Identifiers and Description

Gene Model Identifier

TTHERM_00094000

Standard Name

RDN2 (Rdr1-associated nucleotidyltransferase)

Aliases

PreTt16555 | 6.m00629 | 3836.m02213

Description

exhibits RNA terminal uridine transferase activity in vitro; involved in 23-24 nt small RNA metabolism

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

• ( PF03828 ) PAP/25A associated domain
• ( PF01909 ) Nucleotidyltransferase domain

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 9.6%

TetraMine Data

TTHERM_00094000

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_02566.1	2.0004485223439647e-69	hypothetical protein (538 aa)
DictyBase	DDB_G0268914	0.00000000000009996062864481225	DDB_G0268914 on chromosome: 1 position 2371552 to 2385174
Oxytricha	Contig10883.0.g40	0.000000000004997916451710233	Nucleotidyltransferase domain
WormBase	WBGene00001596	0.0000000039998859049333245	locus:gld-2 Poly(A) RNA poly merase gld-2 status:Confirme d UniProt:O17087 protein_i d:CCD72661.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:22706992: Talsky KB, Collins K (2012) Strand-asymmetric endogenous Tetrahymena small RNA production requires a previously uncharacterized uridylyltransferase protein partner. RNA (New York, N.Y.) 18(8):1553-62
2. Ref:20622019: Talsky KB, Collins K (2010) Initiation by a eukaryotic RNA-dependent RNA polymerase requires looping of the template end and is influenced by the template-tailing activity of an associated uridyltransferase. The Journal of biological chemistry 285(36):27614-23
3. Ref:19656801: Couvillion MT, Lee SR, Hogstad B, Malone CD, Tonkin LA, Sachidanandam R, Hannon GJ, Collins K (2009) Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila. Genes & development 23(17):2016-32
4. Ref:19451546: Lee SR, Talsky KB, Collins K (2009) A single RNA-dependent RNA polymerase assembles with mutually exclusive nucleotidyl transferase subunits to direct different pathways of small RNA biogenesis. RNA (New York, N.Y.) 15(7):1363-74

Sequences

>TTHERM_00094000(coding)
ATGGAAGGCGATTTCTTTTAGCAAACATTTCTAAAATATATAAAGTATAGACCAAGCAAG
AATATAAATGTGCATTAGTATTTATTGAAGAAATTAGAAGTTGAGTAATTAAGTTAAAGT
TAATTATTAAGCTTAAAAAATAGTTTAGATGATTTTATTCGTAAATATAATTTTCATAAT
GATGAATGGATTCTAATTAGTCTAATTGAAAATTTAGCACATTCAGACTTATTATTTTCA
AGCGATACTGAAAAATATATTTTAATTATTAAGAAAAGATTCTACCTCAATTTACTGAAT
AAACTTGAGAATAATATTTCAAGTAAATTTGATCTTTAGGAGCTCTAGAAGTGTTTAAAG
TCATTTTACTTAAGCTATAAAAATAATGTTTATGATTTGTTTTTAAATGCTTCAAATGAT
ATTTAAATAATAAAGTAGATAGATAGCAACCTAGGAGAAAAATTAAAAAAAATTGAAAAG
CATGTATCTGAGATTTTAAAGAGGCTTAAAAGTAATGAATCGTAGTAAATGTCTATTAAT
TAGAATGAGTAGAACATCTAATAAAATAAAGAAAATATTAATGAAATAACCAGTAGCAAT
TAATTAGAAATTTTATTAAATTAAATTTATAAGTAAGAAAAGATCAGTATTTAGTTTAAT
GAAGAATTACTTAATCAAGAAGTCAATATGGTAAATTAAATTGTGAGTGAGATGAATTTA
AATAAAATTATTGGGCTATAAAATGTGTATGTTCATCCGTATGGGTCAGTTGTTAGTGGG
TTTGGTTAGAATGATAGTGACATTGATATAAGCATAAATACAGATTGCTATTTAGATGAA
AGAGTATTTCTTTCTCTTATTTATGATTTCATGAAAAATTATTTGCATAAATATAAAATC
AAATATTAAAAACTTGAATTAAAATTAGATGCGCGTATTCCTTTAATAACTCTTGTTAAA
CAGAAAGATAATGTTAATTTGAAAAGTAATACAGTTTCAATAGACATATGTATAAATAAT
CTACTAGGATGCGCAAATTCAAAAATGCTAAAAGTTATATCTTAGATTCATCCCTTAGTA
AAGTAGCTAGGAATAATCATTAAATATTGGGCGAAGTAGAATGGTCTTATAAGCAAAAAA
ACTCTTAGTTCATATGCATTTATCCTCATAATGATCTGCTTTTTATAGAGAAAGAAGCTA
ATTGATCCTTATTTTTAAGAGAAAGTTTAAAAAAGATAAAGTGATCCAAAATATTCTACT
TTGATTAAGAGGACAAAGGAAACTGATTAGGAATTTTAAACAAACCTTTATTATGTGCAA
GATCCCTCGCATTTACAGAAATCTCTAAAAAAGTATAAAGAAAACAATCCAAACTAAAAA
ACTTTATTAGACATGAATCTTGCAAGCTTATTCAGTGAGTTTATTGAATATTACTCAGAC
ACCACTGATGAGAATAGAAGATATATAGATATTATGAATAATTATATAGTAAAATCATAT
AATAAAAATTTATTCTTTTATATTATTGACCCATTTGATAATTATCATAACCCAGGAGAA
AGAAGCAGAGTAGAGAATATAGATGATAACATATTTATAAATAGATTTAGGTTTGCTAAG
TAAAAATTGCAAGACAAACAATATTCGCAAATATTTGAATTAAAATTTCAATGA

>TTHERM_00094000(protein)
MEGDFFQQTFLKYIKYRPSKNINVHQYLLKKLEVEQLSQSQLLSLKNSLDDFIRKYNFHN
DEWILISLIENLAHSDLLFSSDTEKYILIIKKRFYLNLLNKLENNISSKFDLQELQKCLK
SFYLSYKNNVYDLFLNASNDIQIIKQIDSNLGEKLKKIEKHVSEILKRLKSNESQQMSIN
QNEQNIQQNKENINEITSSNQLEILLNQIYKQEKISIQFNEELLNQEVNMVNQIVSEMNL
NKIIGLQNVYVHPYGSVVSGFGQNDSDIDISINTDCYLDERVFLSLIYDFMKNYLHKYKI
KYQKLELKLDARIPLITLVKQKDNVNLKSNTVSIDICINNLLGCANSKMLKVISQIHPLV
KQLGIIIKYWAKQNGLISKKTLSSYAFILIMICFLQRKKLIDPYFQEKVQKRQSDPKYST
LIKRTKETDQEFQTNLYYVQDPSHLQKSLKKYKENNPNQKTLLDMNLASLFSEFIEYYSD
TTDENRRYIDIMNNYIVKSYNKNLFFYIIDPFDNYHNPGERSRVENIDDNIFINRFRFAK
QKLQDKQYSQIFELKFQ

>TTHERM_00094000(gene)
ATGGAAGGCGATTTCTTTTAGCAAACATTTCTAAAATATATAAAGTATAGACCAAGCAAG
AATATAAATGTGCATTAGTATTTATTGAAGAAATTAGAAGTTGAGTAATTAAGTTAAAGT
TAATTATTAAGCTTAAAAAATAGTTTAGATGATTTTATTCGTAAATATAATTTTCATAAT
GATGAATGGATTCTAATTAGTCTAATTGAAAATTTAGCACATTCAGACTTATTATTTTCA
AGCGATACTGAAAAATATATTTTAATTATTAAGAAAAGATTCTACCTCAATTTACTGAAT
AAACTTGAGAATAATATTTCAAGTAAATTTGATCTTTAGGAGCTCTAGAAGTGTTTAAAG
TCATTTTACTTAAGCTATAAAAATAATGTTTATGATTTGTTTTTAAATGCTTCAAATGAT
ATTTAAATAATAAAGTAGATAGATAGCAACCTAGGAGAAAAATTAAAAAAAATTGAAAAG
CATGTATCTGAGATTTTAAAGAGGCTTAAAAGTAATGAATCGTAGTAAATGTCTATTAAT
TAGAATGAGTAGAACATCTAATAAAATAAAGAAAATATTAATGAAATAACCAGTAGCAAT
TAATTAGAAATTTTATTAAATTAAATTTATAAGTAAGAAAAGATCAGTATTTAGTTTAAT
GAAGAATTACTTAATCAAGAAGTCAATATGGTAAATTAAATTGTGAGTGAGATGAATTTA
AATAAAATTATTGGGCTATAAAATGTGTATGTTCATCCGTATGGGTCAGTTGTTAGTGGG
TTTGGTTAGAATGATAGTGACATTGATATAAGCATAAATACAGATTGCTATTTAGATGAA
AGAGTATTTCTTTCTCTTATTTATGATTTCATGAAAAATTATTTGCATAAATATAAAATC
AAATATTAAAAACTTGAATTAAAATTAGATGCGCGTATTCCTTTAATAACTCTTGTTAAA
CAGAAAGATAATGTTAATTTGAAAAGTAATACAGTTTCAATAGACATATGTATAAATAAT
CTACTAGGATGCGCAAATTCAAAAATGCTAAAAGTTATATCTTAGATTCATCCCTTAGTA
AAGTAGCTAGGAATAATCATTAAATATTGGGCGAAGTAGAATGGTCTTATAAGCAAAAAA
ACTCTTAGTTCATATGCATTTATCCTCATAATGATCTGCTTTTTATAGAGAAAGAAGCTA
ATTGATCCTTATTTTTAAGAGAAAGTTTAAAAAAGATAAAGTGATCCAAAATATTCTACT
TTGATTAAGAGGACAAAGGAAACTGATTAGGAATTTTAAACAAACCTTTATTATGTGCAA
GATCCCTCGCATTTACAGAAATCTCTAAAAAAGTATAAAGAAAACAATCCAAACTAAAAA
ACTTTATTAGACATGAATCTTGCAAGCTTATTCAGTGAGTTTATTGAATATTACTCAGAC
ACCACTGATGAGAATAGAAGATATATAGATATTATGAATAATTATATAGTAAAATCATAT
AATAAAAATTTATTCTTTTATATTATTGACCCATTTGATAATTATCATAACCCAGGAGAA
AGAAGCAGAGTAGAGAATATAGATGATAACATATTTATAAATAGATTTAGGTTTGCTAAG
TAAAAATTGCAAGACAAACAATATTCGCAAATATTTGAATTAAAATTTCAATGA