Identifiers and Description

Gene Model Identifier

TTHERM_00295920

Standard Name

MSH2 (mismatch repair gene )

Aliases

PreTt15702 | 27.m00362 | 3692.m00165

Description

MutS domain III family protein; homolog to human MSH2

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• mismatched DNA binding (IEA) | GO:0030983

Biological Process

• mismatch repair (IEA) | GO:0006298

Domains

• ( PF00488 ) MutS domain V
• ( PF05188 ) MutS domain II
• ( PF05192 ) MutS domain III
• ( PF05190 ) MutS family domain IV
• ( TIGR01069 ) MutS2 family protein
• ( TIGR01070 ) DNA mismatch repair protein MutS
• ( PF03904 ) Domain of unknown function (DUF334)
• ( PF08011 ) Protein of unknown function (DUF1703)
• ( PF08385 ) Dynein heavy chain, N-terminal region

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 15.3%

TetraMine Data

TTHERM_00295920

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_08853.1	9.997093137033517e-262	MutS domain III family protein (815 aa)
Oxytricha	Contig22029.0.g67	9.997093137033517e-262	MutS domain V
SGD	YOL090W	8.995855300591991e-150	MSH2 Protein that forms hetero dimers with Msh3p and Msh6p th at bind to DNA mismatches to i nitiate the mismatch repair pr ocess; contains a Walker ATP-b inding motif required for repa ir activity; Msh2p-Msh6p binds to and hydrolyzes ATP
DictyBase	DDB_G0275809	7.000020090806431e-140	msh2 on chromosome: 2 position 5513128 to 5516287
WormBase	WBGene00003418	1.0000732791548452e-89	locus:msh-2 status:Confirmed UniProt:Q9TXR4 protein_id :CCD68358.1
Stentor Coeruleus	SteCoe_34271	1.368539471173853e-44

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00295920(coding)
ATGGAAGAGGAAATTGAATTAGTTAATGATAAGAACTTGATGGTTCTTGCTGTTTATTTT
ACTTACCCAAACAATACTCGTTAAGTAAATGCTGCTATTTTAGACAGTGATTAAAGAAAA
TTCTAAGTTACAGAATTCTAAGACACAGAATATTACTCAAATTTTGAGTCCCTCATTCTC
TAGACCAACCCTTAAAATTAGCATACCCAATTTTTGTTGTTAATCCAGTATCCAGATTTG
ACAACAGAAAAAGAAAAAGTCAATGATATTGTTTAACAATGCGACATTAATGTGAAAGAA
AAGGATAAGAAAAGTTTTTTAGAAAAGGGTTATGAAGATGACCTTAATAAATTATTAAAA
AAACCTTTAGCCTAATATATTTAAGAAAGTTAACTTACTCATGCTTTGAGTAGTTTGGCT
TGTATTGTAGGTGATTTATAACTGTCTAAAGAACCTACTAATTAAAATTAATTCACTGTT
GAGACATTGATCTTGAATAATTTTATGAAATTGGATCTCGCTGCTATTAATGCCCTTTTA
ATTTTCCCAAAAGAAAAAGATATCTAGAGAAGAAACTTAATGGGTGGTCAAGAAAATAAT
TTTAGTACATTAGTTGACTTATTAGACAAGTGCAAAACTCAAATTGGCAGTAGAACCTTA
AAGCGCTGGATAAAGCAACCTCTTAAAAATGAGGCTGAAATCAATAGAAGACTTGATATT
GTTGAATATTTTGTCAACAATTAAGATTTGAGAAACTACATTCAAAATGAATTTTTAAGA
AAAATAGCTGACTTAGATAAGCTATATGCTAAATTCTATAAAGTCGCTAGTAAGAAAAAG
CATAACGCTAGTTTAGCTGATTGTATCAAAGTCTATCAACTTGTTACTAATCTAAGTACT
TTAGCACAATATATTGAAAATAACCACTCAGCTGATGAATTAGCATAGAGGGAATTTTTA
ATACCTTTAGGGGAAATACTTGAAAATTTTGAAAAGCTTTCTAGTATGATTGATTAATCA
ATAGATATGGAAAAGGCGAGACGTGATAATGAATACTAAGTTAGTTCTAAATTCTCTCCA
ACTTTAGCAGAACTTGCAAAACAAATGAAATAAATCATGAAGTAAATTGAATCATTAAGA
AATGAATATGCATAAGAATTAGGAGTTGAGCCTAAATTAGTGGAATCTACTACTCACACT
TATTTGTTTGAAAGTAAAAAGAAAGAGACAGATGAAGCCTTCCGTCGTCTCCATAGTCGT
AAGTATAAATCTATTTCAGTTAAGAAAGGCTGTATTTCCTTTACAACTGATGAATTATAA
GCTTGTGTAGCTGAGTATAACAGCTTAAAAGATAACTATTAAGAAGAGTAGAAGTCTGTA
GTTTAGAAAATATTAGACGTCGTTTCTACATACTACCCTGCTATGGAACGTGCAAGTTTC
GTTATTTCTGAATTGGATGTTCTTGCTAACTTTGCTTCTTTAGTTAACTCAGCCACTCGT
CCATATGTCAAACCCAATATTCATGCATCAAATAAGCAAATTAACTTAGTAGAATCTCGT
CATCCCTGCTTAGAAGTAATGGACAATAATTGTGTAGCAAATGACTGCTTTATGGATAAT
GACAAGTCTCGTTTCCATATCATTACTGGGCCAAATATGGGTGGTAAAAGTACTTTTATT
AGATAAGTTGCCATATGCGTTCTATTAGCTCATATTGGTTGCTTTATACCCTGCAAGAGT
GGTGAAATGCCTATCATTGATGCAATCATTACAAGAGTAGGTGCAAGTGATATGCAACTT
CGTGGTATTAGTACTTTCATGAGTGAAATGTTAGAAGCTTCTAACATGTTAATGACAGCA
ACTGAAAATTCTTTAATTATAATCGATGAACTTGGTCGTGGTACTTCTACAAGTGAAGGA
TTTGGTATCGCATGGGCTATTTCAGAACATATTGCTAATAAAATCAAATGTTATTGCTTA
TTTGCAACTCATTTCCATGAAATGACCAAAATGGAACAAGAAGTTAAAGGAGTAATTAAC
TATTATGTAAGCTGTGTAACAATAGACAATAAATTGACTATGCAATATAAATTAAAGAGA
GGTTTTGCTGAGCGTAGTTATGGTTTGTTTGTTGCAGAAACTTTAGATTTCCCTAGAGAA
ATTCTTGAGCATGCCTCAAATAAGCTTTTAGAACTGGAAAGTTATTCAAAGGGAATTTCT
GAAAACCAGAGCTCGGATTAAAATTTTGAGAATTTCAATAAAAATAGCTAAACAGACGAC
ATATTTTTACTTAGTAAGAACTCAACAATTGCTCAAAAAGAAGCTGTTGTTGATCTTGCT
TCTTCCTATAATGAAAAAATAAGAAATGCTGCTTCTAAAGAATAAAAGAAGTAACTACTT
AATGAATTAAAATAAAAAATTATTTCTGCTTTAAAATCTTGA

>TTHERM_00295920(protein)
MEEEIELVNDKNLMVLAVYFTYPNNTRQVNAAILDSDQRKFQVTEFQDTEYYSNFESLIL
QTNPQNQHTQFLLLIQYPDLTTEKEKVNDIVQQCDINVKEKDKKSFLEKGYEDDLNKLLK
KPLAQYIQESQLTHALSSLACIVGDLQLSKEPTNQNQFTVETLILNNFMKLDLAAINALL
IFPKEKDIQRRNLMGGQENNFSTLVDLLDKCKTQIGSRTLKRWIKQPLKNEAEINRRLDI
VEYFVNNQDLRNYIQNEFLRKIADLDKLYAKFYKVASKKKHNASLADCIKVYQLVTNLST
LAQYIENNHSADELAQREFLIPLGEILENFEKLSSMIDQSIDMEKARRDNEYQVSSKFSP
TLAELAKQMKQIMKQIESLRNEYAQELGVEPKLVESTTHTYLFESKKKETDEAFRRLHSR
KYKSISVKKGCISFTTDELQACVAEYNSLKDNYQEEQKSVVQKILDVVSTYYPAMERASF
VISELDVLANFASLVNSATRPYVKPNIHASNKQINLVESRHPCLEVMDNNCVANDCFMDN
DKSRFHIITGPNMGGKSTFIRQVAICVLLAHIGCFIPCKSGEMPIIDAIITRVGASDMQL
RGISTFMSEMLEASNMLMTATENSLIIIDELGRGTSTSEGFGIAWAISEHIANKIKCYCL
FATHFHEMTKMEQEVKGVINYYVSCVTIDNKLTMQYKLKRGFAERSYGLFVAETLDFPRE
ILEHASNKLLELESYSKGISENQSSDQNFENFNKNSQTDDIFLLSKNSTIAQKEAVVDLA
SSYNEKIRNAASKEQKKQLLNELKQKIISALKS

>TTHERM_00295920(gene)
ATGGAAGAGGAAATTGAATTAGTTAATGATAAGAACTTGATGGTTCTTGCTGTTTATTTT
ACTTACCCAAACAATACTCGTTAAGTAAATGCTGCTATTTTAGACAGTGATTAAAGAAAA
TTCTAAGTTACAGAATTCTAAGACACAGAATATTACTCAAATTTTGAGTCCCTCATTCTC
TAGACCAACCCTTAAAATTAGCATACCCAATTTTTGTTGTTAATCCAGTATCCAGATTTG
ACAACAGAAAAAGAAAAAGTCAATGATATTGTTTAACAATGCGACATTAATGTGAAAGAA
AAGTAATTTTTATTGAATAAAATTGAAATTTCATTTTAAAAATCTTATTTAAATGTAAAA
ATTATAGGGATAAGAAAAGTTTTTTAGAAAAGGGTTATGAAGATGACCTTAATAAATTAT
TAAAAAAACCTTTAGCCTAATATATTTAAGAAAGTTAACTTACTCATGCTTTGAGTAGTT
TGGCTTGTATTGTAGGTGATTTATAACTGTCTAAAGAACCTACTAATTAAAATTAATTCA
CTGTTGAGACATTGATCTTGAATAATTTTATGAAATTGGATCTCGCTGCTATTAATGCCC
TTTTAATTTTCCCAAAAGAAAAAGATATCTAGAGAAGAAACTTAATGGGTGGTCAAGAAA
ATAATTTTAGTACATTAGTTGACTTATTAGACAAGTGCAAAACTCAAATTGGCAGTAGAA
CCTTAAAGCGCTGGATAAAGCAACCTCTTAAAAATGAGGCTGAAATCAATAGAAGACTTG
ATATTGTTGAATATTTTGTCAACAATTAAGATTTGAGAAACTACATTCAAAATGAATTTT
TAAGAAAAATAGCTGACTTAGATAAGCTATATGCTAAATTCTATAAAGTCGCTAGTAAGA
AAAAGCATAACGCTAGTTTAGCTGATTGTATCAAAGTCTATCAACTTGTTACTAATCTAA
GTACTTTAGCACAATATATTGAAAATAACCACTCGTAAATTCTATTTGCATGTTATTAAT
AATATTTTATTGATTAAATTATAAAAAAAAAGAGCTGATGAATTAGCATAGAGGGAATTT
TTAATACCTTTAGGGGAAATACTTGAAAATTTTGAAAAGCTTTCTAGTATGATTGATTAA
TCAATAGATATGGAAAAGGCGAGACGTGATAATGAATACTAAGTTAGTTCTAAATTCTCT
CCAACTTTAGCAGAACTTGCAAAACAAATGAAATAAATCATGAAGTAAATTGAATCATTA
AGAAATGAATATGCATAAGAATTAGGAGTTGAGCCTAAATTAGTGGAATCTACTACTCAC
ACTTATTTGTTTGAAAGTAAAAAGAAAGAGACAGATGAAGCCTTCCGTCGTCTCCATAGT
CGTAAGTATAAATCTATTTCAGTTAAGAAAGGCTGTATTTCCTTTACAACTGATGAATTA
TAAGCTTGTGTAGCTGAGTATAACAGCTTAAAAGATAACTATTAAGAAGAGTAGAAGTCT
GTAGTTTAGAAAATATTAGACGTCGTTTCTACATACTACCCTGCTATGGAACGTGCAAGT
TTCGTTATTTCTGAATTGGATGTTCTTGCTAACTTTGCTTCTTTAGTTAACTCAGCCACT
CGTCCATATGTCAAACCCAATATTCATGCATCAAATAAGCAAATTAACTTAGTAGAATCT
CGTCATCCCTGCTTAGAAGTAATGGACAATAATTGTGTAGCAAATGACTGCTTTATGGAT
AATGACAAGTCTCGTTTCCATATCATTACTGGGCCAAATATGGGTGGTAAAAGTACTTTT
ATTAGATAAGTTGCCATATGCGTTCTATTAGCTCATATTGGTTGCTTTATACCCTGCAAG
AGTGGTGAAATGCCTATCATTGATGCAATCATTACAAGAGTAGGTGCAAGTGATATGCAA
CTTCGTGGTATTAGTACTTTCATGAGTGAAATGTTAGAAGCTTCTAACATGTTAATGACA
GCAACTGAAAATTCTTTAATTATAATCGATGAACTTGGTCGTGGTACTTCTACAAGTGAA
GGATTTGGTATCGCATGGGCTATTTCAGGTAATTTAAAACCTTATTATAAATTAATTTAT
TATAATTATAATTATTTAATTACTAGAACATATTGCTAATAAAATCAAATGTTATTGCTT
ATTTGCAACTCATTTCCATGAAATGACCAAAATGGAACAAGAAGTTAAAGGAGTAATTAA
CTATTATGTAAGCTGTGTAACAATAGACAATAAATTGACTATGCAATATAAATTAAAGAG
AGGTTTTGCTGAGCGTAGTTATGGTTTGTTTGTTGCAGAAACTTTAGATTTCCCTAGAGA
AATTCTTGAGCATGCCTCAAATAAGCTTTTAGAACTGGAAAGTTATTCAAAGGGAATTTC
TGAAAACCAGAGCTCGGATTAAAATTTTGAGAATTTCAATAAAAATAGCTAAACAGACGA
CATATTTTTACTTAGTAAGAACTCAACAATTGCTCAAAAAGAAGCTGTTGTTGATCTTGC
TTCTTCCTATAATGAAAAAATAAGAAATGCTGCTTCTAAAGAATAAAAGAAGTAACTACT
TAATGAATTAAAATAAAAAATTATTTCTGCTTTAAAATCTTGA