Identifiers and Description

Gene Model Identifier

TTHERM_00355550

Standard Name

MPK10 (Mitogen-activated Protein Kinase)

Aliases

PreTt27541 | 37.m00258 | 3836.m02347 | XP_001010453

Description

Protein kinase domain containing protein. Sequence similarity to the ERK7 subfamily of the protein kinase MAPK family (Eisen et al., 2006). Putative ERK7 subfamily mitogen-activated protein (MAP) kinase (Yildiz & Arslanyolu, 2014)

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein tyrosine kinase activity (IEA) | GO:0004713
• protein kinase activity (IEA) | GO:0004672

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.9%

TetraMine Data

TTHERM_00355550

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Stentor Coeruleus	SteCoe_6250	0
Tetrahymena borealis	EI9_02275.1	9.997093137033517e-262	hypothetical protein (720 aa)
Oxytricha	Contig194.1.g74	4.999394169176705e-180	Protein kinase domain
DictyBase	DDB_G0283903	1.9994249217050915e-157	erkB on chromosome: 4 position 1385123 to 1386548
WormBase	WBGene00015478	9.995727384924316e-137	Putative serine/threonine-prot ein kinase C05D10.2 status:C onfirmed UniProt:Q11179 pr otein_id:CCD63173.1
SGD	YBL016W	1.0002223712504345e-79	FUS3 Mitogen-activated serine/ threonine protein kinase invol ved in mating; phosphoactivate d by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth durin g mating by phosphorylating Te c1p, promoting its degradation

General Information

No Data fetched for General Information

Associated Literature

1. Ref:25286252: Yıldız MT, Arslanyolu M (2014) In silico identification and characterization of the MAPK family members of unicellular model eukaryote Tetrahymena thermophila. European journal of protistology 50(5):538-50
2. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,

Sequences

>TTHERM_00355550(coding)
ATGAGTGAAGAAATAGAACCTCATATTATGAGAAAATTTGAGATCATATAAAAAATAGGA
AAGGGTGCATATGGTATAGTTTGGAAAGCTATTGATAGAAAATTGAGGTAAGTTGTGGCT
GTCAAGAAAGTTTTTGACGCTTTCCATAATCCTACTGATGCTTAGCGTACTTTTAGAGAG
GTTATGTTTTTATAAGAGCTGAATGGGCATGAGAACATAGTAAAACTACTGAATATTATC
AAAGCAGAAAATAATAAAGACTTATACTTAGTTTTTGATTTCATGGAGACAGATTTACAC
GCTGTCATTCGTGCAGATATATTAGAAGAAATTCACAAGAAATACGTTATGTATTAGATT
TTAAAAGCACTTAAATATATGCATTCAGGCGATTTAATTCACCGTGACTTAAAACCATCC
AATATTCTTTTAAATAGTGAATGCCACGTTAAACTTGCTGATTTCGGTTTAGCTCGTTCG
GTAGCCTAAAAAGAAGATGATGCTCCACCTGTTTTAACTGAATACGTAGCTACTCGTTGG
TATCGTGCTCCGGAAATTCTTTTAGGTAGCACTAAATATACTAAGGCTGTCGATATGTGG
AGTGTCGGATGTATTTTAGGTGAACTTATTATAGGAAAATCTATTTTCCCTGGTGTAAGT
ACTCTTAATTAAATTGAGCGTGTCCTCGAATTAACAGGCAAACCTAAAAATGAAGATATT
GAAGCTATTGAAAGTTCTTTAGCCTGGAATATTTTAAATTCTATTAACATTACTAAGCAA
AAGAAGTTCGAGCAATTTTTCCAAGGCGCTTCTCCCGATGCTTTAGATTTATTGAAGAAA
CTTCTCGTGTTCAATCCTAAATTGCGTTTGGATGCAGAACAAGCTCTCTAGCATCGTTAT
GTAGCTGAATTCCACAATCCTGCTGAAGAGCATGTATGTTCCAAGCCTATCTAGATTCCT
CTAAATGACCACGAAAAATTCTCCATAAGAAAATATCGTGAGTCTCTTTACGCTGACATA
AATGAGCGTAAGAAAAAGCAAAGAATTGAGTGGAGAAATAAATATTTAAGATAATTAGGT
TTATCAATAGGAGATGAAGGTTAGTAAGCTGCAGTGTAAAACGGTTAATAAATAGCAGAA
GGTTAATAATAGCAACCCTAACAGCAAGTACAGTAGTAATAATAGTAAATATAATACTCT
CAGTATTAGCAACAATCTTCTACAGTTAAAAATAACTCTGCTCAATAACCTGAAAAGCGT
AATGCTCGTTAAGTCTCTTAAGAAAATATAGAACAAGTTTCTTAGTAATAGCAATAGTAG
TAATAATCATCAAATTAATAGTAATACCAGCAATAATAAGTTAGATAACAAAACAATCGT
GAACAAGCTCAACAAGGATCTGTGTAGTAAAGCTAATAATTACAATAATAAAACAGTAGT
GTGTAATCCTCCACACAACAATAGCCAAGCAAATACTAGCCCTACTAGGCAAATTAATAT
GGAGCTAAGTATTAGCCACAAGCCAACTAATAAGTTCAATAGCCTCAACAGTAAAGCTTA
ACCTAATCACAAAACAATACACAAGCAAATGGTACAACCTAGTAGACATCTCAACTTAAA
TCATAAAATGCACCTATGTATTAGACTTAATCTCAGTTTTAAAATCAAAATAATGTTACT
GCTGCAAATAATAATGGCACTGGACCTAACAAGGCCATGTACTAAACAAACTATAATAAC
TACATTCCAGCTAAGAATAACTACGGACAAGTACCAAACAGTTAAAATGTTGCTGCTAAC
GGAAATGCTGGTGCAGTTTCAAATAACAGCTCTGGTGTTTACAAATCTGATGCTTAAAAC
TAGCCTGTGTAATACGGCAGCTATGTTCCACAATAAAAGTAATATAAATATTAGCCAGGT
AGCAATGCTACTGCTTCTTAAAGTCAACAAAACCAACCTTAAGGAGCAAGCGGTGCTACA
TATGCAAATTATGTTCAAAGATAATAGTAGTAATAATAGTAGGGAAGTAACCCATCTTAA
ACCTAGGCACAGTAGTACTATTAAATGAAAAACTAATAACAATAACAATAAATTTAGCAG
CAACAACAGCCATCACAAGTTACTAAATAGATGCAATACGCATAGCAATACAAACAATAA
TGA

>TTHERM_00355550(protein)
MSEEIEPHIMRKFEIIQKIGKGAYGIVWKAIDRKLRQVVAVKKVFDAFHNPTDAQRTFRE
VMFLQELNGHENIVKLLNIIKAENNKDLYLVFDFMETDLHAVIRADILEEIHKKYVMYQI
LKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQKEDDAPPVLTEYVATRW
YRAPEILLGSTKYTKAVDMWSVGCILGELIIGKSIFPGVSTLNQIERVLELTGKPKNEDI
EAIESSLAWNILNSINITKQKKFEQFFQGASPDALDLLKKLLVFNPKLRLDAEQALQHRY
VAEFHNPAEEHVCSKPIQIPLNDHEKFSIRKYRESLYADINERKKKQRIEWRNKYLRQLG
LSIGDEGQQAAVQNGQQIAEGQQQQPQQQVQQQQQQIQYSQYQQQSSTVKNNSAQQPEKR
NARQVSQENIEQVSQQQQQQQQSSNQQQYQQQQVRQQNNREQAQQGSVQQSQQLQQQNSS
VQSSTQQQPSKYQPYQANQYGAKYQPQANQQVQQPQQQSLTQSQNNTQANGTTQQTSQLK
SQNAPMYQTQSQFQNQNNVTAANNNGTGPNKAMYQTNYNNYIPAKNNYGQVPNSQNVAAN
GNAGAVSNNSSGVYKSDAQNQPVQYGSYVPQQKQYKYQPGSNATASQSQQNQPQGASGAT
YANYVQRQQQQQQQGSNPSQTQAQQYYQMKNQQQQQQIQQQQQPSQVTKQMQYAQQYKQQ

>TTHERM_00355550(gene)
ATGAGTGAAGAAATAGAACCTCATATTATGAGAAAATTTGAGATCATATAAAAAATAGGA
AAGGGTGCATATGGTATAGTTTGGAAAGCTATTGATAGAAAATTGAGGTAAGTTGTGGCT
GTCAAGAAAGTTTTTGACGCTTTCCATAATCCTACTGATGCTTAGCGTACTTTTAGAGAG
GTAATTATTGCTATTTAGCTGAGTTAAATTTTTTATTAAAGTGGAATATCACTGAAGATA
ATAACATTTTTTTTAAAGATTATAAAATGATCGATTCTTAGATAGAGTTTATATCTAAAT
ATTTTTCTACGTTTTCATAGCTTAATTCAAAACATGTTACACTCACAAAATCTCAAAAAA
AATATTTGAAACAAACATACTTGACAAAATAATAATAATTCAGTTAATAGAAAAAATATG
AAGGCAAATTTTAATAAATCTAAAATTATATTAATAAGGTTTCTACTTTATAAAATAAGC
TTATTCTAACCCTATTTAAAAAACTACTCTTTGCAAGTATATTTGTAAACATGAAGCATA
TTTTCCGAAATTAGGATACTTTAGTAAAATTGATGATCGTTGCGTTTTAAAATAAATATC
ATTATGAAATAATAATAATAAATTTAAAAAATATTTACAATATCTTCATTAACTCTTTAA
TGTTAAAACAAATTTGATATGTAATTTAATTTAACTCTTTTCTTATGAATAGGTTATGTT
TTTATAAGAGCTGAATGGGCATGAGAACATAGTAAAACTACTGAATATTATCAAAGCAGA
AAATAATAAAGACTTATACTTAGTTTTTGATTTCATGGAGACAGATTTACACGCTGTCAT
TCGTGCAGATATATTAGAAGAAATTCACAAGAAATACGTTATGTATTAGATTTTAAAAGC
ACTTAAATATATGCATTCAGGCGATTTAATTCACCGTGACTTAAAACCATCCAATATTCT
TTTAAATAGTGAATGCCACGTTAAACTTGCTGATTTCGGTTTAGCTCGTTCGGTAGCCTA
AAAAGAAGATGATGCTCCACCTGTTTTAACTGAATACGTAGCTACTCGTTGGTATCGTGC
TCCGGAAATTCTTTTAGGTAGCACTAAATATACTAAGGCTGTCGATATGTGGAGTGTCGG
ATGTATTTTAGGTGAACTTATTATAGGAAAATCTATTTTCCCTGGTGTAAGTACTCTTAA
TTAAATTGAGCGTGTCCTCGAATTAACAGGCAAACCTAAAAATGAAGATATTGAAGCTAT
TGAAAGTTCTTTAGCCTGGAATATTTTAAATTCTATTAACATTACTAAGCAAAAGAAGTT
CGAGCAATTTTTCCAAGGCGCTTCTCCCGATGCTTTAGATTTATTGAAGAAACTTCTCGT
GTTCAATCCTAAATTGCGTTTGGATGCAGAACAAGCTCTCTAGCATCGTTATGTAGCTGA
ATTCCACAATCCTGCTGAAGAGCATGTATGTTCCAAGCCTATCTAGATTCCTCTAAATGA
CCACGAAAAATTCTCCATAAGAAAATATCGTGAGTCTCTTTACGCTGACATAAATGAGCG
TAAGAAAAAGCAAAGAATTGAGTGGAGAAATAAATATTTAAGATAATTAGGTTTATCAAT
AGGAGATGAAGGTTAGTAAGCTGCAGTGTAAAACGGTTAATAAATAGCAGAAGGTTAATA
ATAGCAACCCTAACAGCAAGTACAGTAGTAATAATAGTAAATATAATACTCTCAGTATTA
GCAACAATCTTCTACAGTTAAAAATAACTCTGCTCAATAACCTGAAAAGCGTAATGCTCG
TTAAGTCTCTTAAGAAAATATAGAACAAGTTTCTTAGTAATAGCAATAGTAGTAATAATC
ATCAAATTAATAGTAATACCAGCAATAATAAGTTAGATAACAAAACAATCGTGAACAAGC
TCAACAAGGATCTGTGTAGTAAAGCTAATAATTACAATAATAAAACAGTAGTGTGTAATC
CTCCACACAACAATAGCCAAGCAAATACTAGCCCTACTAGGCAAATTAATATGGAGCTAA
GTATTAGCCACAAGCCAACTAATAAGTTCAATAGCCTCAACAGTAAAGCTTAACCTAATC
ACAAAACAATACACAAGCAAATGGTACAACCTAGTAGACATCTCAACTTAAATCATAAAA
TGCACCTATGTATTAGACTTAATCTCAGTTTTAAAATCAAAATAATGTTACTGCTGCAAA
TAATAATGGCACTGGACCTAACAAGGCCATGTACTAAACAAACTATAATAACTACATTCC
AGCTAAGAATAACTACGGACAAGTACCAAACAGTTAAAATGTTGCTGCTAACGGAAATGC
TGGTGCAGTTTCAAATAACAGCTCTGGTGTTTACAAATCTGATGCTTAAAACTAGCCTGT
GTAATACGGCAGCTATGTTCCACAATAAAAGTAATATAAATATTAGCCAGGTAGCAATGC
TACTGCTTCTTAAAGTCAACAAAACCAACCTTAAGGAGCAAGCGGTGCTACATATGCAAA
TTATGTTCAAAGATAATAGTAGTAATAATAGTAGGGAAGTAACCCATCTTAAACCTAGGC
ACAGTAGTACTATTAAATGAAAAACTAATAACAATAACAATAAATTTAGCAGCAACAACA
GCCATCACAAGTTACTAAATAGATGCAATACGCATAGCAATACAAACAATAATGA