Identifiers and Description

Gene Model Identifier

TTHERM_00387050

Standard Name

LIG4 (DNA ligase IV)

Aliases

PreTt24799 | 41.m00206

Description

DNA ligase required for nonhomologous end-joining (NHEJ)

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• DNA ligase (ATP) activity (IEA) | GO:0003910
• DNA binding (IEA) | GO:0003677

Biological Process

• DNA repair (IEA) | GO:0006281
• DNA replication (IEA) | GO:0006260
• DNA recombination (IEA) | GO:0006310

Domains

• ( TIGR02776 ) DNA ligase D
• ( PF04675 ) DNA ligase N terminus
• ( PF01779 ) ribosomal L29e protein family
• ( PF00533 ) BRCA1 C Terminus (BRCT) domain
• ( PF01068 ) ATP-dependent DNA ligase domain
• ( TIGR00574 ) DNA ligase I, ATP-dependent (dnl1)
• ( TIGR02779 ) DNA polymerase LigD, ligase domain
• ( PF01331 ) mRNA capping enzyme, catalytic domain
• ( PF04679 ) ATP dependent DNA ligase C

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.3%

TetraMine Data

TTHERM_00387050

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_04427.1	9.997093137033517e-262	DNA ligase IV (1028 aa)
Oxytricha	Contig17485.0.g101	6.001048086731027e-152	ATP dependent DNA ligase domai n
DictyBase	DDB_G0292760	9.995094197784295e-101	lig4 on chromosome: 6 position 2052081 to 2055347
Stentor Coeruleus	SteCoe_12774	1.1677812485237086e-60
SGD	YOR005C	9.998397555368434e-52	DNL4 DNA ligase required for n onhomologous end-joining (NHEJ ), forms stable heterodimer wi th required cofactor Lif1p, in teracts with Nej1p; involved i n meiosis, not essential for v egetative growth
WormBase	WBGene00002985	2.0003218023735366e-33	locus:lig-1 DNA ligase 1 s tatus:Partially_confirmed Un iProt:Q27474 protein_id:CAA9 8242.2

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00387050(coding)
ATGCAAAACTATTATAAATGGCATAAGATAAAATAAGAATAAAATCAAGAATTGTCTGTT
AATATAAAGCCAATTTCTTCATCAAAGATGAAACAAAGTGATATTTCTACTAGGAAGAAA
AAAGCTTAAGAGTATAATATGGATTTTGATGAATTTTAGCAAGAGGATTCTAAAATTAAC
TAAAATTCTGATAATTTTCACTTTGGTGATTCAGCAGATGAATATGGTATTGATTCACCA
AAAATGAAAAGAGAAAAAGCAGTTAAAGAAGAAGATAATACCTTTCGCTTAGAAATTAAA
AAATCTCCTATCCTAGAGAAAACACTCTTTTCATTTTTAGTCAAATTTTATAATTAAGTC
TAGCAATCTAAAAAAGGGCAAAGAAAAAAATTTGTATAAAGATTCATTGACTCTACATTT
AAAACAAATAGATGTCCATCTTACACATTTACTATCCTTAGGTTAATAATGCCTCATCAT
GATAAATAACGTCTTAATTATGGCTTAAACTATAAAAATTTAGCTAAAGTTTTAAGCGAA
GTGTTTGCCTTATCAGAAGATAAACGTCAATAGCTTTTGAATTATAAAAGACCTTTAAAA
GACAACTAGCAAGTAGTTGGTGATTTTGGTGAAGTTGTATAAAATGTTTTGTAAGCATTT
ACTTAGAAAGCCACACTAACAATCAACGATGTGGATAGATGTCTTGATGAGCTTGCATAA
CCTCAAAATAGAGATCTAGCATCCAAAGAAAAAGTTTTAAGAAACTGCTTGAAGAATGCA
ACATCAGAAGAAATAAAATGGATTTCACGTTTGATCTTAAAGGACCTTAATCTTGGTATT
AATCACGAAATAATACTTGCACTTTTTCATCCTGATGCAGTAGTATTATTTAATTCTACT
TCTAGTCTTTGGGAGGTTTGCAAGGAATTTGTAGATCCAAATCATAAATTATCTAATGTC
CTTAGGCTATTTCATCCTATAAAACCTATGCTTGCAGGACGTAAGACTCTCAAAAGTATT
GAAGCTATTCTTAAAGGTAAAAACTATTTAGTTGAAACAAAATTTGATGGGGAGAGAATT
TAGTGTCATGTATCTCCTGAATCTTTAATGTTTTTCACTAGAAACTCAAACAATTATACA
AATATTTATGAAAGAATGATAGAGCATGTTAGAAGAAGTTTAAAAGATGCTGTTCATAGT
TGTATTTTAGATGGAGAAATGGTTGTAGTAAATAAAATAACAGGATAAAGAGTTTAATTT
GGTCTTAATAAAACTGTTGCAATGGAAAGAGAGGATGATGAATTATGTATATGTTATAAA
ATTTTTGACATTTTATATTTGAAGACTAAAGATAATAAAGAATATGCACTGACAGAATAC
ACATTGCAATATAGAAAAAAAATTTTAGAAAATTTAATTGACAATCAATAAGACAGAGTT
GAAGTTATTTTTGGTAGAGAATACTCAGATATAAATGACATACTGACTGAATTTAATGAG
GCAATACATAGAAACGATGAAGGTATAGTCATAAAGCAGCTCGATACTCTGTATTACCCA
GATGATAGATCTGATAAGTGGATTAAAATGAAAGGTGACTACTATGAAGGAATAATAGAT
ACCTTAGATTTGATAGTTATTGGAGGATATTTTGGTGAAAAGTCTTATAAAATTAATGGC
ATAGGAGATTGGACAGATCATATCACACATTATCTTGTTGCTGTAGCGAAAAAGATTGAT
CTACAAAACCCCTCTAACTCTATACTTGTGCCTTTTGCTAAAGTGGGAGCAGGTTTTACA
GCTAGAGACTATGCTGATATAAAAGCTAGAATGAGAGATCAATGGGTAAGAACTAATCAT
TCAAATAAAACGCCTTCTTTCATCATATAAAACTGGAAACCTGGAGAAAAAGATAAGCCA
GATGCATATATTTTATCTCCTCAAAACTCTCTTATTTTAGAGATTAGGGCAACTGAAATT
ATATAATCTTCTTAATATCCGACCAACTACACCTTAAGATTTCCGAGATTTGAAAAATTT
AGAAGAGATAAAGATTGGTTTGATTGCATGAAATTTAATGAAATTATAGAAATGACTTAA
AATTTAAAGAAAAAAGAATAAAAAGAGAGTGACAAAGAAGATAATGCAAGCGATGAAGAG
TAGGACGAAAATGGAGGAAAATTAAAGAAAAAAAGAAAAGGGTAAAATGGAGAAGAGATA
GAAGTAAATAGACAAGGTAGAAAGCCAAACTGGAAGACCAATAAAGTTATGGCTCAATAT
CTTGATATTGATGTTTCTGATGTCAAAGTAGAATCAAATATATTTAATAACTTTGTATTT
AATATAATTAATTTACCTCATGAAGTATCCTTGAGTGAGGAAAAGATATTGTTAGAGAAA
GCCTAGATTGAAAAAGGTATAGTTGCTAATGGTGGTAAAAAAGTATAAAATGATAGCAAT
CTTGTAACTCATTACATAGCTTCACATTATGATTTTAAAGTTTAAGTAATTGGTGATCAC
TATAAAGTAAATGTTCTATCCTTATAATGGGTAAAAGACTGTATCAAAAAAAAAACTTTA
TTAGATTACTCTCCCCGCTACATTATATATGGTTAAGATTAATTGCTTGAGAGAAATAAA
TTGCTTTATGATTAATATGGAGATTCTTATTACAAAGATGTTGATGAAGATGAGTTATTG
GATATTTTAAAATCTATGAAAATTGATTAAATAGAAGAAGAATTCTAGGAGAATGAAGAG
TTTGAAGAGGCTGTTAAAGATATTATTTCCATGAAAAACCAACTTTTCAAAGAATGTTTT
CCGTAAGGATAAACTTATTGCTTTTATAATGCAAATGATAAATTGAATTCAGATATAGAC
TTAAGATATTTAGTTGATCTAATTTAATTTAGTGGAAATTAAGTTGTATTTGACTTATAG
GACGAAATTGATTACATAGTGGCTTTAGATTATAGTGAAGCTGAAAACGAAAAAATTATT
ACCTTCAGAGAAAAAAACAGAAGTATGGAAGTTATAACTCCTAAAAACTTGTTGAATAAT
TTTGGAATAGCTCTAGAATGA

>TTHERM_00387050(protein)
MQNYYKWHKIKQEQNQELSVNIKPISSSKMKQSDISTRKKKAQEYNMDFDEFQQEDSKIN
QNSDNFHFGDSADEYGIDSPKMKREKAVKEEDNTFRLEIKKSPILEKTLFSFLVKFYNQV
QQSKKGQRKKFVQRFIDSTFKTNRCPSYTFTILRLIMPHHDKQRLNYGLNYKNLAKVLSE
VFALSEDKRQQLLNYKRPLKDNQQVVGDFGEVVQNVLQAFTQKATLTINDVDRCLDELAQ
PQNRDLASKEKVLRNCLKNATSEEIKWISRLILKDLNLGINHEIILALFHPDAVVLFNST
SSLWEVCKEFVDPNHKLSNVLRLFHPIKPMLAGRKTLKSIEAILKGKNYLVETKFDGERI
QCHVSPESLMFFTRNSNNYTNIYERMIEHVRRSLKDAVHSCILDGEMVVVNKITGQRVQF
GLNKTVAMEREDDELCICYKIFDILYLKTKDNKEYALTEYTLQYRKKILENLIDNQQDRV
EVIFGREYSDINDILTEFNEAIHRNDEGIVIKQLDTLYYPDDRSDKWIKMKGDYYEGIID
TLDLIVIGGYFGEKSYKINGIGDWTDHITHYLVAVAKKIDLQNPSNSILVPFAKVGAGFT
ARDYADIKARMRDQWVRTNHSNKTPSFIIQNWKPGEKDKPDAYILSPQNSLILEIRATEI
IQSSQYPTNYTLRFPRFEKFRRDKDWFDCMKFNEIIEMTQNLKKKEQKESDKEDNASDEE
QDENGGKLKKKRKGQNGEEIEVNRQGRKPNWKTNKVMAQYLDIDVSDVKVESNIFNNFVF
NIINLPHEVSLSEEKILLEKAQIEKGIVANGGKKVQNDSNLVTHYIASHYDFKVQVIGDH
YKVNVLSLQWVKDCIKKKTLLDYSPRYIIYGQDQLLERNKLLYDQYGDSYYKDVDEDELL
DILKSMKIDQIEEEFQENEEFEEAVKDIISMKNQLFKECFPQGQTYCFYNANDKLNSDID
LRYLVDLIQFSGNQVVFDLQDEIDYIVALDYSEAENEKIITFREKNRSMEVITPKNLLNN
FGIALE

>TTHERM_00387050(gene)
ATGCAAAACTATTATAAATGGCATAAGATAAAATAAGAATAAAATCAAGAATTGTCTGTT
AATATAAAGCCAATTTCTTCATCAAAGATGAAACAAAGTGATATTTCTACTAGGAAGAAA
AAAGCTTAAGAGTATAATATGGATTTTGATGAATTTTAGCAAGAGGATTCTAAAATTAAC
TAAAATTCTGATAATTTTCACTTTGGTGATTCAGCAGATGAATATGGTATTGATTCACCA
AAAATGAAAAGAGAAAAAGCAGTTAAAGAAGAAGATAATACCTTTCGCTTAGAAATTAAA
AAATCTCCTATCCTAGAGAAAACACTCTTTTCATTTTTAGTCAAATTTTATAATTAAGTC
TAGCAATCTAAAAAAGGGCAAAGAAAAAAATTTGTATAAAGATTCATTGACTCTACATTT
AAAACAAATAGATGTCCATCTTACACATTTACTATCCTTAGGTTAATAATGCCTCATCAT
GATAAATAACGTCTTAATTATGGCTTAAACTATAAAAATTTAGCTAAAGTTTTAAGCGAA
GTGTTTGCCTTATCAGAAGATAAACGTCAATAGCTTTTGAATTATAAAAGACCTTTAAAA
GACAACTAGCAAGTAGTTGGTGATTTTGGTGAAGTTGTATAAAATGTTTTGTAAGCATTT
ACTTAGAAAGCCACACTAACAATCAACGATGTGGATAGATGTCTTGATGAGCTTGCATAA
CCTCAAAATAGAGATCTAGCATCCAAAGAAAAAGTTTTAAGAAACTGCTTGAAGAATGCA
ACATCAGAAGAAATAAAATGGATTTCACGGTAATTTAATTTATTTTAATTAATATTAAAT
AAAAATCTATAAAAGTTTGATCTTAAAGGACCTTAATCTTGGTATTAATCACGAAATAAT
ACTTGCACTTTTTCATCCTGATGCAGTAGTATTATTTAATTCTACTTCTAGTCTTTGGGA
GGTTTGCAAGGAATTTGTAGATCCAAATCATAAATTATCTAATGTCCTTAGGCTATTTCA
TCCTATAAAACCTATGCTTGCAGGACGTAAGACTCTCAAAAGTATTGAAGCTATTCTTAA
AGGTAAGTAAAATATTAATTAATTTGAAACATTTAACATCCTTTTTACTTTTTTTTATAC
AGGTAAAAACTATTTAGTTGAAACAAAATTTGATGGGGAGAGAATTTAGTGTCATGTATC
TCCTGAATCTTTAATGTAAAAAAATTTTTTTTATATTTTTTTTGGTTTAACTTAATAATA
AAAATAGGTTTTTCACTAGAAACTCAAACAATTATACAAATATTTATGAAAGAATGATAG
AGCATGTTAGAAGAAGTTTAAAAGATGCTGTTCATAGTTGTATTTTAGATGGAGAAATGG
TTGTAGTAAATAAAATAACAGGATAAAGAGTTTAATTTGGTCTTAATAAAACTGTTGCAA
TGGAAAGAGAGGATGATGAATTATGTATATGTTATAAAATTTTTGACATTTTATATTTGA
AGACTAAAGATAATAAAGAATATGCACTGACAGAATACACATTGCAATATAGAAAAAAAA
TTTTAGAAAATTTAATTGACAATCAATAAGACAGAGTTGAAGTTATTTTTGGTAGAGAAT
ACTCAGATATAAATGACATACTGACTGAATTTAATGAGGCAATACATAGAAACGATGAAG
GTATAGTCATAAAGCAGCTCGATACTCTGTATTACCCAGATGATAGATCTGATAAGTGGA
TTAAAATGAAAGGTGACTACTATGAAGGAATAATAGATACCTTAGATTTGATAGTTATTG
GAGGATATTTTGGTGAAAAGTCTTATAAAATTAATGGCATAGGAGATTGGACAGATCATA
TCACACATTATCTTGTTGCTGTAGCGAAAAAGATTGATCTACAAAACCCCTCTAACTCTA
TACTTGTGCCTTTTGCTAAAGTGGGAGCAGGTTTTACAGCTAGAGACTATGCTGATATAA
AAGCTAGAATGAGAGATCAATGGGTAAGAACTAATCATTCAAATAAAACGCCTTCTTTCA
TCATATAAAACTGGAAACCTGGAGAAAAAGTAAGTTATTTAGAAAAATAATGACTTTTTA
AAAAAATAAAATTTAAGGATAAGCCAGATGCATATATTTTATCTCCTCAAAACTCTCTTA
TTTTAGAGATTAGGGCAACTGAAATTATATAATCTTCTTAATATCCGACCAACTACACCT
TAAGGTATTTATCTATTTTTAAAATACAATTTAAATGAAGTTTTGTAATATCCTAAATTA
AATTTTAGATTTCCGAGATTTGAAAAATTTAGAAGAGATAAAGATTGGTTTGATTGCATG
AAATTTAATGAAATTATAGAAATGACTTAAAATTTAAAGAAAAAAGAATAAAAAGAGAGT
GACAAAGAAGATAATGCAAGCGATGAAGAGTAGGACGAAAATGGAGGAAAATTAAAGAAA
AAAAGAAAAGGGTAAAATGGAGAAGAGATAGAAGTAAATAGACAAGGTAGAAAGCCAAAC
TGGAAGACCAATAAAGTTATGGCTCAATATCTTGATATTGATGTTTCTGATGTCAAAGTA
GAATCAAATATATTTAATAACTTTGTATTTAATATAATTAATTTACCTCATGAAGTATCC
TTGAGTGAGGAAAAGATATTGTTAGAGAAAGCCTAGATTGAAAAAGGTATAGTTGCTAAT
GGTGGTAAAAAAGTATAAAATGATAGCAATCTTGTAACTCATTACATAGCTTCACATTAT
GATTTTAAAGTTTAAGTAATTGGTGATCACTATAAAGTAAATGTTCTATCCTTATAATGG
GTAAAAGACTGTATCAAAAAAAAAACTTTATTAGATTACTCTCCCCGCTACATTATATAT
GGTTAAGATTAATTGCTTGAGAGAAATAAATTGCTTTATGATTAATATGGAGATTCTTAT
TACAAAGATGTTGATGAAGATGAGTTATTGGATATTTTAAAATCTATGAAAATTGATTAA
ATAGAAGAAGAATTCTAGGAGAATGAAGAGTTTGAAGAGGCTGTTAAAGATATTATTTCC
ATGAAAAACCAACTTTTCAAAGAATGTTTTCCGTAAGGATAAACTTATTGCTTTTATAAT
GCAAATGATAAATTGAATTCAGATATAGACTTAAGATATTTAGTTGATCTAATTTAATTT
AGTGGAAATTAAGTTGTATTTGACTTATAGGACGAAATTGATTACATAGTGGCTTTAGAT
TATAGTGAAGCTGAAAACGAAAAAATTATTACCTTCAGAGAAAAAAACAGAAGTATGGAA
GTTATAACTCCTAAAAACTTGTTGAATAATTTTGGAATAGCTCTAGAATGA