Identifiers and Description

Gene Model Identifier

TTHERM_00106890

Standard Name

RFA1 (Homolog of budding yeast RFA1 and mouse RPA1)

Aliases

PreTt23083 | 7.m00532

Description

Encodes Replication Protein A (RPA). Protein involved in recombination and DNA repair

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Biological Process

• DNA recombination (ISA) | GO:0006310 | Ref:18522989
• DNA repair (ISA) | GO:0006281 | Ref:18522989

Domains

• ( PF07656 ) KWG Leptospira
• ( PF07975 ) TFIIH C1-like domain
• ( PF01336 ) OB-fold nucleic acid binding domain
• ( PF08646 ) Replication factor-A C terminal domain
• ( TIGR00617 ) replication factor-a protein 1 (rpa1)
• ( PF04057 ) Replication factor-A protein 1, N-terminal

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.9%

TetraMine Data

TTHERM_00106890

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_00409.1	9.997093137033517e-262	hypothetical protein (659 aa)
Oxytricha	Contig5713.0.g13	4.000054831110256e-33	Replication factor-A C termina l domain
SGD	YAR007C	6.001249495680822e-29	RFA1 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved si ngle-stranded DNA binding prot ein involved in DNA replicatio n, repair, and recombination
WormBase	WBGene00017546	1.9993007828132465e-27	locus:rpa-1 Probable replica tion factor A 73 kDa subunit status:Confirmed UniProt:Q1 9537 protein_id:CCD62042.1
DictyBase	DDB_G0289513	0.0000000000599805963605737	rfa1 on chromosome: 5 position 2891660 to 2893699
Stentor Coeruleus	SteCoe_15423	0.0000000001026187963170189

General Information

No Data fetched for General Information

Associated Literature

1. Ref:20363756: Min B, Collins K (2010) Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme. The Journal of biological chemistry 285(22):16434-43

Sequences

>TTHERM_00106890(coding)
ATGGTTACTCAATTAACAAAAAATGCTATTGATTCTCTAATAAATAGCACTAATCCTGAT
GAATAGTATGTTATTCAAGTTTTAAAAGCTCCTCAATCTGTTGCTGAAAATCTTTTCAAG
ATTTGCATTTCTGATGGCTTTTGCAAATTCAAGAAAGGATATTTCGTTAGTGATGCTGCT
ACCAAATGCCAAGATTTGAAGGATCTCTGTATTATCAAATGCAAAAAATATATTGATGAC
TCAAACCACGATAAGGAAAGAATTATTATCTCTAACTACGAATTAATATATTCTAATATC
TAAGAGCAAATTGGAAAACCAATCGAATACAAATAATACAAGTCAAGTGGATTCTCTAAT
CCAGAAGGATCAACTGTAATTCCCTCATAATACTTGAGCAGAAACGCTTAAATACTTCAA
TAAAATTAAGTTTCTTAACCTAAGCAAATGGTAACTCCTCCAGTTAGCAACATAAATAAG
CCTACTCCTGCTGTAAATAACACATTTGCTTAAAAACCAGCAGTTACAAACTAAAACATT
TAAAGAGTAAACTAGAATCCATAACAAATGAACAAAACTGCACCTGTAAAGCAAAATAAT
AATAATAACAATAATAACAATGGCAACAACAAAAATAATTCTAGTTTGTAGATTTCTACT
GATGGAGATGAGTAAAATTTGGAATACATTAGAAACTTATAGCCAAATGGTTAACCATAA
ACAATCAAAGTTAGAATCACCAAAAAGGGTGATTTGAAAAGCTTTAAGGAAAAGTAAGGA
AAACTCTTTTCAATAGATGTTATTGATAAGTTTGGAGACGAATGTAGTATTTCTTTCTTC
AACGAAATAGCTGAATAGTATGATGGCTTATTTAAAGTAGGTTAAGTTATAGTCTTGAAA
TAATTTTCAGTGAAAGTCAACAATAATCATCAATACAATAAGGGAGATCACACTGTAACT
GTCAATAAAGAGAGTAAAATATTGATATGTCAAGAAGATCCATCTATTCCTATGATCAAA
TTAAATAGATAATTCATTTAAGATATGTAGAATAAATAGAAAGGAGATTTAATCGATTTG
ATTGTTGTTGTAAAGGCAGACACAGAAGTTAAAACCATGATCTTAAAGAAAGATAATTAA
TAATAATCTAAAAGAGACATAATATCATTTGATGAATCTCTAATTGAAACAGAAATCACA
CTCTGGGGAGAAACTGCTAAAGACTATGATGCAAAGTAGGGAGATATCATTGTATTTAAA
GATGCCAAAATAGGTGAATTTAAAGATAAAAAGTAAATTAATATCGGATATGGAACATAA
ATCTTCATGAATCCAGATGAATAACTCTTCCCATAGATCCATGATGTCAAAAAATGGTAC
CTAAGCTTAAATTCCGACTAATTAAGCACTATTCAAAAGGCATAAGGAAATGATACTGGT
CCTAGAGAAGTAACTAGCTTTGAATCTTCTCTAAACATTTTGAAAGAAGAAATTAAAAAC
CTTTAAACTGACCCAGAAATGAAAATTTGGAAAGAAATTCGTGGTTAAATTATGTACATT
AAAGATACTCCTCTTTATTATAATGCTTGTTTTAGTTGCAAAAAGAAAATCGCACGTAAT
AACGAAGTATGGACTTGCATAAATTGCAATAAAGATTTTAATGAACCTGACTCTAGATAT
ATTCTCTCCCTCAATATAAGTGACTCTACAGATACTATTTGGGTAAGTGCATTCGATGAA
GTAGGTCAAAAAATTCTTGGTAAATTTATTTTTTAAAAGTTAAACTAAGTTAATTTATTT
TTATCATATTTAATTAACTTATTAATTAAACAGGTGTTAAGGGTGATGTATTTAGATATG
CTGATGAAGATACAGAACACGGTACAGAAACAAAAAAGAAATTGCTTATGGCTGCCTAAA
ATAAGGAATATAGATTCCTGTTACTTACTAAATAAGAAAGAGACTAAAATGGCAACGCCA
GAGATAAGACAGTTATTCATGCTATAAAAGACTTTTAACCTGCTTATGAGGCCAAAAAGA
TCATCAATTCTTTGGAGAAATTTATGGTGA

>TTHERM_00106890(protein)
MVTQLTKNAIDSLINSTNPDEQYVIQVLKAPQSVAENLFKICISDGFCKFKKGYFVSDAA
TKCQDLKDLCIIKCKKYIDDSNHDKERIIISNYELIYSNIQEQIGKPIEYKQYKSSGFSN
PEGSTVIPSQYLSRNAQILQQNQVSQPKQMVTPPVSNINKPTPAVNNTFAQKPAVTNQNI
QRVNQNPQQMNKTAPVKQNNNNNNNNNGNNKNNSSLQISTDGDEQNLEYIRNLQPNGQPQ
TIKVRITKKGDLKSFKEKQGKLFSIDVIDKFGDECSISFFNEIAEQYDGLFKVGQVIVLK
QFSVKVNNNHQYNKGDHTVTVNKESKILICQEDPSIPMIKLNRQFIQDMQNKQKGDLIDL
IVVVKADTEVKTMILKKDNQQQSKRDIISFDESLIETEITLWGETAKDYDAKQGDIIVFK
DAKIGEFKDKKQINIGYGTQIFMNPDEQLFPQIHDVKKWYLSLNSDQLSTIQKAQGNDTG
PREVTSFESSLNILKEEIKNLQTDPEMKIWKEIRGQIMYIKDTPLYYNACFSCKKKIARN
NEVWTCINCNKDFNEPDSRYILSLNISDSTDTIWVSAFDEVGQKILGKFIFQKLNQVNLF
LSYLINLLIKQVLRVMYLDMLMKIQNTVQKQKRNCLWLPKIRNIDSCYLLNKKETKMATP
EIRQLFMLQKTFNLLMRPKRSSILWRNLW

>TTHERM_00106890(gene)
ATGGTTACTCAATTAACAAAAAATGCTATTGATTCTCTAATAAATAGCACTAATCCTGAT
GAATAGTATGTTATTCAAGTTTTAAAAGCTCCTCAATCTGTTGCTGAAAATCTTTTCAAG
TAATTTAATTGATTGATCGATTGAAAAAAACTAATTTTATTCATTTCTTTTTTTTGTTGA
CAAATAGGATTTGCATTTCTGATGGCTTTTGCAAATTCAAGAAAGGATATTTCGTTAGTG
ATGCTGCTACCAAATGCCAAGATTGTAATTAATTTTTCTTAATTTTTTGTGAAGAATTGT
ATATGGAAAAGTACTATCATTTTTAACTCTACTTTAATAATTTAATAGTGAAGGATCTCT
GTATTATCAAATGCAAAAAATATATTGATGACTCAAACCACGATAAGGAAAGAATTATTA
TCTCTAACTACGAATTAATATATTCTAATATCTAAGAGCAAATTGGAAAACCAATCGAAT
ACAAATAATACAAGTCAAGTGTAATAAAATATTTCTAAAGTTCTATATAATTTATTTTAT
TCTTTGCTACTTGATCAAAAATGCTCTTTAAAGGGAGTTTTCAAGATATGGCAAAAAAAT
AAAAATATGTTCTTGAAAATTAATAATTTTTAAATTAAATATAAAAGGGATTCTCTAATC
CAGAAGGATCAACTGTAATTCCCTCATAATACTTGAGCAGAAACGCTTAAATACTTCAAT
AAAATTAAGTTTCTTAACCTAAGCAAATGGTAACTCCTCCAGTTAGCAACATAAATAAGC
CTACTCCTGCTGTAAATAACACATTTGCTTAAAAACCAGCAGTTACAAACTAAAACATTT
AAAGAGTAAACTAGAATCCATAACAAATGAACAAAACTGCACCTGTAAAGCAAAATAATA
ATAATAACAATAATAACAATGGCAACAACAAAAATAATTCTAGTTTGTAGATTTCTACTG
ATGGAGATGAGTAAAATTTGGAATACATTAGAAACTTATAGCCAAATGGTTAACCATAAA
CAATCAAAGTTAGAATCACCAAAAAGGGTGATTTGAAAAGCTTTAAGGAAAAGTAAGGAA
AACTCTTTTCAATAGATGTTATTGATAAGTTTGGAGACGAATGTAGTATTTCTTTCTTCA
ACGAAATAGCTGAATAGTATGATGGCTTATTTAAAGTAGGTTAAGTTATAGTCTTGAAAT
AATTTTCAGTGAAAGTCAACAATAATCATCAATAGTAAATTAATTTATTTAAGTTTTAGC
AATTACTATTACATAATATTTAATAAATAGCAATAAGGGAGATCACACTGTAACTGTCAA
TAAAGAGAGTAAAATATTGATATGTCAAGAAGATCCATCTATTCCTATGATCAAATTAAA
TAGATAATTCATTTAAGATATGTAGAATAAATAGAAAGGAGATTTAATCGATTTGATTGT
TGTTGTAAAGGCAGACACAGAAGTTAAAACCATGATCTTAAAGAAAGATAATTAATAATA
ATCTAAAAGAGACATAATATCATTTGATGAATCTCTAATTGAAACAGAAATCACACTCTG
GGGAGAAACTGCTAAAGACTATGATGCAAAGTAGGGAGATATCATTGTATTTAAAGATGC
CAAAATAGGTGAATTTAAAGATAAAAAGTAAATTAATATCGGATATGGAACATAAATCTT
CATGAATCCAGATGAATAACTCTTCCCATAGATCCATGATGTCAAAAAATGGTACCTAAG
CTTAAATTCCGACTAATTAAGCACTATTCAAAAGGCATAAGGAAATGATACTGGTCCTAG
AGAAGTAACTAGCTTTGAATCTTCTCTAAACATTTTGAAAGAAGAAATTAAAAACCTTTA
AACTGACCCAGAAATGAAAATTTGGAAAGAAATTCGTGGTTAAATTATGTACATTAAAGA
TACTCCTCTTTATTATAATGCTTGTTTTAGTTGCAAAAAGAAAATCGCACGTAATAACGA
AGTATGGACTTGCATAAATTGCAATAAAGATTTTAATGAAGTAATATTTTTTCTTATTCA
TCTTTAAAATTTTAGTTAATAAAATTAATTTTATTAAAATATAATTGAATTTATTTTAAA
TAATAATTTTATTAGCCTGACTCTAGATATATTCTCTCCCTCAATATAAGTGACTCTACA
GATACTATTTGGGTAAGTGCATTCGATGAAGTAGGTCAAAAAATTCTTGGTAAATTTATT
TTTTAAAAGTTAAACTAAGTTAATTTATTTTTATCATATTTAATTAACTTATTAATTAAA
CAGGTGTTAAGGGTGATGTATTTAGATATGCTGATGAAGATACAGAACACGGTACAGAAA
CAAAAAAGAAATTGCTTATGGCTGCCTAAAATAAGGAATATAGATTCCTGTTACTTACTA
AATAAGAAAGAGACTAAAATGGCAACGCCAGAGATAAGACAGTTATTCATGCTATAAAAG
ACTTTTAACCTGCTTATGAGGCCAAAAAGATCATCAATTCTTTGGAGAAATTTATGGTGA