Identifiers and Description

Gene Model Identifier

TTHERM_00721400

Standard Name

NRK3 (NIMA-Related Kinase)

Aliases

PreTt18448 | 115.m00104

Description

NIMA-Related Kinase, Protein kinase domain containing protein. Sequence similarity to the NEK protein kinase family (Eisen et al., 2006)."

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• protein tyrosine kinase activity (IEA) | GO:0004713
• protein kinase activity (IEA) | GO:0004672
• ATP binding (IEA) | GO:0005524

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF01163 ) RIO1 family
• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.2%

TetraMine Data

TTHERM_00721400

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_17477.1	9.997093137033517e-262	protein kinase domain-containi ng protein (499 aa)
Oxytricha	Contig16193.0.g77	6.999576669079256e-104	Protein kinase domain
DictyBase	DDB_G0270814	4.998338612125368e-60	nek2 on chromosome: 1 position 4847143 to 4848761
WormBase	WBGene00008956	5.00115835552873e-49	locus:nekl-3 status:Confirme d UniProt:G5EFM9 protein_i d:CAA92169.2
Stentor Coeruleus	SteCoe_34801	2.506567475899953e-46
SGD	YAR018C	1.0002335610448659e-38	KIN3 Nonessential serine/threo nine protein kinase; possible role in DNA damage response

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16611747: Wloga D, Camba A, Rogowski K, Manning G, Jerka-Dziadosz M, Gaertig J (2006) Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Molecular biology of the cell 17(6):2799-810

Sequences

>TTHERM_00721400(coding)
ATGAGTTCAGTTTCATTGAGCGATTTCAACGTTTAAAAAACTTTAGGAAATGGAGCATTT
TCATGGGTATATAAAGTATAGCGCAAACAAGATGGCTAAGTTTACGCTCTTAAAAAGGTT
AAATTGAGGGAACTCTCTTACAAAGAGAAAGAAAATGCTTTAAACGAAATCAGAATTTTA
GCTTCAATAAACTCTCCTCACATTATCAGATACAAAGATGCATTTTATGATAATGCAAGC
GGATGTCTTTGCATTGTGATGGAATATGCAGAGAACGGCGATTTAATGGCTAAATTGCAA
GATTATAAAAAAAGAAACATGTTTATGGACGAGGCAAAAATTTGGAAATATGCAGCATAG
ATTTTACTGGGTTTAAAATCATTGCATGATCTGAAAATTCTTCATCGTGACTTAAAGTGT
GCAAATATTTTCTTGGGTGCTAATAATAAAGTAAAGTTAGGGGATTTAAATGTCTCTAAA
ATTATGAAGAGAGACCTAGCTTACACTCAAACTGGAACACCTTATTACACATCCCCTGAA
GTTTGGTAAAATCAACCATATGATTCAAAGTGTGATGTTTGGAGCATGGGATGTGTTCTA
TATGAATTGATGGCTCATCATCCTCCATTCGAAGCTAAATCCATGGAGGAACTCTATAAG
AAAGTATGTAAAGGCACCTATTAAAAGCTTCCCAAGTAATATAGCCAAGAAATGAATGAC
TTTATTAATCTTTGCTTGAGAAAAAACCCTAAATAACGTCCTTCTGTGAATTCTCTACTA
GAGTTTTAGGGCCTATTGCCTTACGTTTAAAATATATTGGAGAATGAAGAAGATAAAGAA
AATAAGCAACCCAATATTTAGAAAAATAACTCTTTGAATCTTCTATAGACAATGAAAATG
CCTTATGGAAATCTAAATGCTTTAAAAAACATTTTGCCTAAAGCTTAATTTGAAGATTCA
ATAGATTCCTTTATGGAAGAGTAGTCTTTAGCAAAGAAGTCATCTGGAAATAGACCAATC
TCAGCTGTAAACAATAACGATTTTAAAAACAACATTAACTAAAGACATTCACTTGAGCCT
CAACAAGGAAAGTAATAAAATCAATAGCCTAGCTCAAATATTTAAAGACATGCATAGTCT
CCTCCTTCTCATTCTAATTAATAAATTTTGAGCAGTAGACAAAGAATACAATCTGCTCAT
AACGCAATACTATGCCGTTAAGACTCAAATTCCTCAGTTTAAAATTAACTAAAATCCAAT
AATAATAACGTACCAAACGGAATTAATAATTGCCCTTTACCAAAAAGTCCTGAAATTTTA
GGTAGCAAAAAAATATCTGCCTTATAACGTAATGGAATTGAAATGGTTAAGCCCAGAAAT
TCCATCGAAGAAGGAATACCATTAAGAAACGATAGAGAGAGAGGAAGTGTAAATATTCCT
GTAAATAATAACAGATACCCCTCAGCAGGAAGAAGAAACATTTTATGCTGA

>TTHERM_00721400(protein)
MSSVSLSDFNVQKTLGNGAFSWVYKVQRKQDGQVYALKKVKLRELSYKEKENALNEIRIL
ASINSPHIIRYKDAFYDNASGCLCIVMEYAENGDLMAKLQDYKKRNMFMDEAKIWKYAAQ
ILLGLKSLHDLKILHRDLKCANIFLGANNKVKLGDLNVSKIMKRDLAYTQTGTPYYTSPE
VWQNQPYDSKCDVWSMGCVLYELMAHHPPFEAKSMEELYKKVCKGTYQKLPKQYSQEMND
FINLCLRKNPKQRPSVNSLLEFQGLLPYVQNILENEEDKENKQPNIQKNNSLNLLQTMKM
PYGNLNALKNILPKAQFEDSIDSFMEEQSLAKKSSGNRPISAVNNNDFKNNINQRHSLEP
QQGKQQNQQPSSNIQRHAQSPPSHSNQQILSSRQRIQSAHNAILCRQDSNSSVQNQLKSN
NNNVPNGINNCPLPKSPEILGSKKISALQRNGIEMVKPRNSIEEGIPLRNDRERGSVNIP
VNNNRYPSAGRRNILC

>TTHERM_00721400(gene)
ATGAGTTCAGTTTCATTGAGCGATTTCAACGTTTAAAAAACTTTAGGAAATGGAGCATTT
TCATGGGTATATAAAGTATAGCGCAAACAAGATGGCTAAGTTTACGCTCTTAAAAAGGTT
AAATTGAGGGAACTCTCTTACAAAGAGAAAGAAAATGCTTTAAACGAAATCAGAATTTTA
GCTTCAATAAACTCTCCTCACATTATCAGATACAAAGATGCATTTTATGATAATGCAAGC
GGATGTCTTTGCATTGTGATGGAATATGCAGAGAACGGCGATTTAATGGCTAAATTGCAA
GATTATAAAAAAAGAAACATGTTTATGGACGAGGCAAAAATTTGGAAATATGCAGCATAG
ATTTTACTGGGTTTAAAATCATTGCATGATCTGAAAATTCTTCATCGTGACTTAAAGTGT
GCAAATATTTTCTTGGGTGCTAATAATAAAGTAAAGTTAGGGGATTTAAATGTCTCTAAA
ATTATGAAGAGAGACCTAGCTTACACTCAAACTGGAACACCTTATTACACATCCCCTGAA
GTTTGGTAAAATCAACCATATGATTCAAAGTGTGATGTTTGGAGCATGGGATGTGTTCTA
TATGAATTGATGGCTCATCATCCTCCATTCGAAGCTAAATCCATGGAGGAACTCTATAAG
AAAGTATGTAAAGGCACCTATTAAAAGCTTCCCAAGTAATATAGCCAAGAAATGAATGAC
TTTATTAATCTTTGCTTGAGAAAAAACCCTAAATAACGTCCTTCTGTGAATTCTCTACTA
GAGTTTTAGGGCCTATTGCCTTACGTTTAAAATATATTGGAGAATGAAGAAGATAAAGAA
AATAAGCAACCCAATATTTAGAAAAATAACTCTTTGAATCTTCTATAGACAATGAAAATG
CCTTATGGAAATCTAAATGCTTTAAAAAACATTTTGCCTAAAGCTTAATTTGAAGATTCA
ATAGATTCCTTTATGGAAGAGTAGTCTTTAGCAAAGAAGTCATCTGGAAATAGACCAATC
TCAGCTGTAAACAATAACGATTTTAAAAACAACATTAACTAAAGACATTCACTTGAGCCT
CAACAAGGAAAGTAATAAAATCAATAGCCTAGCTCAAATATTTAAAGACATGCATAGTCT
CCTCCTTCTCATTCTAATTAATAAATTTTGAGCAGTAGACAAAGAATACAATCTGCTCAT
AACGCAATACTATGCCGTTAAGACTCAAATTCCTCAGTTTAAAATTAACTAAAATCCAAT
AATAATAACGTACCAAACGGAATTAATAATTGCCCTTTACCAAAAAGTCCTGAAATTTTA
GGTAGCAAAAAAATATCTGCCTTATAACGTAATGGAATTGAAATGGTTAAGCCCAGAAAT
TCCATCGAAGAAGGAATACCATTAAGAAACGATAGAGAGAGAGGAAGTGTAAATATTCCT
GTAAATAATAACAGATACCCCTCAGCAGGAAGAAGAAACATTTTATGCTGA