Identifiers and Description

Gene Model Identifier

TTHERM_00475140

Standard Name

PDI1 (Protein Disulfide-Isomerase)

Aliases

PreTt02313 | 57.m00252 | 3709.m00112

Description

protein disulfide-isomerase domain containing protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• endoplasmic reticulum lumen (IEA) | GO:0005788

Biological Process

• protein secretion (IEA) | GO:0009306
• cell redox homeostasis (IEA) | GO:0045454

Domains

• ( PF00085 ) Thioredoxin
• ( PF01216 ) Calsequestrin
• ( TIGR01068 ) thioredoxin
• ( PF08534 ) redoxin family protein
• ( PF07912 ) ERp29, N-terminal domain
• ( PF01323 ) DSBA-like thioredoxin domain
• ( TIGR01130 ) protein disulfide isomerases
• ( TIGR00411 ) redox-active disulfide protein 1
• ( TIGR01126 ) protein disulfide-isomerase domain

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: Yes
Presense Probability: 80.4%

TetraMine Data

TTHERM_00475140

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_13191.1	9.997093137033517e-262	protein disulfide-isomerase do main-containing protein (485 a a)
Oxytricha	Contig9681.0.g59	5.997731685152085e-122	Thioredoxin
WormBase	WBGene00003963	1.0000198575659891e-106	locus:pdi-2 Protein disulfid e-isomerase 2 status:Confirm ed UniProt:Q17770 protein_ id:CCD63277.1
DictyBase	DDB_G0291434	7.000472351131044e-82	pdi2 on chromosome: 6 position 299936 to 301894
SGD	YCL043C	9.997863464222902e-69	PDI1 Protein disulfide isomera se; multifunctional protein re sident in the endoplasmic reti culum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-nati ve disulfide bonds; forms a co mplex with Mnl1p that has exom annosidase activity, processin g unfolded protein-bound Man8G lcNAc2 oligosaccharides to Man 7GlcNAc2 which promotes degrad ation in the unfolded protein response
Stentor Coeruleus	SteCoe_35059	7.667648073722e-53

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00475140(coding)
ATGAACAAGACTTTGCTTTTGTTAACTATTTTGGCTGTCGGTGCTTTGGCTTCCACTGCC
CCTGCTGTCGAAGAAGGTGTCTATGTCTTAACTGACTCCAACTTCAACGAATTCATTGCC
TCCAAGCCTTTTGTTTTGGTTGAATTCTACGCCCCTTGGTGTGGTCACTGCAAGAAGCTC
GCCCCCGAATATGCTAAGGCTGCTTAAGCTTTAGCCAGTGAAAACTCCTAAGCTGTTCTC
GCTAAGGTTGATGCCACTGAATAAAAGGACCTCGGTACTAGATTCTCCATCCAAGGTTTC
CCTACCTTGAAGTTCTTCATCAACGGTTCCACTGAAAACCCTGTTGACTTCAATGGTGGT
AGAACTGAAAAGGACATCCTTAACTGGATCAAGAAGAGAACCGGTTCCGTTTCTGAAGCT
CTTAACACTGCTGAAGAATTAACCGCCTTCACTCAAAAGAACCAAGTCGCCATCGTTTAT
TTCGGTGAAAGTGAAAAGGATGCCAACTACGAAGCCTTCAAGTCTTTGGCTATGTCTTAT
GATGACCTCGCCTTCGCTCACGTTTTCAACGCTGACTTGAGAACTGCTTAAAACGCTGCT
GCTCACAACCTCGTCCTCTACAAGCACTTCGATGAAAAGAGAAACGACTTCACTGGTACC
TTCAACGTTGCTAACTTAAAGACTTTCGTTGACACCAACTCTTTCCCCATCGTTATGCCC
TTCAACGACAGAGCCATCCAAAAGGTCTTCTAACAAGGTAACCCCACTTTGTTCCTTTTC
TCCAACAGCAACGAAGCTTCCCTTGCTGCTGAAAAGGCTTTCGCTGCTTCTGCTGAAGAA
AACAGAGGTAAGATCGTCTTCTCTATCTCCAAGCCTGATGACACCTTCGGTCACTACTAA
AAACTCGCTGACTACATCGGTGTTAACACTGCTTAAGTCCCCGCTTTAATGCTCGTTCAC
TCCAGCCACGAAGTTCTTAAGTACAAGTTCACTGCTTCTGAAATCACCCATGCCACCATT
AACTAATTCGTTAGTGACTACCTTGCTGGTAAGCTCTCAACTTACTTGAAGTCTGAAGAT
ATCCCTGCCACCAACGACGAACCCGTCAAGGTCCTCGTCGGCAAGAGTTTCGATGACCTC
GTCATTAACAGCAACAAGGATGTCTTAGTTGAATTCTACGCTCCCTGGTGCGGTCACTGC
AAGCAACTTGCTCCCATCTATGATGCCGTTGCCAAGAAGCTCTCCCACAACCACAACATC
GTCATCGCTAAGATCGATTCCACCGCTAACGAAGTTCCCGGAGTCAATATTAGAGGTTTC
CCCACCATTAAGTTCTATCAAAACGGTAAGAAATCTACTCCTCTTGATTTCGAAGGTGAC
AGAACTGAAGAAGGTATCCTCAAGTACCTCAAGGAAAAGACCACCTTCCCTTGGGTTGAA
AAGAACGAAGATCTCTGA

>TTHERM_00475140(protein)
MNKTLLLLTILAVGALASTAPAVEEGVYVLTDSNFNEFIASKPFVLVEFYAPWCGHCKKL
APEYAKAAQALASENSQAVLAKVDATEQKDLGTRFSIQGFPTLKFFINGSTENPVDFNGG
RTEKDILNWIKKRTGSVSEALNTAEELTAFTQKNQVAIVYFGESEKDANYEAFKSLAMSY
DDLAFAHVFNADLRTAQNAAAHNLVLYKHFDEKRNDFTGTFNVANLKTFVDTNSFPIVMP
FNDRAIQKVFQQGNPTLFLFSNSNEASLAAEKAFAASAEENRGKIVFSISKPDDTFGHYQ
KLADYIGVNTAQVPALMLVHSSHEVLKYKFTASEITHATINQFVSDYLAGKLSTYLKSED
IPATNDEPVKVLVGKSFDDLVINSNKDVLVEFYAPWCGHCKQLAPIYDAVAKKLSHNHNI
VIAKIDSTANEVPGVNIRGFPTIKFYQNGKKSTPLDFEGDRTEEGILKYLKEKTTFPWVE
KNEDL

>TTHERM_00475140(gene)
ATGAACAAGACTTTGCTTTTGTTAACTATTTTGGCTGTCGGTGCTTTGGCTTCCACTGCC
CCTGCTGTCGAAGAAGGTGTCTATGTCTTAACTGACTCCAACTTCAACGAATTCATTGCC
TCCAAGCCTTTTGTTTTGGTTGAATTCTACGCCCCTTGGTGTGGTCACTGCAAGAAGCTC
GCCCCCGAATATGCTAAGGCTGCTTAAGCTTTAGCCAGTGAAAACTCCTAAGCTGTTCTC
GCTAAGGTTGATGCCACTGAATAAAAGGACCTCGGTACTAGATTCTCCATCCAAGGTTTC
CCTACCTTGAAGTTCTTCATCAACGGTTCCACTGAAAACCCTGTTGACTTCAATGGTGGT
AGAACTGAAAAGGACATCCTTAACTGGATCAAGAAGAGAACCGGTTCCGTTTCTGAAGCT
CTTAACACTGCTGAAGAATTAACCGCCTTCACTCAAAAGAACCAAGTCGCCATCGTTTAT
TTCGGTAAGCATATTTTATTTTTATCGTTTAGATGCAAACAATAAAGAGTATTTATAAAC
AAACGAATGGCTATCATATCAAATTTTTGTCTAATGGAAATCAGCATTCCATTAAGATAA
GTTAACTAACTCCCAAGAAAATTAATACATTAAATAGACTGCAAATAATTTTAATGTAGT
AACAAACTTTAAAGGATTATGAAAGCCATATAGGATAGCAGAGAAGTTACATGAAAGAAT
ATCATGAATGGAAGCCTTACAAATAATATAAAAGTTAGCTCCATAAAATTCCTATTCTGT
TATTTAAGAAAAAAAAAATAATTAGATGCAAAGCACTAACAAACAAATGAAATTATATAC
AGATTAAATACAATCAAGAGCAACTCATATAAAAATAAGCCTTTTTTAAGATGTTTCATC
AAAGCTTTTAAAGTTCTTGTTGACGTCAAAAAAAAAAAATTAAATTTTAAAAAATTTAAA
AAATATATTTTTCAAATAAAAAATACTAACACTAGCTAAATTGATAGTCATTCATTCATT
TATTCATTCATTATTAATAGAACATACTTCCACATAAATAACCAATAAGCCATCAAAAAA
TTTTATAATACTTAACCTAGAAAGAATGATAAGCCATTAATATTCAGTCATTAATTAATT
TGTTTTTAATCATTAGGTGAAAGTGAAAAGGATGCCAACTACGAAGCCTTCAAGTCTTTG
GCTATGTCTTATGATGACCTCGCCTTCGCTCACGTTTTCAACGCTGACTTGAGAACTGCT
TAAAACGCTGCTGCTCACAACCTCGTCCTCTACAAGCACTTCGATGAAAAGAGAAACGAC
TTCACTGGTACCTTCAACGTTGCTAACTTAAAGACTTTCGTTGACACCAACTCTTTCCCC
ATCGTTATGCCCTTCAACGACAGAGCCATCCAAAAGGTCTTCTAACAAGGTAACCCCACT
TTGTTCCTTTTCTCCAACAGCAACGAAGCTTCCCTTGCTGCTGAAAAGGCTTTCGCTGCT
TCTGCTGAAGAAAACAGAGGTAAGATCGTCTTCTCTATCTCCAAGCCTGATGACACCTTC
GGTCACTACTAAAAACTCGCTGACTACATCGGTGTTAACACTGCTTAAGTCCCCGCTTTA
ATGCTCGTTCACTCCAGCCACGAAGTTCTTAAGTACAAGTTCACTGCTTCTGAAATCACC
CATGCCACCATTAACTAATTCGTTAGTGACTACCTTGCTGGTAAGCTCTCAACTTACTTG
AAGTCTGAAGATATCCCTGCCACCAACGACGAACCCGTCAAGGTCCTCGTCGGCAAGAGT
TTCGATGACCTCGTCATTAACAGCAACAAGGATGTCTTAGTTGAATTCTACGCTCCCTGG
TGCGGTCACTGCAAGCAACTTGCTCCCATCTATGATGCCGTTGCCAAGAAGCTCTCCCAC
AACCACAACATCGTCATCGCTAAGATCGATTCCACCGCTAACGAAGTTCCCGGAGTCAAT
ATTAGAGGTTTCCCCACCATTAAGTTCTATCAAAACGGTAAGAAATCTACTCCTCTTGAT
TTCGAAGGTGACAGAACTGAAGAAGGTATCCTCAAGTACCTCAAGGAAAAGACCACGTAA
ATAACATTTTATACAAAATTTTATTCAAAAGTTATTGATTGTAAAGAAATCATATCTAAA
TATATTTTTTTTTAATTTATAGCTTCCCTTGGGTTGAAAAGAACGAAGATCTCTGA