Identifiers and Description

Gene Model Identifier

TTHERM_00434040

Standard Name

RPS12 (Ribosomal Protein of the Small subunit )

Aliases

PreTt26545 | 48.m00308 | ribosomal protein S12 | S25 | 3831.m01641 | RPS23

Description

Homolog of yeast RPS23, human RPS23 and bacterial RPS12; small (40S) ribosomal subunit protein with sequence similarity to E.coli ribosomal protein S12

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• cytosolic small ribosomal subunit (sensu Eukaryota) (ISS) | GO:0005843 | Ref:8496146
• ribosome (IEA) | GO:0005840
• intracellular (IEA) | GO:0005622

Molecular Function

• structural constituent of ribosome (ISS) | GO:0003735 | Ref:8496146
• structural constituent of ribosome (IEA) | GO:0003735

Biological Process

• translation (IEA) | GO:0006412
• translation (ISS) | GO:0006412 | Ref:8496146

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.8%

TetraMine Data

TTHERM_00434040

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_04231.1	2.999180586171967e-98	ribosomal protein S25 (143 aa)
WormBase	WBGene00004492	3.0012565309061457e-65	locus:rps-23 40S ribosomal p rotein S23 status:Confirmed UniProt:Q19877 protein_id: CAA94601.1
SGD	YPR132W	3.9989468726312675e-65	RPS23B Ribosomal protein 28 (r p28) of the small (40S) riboso mal subunit, required for tran slational accuracy; nearly ide ntical to Rps23Ap and similar to E. coli S12 and rat S23 rib osomal proteins; deletion of b oth RPS23A and RPS23B is letha l
Oxytricha	Contig12890.0.g103	6.000608367221491e-63	Ribosomal protein S12
DictyBase	DDB_G0272250	2.9997246065828143e-59	rps23 on chromosome: 2 positio n 1373618 to 1374599
Stentor Coeruleus	SteCoe_33685	5.380186160021138e-32

General Information

No Data fetched for General Information

Associated Literature

1. Ref:21205638: Rabl J, Leibundgut M, Ataide SF, Haag A, Ban N (2011) Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1. Science (New York, N.Y.) 331(6018):730-6
2. Ref:8496146: Alksne LE, Warner JR (1993) A novel cloning strategy reveals the gene for the yeast homologue to Escherichia coli ribosomal protein S12. The Journal of biological chemistry 268(15):10813-9
3. Ref:8415737: Alksne LE, Anthony RA, Liebman SW, Warner JR (1993) An accuracy center in the ribosome conserved over 2 billion years. Proceedings of the National Academy of Sciences of the United States of America 90(20):9538-41
4. Ref:1459144: Nørgaard P, Dreisig H, Kristiansen K (1992) Chromatin structure and conserved sequence elements in genes encoding ribosomal proteins in Tetrahymena thermophila. European journal of biochemistry 210(2):621-7
5. Ref:16453715: Nielsen H, Andreasen PH, Dreisig H, Kristiansen K, Engberg J (1986) An intron in a ribosomal protein gene from Tetrahymena. The EMBO journal 5(10):2711-7

Sequences

>TTHERM_00434040(coding)
ATGGGTGTTGGTAAACCTAGAGGTATTAGAGCCGGTAGAAAATTGGCTAGACACAGAAAG
GACCAAAGATGGGCTGATAACGATTTCAACAAGAGACTTTTGGGCTCCAGATGGAGAAAT
CCTTTTATGGGTGCTTCTCACGCTAAGGGTTTAGTCACTGAAAAGATCGGTATTGAATCT
AAGCAACCTAACTCTGCCGTCAGAAAGTGTGTTAGAGTTTTGCTCAGAAAGAACTCCAAG
AAGATCGCTGCTTTCGTTCCTATGGATGGTTGCCTTAACTTCTTAGCTGAAAACGACGAA
GTCTTGGTTGCTGGTCTTGGTAGACAAGGTCACGCCGTCGGTGATATTCCGGGTGTTAGA
TTCAAAGTTGTTTGTGTCAAGGGTATTTCTCTCTTGGCTCTTTTCAAGGGTAAGAAGGAA
AAGCGTTGA

>TTHERM_00434040(protein)
MGVGKPRGIRAGRKLARHRKDQRWADNDFNKRLLGSRWRNPFMGASHAKGLVTEKIGIES
KQPNSAVRKCVRVLLRKNSKKIAAFVPMDGCLNFLAENDEVLVAGLGRQGHAVGDIPGVR
FKVVCVKGISLLALFKGKKEKR

>TTHERM_00434040(gene)
ATGGGTGTTGGTAAACCTAGAGGTATTAGAGCCGGTAGAAAATTGGCTAGACACAGAAAG
GACCAAAGGTGAAATATTTTTTTAATAACAATCAATCTACAGCAAGCATGAATCTGAGGA
GTGTTGCATCAAAGCTATAGCAATCCTTCTCTTTATTTTTCAAAACGCTCTCAAATGAAT
GATAAATCAATTACAAATCCATTCCATTACATTCCCCAATTTTGACAAACATTTAAAAAT
TATTTTTATTCATTCTCATCAATTTTGTTAAATGCATCTAATTAATGTCTTCAACCAACA
ATTCTACTAAGATATAATCGTTTCTCTGCGCTTAGTTTGCTTTATCCTTCTTACGGACCT
ATTGAAAATATTTTGTATATAGCTCAAAAAGCCAAATAATCTTTAATAAATAAAAGCAGA
CAGATTTTGTTTTATTTTTTGAGTTAGAATCTGAATTCTAAAGTTTCTAGCTAACTTTCA
ATCAACAAAGCTGTTGCAAAGATTTAAGAAATAGAATAAAAAGCAAACCCCTAAATTAGA
TTATTTGAAATAATTAGGTTTTTATCTAGAATGATTGATTGAAATTCTCAGATTGAATAT
TAATCGATCAAATTACAAAAATTATGAACTATATATAAAATAGAAGTTAAATAGAGGAGA
CTATGTATAACAAAAGCAGCAATAAATAAATAAATGAACAAATGGTTTGATAAAGCATTT
AGTAAAATTAAAGAGCATTAACGCTTTATAACGAATTTGAAAAATGAATGTTTAAAAATG
AATAATAAATAGGTTTGTTGTTTGTAATTTCCAAATAAATTTTACTTGAAATTTTTGTCT
TTTGAAAGAAAGATCTCAACTAACTTTAACAAGCATATAAACTAATAAAGATTTTTGCTT
AATTTATTTCGAAGGATGGATGGATATAAAAATATCATCTTAAAAGATAAGCGGATATGA
AAACATAAACAAATTAATAAAAAAATAAATGATTGCTTGCCATTATTCTCTTCCTCTCAA
AATAAATTTATTAAATTCAATTTTAAATAAAAAGATGGGCTGATAACGATTTCAACAAGA
GACTTTTGGGCTCCAGATGGAGAAATCCTTTTATGGGTGCTTCTCACGCTAAGGGTTTAG
TCACTGAAAAGATCGGTATTGAATCTAAGCAACCTAACTCTGCCGTCAGAAAGTGTGTTA
GAGTTTTGCTCAGAAAGAACTCCAAGAAGATCGCTGCTTTCGTTCCTATGGATGGTTGCC
TTAACTTCTTAGCTGAAAACGACGAAGTCTTGGTTGCTGGTCTTGGTAGACAAGGTCACG
CCGTCGGTGATATTCCGGGTGTTAGATTCAAAGTTGTTTGTGTCAAGGGTATTTCTCTCT
TGGCTCTTTTCAAGGGTAAGAAGGAAAAGCGTTGA