Identifiers and Description

Gene Model Identifier

TTHERM_00245740

Standard Name

NRK2 (NIMA-Related Kinase )

Aliases

PreTt02469 | 21.m00300

Description

NIMA (Never In Mitosis) related kinase

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein tyrosine kinase activity (IEA) | GO:0004713
• protein kinase activity (IEA) | GO:0004672

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF01163 ) RIO1 family
• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase
• ( PF04394 ) Protein of unknown function, DUF536

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 9.9%

TetraMine Data

TTHERM_00245740

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_00513.1	9.997093137033517e-262	protein kinase domain-containi ng protein (544 aa)
Oxytricha	Contig16193.0.g77	6.000667945664035e-116	Protein kinase domain
DictyBase	DDB_G0270814	6.997794455893953e-54	nek2 on chromosome: 1 position 4847143 to 4848761
Stentor Coeruleus	SteCoe_34801	1.0377033238158346e-53
WormBase	WBGene00008956	1.9998745702418095e-48	locus:nekl-3 status:Confirme d UniProt:G5EFM9 protein_i d:CAA92169.2
SGD	YAR018C	4.9986056260133516e-43	KIN3 Nonessential serine/threo nine protein kinase; possible role in DNA damage response

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16611747: Wloga D, Camba A, Rogowski K, Manning G, Jerka-Dziadosz M, Gaertig J (2006) Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Molecular biology of the cell 17(6):2799-810

Sequences

>TTHERM_00245740(coding)
ATGTCCTTGAAAGATTTTGTGAATTTATAGAAGATAGGTGAGGGCTCTTACTCAAGTGTC
CATAAAGTAAGAAGGATCTCAGATAACTAAGAATACGCCCTCAAAAAGGTTAAATTATCT
GGTTTAAGCGAAAAAGAGAAAGATAACGCTCTTAATGAGATAAGAATATTAGCAAGTATA
GCTCATCCAAACATGATTGCATATAAGGATGCCTTTTTTGATGAATCTTCTCACTCACTT
TGCATTGTTATGGAGTTAGCCGTCAACGGTGATCTTTCTAAAAAAATTGATAGTGCAAAA
AAAAGAAATAGCTTTGTTCCAGAAGAAGAAATTTGGACAGTAGCGTTGCATATGTTAAGA
GGTTTGAAAGCTATGCACTCCAAAAAGATTCTTCACAGAGACCTCAAGTGTGCAAATGTC
TTTATTTCCAAGCAAGATGAATACAAAATTGGTGATCTCAATGTCTCAAAAGTCGCCAAA
AGAGGACTAGTATACACTTAAACTGGTACTCCTTATTACGCATCACCTGAAGTTTGGAGA
GATGAACCATATGACAGTTCAAGCGATATTTGGTCATTTGGATGCATTTTATACGAATTA
GCAGCTCTTAATCCACCATTTAGAGCTAAAGATATGGAAGGATTGTATAAAAAAGTATAG
AAAGGTATATTTGAGAGAATTCCATAAAGATATTCTAATGATTTGTAGAAGTTTATTGCA
TTATGCCTTTAGGTTAGTAGTGTATAACGTCCTTCTGTTACTTAGCTTTTAAACAATGTA
CTTCTTAAGCGTAATACCTAATTTTTAGCAGAATCTCCTGAAGAGTAATAAGATAAGGAA
AACACCCTTAGCCCAGAAGACCTTTTAAACACAATCAAAATGCCTAAAAACCCTCGTTAG
CTTAAGGAAAAGCTCCCAAAGCCTTAATATGATAAAGAGATATTAAATAATTCATATGAT
GGAGAAATACAACGCAAGGAGCGTAACCACAATAGGAATATGTCTGTAAAAATGAATAGG
ATATAATCTGTAACCAACCATAAATAGCATTAATACCTATAATAGTAATAGCAACTAATG
TTGGAGTAGGAAGGAAAAGATGTTGTTTTACCTTTAATTCCCAGATCATAATAATAAAAA
ATATTAGAACCTATAAGTAACAGCTAGTTACAGGCATAACAAAATAATAGCAATATTATA
GGTAGCTAAAATGATATTTATTCTAGAATAGGTAGCAACAGATATGAAAATTCTTCATCC
ATAGTTAGTGATTCCAGAAATTACTTGCAGGAAATACAGCCAAAAAAGCGAATTAATTAA
AATGGTTCAAGTGGTAACTACAATGAAGATTACTCCTAAAAATATAATAGATATGATTAA
CAACCAAGGTCAATAAACTCTCCAACTATATCTGTAATTTCTAAAAAGGATACAGGGTAT
TCAAATCCAGTGAACTCCATTAATCCACTAAGAAACAGAGTTAATTCTATAAATCAAATC
AATAGTTATGCAAGAATAGCTAATTTATATTAAAATTCTAAAAATCCCTATAACAACTAC
AGCGGAAATTCGATGCAGAGTGTTTCAATCGACTACAATCCTTAATATTCTCGTCCTGTT
TGGTGGGGTTGA

>TTHERM_00245740(protein)
MSLKDFVNLQKIGEGSYSSVHKVRRISDNQEYALKKVKLSGLSEKEKDNALNEIRILASI
AHPNMIAYKDAFFDESSHSLCIVMELAVNGDLSKKIDSAKKRNSFVPEEEIWTVALHMLR
GLKAMHSKKILHRDLKCANVFISKQDEYKIGDLNVSKVAKRGLVYTQTGTPYYASPEVWR
DEPYDSSSDIWSFGCILYELAALNPPFRAKDMEGLYKKVQKGIFERIPQRYSNDLQKFIA
LCLQVSSVQRPSVTQLLNNVLLKRNTQFLAESPEEQQDKENTLSPEDLLNTIKMPKNPRQ
LKEKLPKPQYDKEILNNSYDGEIQRKERNHNRNMSVKMNRIQSVTNHKQHQYLQQQQQLM
LEQEGKDVVLPLIPRSQQQKILEPISNSQLQAQQNNSNIIGSQNDIYSRIGSNRYENSSS
IVSDSRNYLQEIQPKKRINQNGSSGNYNEDYSQKYNRYDQQPRSINSPTISVISKKDTGY
SNPVNSINPLRNRVNSINQINSYARIANLYQNSKNPYNNYSGNSMQSVSIDYNPQYSRPV
WWG

>TTHERM_00245740(gene)
ATGTCCTTGAAAGATTTTGTGAATTTATAGAAGATAGGTGAGGGCTCTTACTCAAGTGTC
CATAAAGTAAGAAGGATCTCAGATAACTAAGAATACGCCCTCAAAAAGGTTAAATTATCT
GGTTTAAGCGAAAAAGAGAAAGATAACGCTCTTAATGAGATAAGAATATTAGCAAGTATA
GCTCATCCAAACATGATTGCATATAAGGATGCCTTTTTTGATGAATCTTCTCACTCACTT
TGCATTGTTATGGAGTTAGCCGTCAACGGTGATCTTTCTAAAAAAATTGATAGTGCAAAA
AAAAGAAATAGCTTTGTTCCAGAAGAAGAAATTTGGACAGTAGCGTTGCATATGTTAAGA
GGTTTGAAAGCTATGCACTCCAAAAAGATTCTTCACAGAGACCTCAAGTGTGCAAATGTC
TTTATTTCCAAGCAAGATGAATACAAAATTGGTGATCTCAATGTCTCAAAAGTCGCCAAA
AGAGGACTAGTATACACTTAAACTGGTACTCCTTATTACGCATCACCTGAAGTTTGGGTA
ATTTAGTTTAAAAAATAATTTATACAAATCATGATTTAAATATTTGAAGAGGATTGGTAT
GTTTTTAATTTTTATCAAGCCAATAACATTCAAAAAAAAAATGGAAATATATTAAGCAAA
TAAATGAAAGGTTATCTTACCAAATGAATGATGGTACATTTCATTTTACATCTTAGTGCA
ATAATTAGTAATAGTTTTGATAAATAGAATTAAAGAACAAGTTAACAAACAAACAACAAA
TTCCTATTGATTTATTAACTACTTTGTCAAAAATAACTCTTATTTAATCTTTGATTCTAT
TTTTTACGTTCCATTCAATTTGCTATTAAAAATAGAATTTTTAAATTTTAAGAGATTCTT
TAAGATATTATCTTAATTGCGTTTCTTTTTTCAGTCAATCTTTGATTTAATCGTTCATGA
ATGAAATGTTATATATTATTGCTGCCTTTATAGAATAACAAATACAAAAAAAATTATAAA
TTTTAACTCATTATCAAATCTAAAAGCTAATTAATTCCTTAATTTGTTTGGACTAAAGAG
AAGCAACGCACATATAAAAAAATTTATAATTTTAAAATCAAGCAAGATAAATTTTAAAGA
GTTTATTTTTGAGGGTAGCATAGATCAATTAATTCATAAGAAATTTTTAAATATACTGAA
TAGAAATTTAATCATAAATTAATTCTAGAATAAAAAAATCCTCTTATTTTTTATGATGAA
AAATAATTAAATATACAAATAAATTAATAACTATATTTTTTATTTTAGAGAGATGAACCA
TATGACAGTTCAAGCGATATTTGGTCATTTGGATGCATTTTATACGAATTAGCAGCTCTT
AATCCACCATTTAGAGCTAAAGATATGGAAGGATTGTATAAAAAAGTATAGAAAGGTATA
TTTGAGAGAATTCCATAAAGATATTCTAATGATTTGTAGAAGTTTATTGCATTATGCCTT
TAGGTTAGTAGTGTATAACGTCCTTCTGTTACTTAGCTTTTAAACAATGTACTTCTTAAG
CGTAATACCTAATTTTTAGCAGAATCTCCTGAAGAGTAATAAGATAAGGAAAACACCCTT
AGCCCAGAAGACCTTTTAAACACAATCAAAATGCCTAAAAACCCTCGTTAGCTTAAGGAA
AAGCTCCCAAAGCCTTAATATGATAAAGAGATATTAAATAATTCATATGATGGAGAAATA
CAACGCAAGGAGCGTAACCACAATAGGAATATGTCTGTAAAAATGAATAGGATATAATCT
GTAACCAACCATAAATAGCATTAATACCTATAATAGTAATAGCAACTAATGTTGGAGTAG
GAAGGAAAAGATGTTGTTTTACCTTTAATTCCCAGATCATAATAATAAAAAATATTAGAA
CCTATAAGTAACAGCTAGTTACAGGCATAACAAAATAATAGCAATATTATAGGTAGCTAA
AATGATATTTATTCTAGAATAGGTAGCAACAGATATGAAAATTCTTCATCCATAGTTAGT
GATTCCAGAAATTACTTGCAGGAAATACAGCCAAAAAAGCGAATTAATTAAAATGGTTCA
AGTGGTAACTACAATGAAGATTACTCCTAAAAATATAATAGATATGATTAACAACCAAGG
TCAATAAACTCTCCAACTATATCTGTAATTTCTAAAAAGGATACAGGGTATTCAAATCCA
GTGAACTCCATTAATCCACTAAGAAACAGAGTTAATTCTATAAATCAAATCAATAGTTAT
GCAAGAATAGCTAATTTATATTAAAATTCTAAAAATCCCTATAACAACTACAGCGGAAAT
TCGATGCAGAGTGTTTCAATCGACTACAATCCTTAATATTCTCGTCCTGTTTGGTGGGGT
TGA