Identifiers and Description

Gene Model Identifier

TTHERM_00265180

Standard Name

NRK16 (NIMA-Related Kinase)

Aliases

PreTt29473 | 23.m00369

Description

NIMA-Related Kinase

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• protein tyrosine kinase activity (IEA) | GO:0004713
• protein kinase activity (IEA) | GO:0004672
• phosphorelay response regulator activity (IEA) | GO:0000156
• ATP binding (IEA) | GO:0005524

Biological Process

• phosphorelay signal transduction system (IEA) | GO:0000160
• protein phosphorylation (IEA) | GO:0006468
• regulation of transcription, DNA-templated (IEA) | GO:0006355

Domains

• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase
• ( TIGR01387 ) heavy metal response regulator
• ( PF00072 ) response regulator receiver domain
• ( TIGR01818 ) nitrogen regulation protein NR(I)
• ( TIGR02875 ) sporulation transcription factor Spo0A
• ( TIGR02154 ) phosphate regulon transcriptional regulatory protein

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 14.4%

TetraMine Data

TTHERM_00265180

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_06009.1	9.997093137033517e-262	protein kinase domain-containi ng protein (835 aa)
Oxytricha	Contig8286.0.g25	1.999765224767555e-159	Protein kinase domain
Stentor Coeruleus	SteCoe_21781	1.0648786602415064e-63
DictyBase	DDB_G0289277	2.0004062814618821e-57	nek4 on chromosome: 5 position 2561379 to 2563106
WormBase	WBGene00022631	1.9997255150861791e-53	locus:nekl-2 status:Confirme d UniProt:O01775 protein_i d:CCD64899.1
SGD	YMR001C	6.0018235484001396e-36	CDC5 Polo-like kinase with mul tiple functions in mitosis and cytokinesis through substrate phosphorylation, also functio ns in adaptation to DNA damage during meiosis; has similarit y to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substr ate

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16611747: Wloga D, Camba A, Rogowski K, Manning G, Jerka-Dziadosz M, Gaertig J (2006) Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Molecular biology of the cell 17(6):2799-810

Sequences

>TTHERM_00265180(coding)
ATGGCTGATAAATAATACATGAATATACATGTCCTCGTAGCAGAGGATGACAATTTCTAA
AGGTTAGCTCTTATAGACATTTTAACTCTATGCGATTATTAGGTCACTGCTGTGGAAAAT
GGCAGATTGGCTAGAGATGAGCTTCTGAAATAAGATTCAAATATTGACATAGTTTTATTA
GATTTATATATGCCAGAAATGGATGGATTTGAATTATTAAGTTTAATGCAAGAACATGAA
AATTTACAAAAGATTCCAGTTATCATGATGAGTTCAGATAAAGAAGAAGAAAAGGTGGCA
ACATGTATTGCAAAAGGAGCAAAAGATTACATATTCAAGCCACTAAGAGTACAAAATGTA
AAAGCTATTGCAAAATACGTACAGTACAAAGATTAAGGAGATAAAAATTCTAATCTAGTC
GGAATTTAATAATATAAGGTTCTTAAAACATTAGGTTAAGGTGCTTCAGGAAGCGTAGAG
TTAGTGTAAAAAAATGATGGAAATTTATATGCATTAAAGACTATATCCATGAAATATATG
AATGATACAGAAAAAAGATCTGCTCAATCAGAAGTTACTTTGCTAAAGGTCTTAGTTGCA
CCAACTATTATTCGTTATTATGAAGCATTTGTCTAAAATGATTCAATTTATATAGTTATG
GAATATGCAAAAGAAGGAGCCTTAAGCGATAAAATACAAGAGCATAAAACTAAAGGCATA
AGGATAGATGAAGAAACTATTCTTTACTTTACTGCATAGATCGTCATAGCTTTGTTCTTT
ATGCATTAAAAGAAAATTCTTCATAGAGATATTAAGTCTCAAAATCTTTTTTTAACTAAA
GAAAATGTAGTTAAGCTAGGAGACTTTGGTATTTCTAAAGCTCTTGGAACAAATGCTGAT
TTCACTAAAACCTTGGTAGGAACTCCTTATTTTATGTCTCCTGAAGTGTGTGCTGGTTAA
TCTTATGGAGACAAAGCAGATATTTGGGCTTTAGGTTGTACTCTATATGAAATGGTCATG
CTTCGTAGACCTTTTGATTGTGAAAATATAAACACTCTCTTTACTATGATCAGATAATAA
GACCCTTCTCCTTTGCACGATAACTGCAGTACAGACATTAGAATGCTAATTACTCTCATG
CTTAACAAAGATCCACTAAAAAGACCATTTATTTGGGATTTAGTAAACATTCCAATCATA
AATAAGAATATTAGAAAATATCATTAGCAAGAAGCTCCTGATGATCCCTTTTTGATAGAA
TTATTGAAAAGACCAACTTCAGGTAATCCTCTTTCAATGCCTAATACTCCATCCAACTCT
AACTCCTCCACTTAACCGCCAGCTAACTCTAACTCGGTAGCAAATAACAACTCAAATGTC
TCTAACAACCCATAAGAAGCATAATGTAATACTTTAGAATAAATTAGTAAGGCTATGAGT
GAAGAATTAAAACCTTACGACCAAAAAACAGGAATGTTTCATGTGGAAAGAAATGTAATC
AACGGAAAACAAATTTTTGATTGGTTTAATAAATATTATCCAAATTATCAAACTTCTCAG
CTTGTAGAATTACTCTAAAATTTAGTAGAAAAGAAGTATATTCATCATATATCAGGTCCA
CAGTATGAAGCAAATGTTAATTCATTATTCAGATTCTAATTTGATATGCCTGGTATACCT
TAAAACTATTACAAAATATGGAGCAAATAAGCAAGAGCACCTAGTGATATAATGTAAGAG
ATAATTTAATAGGCTAATTTCGTTCTCTAAGAAATTTGCGAATAATACACAGGAGTGATA
TCAGAAGATAAGCTTATCCAAAGTAAGAAATATACAAAATTCTAGGAAATGGTGTGTGAA
CTTCAAAAAATTTACTTGCAAGACCTTACTTAAGAAGATTAAAGAAAATCTTTCTTCTTG
AATCTGATTTAAATAATGTAATTTCACCAGTTTATGAAAGAAAAGTATGACCATAAAAGA
AATGAATAAAAAAAAAATGTATCAACAATTCTAGATTTGATCTAATCATTTCTTCCATTC
TTTAAAAAATAATAAAAATTTGAGTACAGAATTGGGCATTAAACTTTTTCTATAGAAGAT
GTGAAACATGGAATTCTAAGGTGTAATAAAAAGCATAAAGGAAGTAGCTTCCGTCCATTT
ACTGGAAGCGATGATAAATATCAGCTCATTTAATAGTAAGATTTAAGAGTTCTTATTCTT
TTTAAAGAAGAAAATGCTTCACCTTCACCTTTGCTTTTCATAACACCTGAAACATTTGAG
GAGCAACTGAATCAACTTTGTGCTAAATTTATGAGCAGATTTGTTTGCTATGATAGGGTT
GAGAACGATCTAACTTTGCATAAAATATTTTAAATATATCAAAATGACTTTGGAAAAGAT
TAATCTGATACAATAAAATGGGCTTCGAAATATACTAAGGGTATAGGAAATGTAAACGAT
CTCATATCAAGCATTTAACAAGGAGAAGTCTTTATATAATTCTAAGAAAAGTTTGAAATC
TGA

>TTHERM_00265180(protein)
MADKQYMNIHVLVAEDDNFQRLALIDILTLCDYQVTAVENGRLARDELLKQDSNIDIVLL
DLYMPEMDGFELLSLMQEHENLQKIPVIMMSSDKEEEKVATCIAKGAKDYIFKPLRVQNV
KAIAKYVQYKDQGDKNSNLVGIQQYKVLKTLGQGASGSVELVQKNDGNLYALKTISMKYM
NDTEKRSAQSEVTLLKVLVAPTIIRYYEAFVQNDSIYIVMEYAKEGALSDKIQEHKTKGI
RIDEETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKENVVKLGDFGISKALGTNAD
FTKTLVGTPYFMSPEVCAGQSYGDKADIWALGCTLYEMVMLRRPFDCENINTLFTMIRQQ
DPSPLHDNCSTDIRMLITLMLNKDPLKRPFIWDLVNIPIINKNIRKYHQQEAPDDPFLIE
LLKRPTSGNPLSMPNTPSNSNSSTQPPANSNSVANNNSNVSNNPQEAQCNTLEQISKAMS
EELKPYDQKTGMFHVERNVINGKQIFDWFNKYYPNYQTSQLVELLQNLVEKKYIHHISGP
QYEANVNSLFRFQFDMPGIPQNYYKIWSKQARAPSDIMQEIIQQANFVLQEICEQYTGVI
SEDKLIQSKKYTKFQEMVCELQKIYLQDLTQEDQRKSFFLNLIQIMQFHQFMKEKYDHKR
NEQKKNVSTILDLIQSFLPFFKKQQKFEYRIGHQTFSIEDVKHGILRCNKKHKGSSFRPF
TGSDDKYQLIQQQDLRVLILFKEENASPSPLLFITPETFEEQLNQLCAKFMSRFVCYDRV
ENDLTLHKIFQIYQNDFGKDQSDTIKWASKYTKGIGNVNDLISSIQQGEVFIQFQEKFEI

>TTHERM_00265180(gene)
ATGGCTGATAAATAATACATGAATATACATGTCCTCGTAGCAGAGGATGACAATTTCTAA
AGGTTAGCTCTTATAGACATTTTAACTCTATGCGATTATTAGGTCACTGCTGTGGAAAAT
GGCAGATTGGCTAGAGATGAGCTTCTGAAATAAGATTCAAATATTGACATAGTTTTATTA
GATTTATATATGCCAGAAATGGATGGATTTGAATTATTAAGTTTAATGCAAGAACATGAA
AATTTACAAAAGATTCCAGTTATCATGATGAGTTCAGATAAAGAAGAAGAAAAGGTGGCA
ACATGTATTGCAAAAGGAGCAAAAGATTACATATTCAAGCCACTAAGAGTACAAAATGTA
AAAGGTAAATCAATAAATGTTAATTTATTTCTAAAAAGCGTTTTTCAAAATTTTCCTCTA
TTTTGATAAAATAACCAAATAGGGAAGTAAAATATTTGAATAGCCAAATCAAAAAGATTT
TAAAACAAGTATAATAAGAAAGTTTATATTTTTAAATTTAAGCTTATTAGGTGCTATTGT
TTTTTTATAAGCTGATTAGAAAAAAATAAGAAAATCAATAAATAATATATTTATTCGTTT
ATTAATTTTAAATAGCTATTGCAAAATACGTACAGTACAAAGATTAAGGAGATAAAAATT
CTAATCTAGTCGGAATTTAATAATATAAGGTTCTTAAAACATTAGGTTAAGGTGCTTCAG
GAAGCGTAGAGTTAGTGTAAAAAAATGATGGAAATTTATATGCATTAAAGACTATATCCA
TGAAATATATGAATGATACAGAAAAAAGATCTGCTCAATCAGAAGTTACTTTGCTAAAGG
TCTTAGTTGCACCAACTATTATTCGTTATTATGAAGCATTTGTCTAAAATGATTCAATTT
ATATGTAAATACAGCAAAAAATTATATAATTATGTCATAATTTATTTTTTTAAAATTTGA
TTAGAGTTATGGAATATGCAAAAGAAGGAGCCTTAAGCGATAAAATACAAGAGCATAAAA
CTAAAGGCATAAGGATAGATGAAGAAACTATTCTTTACTTTACTGCATAGATCGTCATAG
CTTTGTTCTTTATGCATTAAAAGAAAATTCTTCATAGAGATATTAAGTCTCAAAATCTTT
TTTTAACTAAAGAAAATGTAGTTAAGCTAGGAGACTTTGGTATTTCTAAAGCTCTTGGAA
CAAATGCTGATTTCACTAAAACCTTGGTAGGAACTCCTTATTTTATGTCTCCTGAAGTGT
GTGCTGGTTAATCTTATGGAGACAAAGCAGATATTTGGGCTTTAGGTTGTACTCTATATG
AAATGGTCATGCTTCGTAGACCTTTTGATTGTGAAAATATAAACACTCTCTTTACTATGA
TCAGATAATAAGTAATTAATTTTTTTATTTTAAGTATAAACTTTGACCAGTTTTAACATT
TGTTAATAGGACCCTTCTCCTTTGCACGATAACTGCAGTACAGACATTAGAATGCTAATT
ACTCTCATGCTTAACAAAGATCCACTAAAAAGACCATTTATTTGGGATTTAGTAAACATT
CCAATCATAAATAAGAATATTAGAAAATATCATTAGCAAGAAGCTCCTGATGATCCCTTT
TTGATAGAATTATTGAAAAGACCAACTTCAGGTAATCCTCTTTCAATGCCTAATACTCCA
TCCAACTCTAACTCCTCCACTTAACCGCCAGCTAACTCTAACTCGGTAGCAAATAACAAC
TCAAATGTCTCTAACAACCCATAAGAAGCATAATGTAATACTTTAGAATAAATTAGTAAG
GCTATGAGTGAAGAATTAAAACCTTACGACCAAAAAACAGGAATGTTTCATGTGGAAAGA
AATGTAATCAACGGAAAACAAATTTTTGATTGGTTTAATAAATATTATCCAAATTATCAA
ACTTCTCAGCTTGTAGAATTACTCTAAAATTTAGTAGAAAAGAAGTATATTCATCATATA
TCAGGTCCACAGTATGAAGCAAATGTTAATTCATTATTCAGATTCTAATTTGATATGCCT
GGTATACCTTAAAACTATTACAAAATATGGAGCAAATAAGCAAGAGCACCTAGTGATATA
ATGTAAGAGATAATTTAATAGGCTAATTTCGTTCTCTAAGAAGTAAAAAATGCATTAATT
AACTAACTAATTCATCTTTTATAAATATTTTTTACATTCTAATAAGATTTGCGAATAATA
CACAGGAGTGATATCAGAAGATAAGCTTATCCAAAGTAAGAAATATACAAAATTCTAGGA
AATGGTGTGTGAACTTCAAAAAATTTACTTGCAAGACCTTACTTAAGAAGATTAAAGAAA
ATCTTTCTTCTTGAATCTGATTTAAATAATGTAATTTCACCAGTTTATGAAAGAAAAGTA
TGACCATAAAAGAAATGAATAAAAAAAAAATGTATCAACAATTCTAGATTTGATCTAATC
ATTTCTTCCATTCTTTAAAAGTAAATTTAAAGAATAAAAAAATAAAGTTCAATAAAAAAT
ATTATTTTATTTATCTAAAAAGAATAATAAAAATTTGAGTACAGAATTGGGCATTAAACT
TTTTCTATAGAAGATGTGAAACATGGAATTCTAAGGTGTAATAAAAAGCATAAAGGAAGT
AGCTTCCGTCCATTTACTGGAAGCGATGATAAATATCAGCTCATTTAATAGTAAGATTTA
AGAGTTCTTATTCTTTTTAAAGAAGAAAATGCTTCACCTTCACCTTTGCTTTTCATAACA
CCTGAAACATTTGAGGAGCAACTGAATCAACTTTGTGCTAAATTTATGAGCAGATTTGTT
TGCTATGATAGGGTTGAGAACGATCTAACTTTGCATAAAATATTTTAAATATATCAAAAT
GACTTTGGAAAAGATTAATCTGATACAATAAAATGGGCTTCGAAATATACTAAGGGTATA
GGAAATGTAAACGATCTCATATCAAGCATTTAACAAGGAGAAGTCTTTATATAATTCTAA
GAAAAGTTTGAAATCTGA