Identifiers and Description

Gene Model Identifier

TTHERM_00193230

Standard Name

PDA1 (Pyruvate Dehydrogenase Alpha 1)

Aliases

PreTt06606 | 16.m00262

Description

pyruvate dehydrogenase complex E1 component, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (IEA) | GO:0016624

Biological Process

• metabolic process (IEA) | GO:0008152

Domains

• ( PF00676 ) Dehydrogenase E1 component
• ( PF02775 ) Thiamine pyrophosphate enzyme, C-terminal TPP
• ( TIGR03181 ) pyruvate dehydrogenase (acetyl-transferring) E1 component,
• ( TIGR03182 ) pyruvate dehydrogenase (acetyl-transferring) E1 component,

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.5%

TetraMine Data

TTHERM_00193230

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_03605.1	9.997093137033517e-262	pyruvate dehydrogenase E1 comp onent (388 aa)
Oxytricha	Contig9079.0.0.g83	2.998923500611476e-144	Dehydrogenase E1 component
DictyBase	DDB_G0292994	9.995516318087232e-125	pdhA on chromosome: 6 position 2563001 to 2564757
WormBase	WBGene00011510	1.000211181581171e-120	locus:pdha-1 Probable pyruva te dehydrogenase E1 component subunit alpha, mitochondrial status:Confirmed UniProt:P5 2899 protein_id:CAA87793.1
SGD	YER178W	1.0001900614163146e-108	PDA1 E1 alpha subunit of the p yruvate dehydrogenase (PDH) co mplex, catalyzes the direct ox idative decarboxylation of pyr uvate to acetyl-CoA; phosphory lated; regulated by glucose
Stentor Coeruleus	SteCoe_7851	1.7785284761271306e-68

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00193230(coding)
ATGAGGTACTAAAGAGTATAATTATTCCTTGCTCAAATCAAAAGAAAGGAAAGAAAGAAA
GAAGAAAAGAAAGAAAAAAAATAAAAATAAAATACAAATAAATAAAATAATCATCAAAAA
GCTAAACTAATGATATCTAAGTTCTTCAATCCTGTTGCTGGTAAGACCTTCAACAGACTT
AACAAGTATGCCTTCTCTTCAGTCACTATTAACCTTGAAGGATACTAGACTAAGATGTTA
GACGGATTCAAATTGCCCACCTAATCAACTGCTACCAAGGAAGAATTATTGAAGCTCTAC
AAAGATATGAACGTTATGAGAAAGATCGAACTTGCATGCGATAAGCTTTATAAGCAAAGA
GAAATTAGAGGTTTCTGCCATCTCTACGACGGTTAAGAAGCTGTTATCTCAGGTATTGAA
GCTGCTTGCAATCTTGAGGATGCAATAATCACTGCCTATAGATGCCATTGTCACGCTTAC
ACAAGAGGTGACACTCCCCATTAAATTATTGCTGAACTTATGGGAAGAAAGACTGGTTCT
ACAGGTGGTAAGGGTGGTTCTATGCACTTCTACAGAAAGAAAACTCACTTCTATGGTGGT
CACGGTATTGTCGGTGCTCAAGTTCCCATGGGTGCTGGATTAGCCTTTGCTTTGAAATAT
GAAAAGAAGCCCAACGTTTCTATCACTATGTACGGTGACGGTGCTGCCAATCAAGGTTAA
ATTGCTGAAGCTGCCAACATGGCTGGTTTATGGAATTTACCATGCTTGTTTGTTTGTGAA
AACAATCTTTACGGTATGGGTACCTCTACTGCAAGAGCTTCTCACAATACTGATTTCTAC
ACCAGAGGTGACAAGATTCCTGGTATCAGAATGGACGGTAATAACTATTTCCATGTTAAG
GAAGGTTTCAAGTTTGCTAAGCAATATGCCTTAGAACATGGTCCTCTCTTCATTGAATTG
AGAACTTACAGATATCACGGTCACTCTATGTCTGACTCCGGTACTACTTATAGAACTCAA
GAAGAAATCAAAGAATTCAGATAAAAGAAGGATTGCATATAATTTATTGCTAATACCATT
TTATAAAATAACTTTGCTACTCAAGAATAACTCGAAGCTATCCAAGATGAAACTAGAGAA
ATTGTTGATAAAGCCGTTGAACAAGCTCTTAAAGACCCATTACCTGATGATCACGAATTG
TGCACCGATGTTTACATTAACAACGATAAATACTACATCAGAGGTATTGAATACGAATAA
GGTTACTTCCCTGAAGGCAAGCCCTACTGA

>TTHERM_00193230(protein)
MRYQRVQLFLAQIKRKERKKEEKKEKKQKQNTNKQNNHQKAKLMISKFFNPVAGKTFNRL
NKYAFSSVTINLEGYQTKMLDGFKLPTQSTATKEELLKLYKDMNVMRKIELACDKLYKQR
EIRGFCHLYDGQEAVISGIEAACNLEDAIITAYRCHCHAYTRGDTPHQIIAELMGRKTGS
TGGKGGSMHFYRKKTHFYGGHGIVGAQVPMGAGLAFALKYEKKPNVSITMYGDGAANQGQ
IAEAANMAGLWNLPCLFVCENNLYGMGTSTARASHNTDFYTRGDKIPGIRMDGNNYFHVK
EGFKFAKQYALEHGPLFIELRTYRYHGHSMSDSGTTYRTQEEIKEFRQKKDCIQFIANTI
LQNNFATQEQLEAIQDETREIVDKAVEQALKDPLPDDHELCTDVYINNDKYYIRGIEYEQ
GYFPEGKPY

>TTHERM_00193230(gene)
ATGAGGTACTAAAGAGTATAATTATTCCTTGCTCAAATCAAAAGAAAGGAAAGAAAGAAA
GAAGAAAAGAAAGAAAAAAAATAAAAATAAAATACAAATAAATAAAATAATCATCAAAAA
GCTAAACTAATGATATCTAAGTTCTTCAATCCTGTTGCTGGTAAGACCTTCAACAGACTT
AACAAGTATGCCTTCTCTTCAGTCACTATTAACCTTGTAATTCAATTATTTATTTAATCT
TTTGCTAAGAATATAAATTTAGATAGAAATAGTTTATATTTTTCATTTTTTGACAGAATA
ACTAACTAACTCTCCAATGTTCGAATATTTGATTATATGGCGATAACTACTAAAATATTT
CAAATTCTTGCAAACATTCAACAAAAAAGCTTATAAACTTTAATTTAAATTTACAAAATA
TTTAAGAAAAATAACTTAAATATGATACCAAGCATTTCTTTAGTTAAATATTGCAGTATC
CCACGAATATCCTTATTGTCTAATTTCTGTTTTAAGAAATCTATTTCTACCTAATTATTT
AGCAATCCTAAAACAAAAAAATAGAAAAAAATGATTGCAACTAGAATTTAAATGAAATAA
ATAGTGCTTAACAACCCTTACTTAATCTGATTTTTTTATGAATGATATATGATAGGAAGG
ATACTAGACTAAGATGTTAGACGGATTCAAATTGCCCACCTAATCAACTGCTACCAAGGA
AGAATTATTGAAGCTCTACAAAGATATGAACGTTATGAGAAAGATCGAACTTGCATGCGA
TAAGCTTTATAAGCAAAGAGAAATTAGAGGTTTCTGCCATCTCTACGACGGTTAAGTAAA
TATCATATCATCAATTTTCTTATTATATAGCAAGTTTTTTACATTGACAAGATAACATAA
TGAGATCAATAGTATGACTTTTTAAATTTATAATAAAATATCTTTTAAAAATAATAGGAA
GCTGTTATCTCAGGTATTGAAGCTGCTTGCAATCTTGAGGATGCAATAATCACTGCCTAT
AGATGCCATTGTCACGCTTACACAAGAGGTGACACTCCCCATTAAATTATTGCTGAACTT
ATGGGAAGAAAGACTGGTTCTACAGGTGGTAAGGGTGGTTCTATGCACTTCTACAGAAAG
AAAACTCACTTCTATGGTGGTCACGGTATTGTCGGTGCTCAAGTAAAAATAATTTTCTAA
TTTATTATTTATTTTTCAGATATCATTTTTTCAGTTGTTAATTTAATTGAATAAAGGGAC
ATGGTTTTTTTTTTAAAAAAGTAAGTATCTTTATTCAAAAAATAAAAAATTAATTAAAAA
AAATAAAATTATATCAAAGACCTAGCTTTAATTAATATTCTTAATTTAACAATTTTTTTA
AAAAAAGGTTCCCATGGGTGCTGGATTAGCCTTTGCTTTGAAATATGAAAAGAAGCCCAA
CGTTTCTATCACTATGTACGGTGACGGTGCTGCCAATCAAGGTTAAATTGCTGAAGCTGC
CAACATGGCTGGTTTATGGAATTTACCATGCTTGTTTGTTTGTGAAAACAATCTTTACGG
TATGGGTACCTCTACTGCAAGAGCTTCTCACAATACTGATTTCTACACCAGAGGTGACAA
GATTCCTGGTATCAGAGTAATCAAAATCAAATAAAAATATAAAAGTTGTGTCTAAATAAT
TTTTTAAATCAATAAAAGATGGACGGTAATAACTATTTCCATGTTAAGGAAGGTTTCAAG
TTTGCTAAGCAATATGCCTTAGAACATGGTCCTCTCTTCATTGAATTGAGAACTTACAGA
TATCACGGTCACTCTATGTCTGACTCCGGTACTACTTATAGAACTCAAGAAGAAATCAAA
GAATTCAGATAAAAGAAGGATTGCATATAATTTATTGCTAATACCATTTTATAAAATAAC
TTTGCTACTCAAGAATAACTCGAAGTGATAATTTTAAATTACATTTTTAATAGAAATTAA
AACTTTATTTTTCTCAAAATTAGGCTATCCAAGATGAAACTAGAGAAATTGTTGATAAAG
CCGTTGAACAAGCTCTTAAAGACCCATTACCTGATGATCACGAATTGTGCACCGATGTTT
ACATTAACAACGATAAATGTAAATTGAAAAATTTCCAAAAAAAAATTTATTTAATTTAAT
TTTAACAAATAAAGACTACATCAGAGGTATTGAATACGAATAAGGTTACTTCCCTGAAGG
CAAGCCCTACTGA