAAATTAAAAGTTTAAAATTAAATTTAGTAATTATTAAGTT
TTACAATATATATTGAATATTTATATATAGATATTGCGAAGATACAATTAATTGTAGAAG
GGTTTTGCAATTAGCACACTTGGGTGAAAAATTTGAACCTAAATTTTGCAATAAAATGTG
CGATAACTGCAGAAATTAAACTTCTAAAAGCAATATAATACAAAAAGATTTTACTTAAGA
TTGCAAAAATATACTATAAGAATATTTGAGTATGTATAATAAAAACATACAGCTGACTTA
AAAGCAATTAGTAGACGTTCTCAGAGGTAAAAAACTACAAAAAAAGGCAGGTTAAAACCT
ACTTAAAATGATTGAAAACAGCTCAATCTATAGTCTATTAAAGAATTATGATTAATTAAC
TGTTGAAAATATTGTTAAAGAAATGATGTCTTAGGGTTATTTGAGTGAAAAAATTAAAAA
GTTTCGTGCTTATACTTAAGTATTTCTTGAAGTAGTTAAGTCTAAGTATAATGAGTTATG
TAATCCAAACAAAATGACTGACAAAATCATGATCAATTAAGTAGTTTCTCAAAGCTCTAA
ATCAAAAGTAGATAGTCAATTTTTATTTGACAAAGAATTAATTGATGATATTACAGAATC
AGATTTACCTAAAGAGTAAGAATTTTTTGATTAAAATAAAAATCTCATTTTTGATGATGA
AGAATCACTATCTTAAATGTCTGAAGGTGATTTAATAGATTTAATTGATCTTGCAAATAA
GAATAAAACTTCTTGCAACCAAAATGATTCGTCAGATAACATGTAAGAACTAAATAAATA
GTATAGCGAAGATGATTCAGACTTTTAATTTTAAATACCTTCTGAGAGAAACTAATAAAG
TAGAAGTGGGATTATTTATGAAGAAAATGATGAATAAAATTAAATTGGTCAAGCATATAG
TGAGGATTATAACAGTCAAAATAAATAAGCTAATGAAAAACTAAACTAAGAACAGATATA
AATTGAAGAGGATGATGATGACGATGATGACGACGATGATGATATTTTACAAATAGCAGC
TAAAACAAATCTTTTAGAATAAATAAAAAAATAAAACACGATGAGTGTAGAAAAATAAAA
TAGTTTGAAAGAAAATTATCTTTATAAATCTCCTCAAGAATAAGATAATTTCTTTTCTGA
ATTTAAATTAGGCAATAATAACAATAAACCTTAAACTTCTTTAGGATAAACAGGTCATAA
GCCACCTTAATAAAACAATTAAAATATGAGCTCATTGAATAATTTTAAATTTTCTACAGG
AAACAATAAATTAAAATAAGACTAAGCTGATCTTTTTTCATTTAACTTTCAAAAACTTGC
AAAAAATTGA
