Identifiers and Description

Gene Model Identifier

TTHERM_00469230

Standard Name

MPK1 (Mitogen-activated Protein Kinase )

Aliases

PreTt18725 | 55.m00280 | 3710.m00128

Description

Putative ERK1/2 subfamily mitogen-activated protein (MAP) kinase

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• protein tyrosine kinase activity (IEA) | GO:0004713
• protein kinase activity (IEA) | GO:0004672
• ATP binding (IEA) | GO:0005524

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF08194 ) DIM protein
• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.1%

TetraMine Data

TTHERM_00469230

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Stentor Coeruleus	SteCoe_13752	0
Tetrahymena borealis	EI9_15672.1	9.997093137033517e-262	protein kinase domain-containi ng protein (758 aa)
Oxytricha	Contig19712.0.g79	9.997093137033517e-262	Protein kinase domain
DictyBase	DDB_G0286353	2.9995941501461703e-129	erkA on chromosome: 4 position 4355028 to 4356796
SGD	YBL016W	5.0008352594020174e-107	FUS3 Mitogen-activated serine/ threonine protein kinase invol ved in mating; phosphoactivate d by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth durin g mating by phosphorylating Te c1p, promoting its degradation
WormBase	WBGene00003401	3.001222955304439e-106	locus:mpk-1 Mitogen-activate d protein kinase mpk-1 statu s:Confirmed UniProt:P39745 protein_id:CAA87057.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,

Sequences

>TTHERM_00469230(coding)
ATGGACAAAGAAAATATAAAAATGCAGCAATAATAATTATAGAATTAATATAATCACGTT
AAGTAGATGTAGTAATAATAAAATTAGCAATAACAAGCACAATAGTAATAGCTGTAACAA
CAATAGTAGCAATAGTAGTAGCATTAGTAGGCACAACAGCACCAAGAAAAGCCTCAAAAA
CCAATTCAAGTACCTCCTGGTAAGCACAAATTTGATTGTGGGCAGACTATTTTTGTTGTC
GATGAGAAATATGAATATATAAAATAGATCGGATATGGAGCTTACGGTGTGGTTTGCTCA
GCAGTAAATAAAGAAAATGGTTCAAAAGTTGCAATTAAAAAGGTTTAAAATGCTTATGAT
GATTTGATCGATGCAAAGCGTATTGTCAGAGAAATCAAACTTTTAAAATTCTTTGAACAC
GATAATATTATTTCACTTTTAGATGTTATTAAGCCTAACGCGCCAGTAGGTGACGAAGAT
ATCTACATGGTATTTGATTTGATGGAAACTGATTTGCACCGTGTTATTTATTCTCGTTAA
GAACTCAGCGATGAGCATATCTAATATTTTGTCTATTAAATTCTTCGTGGTCTCTTATAC
ATTCATTCTGCAAATGTTATTCATCGTGATCTAAAGCCCAGCAATATTTTGCTTAATAAG
AACTGTGATCTTAAAATTTGCGATTTTGGTCTGGCCCGTGGATTCGAAGAGCCTGGTGAA
AGCTTGACTGAATACGTAATTACTCGTTGGTACCGTGCTCCTGAAGTTATTTTGAATGCT
AGTGAGTACAATCAAGCTGTTGATATTTGGTCAGTTGGTTGCATCACTGCTGAATTATTA
GGAAGAACACCCCTTTTCCCAGGAGAAAATTATCTAGATTAAGTTTAGCGTGTCATAGCA
GTTTTAGGAACCCCTACTCAAGAAGATATGGCTTATATTGGCAATTAAGATGCTATTAAA
TATATAAAATCTCAACCAAAAAGAACTAAATAATCATGGTAGAGTCTTTATCCGAAAGCA
AATCCACTAGCTCTTGACCTTTTAAGTAAAATGCTCACTTTCAATCCAGAAAAACGCTAT
ACTGTTAAAGAATGCATCGAACATCCTTACTTCGAAGGACTTCATTACCCTGATGAAGAA
CCTGAGTGTGAGTAAGTTTTTGATTGGTCTTGGGATAAATTCACACCTACTAAAGAAATA
TTGTAGAAGATGATCTACTAAGAAGCTAAATCTTTCCATCCTATTCACTGA

>TTHERM_00469230(protein)
MDKENIKMQQQQLQNQYNHVKQMQQQQNQQQQAQQQQLQQQQQQQQQHQQAQQHQEKPQK
PIQVPPGKHKFDCGQTIFVVDEKYEYIKQIGYGAYGVVCSAVNKENGSKVAIKKVQNAYD
DLIDAKRIVREIKLLKFFEHDNIISLLDVIKPNAPVGDEDIYMVFDLMETDLHRVIYSRQ
ELSDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEEPGE
SLTEYVITRWYRAPEVILNASEYNQAVDIWSVGCITAELLGRTPLFPGENYLDQVQRVIA
VLGTPTQEDMAYIGNQDAIKYIKSQPKRTKQSWQSLYPKANPLALDLLSKMLTFNPEKRY
TVKECIEHPYFEGLHYPDEEPECEQVFDWSWDKFTPTKEILQKMIYQEAKSFHPIH

>TTHERM_00469230(gene)
ATGGACAAAGAAAATATAAAAATGCAGCAATAATAATTATAGAATTAATATAATCACGTT
AAGTAGATGTAGTAATAATAAAATTAGCAATAACAAGCACAATAGTAATAGCTGTAACAA
CAATAGTAGCAATAGTAGTAGCATTAGTAGGCACAACAGCACCAAGAAAAGCCTCAAAAA
CCAATTCAAGTACCTCCTGGTAAGCACAAATTTGATTGTGGGCAGACTATTTTTGTTGTC
GATGAGAAATATGAATATATAAAATAGATCGGATATGGAGCTTACGGTGTGGTTTGCTCA
GCAGTAAATAAAGAAAATGGTTCAAAAGTTGCAATTAAAAAGGTTTAAAATGCTTATGAT
GATTTGATCGATGCAAAGCGTATTGTCAGAGAAATCAAACTTTTAAAATTCTTTGAACAC
GATAATATTATTTCACTTTTAGATGTTATTAAGCCTAACGCGCCAGTAGGTGACGAAGAT
ATCTACATGGTATTTGATTTGATGGAAACTGATTTGCACCGTGTTATTTATTCTCGTTAA
GAACTCAGCGATGAGCATATCTAATATTTTGTCTATTAAATTCTTCGTGGTCTCTTATAC
ATTCATTCTGCAAATGTTATTCATCGTGATCTAAAGCCCAGCAATATTTTGCTTAATAAG
AACTGTGATCTTAAAATTTGCGATTTTGGTCTGGCCCGTGGATTCGAAGAGCCTGGTGAA
AGCTTGACTGAATACGTAATTACTCGTTGGTACCGTGCTCCTGAAGTTATTTTGAATGCT
AGTGAGTACAATCAAGCTGTTGATATTTGGTCAGTTGGTTGCATCACTGCTGAATTATTA
GGAAGAACACCCCTTTTCCCAGGAGAAAATTATCTAGATTAAGTTTAGCGTGTCATAGCA
GTTTTAGGAACCCCTACTCAAGAAGATATGGCTTATATTGGCAATTAAGATGCTATTAAA
TATATAAAATCTCAACCAAAAAGAACTAAATAATCATGGTAGAGTCTTTATCCGAAAGCA
AATCCACTAGCTCTTGACCTTTTAAGTAAAATGCTCACTTTCAATCCAGAAAAACGCTAT
ACTGTTAAAGAATGCATCGAACATCCTTACTTCGAAGGACTTCATTACCCTGATGAAGAA
CCTGAGTGTGAGTAAGTTTTTGATTGGTCTTGGGATAAATTCACACCTACTAAAGAAATA
TTGTAGAAGATGATCTACTAAGAAGCTAAATCTTTCCATCCTATTCACTGA