Identifiers and Description

Gene Model Identifier

TTHERM_01030010

Standard Name

PTK1 (Protein Tyrosine Kinase)

Aliases

PreTt10831 | 204.m00060

Description

Putative insulin receptor-like tyrosine kinase; 66 kDa ciliary membrane protein, tyrosine phosphorylated in response to insulin; sequence similarity to DAF2, a C.elegans insulin receptor; contains SH2/SH3 domain binding motifs

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• protein kinase activity (IEA) | GO:0004672
• SH2 domain binding (ISS) | GO:0042169 | Ref:12546802
• SH3 domain binding (ISS) | GO:0017124 | Ref:12546802
• ATP binding (IEA) | GO:0005524
• protein tyrosine kinase activity (IEA) | GO:0004713

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 9.9%

TetraMine Data

TTHERM_01030010

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_10498.1	9.997093137033517e-262	protein kinase domain-containi ng protein (557 aa)
Oxytricha	Contig16193.0.g77	3.000712232670428e-104	Protein kinase domain
DictyBase	DDB_G0270814	7.999270105144775e-57	nek2 on chromosome: 1 position 4847143 to 4848761
Stentor Coeruleus	SteCoe_11057	4.590938473882946e-48
SGD	YAR018C	2.0000236365077126e-43	KIN3 Nonessential serine/threo nine protein kinase; possible role in DNA damage response
WormBase	WBGene00008956	2.0008536325002377e-42	locus:nekl-3 status:Confirme d UniProt:G5EFM9 protein_i d:CAA92169.2

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16850526: Csaba G, Kovács P, Pállinger E (2007) Effect of starvation on insulin production and insulin binding in Tetrahymena. Cell biochemistry and function 25(4):473-7
2. Ref:16611747: Wloga D, Camba A, Rogowski K, Manning G, Jerka-Dziadosz M, Gaertig J (2006) Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Molecular biology of the cell 17(6):2799-810
3. Ref:12546802: Christensen ST, Guerra CF, Awan A, Wheatley DN, Satir P (2003) Insulin receptor-like proteins in Tetrahymena thermophila ciliary membranes. Current biology : CB 13(2):R50-2

Sequences

>TTHERM_01030010(coding)
ATGCAAAATTCACAATCTCAAATTACTGACTTTGAAATACTAAAGCGTCTTGGTGAAGGT
TCTTTTGGGTCTGTCTACTAGGTTAAGAGAAAAAGTGATGAGAAGATTTATGCCATGAAA
AAGGTTAAAATGATGTCTCTTTCAACCAAGGAAAAGGAGAATGCCTTAAATGAAGTGCGT
ATCCTTGCTTCCATCAAAAGCGACAATATTATCAGCTACAAAGAAGCTTTTTATGACGAA
AAGTCATCCACATTATGCATAATCATGGAGTTTGCAACAAAAGGTGATGTTTTATAATAA
ATTAGTGAAAAGAAGAAGAAACATTCTTATTTTGAAGAAAACCTTATTTGGAAATATGCA
GCAGATATGCTCTTGGGACTAAAGTCCCTTCATGATATGAAAATTCTACACAGAGACTTG
AAAGGAGCAAACGTTTTCATTGCAGAAGATGGGTCATTAAAGCTTGGAGATTTGAATGTT
TCCAAAGTTTAAAAGAGAGATTTTGCCTACACCTAAACAGGAACACCATATTATACCTCT
CCTGAAGTTTGGTAAAATCGTCCATATGATTCTAAATGTGATGTCTGGTCTTTAGGATGT
GTATTATATGAAATAGTCACTCTTGAACCACCCTTTAAAGGCACTTCCATGGAAGATCTC
TATAAAAGAGTCTTGAGAGGCAACTTTTCTCCAATCAACTTGTAAAGATACAGCTCTGAC
CTCTAGAAGTTCATCGAGTCATGCTTAAAAGTTGAGCCTAAAATGAGATCTTCAGTAGAG
TCTCTATTAAACCATAAGTGCATAATGCCTCATCTAAAACCAGAACAGATAGCCATGCTC
GAAAAGAAGAAAAAGGAAAAAATAGATTTATTGCAGACCATCAAGCTTCCTTATGGAAAC
AACTTGAAAGAAATTAACAAGCGCTTACCCAAATCAAATTATGACATATTAGATGAAAAA
ATAGAAGAATATGAGCAAGAAATAAAAACTGATTAAATTCGTCTTAAGAAAAAAAATGAA
GACCGTCCCTACTCAGCAGTGGATCCTACAAGTAATTTAATAAAAAATAACTTAGCATAA
AAGCCAAGCGAAAACCCAATTTAAAGACCTAGAGATAATTCAGCCCATAACAACAACAAC
AACAATAATAATAACTATTATAATTATTCTCCACAACCAAATAATAGATTATAGTCAGCT
CAACCCTAAGTAAAAAGAGTTTTAAGCAATAACGATCTAGGAGTTATTAATAATCCAGGA
AAGTACTATATGCCTCCAATTGGCAATAATTAACAAAAATACAATTATCACTATTATAAT
TAAGAGAAGCCTTATTAACCTAAAATTGCGATCCACTAGCAAAAAGACTCAGTTTACAAT
AATGGCGGAATTCAAAGATATAACTCAAAAGAGGTACTTTATAAAAATGCTGAATAAATT
GTTGGAAGAGTCAGAAAATCTACCGATGATCTATTAGAAAATAATAGAAATTATGTTAAC
CAAAGACCTCCTTCTAATTATTATTCTAATGATAATAAAGGTATTCCAAAACCAAAACTC
CAACCCTTAAATAACATTCCTAAAATTCCTGGCTCACCTTAAGTCAATAACAATGCAAAT
TTACCACCAAAACCATTCAGAAATTATTGA

>TTHERM_01030010(protein)
MQNSQSQITDFEILKRLGEGSFGSVYQVKRKSDEKIYAMKKVKMMSLSTKEKENALNEVR
ILASIKSDNIISYKEAFYDEKSSTLCIIMEFATKGDVLQQISEKKKKHSYFEENLIWKYA
ADMLLGLKSLHDMKILHRDLKGANVFIAEDGSLKLGDLNVSKVQKRDFAYTQTGTPYYTS
PEVWQNRPYDSKCDVWSLGCVLYEIVTLEPPFKGTSMEDLYKRVLRGNFSPINLQRYSSD
LQKFIESCLKVEPKMRSSVESLLNHKCIMPHLKPEQIAMLEKKKKEKIDLLQTIKLPYGN
NLKEINKRLPKSNYDILDEKIEEYEQEIKTDQIRLKKKNEDRPYSAVDPTSNLIKNNLAQ
KPSENPIQRPRDNSAHNNNNNNNNNYYNYSPQPNNRLQSAQPQVKRVLSNNDLGVINNPG
KYYMPPIGNNQQKYNYHYYNQEKPYQPKIAIHQQKDSVYNNGGIQRYNSKEVLYKNAEQI
VGRVRKSTDDLLENNRNYVNQRPPSNYYSNDNKGIPKPKLQPLNNIPKIPGSPQVNNNAN
LPPKPFRNY

>TTHERM_01030010(gene)
ATGCAAAATTCACAATCTCAAATTACTGACTTTGAAATACTAAAGCGTCTTGGTGAAGGT
TCTTTTGGGTCTGTCTACTAGGTTAAGAGAAAAAGTGATGAGAAGATTTATGCCATGAAA
AAGGTTAAAATGATGTCTCTTTCAACCAAGGAAAAGGAGAATGCCTTAAATGAAGTGCGT
ATCCTTGCTTCCATCAAAAGCGACAATATTATCAGCTACAAAGAAGCTTTTTATGACGAA
AAGTCATCCACATTATGCATAATCATGGAGTTTGCAACAAAAGGTGATGTTTTATAATAA
ATTAGTGAAAAGAAGAAGAAACATTCTTATTTTGAAGAAAACCTTATTTGGAAATATGCA
GCAGATATGCTCTTGGGACTAAAGTCCCTTCATGATATGAAAATTCTACACAGAGACTTG
AAAGGAGCAAACGTTTTCATTGCAGAAGATGGGTCATTAAAGCTTGGAGATTTGAATGTT
TCCAAAGTTTAAAAGAGAGATTTTGCCTACACCTAAACAGGAACACCATATTATACCTCT
CCTGAAGTTTGGTAAAATCGTCCATATGATTCTAAATGTGATGTCTGGTCTTTAGGATGT
GTATTATATGAAATAGTCACTCTTGAACCACCCTTTAAAGGCACTTCCATGGAAGATCTC
TATAAAAGAGTCTTGAGAGGCAACTTTTCTCCAATCAACTTGTAAAGATACAGCTCTGAC
CTCTAGAAGTTCATCGAGTCATGCTTAAAAGTTGAGCCTAAAATGAGATCTTCAGTAGAG
TCTCTATTAAACCATAAGTGCATAATGCCTCATCTAAAACCAGAACAGATAGCCATGCTC
GAAAAGAAGAAAAAGGAAAAAATAGATTTATTGCAGACCATCAAGCTTCCTTATGGAAAC
AACTTGAAAGAAATTAACAAGCGCTTACCCAAATCAAATTATGACATATTAGATGAAAAA
ATAGAAGAATATGAGCAAGAAATAAAAACTGATTAAATTCGTCTTAAGAAAAAAAATGAA
GACCGTCCCTACTCAGCAGTGGATCCTACAAGTAATTTAATAAAAAATAACTTAGCATAA
AAGCCAAGCGAAAACCCAATTTAAAGACCTAGAGATAATTCAGCCCATAACAACAACAAC
AACAATAATAATAACTATTATAATTATTCTCCACAACCAAATAATAGATTATAGTCAGCT
CAACCCTAAGTAAAAAGAGTTTTAAGCAATAACGATCTAGGAGTTATTAATAATCCAGGA
AAGTACTATATGCCTCCAATTGGCAATAATTAACAAAAATACAATTATCACTATTATAAT
TAAGAGAAGCCTTATTAACCTAAAATTGCGATCCACTAGCAAAAAGACTCAGTTTACAAT
AATGGCGGAATTCAAAGATATAACTCAAAAGAGGTACTTTATAAAAATGCTGAATAAATT
GTTGGAAGAGTCAGAAAATCTACCGATGATCTATTAGAAAATAATAGAAATTATGTTAAC
CAAAGACCTCCTTCTAATTATTATTCTAATGATAATAAAGGTATTCCAAAACCAAAACTC
CAACCCTTAAATAACATTCCTAAAATTCCTGGCTCACCTTAAGTCAATAACAATGCAAAT
TTACCACCAAAACCATTCAGAAATTATTGA