Identifiers and Description

Gene Model Identifier

TTHERM_00660130

Standard Name

MPK3 (Mitogen-activated Protein Kinase)

Aliases

PreTt23757 | 98.m00100 | 3736.m00001

Description

Protein kinase domain containing protein. Sequence similarity to the MAPK protein kinase family (Eisen et al., 2006). ;Putative mitogen-activated ERK1/2 subfamily (MAP) kinase.

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• protein tyrosine kinase activity (IEA) | GO:0004713
• protein kinase activity (IEA) | GO:0004672
• ATP binding (IEA) | GO:0005524

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase
• ( PF01636 ) Phosphotransferase enzyme family
• ( PF07194 ) P2 response regulator binding domain

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.3%

TetraMine Data

TTHERM_00660130

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_17258.1	9.997093137033517e-262	protein kinase domain-containi ng protein (543 aa)
Oxytricha	Contig8762.0.g22	8.996816452944345e-116	Protein kinase domain
DictyBase	DDB_G0286353	1.0000943968537097e-101	erkA on chromosome: 4 position 4355028 to 4356796
SGD	YBL016W	4.0007753645635287e-88	FUS3 Mitogen-activated serine/ threonine protein kinase invol ved in mating; phosphoactivate d by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth durin g mating by phosphorylating Te c1p, promoting its degradation
WormBase	WBGene00003401	5.997798783616184e-81	locus:mpk-1 Mitogen-activate d protein kinase mpk-1 statu s:Confirmed UniProt:P39745 protein_id:CAA87057.1
Stentor Coeruleus	SteCoe_36642	8.408597124803643e-50

General Information

No Data fetched for General Information

Associated Literature

1. Ref:25286252: Yıldız MT, Arslanyolu M (2014) In silico identification and characterization of the MAPK family members of unicellular model eukaryote Tetrahymena thermophila. European journal of protistology 50(5):538-50
2. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,
3. Ref:17821280: Harrison JA, Fowler EH (1945) AN ANTIGEN-ANTIBODY REACTION WITH TETRAHYMENA WHICH RESULTS IN DYSTOMY. Science (New York, N.Y.) 102(2638):65-6

Sequences

>TTHERM_00660130(coding)
ATGTCTAAATCATACTAACAAAACGGGATTACCTTTACAACAGGAGAAAGATATGAAGTT
GATAAGTTATTAGGCTCAGGAGCATATGGCCAAGTAGTGAGAGCCAAAGATAAGAAAAAT
TAGAATCAGTATGTAGCAATAAAGAAATTACACAAAATCGAAGATGTTATAGATGCAAAA
AGAGTTCTTAGAGAAATAAGAATCTTACGTTATTTAGTTCATGAAAATATCTTGTAATTG
AGTGATATTCTTTATGATGACGAAGATGAAAATTAAGAATTCGGCACAATCTATTTAGTA
ACCAATTACATGGAAATCGATTTGTATCAAGTTATTAAGTCTGATCAAAAGCTCAGCGAT
TAGCACATCCAATATATTATCTATTAAATCCTTAAGGGTTTGAAGTATCTCCACTCTGCA
AATATTATCCACAGAGATCTCAAACCATCAAATCTTTTAGCCACAGAAAAATGTGCTATT
CGTATGTGTGATTTTGGTTTATCAAGAAGTATTGAAGATGAGCAGAAGCAAGAACAACAA
CTATAATAAGGTTAATTAACCGAATACGTTGTCACTAGATACTATAGAGCTCCTGAAATC
ATGCTTAGCTCTCATGTTTACTCAAAGGCTGTCGATATTTGGTCTCTTGGTTGCACATTT
GCCGAACTGATTAGCCATTAAATCCTCTTTAAAGCAGATAATTATATTAAATAAATTAAG
TTAATTTTCGATAAGCTTGGTATGCCTCCTGAGGAAGATTTGCAATTTATTGGAAACAGT
AATGCTAAATAATTCGTAAATACTCTCGCTAAAAAGAATTCTGTCAAGGTTAGCAGCTTT
ATTAATTATGAAAATCCATTAGCCCTTGACTTAATAGACAAGATGCTTGCTATAAACCCC
AGCAAACGTATAACTGCTGATGAAGCCCTTGAACACCCTTACTTCTAATCTATTCGTGAT
GTCTAAGAAGAAATCAAATTCACTGGAACTATCAACTTTGATTTCGAAACTGACTCTGAA
ATAACAATTGAAAGCTTGAGAAAATAGATCTTGGAAGAAGTCAACCACTTTAGATAAGTT
AATAAGGTACCTCCCTTGAAAATACCTGATTTACTTGCTCTTTGTGAAAAGCGTACAAAA
GCTATACAAGAAAAAGCAAACCTCCATAAAAAATGA

>TTHERM_00660130(protein)
MSKSYQQNGITFTTGERYEVDKLLGSGAYGQVVRAKDKKNQNQYVAIKKLHKIEDVIDAK
RVLREIRILRYLVHENILQLSDILYDDEDENQEFGTIYLVTNYMEIDLYQVIKSDQKLSD
QHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSIEDEQKQEQQ
LQQGQLTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELISHQILFKADNYIKQIK
LIFDKLGMPPEEDLQFIGNSNAKQFVNTLAKKNSVKVSSFINYENPLALDLIDKMLAINP
SKRITADEALEHPYFQSIRDVQEEIKFTGTINFDFETDSEITIESLRKQILEEVNHFRQV
NKVPPLKIPDLLALCEKRTKAIQEKANLHKK

>TTHERM_00660130(gene)
AGAAACTACTTCAAGCAAATTTTTTCTTCTTCATCTTCTTCATTTTAATTATTCTTTTTT
ACATTAAAGCATTTTTCTTTTCCACAGTAAAAAGATAGCAGGCAAAATTCTATAAAATGA
AATATATTATCCTTCAAGTAAAAAATATACTGAAACTTTAATTTAAAAGCAACAAGCTTA
ATGCTATTAAGTAATATTTAAAATATGGCTTTAAAAAAAATGTTATTTTCTTGAAGGAAA
AAAATTAAGTTATAGATAGAAAAATTAAAAAATGATTGTAAATAAGCATAAATTTTATAA
TTTAACACATAAAATTGATTAAAAAAATGAGCTAATTAGGGTTTAATTAGCTCAATTTGC
TATTATTTAGTAGGATGCAAGTTCAGCAAGCAAAGAAGAAAGATGAAACAAACATATTAG
CCAATTAATAAATAATTATGTGTTTGCATGCTTCAATTAATAGAAAGAATTAAGCAGGAA
AATTAATTATACAAAAAAATAAATTAATAAATAAATAAATTAGATAGTGAGGAAGTATAG
GATAAGAGGGAATGTCAACTTAAAAGAAGAAAAGAAAAAGGAGGAGAAGATTGATTAATT
AATTAATTAATCAATTAAGAAAGAAGAAAGAAAGTAGAGTGATATAGAGACAGAGCCAGA
GACAAGACAAGAGAAAGTGATAGGCAGTGAATGAACAGATAAATAATTTATTTGAAAAGA
AATAGTTAATATAAAAATTAATTAATTGTAATTAATATTAAGAAAAATAAATAAAAATTA
ATTATATCAAACAATTAAATTCAGAAGATAGTGAGCTTCCTTGTTAATCATCACCAACTC
AGTAGTATCCATACAAAATAAATAAGCAAGTAGCAATATAGATATATAAAAACTTAAAAA
ATACTCAGTTTATTCTCTCTTATTTTTCATCTTAAACTCCATTTTCTTTTCTTCCTTTCA
CCTTTCTGTTAGCTTGCTCTATTTATTTGATTCTTTAAGATCTCTTCAGCCCAAATCTGC
TATTTTTTATTGCAATTTAATTGCATGATTCCTTTTATTTAATGACATTTTTATTCCTGC
TGACTCTAATGTTTGCTTTTTGCCCAAGCACTCAAAACGTAGAGTGAGCTCACGTCTTTT
AAGTCGTATACATAGTATGATGGTTAAAGCAGCAACAAAGCTCAGCCTATAGCTTTAAAG
AATCAATCAGCTGAAAAGTTAGAGTGTTTGATTAGGTGAAAAGGCCGTTTTAATTGATAA
AAAACAAAAGACTATCTCTGGAAACCCGAAAGTTTTTTTAGTATTATTAAGTTTTTTAAA
AAGGTGAAGAGAAGGTGAATAGGAGGAATAGAAAAGTAGAAAGAAAGAGATAAATATTAT
AACAAATATCATTTACTTATACATAATTAATATGTCAATAAATATAAAATAGTGTCTAAA
TCATACTAACAAAACGGGATTACCTTTACAACAGGAGAAAGATATGAAGTTGATAAGTTA
TTAGGCTCAGGAGCATATGGCCAAGTAGTGAGAGCCAAAGATAAGAAAAATTAGAATCAG
TATGTAGCAATAAAGAAATTACACAAAATCGAAGATGTTATAGATGCAAAAAGAGTTCTT
AGAGAAATAAGAATCTTACGTTATTTAGTTCATGAAAATATCTTGTAATTGAGTGATATT
CTTTATGATGACGAAGATGAAAATTAAGAATTCGGCACAATCTATTTAGTAACCAATTAC
ATGGAAATCGATTTGTATCAAGTTATTAAGTCTGATCAAAAGCTCAGCGATTAGCACATC
CAATATATTATCTATTAAATCCTTAAGGGTTTGAAGTATCTCCACTCTGCAAATATTATC
CACAGAGATCTCAAACCATCAAATCTTTTAGCCACAGAAAAATGTGCTATTCGTATGTGT
GATTTTGGTTTATCAAGAAGTATTGAAGATGAGCAGAAGCAAGAACAACAACTAGTAAGA
AATCTTATTTTATTTTTCAGCTTCATTATTCTGATGCATAATTTACACAAACAAACAAAC
AAATAAATAAATAAAAAAACTAACAAACCCAACCAATATTTATTTTAAACTCTATTAAGT
TATTCCCTCAAATAATTCATTCATAATTGCAACTAATTTTCTCTCTATGAGTTTTATACA
GTCAACAAAAAGCAAGCAAGCAAACAAATAAATACTTGTAATTAACCTATCTATGATGAA
TTTAAATTGGAAATAACTAAAGAATTCAAATTTTCACAGTGCTCTTCACCTTTACAAAAA
ATATGAAATTAACATAAATATTTTGATTCTCTGACAACAAACAAACAAACAGATCATTAG
ATTTTTTACTTTAAAAATTTTAAAAGTAGTTAGAATAAATAAAATTTGATTAGCATGCAA
AAATTGTTTAAAGAATATGGAATTTATTTCAAGTTATAATTCAGATTTCATTGAATTTAT
AGAATCATTTATATAAAGAGAAAGCACAAATTTTTAAAAACATTGAAATTTTTAGACACG
AATATAATAAAAAGGTAGTAAATAGATCTAATAAGTATCTGATATTTATTGATTTGCTCA
TTAAATCCATTTCTAATTTTTTTAAATTAATAACTAATAATTAAAAAATTGAAAAAAAAT
AATTAGCTAGCCATTTTAGATTAGCATTTTGTTAAAATCAACAGGTTATTATCTAGTTTT
TCTTGTTTCAAACATAAAAATATCATTAAAAAGCTTAAAATATAATGTAGCATATATAAG
CAAAAAGTTAAATAAGATGATAAATTTGAGCTACTTTTTGAGGAAAATTATTTTTTGGTA
TTTTTTTGAACAAACATGTAAAAAAACATACAATATTTTATAATAAAAGTTAAAGCAAAT
GCTTATTGAATAAAGCTTTAGCAATAAATCAGACTGAGTATAAACAATAGAGTTTTTTAT
TCTTGTTTTATTTAATTTAATTTATTTGGGGAATAGAGTTGATTTCAAATAAAGCAGAAT
TAGAAAGAAAGAAATAGAAATATAATTTATTGCTGCCAAATAAAAATTGGTTCTCTTCAA
TAAATTAATTAATTAAAATTTATCAATCTTTTCTAATCCACAAAGCAATTTCTAAAAAAT
TAAATAAAAAATAAACCAATTAATAAATCTAAGACTACTAATTAATTTATTAATTATTTC
ATTCATTTTACTTATAAAAAACTTCACTTATTTTAAACAAATAAATTTAACTAAAAATAG
TAATAAGGTTAATTAACCGAATACGTTGTCACTAGATACTATAGAGCTCCTGAAATCATG
CTTAGCTCTCATGTTTACTCAAAGGCTGTCGATATTTGGTCTCTTGGTTGCACATTTGCC
GAACTGATTAGCCATTAAATCCTCTTTAAAGCAGATAATTATATTAAATAAATTAAGTTA
ATTTTCGATAAGCTTGGTATGCCTCCTGAGGAAGATTTGCAATTTATTGGAAACAGTAAT
GCTAAATAATTCGTAAATACTCTCGCTAAAAAGAATTCTGTCAAGGTTAGCAGCTTTATT
AATTATGAAAATCCATTAGCCCTTGACTTAATAGACAAGATGCTTGCTATAAACCCCAGC
AAACGTATAACTGCTGATGAAGCCCTTGAACACCCTTACTTCTAATCTATTCGTGATGTC
TAAGAAGAAATCAAATTCACTGGAACTATCAACTTTGATTTCGAAACTGACTCTGAAATA
ACAATTGAAAGCTTGAGAAAATAGATCTTGGAAGAAGTCAACCACTTTAGATAAGTTAAT
AAGGTACCTCCCTTGAAAATACCTGATTTACTTGCTCTTTGTGAAAAGCGTACAAAAGCT
ATACAAGAAAAAGCAAACCTCCATAAAAAATGAAAATGAAAGAATGAAAGAAACTATTCA
ATCAATCAACCAATCTATCTATCTATCAATCTAACACAACACAATACAACCGATTTTTAT
TCTAGAATATCAAAATTAACTAAACCTATGACAGTTTTCATTTCTTTTATGACAAACTAA
CTAACTTAAATTTCCAAATTATCATACATTCATTCATTCATACATACATACATTCATTCA
TTATCATTATTATCCTTACATATATATATACACTCTTTCCAACAAACACACTTATTATAA
AAATATGAATATCATCATAACAATTATTAATTATAAATGCATTGAATCATTTGTTCGTTC
GTCCATCCATAAATGTAGTTAGTAGTTCATTAGTTC