Identifiers and Description

Gene Model Identifier

TTHERM_00660130

Standard Name

MPK3 (Mitogen-activated Protein Kinase)

Aliases

PreTt23757 | 98.m00100 | 3736.m00001

Description

MPK3 sporangia induced MAP kinase; Protein kinase domain containing protein. Sequence similarity to the MAPK protein kinase family (Eisen et al.- 2006). ;Putative mitogen-activated ERK1/2 subfamily (MAP) kinase.

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein tyrosine kinase activity (IEA) | GO:0004713
• protein kinase activity (IEA) | GO:0004672

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase
• ( PF01636 ) Phosphotransferase enzyme family
• ( PF07194 ) P2 response regulator binding domain

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.3%

TetraMine Data

TTHERM_00660130

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_17258.1	9.997093137033517e-262	protein kinase domain-containi ng protein (543 aa)
Oxytricha	Contig8762.0.g22	8.996816452944345e-116	Protein kinase domain
DictyBase	DDB_G0286353	1.0000943968537097e-101	erkA on chromosome: 4 position 4355028 to 4356796
SGD	YBL016W	4.0007753645635287e-88	FUS3 Mitogen-activated serine/ threonine protein kinase invol ved in mating; phosphoactivate d by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth durin g mating by phosphorylating Te c1p, promoting its degradation
WormBase	WBGene00003401	5.997798783616184e-81	locus:mpk-1 Mitogen-activate d protein kinase mpk-1 statu s:Confirmed UniProt:P39745 protein_id:CAA87057.1
Stentor Coeruleus	SteCoe_36642	8.408597124803643e-50

General Information

No Data fetched for General Information

Associated Literature

1. Ref:25286252: Yıldız MT, Arslanyolu M (2014) In silico identification and characterization of the MAPK family members of unicellular model eukaryote Tetrahymena thermophila. European journal of protistology 50(5):538-50
2. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,
3. Ref:17821280: Harrison JA, Fowler EH (1945) AN ANTIGEN-ANTIBODY REACTION WITH TETRAHYMENA WHICH RESULTS IN DYSTOMY. Science (New York, N.Y.) 102(2638):65-6

Sequences

>TTHERM_00660130(coding)
ATGGTTAAAGCAGCAACAAAGCTCAGCCTATAGCTTTAAAGAATCAATCAGCTGAAAATG
TCTAAATCATACTAACAAAACGGGATTACCTTTACAACAGGAGAAAGATATGAAGTTGAT
AAGTTATTAGGCTCAGGAGCATATGGCCAAGTAGTGAGAGCCAAAGATAAGAAAAATTAG
AATCAGTATGTAGCAATAAAGAAATTACACAAAATCGAAGATGTTATAGATGCAAAAAGA
GTTCTTAGAGAAATAAGAATCTTACGTTATTTAGTTCATGAAAATATCTTGTAATTGAGT
GATATTCTTTATGATGACGAAGATGAAAATTAAGAATTCGGCACAATCTATTTAGTAACC
AATTACATGGAAATCGATTTGTATCAAGTTATTAAGTCTGATCAAAAGCTCAGCGATTAG
CACATCCAATATATTATCTATTAAATCCTTAAGGGTTTGAAGTATCTCCACTCTGCAAAT
ATTATCCACAGAGATCTCAAACCATCAAATCTTTTAGCCACAGAAAAATGTGCTATTCGT
ATGTGTGATTTTGGTTTATCAAGAAGTATTGAAGATGAGCAGAAGCAAGAACAACAACTA
TAATAAGGTTAATTAACCGAATACGTTGTCACTAGATACTATAGAGCTCCTGAAATCATG
CTTAGCTCTCATGTTTACTCAAAGGCTGTCGATATTTGGTCTCTTGGTTGCACATTTGCC
GAACTGATTAGCCATTAAATCCTCTTTAAAGCAGATAATTATATTAAATAAATTAAGTTA
ATTTTCGATAAGCTTGGTATGCCTCCTGAGGAAGATTTGCAATTTATTGGAAACAGTAAT
GCTAAATAATTCGTAAATACTCTCGCTAAAAAGAATTCTGTCAAGGTTAGCAGCTTTATT
AATTATGAAAATCCATTAGCCCTTGACTTAATAGACAAGATGCTTGCTATAAACCCCAGC
AAACGTATAACTGCTGATGAAGCCCTTGAACACCCTTACTTCTAATCTATTCGTGATGTC
TAAGAAGAAATCAAATTCACTGGAACTATCAACTTTGATTTCGAAACTGACTCTGAAATA
ACAATTGAAAGCTTGAGAAAATAGATCTTGGAAGAAGTCAACCACTTTAGATAAGTTAAT
AAGGTACCTCCCTTGAAAATACCTGATTTACTTGCTCTTTGTGAAAAGCGTACAAAAGCT
ATACAAGAAAAAGCAAACCTCCATAAAAAATGA

>TTHERM_00660130(protein)
MVKAATKLSLQLQRINQLKMSKSYQQNGITFTTGERYEVDKLLGSGAYGQVVRAKDKKNQ
NQYVAIKKLHKIEDVIDAKRVLREIRILRYLVHENILQLSDILYDDEDENQEFGTIYLVT
NYMEIDLYQVIKSDQKLSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIR
MCDFGLSRSIEDEQKQEQQLQQGQLTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFA
ELISHQILFKADNYIKQIKLIFDKLGMPPEEDLQFIGNSNAKQFVNTLAKKNSVKVSSFI
NYENPLALDLIDKMLAINPSKRITADEALEHPYFQSIRDVQEEIKFTGTINFDFETDSEI
TIESLRKQILEEVNHFRQVNKVPPLKIPDLLALCEKRTKAIQEKANLHKK

>TTHERM_00660130(gene)
ATGGTTAAAGCAGCAACAAAGCTCAGCCTATAGCTTTAAAGAATCAATCAGCTGAAAAGT
TAGAGTGTTTGATTAGGTGAAAAGGCCGTTTTAATTGATAAAAAACAAAAGACTATCTCT
GGAAACCCGAAAGTTTTTTTAGTATTATTAAGTTTTTTAAAAAGGTGAAGAGAAGGTGAA
TAGGAGGAATAGAAAAGTAGAAAGAAAGAGATAAATATTATAACAAATATCATTTACTTA
TACATAATTAATATGTCAATAAATATAAAATAGTGTCTAAATCATACTAACAAAACGGGA
TTACCTTTACAACAGGAGAAAGATATGAAGTTGATAAGTTATTAGGCTCAGGAGCATATG
GCCAAGTAGTGAGAGCCAAAGATAAGAAAAATTAGAATCAGTATGTAGCAATAAAGAAAT
TACACAAAATCGAAGATGTTATAGATGCAAAAAGAGTTCTTAGAGAAATAAGAATCTTAC
GTTATTTAGTTCATGAAAATATCTTGTAATTGAGTGATATTCTTTATGATGACGAAGATG
AAAATTAAGAATTCGGCACAATCTATTTAGTAACCAATTACATGGAAATCGATTTGTATC
AAGTTATTAAGTCTGATCAAAAGCTCAGCGATTAGCACATCCAATATATTATCTATTAAA
TCCTTAAGGGTTTGAAGTATCTCCACTCTGCAAATATTATCCACAGAGATCTCAAACCAT
CAAATCTTTTAGCCACAGAAAAATGTGCTATTCGTATGTGTGATTTTGGTTTATCAAGAA
GTATTGAAGATGAGCAGAAGCAAGAACAACAACTAGTAAGAAATCTTATTTTATTTTTCA
GCTTCATTATTCTGATGCATAATTTACACAAACAAACAAACAAATAAATAAATAAAAAAA
CTAACAAACCCAACCAATATTTATTTTAAACTCTATTAAGTTATTCCCTCAAATAATTCA
TTCATAATTGCAACTAATTTTCTCTCTATGAGTTTTATACAGTCAACAAAAAGCAAGCAA
GCAAACAAATAAATACTTGTAATTAACCTATCTATGATGAATTTAAATTGGAAATAACTA
AAGAATTCAAATTTTCACAGTGCTCTTCACCTTTACAAAAAATATGAAATTAACATAAAT
ATTTTGATTCTCTGACAACAAACAAACAAACAGATCATTAGATTTTTTACTTTAAAAATT
TTAAAAGTAGTTAGAATAAATAAAATTTGATTAGCATGCAAAAATTGTTTAAAGAATATG
GAATTTATTTCAAGTTATAATTCAGATTTCATTGAATTTATAGAATCATTTATATAAAGA
GAAAGCACAAATTTTTAAAAACATTGAAATTTTTAGACACGAATATAATAAAAAGGTAGT
AAATAGATCTAATAAGTATCTGATATTTATTGATTTGCTCATTAAATCCATTTCTAATTT
TTTTAAATTAATAACTAATAATTAAAAAATTGAAAAAAAATAATTAGCTAGCCATTTTAG
ATTAGCATTTTGTTAAAATCAACAGGTTATTATCTAGTTTTTCTTGTTTCAAACATAAAA
ATATCATTAAAAAGCTTAAAATATAATGTAGCATATATAAGCAAAAAGTTAAATAAGATG
ATAAATTTGAGCTACTTTTTGAGGAAAATTATTTTTTGGTATTTTTTTGAACAAACATGT
AAAAAAACATACAATATTTTATAATAAAAGTTAAAGCAAATGCTTATTGAATAAAGCTTT
AGCAATAAATCAGACTGAGTATAAACAATAGAGTTTTTTATTCTTGTTTTATTTAATTTA
ATTTATTTGGGGAATAGAGTTGATTTCAAATAAAGCAGAATTAGAAAGAAAGAAATAGAA
ATATAATTTATTGCTGCCAAATAAAAATTGGTTCTCTTCAATAAATTAATTAATTAAAAT
TTATCAATCTTTTCTAATCCACAAAGCAATTTCTAAAAAATTAAATAAAAAATAAACCAA
TTAATAAATCTAAGACTACTAATTAATTTATTAATTATTTCATTCATTTTACTTATAAAA
AACTTCACTTATTTTAAACAAATAAATTTAACTAAAAATAGTAATAAGGTTAATTAACCG
AATACGTTGTCACTAGATACTATAGAGCTCCTGAAATCATGCTTAGCTCTCATGTTTACT
CAAAGGCTGTCGATATTTGGTCTCTTGGTTGCACATTTGCCGAACTGATTAGCCATTAAA
TCCTCTTTAAAGCAGATAATTATATTAAATAAATTAAGTTAATTTTCGATAAGCTTGGTA
TGCCTCCTGAGGAAGATTTGCAATTTATTGGAAACAGTAATGCTAAATAATTCGTAAATA
CTCTCGCTAAAAAGAATTCTGTCAAGGTTAGCAGCTTTATTAATTATGAAAATCCATTAG
CCCTTGACTTAATAGACAAGATGCTTGCTATAAACCCCAGCAAACGTATAACTGCTGATG
AAGCCCTTGAACACCCTTACTTCTAATCTATTCGTGATGTCTAAGAAGAAATCAAATTCA
CTGGAACTATCAACTTTGATTTCGAAACTGACTCTGAAATAACAATTGAAAGCTTGAGAA
AATAGATCTTGGAAGAAGTCAACCACTTTAGATAAGTTAATAAGGTACCTCCCTTGAAAA
TACCTGATTTACTTGCTCTTTGTGAAAAGCGTACAAAAGCTATACAAGAAAAAGCAAACC
TCCATAAAAAATGA