Identifiers and Description

Gene Model Identifier

TTHERM_00085220

Standard Name

MRK1 (MAP-related kinase )

Aliases

PreTt16370 | 6.m00444 | MRK | 3836.m02037

Description

MRK1 MEK kinase; MAP-related kinase; recombinant MRK autophosphorylates- and phosphorylates myelin basic protein (MBP); transcription increases with temperature downshift from 35 to 15 degrees C- or with osmotic shock

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• MAP kinase activity (ISS) | GO:0004707 | Ref:10187773
• ATP binding (IEA) | GO:0005524
• protein tyrosine kinase activity (IEA) | GO:0004713
• protein kinase activity (IEA) | GO:0004672

Biological Process

• response to cold (IEP) | GO:0009409 | Ref:10187773
• response to osmotic stress (IDA) | GO:0006970 | Ref:10187773
• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF08194 ) DIM protein
• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.8%

TetraMine Data

TTHERM_00085220

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_02429.1	7.996875492733741e-171	protein kinase domain-containi ng protein (625 aa)
Oxytricha	Contig10155.0.g64	2.0007864815129413e-165	Protein kinase domain
DictyBase	DDB_G0286353	2.9998512931988133e-83	erkA on chromosome: 4 position 4355028 to 4356796
Stentor Coeruleus	SteCoe_12365	8.854771883513433e-70
WormBase	WBGene00003401	4.001968334034435e-68	locus:mpk-1 Mitogen-activate d protein kinase mpk-1 statu s:Confirmed UniProt:P39745 protein_id:CAA87057.1
SGD	YHR030C	5.999140071902665e-66	SLT2 Serine/threonine MAP kina se; involved in regulating mai ntenance of cell wall integrit y, progression through the cel l cycle, and nuclear mRNA rete ntion in heat shock; required for mitophagy and pexophagy; a ffects recruitment of mitochon dria to the phagophore assembl y site (PAS); regulated by the PKC1-mediated signaling pathw ay

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,
2. Ref:10735176: Nakashima S, Nozawa Y (1999) Stress-responsive gene expression in Tetrahymena. Acta biologica Hungarica 50(4):413-24
3. Ref:10187773: Nakashima S, Wang S, Hisamoto N, Sakai H, Andoh M, Matsumoto K, Nozawa Y (1999) Molecular cloning and expression of a stress-responsive mitogen-activated protein kinase-related kinase from Tetrahymena cells. The Journal of biological chemistry 274(15):9976-83

Sequences

>TTHERM_00085220(coding)
ATGGACAAAAAGTTATCTTCCAAGAATTTTTCCGACTGGGAGGTTGGTGATAGATATGAT
CTTATTAAGGTTGTAGGTAGTGGTTCTTATGGTTCTGTAGCTGAAGCTACTGACAAGAAA
TCAGGCAAGAAAGTTGCCATTAAGAGATTGAATGGTATCTTCGAAGACAATGTTGACTGC
AAACGTATTCTTAGAGAAATTCACTTGTTACGTATTTTAAATCACCCTAACCTTATTAGA
ATCAATGAAATTATTGAACCTAAGGACTTATAGAACTTCGACACTCTTTATGTCGTTACT
GAATATTGCTAATCCGACCTTAAAAAGCTCTTCAAGTCACCTATTCACTTGTGCATGATC
CAAGTTTAAACATTAACCTACAACATTCTCACTGGTATTAAATATCTCCACTCTGCTGAA
GTACTTCATAGAGATCTCAAGCCTGCTAACGTCCTTATCAATGAAGATTGCTCTGTCAAG
ATTTGTGACTTTGGTCTCGCCAGATCTGTAGAAGGTATTGAAGGTGCACATATTTATGAT
GATAGAAATAGCAACAGCCCTCAAAAGTAATAAACCAGTAGCCAAAGCCCTGAAAAGCCT
GCAGCTACCAGCAGTGGAAGACCTAAACTTTCTAAAGAAAAGGGAATTAACTCTAAAACC
ACTAAGAGAGAATTGACTGGCCACGTAGTTACTCGTTGGTACAGAGCTCCCGAATTGATT
CTTTTGGAAAAAGATTACACTGCTGCCATTGATATCTGGAGTATTGGTTGTATCTTCGCT
GAATTGATGAATATGATCAAGGAAAACTCCCCCACCTTCTTAGATAGATCTCCTCTTTTC
CCTGGTAGCAGCTGCTTCCCCCTCTCACCTGATAGAAACAACACAGTTAAGTAGGGTGGA
TTCCCCCACAGCCACAGTGATTAATTGAATGTCATCTTCTCAGTCTTGGGTACCCCTAAT
GAAGAAGATATGGACTTCGTCACTGATGCTAAGGCTATCGAATATTTAAAGAGCTTCAAG
CAAAAGAAGAGAGTCGACTTCAAGGATTTATTCCCAGCTGCCACCCCTGAATGTATTGAT
TTCTTGAACAAAACCCTTGTCTTCAACCCTCGTAAAAGAATTACTATTGATGCTGCCCTC
AACCATCCTCTCTTTACCCCTGTCAGAGATATCAAGAAAGAAGTATTTGCTGATGGCTCC
GTTGTTCTTCCCTTTGAAAAAGAAGGAGACATGGCTATACCTAGACTCCGTGAACTCTTC
ATCGAAGAAATCAAGCGTTATCACACTAAGTGA

>TTHERM_00085220(protein)
MDKKLSSKNFSDWEVGDRYDLIKVVGSGSYGSVAEATDKKSGKKVAIKRLNGIFEDNVDC
KRILREIHLLRILNHPNLIRINEIIEPKDLQNFDTLYVVTEYCQSDLKKLFKSPIHLCMI
QVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSVEGIEGAHIYD
DRNSNSPQKQQTSSQSPEKPAATSSGRPKLSKEKGINSKTTKRELTGHVVTRWYRAPELI
LLEKDYTAAIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGG
FPHSHSDQLNVIFSVLGTPNEEDMDFVTDAKAIEYLKSFKQKKRVDFKDLFPAATPECID
FLNKTLVFNPRKRITIDAALNHPLFTPVRDIKKEVFADGSVVLPFEKEGDMAIPRLRELF
IEEIKRYHTK

>TTHERM_00085220(gene)
ATGGACAAAAAGTTATCTTCCAAGAATTTTTCCGACTGGGAGGTTGGTGATAGATATGAT
CTTATTAAGGTTGTAGGTAGTGGTTCTTATGGTTCTGTAGCTGAAGCTACTGACAAGAAA
TCAGGCAAGAAAGTTGCCATTAAGAGATTGAATGGTATCTTCGAAGACAATGTTGACTGC
AAACGTATTCTTAGAGAAATTCACTTGTTACGTATTTTAAATCACCCTAACCTTATTAGA
ATCAATGAAATTATTGAACCTAAGGACTTATAGAACTTCGACACTCTTTATGTCGTTACT
GAATATTGCTAATCCGACCTTAAAAAGCTCTTCAAGTCACCTATTCACTTGTGCATGATC
CAAGTTTAAACATTAACCTACAACATTCTCACTGGTATTAAATATCTCCACTCTGCTGAA
GTACTTCATAGAGATCTCAAGCCTGCTAACGTCCTTATCAATGAAGATTGCTCTGTCAAG
ATTTGTGACTTTGGTCTCGCCAGATCTGTAGAAGGTAATTAAAATCTCAGATTTTCATTT
TTCACTTTCTCACTTTTGATTGGCTTTATCATTTATTTAACACTTTTAAGGATGAAAATG
ATCCTCCTTCTTCTATTTCTCAAATACCATAAAGTCAAATAGTAATAATAAATGTTAAAT
AACAATATCATGTTAAATTGCTATACAACTTCTACTTTTTGATTCATTTAAAACTCATTT
TTATACATTTTTCTATCAAATATAATCTAATTGGTTTTAAAAAAACCGAATTTCTAAAAC
TAATCTAAAGAAATTCTTAAACAGAATTAATATCCACAGGCAATGACTTCAAGAAGTCGT
TGTTTAAACAAACACTACTCCAAAATATTATTAAAATTAAAAAAAAATCTCCACATTGAA
GATGATCTGCAAGAGTTTATCCTAAAAACTCGAGTAATAAATAAATAAAAGAAATATAAA
TAGATCAAATTGTTAAATGAATAATCGAGTTTGTTTCTAAAAAAATAAAATAAACAATAA
AAGTCTACTTAACATAGCTCATTTCATGATGAATTTAGCTAATAAATAGATGATAACCTA
GCAATCTTAGTAAATTAGGAAAATATAATTCAAGATTAATAATAGATAGTCAAGGCGATA
GAAACAAAGAAAGAAAGAAAAAATAAAAATAGATATTTCAGCAAACAAAATAGCAAAATA
AAATTCTATGAAAAAAAAACATAAAGAAATTTAAATAATTATCAGCAAGCATCAAATTAA
TTATTGTAAAAAGCAGATAGATAGATAGATTAAAAATTCTTATGTTAATCTAAGAATAAA
TTTTAGCCAACAATAATTTTTTTAATTAAAAAATTGTCTTTTTTATTTTTATTAAATAAA
TAATTAATTAAATTAATAAAATAAAGGTATTGAAGGTGCACATATTTATGATGATAGAAA
TAGCAACAGCCCTCAAAAGTAATAAACCAGTAGCCAAAGCCCTGAAAAGCCTGCAGCTAC
CAGCAGTGGAAGACCTAAACTTTCTAAAGAAAAGGGAATTAACTCTAAAACCACTAAGAG
AGAATTGACTGGCCACGTAGTTACTCGTTGGTACAGAGCTCCCGAATTGATTCTTTTGGA
AAAAGATTACACTGCTGCCATTGATATCTGGAGTATTGGTTGTATCTTCGCTGAATTGAT
GAATATGATCAAGGAAAACTCCCCCACCTTCTTAGATAGATCTCCTCTTTTCCCTGGTAG
CAGCTGCTTCCCCCTCTCACCTGATAGAAACAACACAGTTAAGTAGGGTGGATTCCCCCA
CAGCCACAGTGATTAATTGAATGTCATCTTCTCAGTCTTGGGTACCCCTAATGAAGAAGA
TATGGACTTCGTCACTGATGCTAAGGCTATCGAATATTTAAAGAGCTTCAAGCAAAAGAA
GAGAGTCGACTTCAAGGATTTATTCCCAGCTGCCACCCCTGAATGTATTGATTTCTTGAA
CAAAACCCTTGTCTTCAACCCTCGTAAAAGAATTACTATTGATGCTGCCCTCAACCATCC
TCTCTTTACCCCTGTCAGAGATATCAAGAAAGAAGTATTTGCTGATGGCTCCGTTGTTCT
TCCCTTTGAAAAAGAAGGAGACATGGCTATACCTAGACTCCGTGAACTCTTCATCGAAGA
AATCAAGCGTTATCACACTAAGTGA