Identifiers and Description

Gene Model Identifier

TTHERM_00193390

Standard Name

LIA7 (localized in macronuclear anlagen 7)

Aliases

PreTt06622 | 16.m00278

Description

cyclin-dependent kinase-like Serine/Threonine kinase family protein; Protein kinase domain containing protein. Sequence similarity to the STE11 protein kinase family (Eisen et al.- 2006).

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein tyrosine kinase activity (IEA) | GO:0004713
• protein kinase activity (IEA) | GO:0004672

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) protein kinase domain
• ( PF07714 ) protein tyrosine kinase
• ( PF06293 ) Lipopolysaccharide kinase (Kdo/WaaP) family

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 12.2%

TetraMine Data

TTHERM_00193390

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_03618.1	9.997093137033517e-262	protein kinase domain-containi ng protein (787 aa)
Oxytricha	Contig11718.0.g18	2.999564368270328e-76	Protein kinase domain
DictyBase	DDB_G0283265	3.001032840497736e-70	mkkA on chromosome: 4 position 530684 to 534789
SGD	YJL095W	2.0008958828286524e-54	BCK1 Mitogen-activated protein (MAP) kinase kinase kinase ac ting in the protein kinase C s ignaling pathway, which contro ls cell integrity; upon activa tion by Pkc1p phosphorylates d ownstream kinases Mkk1p and Mk k2p
WormBase	WBGene00001526	1.9991939848149086e-44	locus:gck-1 status:Partially _confirmed UniProt:H2L0A0 protein_id:CCD72151.2
Stentor Coeruleus	SteCoe_24084	3.0144087850653746e-40

General Information

No Data fetched for General Information

Associated Literature

1. Ref:17519286: Yao MC, Yao CH, Halasz LM, Fuller P, Rexer CH, Wang SH, Jain R, Coyne RS, Chalker DL (2007) Identification of novel chromatin-associated proteins involved in programmed genome rearrangements in Tetrahymena. Journal of cell science 120(Pt 12):1978-89

Sequences

>TTHERM_00193390(coding)
ATGACTTTGTTATTTTGGTAAATTTAGATAAAGAAATAACAATTCTTGATAGATAATTTA
TAAAATTACTTAATAAACTAGTTTCAATATGGTAAATTGAATATAAATAATACACTAGAT
AATAGTATATTAAGGTAGAGGAACCAATTAAAAACTTGTAGAGTTGAATCTTTAAAGAAA
AACAATACAAGAAAAGAAACACCTAGCATACCAATTTAGTATAAAGTACTGTACCTATTT
ATAGAGTCTTTTAGATAAAATAGCAAATTAGTATATAATATAGTTGGATTGCTATCACTA
TTATTTTAGCAATAAATAAATAATTAGGATTCGGACTGGTTTAAAGAAATGAGCATGTTT
GATAAAGAATATGATAAAAAAGGATTTGATATAAAATAGATTTAAAGTCCAATATTGAAA
TTATATCAAAATGCCAAGTAGGAAATTAATAATAAAAGCGATAATATATTTTCTCCAAGC
CTCAACTCGTAAAATATCCAATCATCTAAGAAAATATATTAACATTAGCTATAACCGCTT
TAATTGGTTTAGAAAGATGATTAAAAGGAACACAAAAAGAAGCCTCAATCAATTTAGTCA
AGTGCATATGGTCGAGTTTATAAAGGATTTGTCAAGAGTACTGGAAAATTTATTGCAATA
AAAGAAATGAAAGAAGAAATGATGTTAGGAGAAGATGCTCACTCTTTATTAGAAAGCATT
TGCAAAGAGATTTAATTGCTGAAGTAGCTTTCTCATAAAAATATAGTAAACTACATTGGA
TCAAAAAAGCAAGAAGGTAGTGTGTATATTTACATGGAATATATGCCAGGAGGATCAATA
TCTGAAATGCTGAAAAAGTATGGAGGATTTGATGAAGAAGTTATTTAAAAATTTGTTAAA
CAGTTACTTGAAGGTTTAATTTATCTACATTCAAAAGGAGTTATTCATCGAGATTTAAAA
GGAGCAAATATTTTATCTGATGGTTAAGGCAATGTGAAGTTAGCAGATTTTGGAGCTGCT
AGAAATATAGAAAATATTTTGTAGCATTCTCTATCATAGTCAGAATTTTGCAATTCTATA
AAAGGATCCCTTTATTGGATGGCTCCAGAATTAATTAAAAATGAAAAACATGGAAGAAGA
ATAGATGTTTGGAGCTTGGGCTGTACTGTAATTGAAATGGCATCTGCTTAGCATCCATGG
GAAAACATTAAAAAATTCTCAGATTTAGCAAATGCTGTGATAGAATAATAACCCATACCA
ATACCTTAGCATTTGAGTGAAGAATGCAAAGATTTTATCTCGAAATGCTGCACTTATGAT
AAAAAAATGAGACCAAAATCTCAATAACTTTTTAATCACCCTTTTCTATAAAAAAAATAC
TCCTGA

>TTHERM_00193390(protein)
MTLLFWQIQIKKQQFLIDNLQNYLINQFQYGKLNINNTLDNSILRQRNQLKTCRVESLKK
NNTRKETPSIPIQYKVLYLFIESFRQNSKLVYNIVGLLSLLFQQQINNQDSDWFKEMSMF
DKEYDKKGFDIKQIQSPILKLYQNAKQEINNKSDNIFSPSLNSQNIQSSKKIYQHQLQPL
QLVQKDDQKEHKKKPQSIQSSAYGRVYKGFVKSTGKFIAIKEMKEEMMLGEDAHSLLESI
CKEIQLLKQLSHKNIVNYIGSKKQEGSVYIYMEYMPGGSISEMLKKYGGFDEEVIQKFVK
QLLEGLIYLHSKGVIHRDLKGANILSDGQGNVKLADFGAARNIENILQHSLSQSEFCNSI
KGSLYWMAPELIKNEKHGRRIDVWSLGCTVIEMASAQHPWENIKKFSDLANAVIEQQPIP
IPQHLSEECKDFISKCCTYDKKMRPKSQQLFNHPFLQKKYS

>TTHERM_00193390(gene)
ATGACTTTGTTATTTTGGTAAATTTAGATAAAGAAATAACAATTCTTGATAGATAATTTA
TAAAATTACTTAATAAACTAGTTTCAATATGGTAAATTGAATATAAATAATACACTAGAT
AATAGTATATTAAGGTAGAGGGTAAAAATTTAGGATTTTTTAATTATTCATTTAATTTCT
AAAAATTTATATTATTTTTAATATGCATTAATATAATATTTATTTATATATTAGAACCAA
TTAAAAACTTGTAGAGTTGAATCTTTAAAGAAAAACAATACAAGAAAAGAAACACCTAGC
ATACCAATTTAGTATAAAGTACTGTACCTATTTATAGAGTCTTTTAGATAAAATAGCAAA
TTAGTATATAATATAGTTGGATTGCTATCACTATTATTTTAGCAATAAATAAATAATTAG
GATTCGGACTGGTTTAAAGAAATGAGCATGTTTGATAAAGAATATGATAAAAAAGGATTT
GATATAAAATAGATTTAAAGTCCAATATTGAAATTATATCAAAATGCCAAGTAGGAAATT
AATAATAAAAGCGATAATATATTTTCTCCAAGCCTCAACTCGTAAAATATCCAATCATCT
AAGAAAAGTAAGCATAGTATTTATTATAATTCAAGTTGCACATTTAATTTAATAATTTAA
TCCAACATAATCAATTGTTCTCATCAAAAAATTAATTTTGCAAGAAAGAAAGGGAAAATT
TTTAAAAAGCAATAAAGTCAACTAACATTAACTCTTTTTTTGCAGTATATTAACATTAGC
TATAACCGCTTTAATTGGTTTAGAAAGATGATTAAAAGGAACACAAAAAGAAGCCTCAAT
CAATTTAGTCAAGTAAGCTTTAAACTTAAAAAAAATAATATTTTCAAAATTGTTTTCACT
TTTGATTCTATTAATATATGAATGATTATGCGGTTCATATAATTTCTAAAATTAGCAATT
AATTATTTTAAATTATAAAATTTGATAAAAAGGTGATCGAATCCTTTCAAAGGACTACTC
TAAAGGGAAAATTTTTTAAATTTAAAAAGATGAAATGAGTGGGTTTGCTATTAACAACTT
TAACAATAACAATAAATTAAGTGCCTTCCAAAGCTATCCATAATCACCCACTTACAAAGA
CTAATTTAATTGTAAATTGTAGAGTAAACAAAGTGAAGAGACTCCGACTTAAAAATCTTA
AAATTAACCTTTATATAGATTACCTAATAATGAAGCTAATCCTTTTAAGGATGGAAATTA
ATTGTAAATTTAGAATGATAATATAAAAGCTATAAAATTAGAAAGCGATTAGAAATCCAT
TTCTTAGCTTTAAAGTCCTAGAGTAAGGATTAAAACAATATAAAAAAATATGAAATCCCC
CACATATTAAAATCTAAACAAAGAAAAATTAAGTTAAAATGATTTAGCTGACTTTGAAAA
TTAGCAAAATTAAAATGGAGAGAAAATAAAAACAGAATAAAACAAAATAGATAACGAAGG
TCAATTTTAAGTCTAAAATGAGGAAGAACAAATATCACCAATAAAAAACAAAATTAATAA
AATTTAATCCATAAATGCTATTATACCAGAAAAATACCTCCCTAAGACACCATCGGGAGA
AAAATTTCATTAGAAATAGGAAAGTTCACGCCCAAGTTCAGGGAGAAATTAAAATTTTAT
TATAAAAATGGTCAATAATCACAATTATTCAGATGTCAATCATATACATAATAACAATTT
AAATAATGCAAATAATGGATCAAATACTGTTATAAGACTTTAGTCAAAAGAAATAAGTGA
TACACCCAAAAGCTAAAATAGAGAAGAAAAGTATTAAGAATCTTATAATGAAATTAAGGA
TAGAATCGACACCCAAAATTCATAATAAATAGGTGATTCTTTGTAAAATTTAGATGAAGA
ATAAAAAAAACGAAAAGCAAATTAGTGAACAAAAATAAAATAAACCTAATTCTAATTAGA
ATATATCTTCAAAAATATAATCCCTTAATTATATAAATGAAGAGAGAGAATTAGATTCAT
CTCCCATAGAATAAGGTTAAAATAGTAAACTGAAAGATAAAAATAATGATAAATAAAATA
TTATCAAAGAGTAATCATAAAATTAAAGATAAGAATCATCCATGATGTTACAAACAGCTT
CTGAAAAAAAAGAAATTAACAATTTAAAATATATTATTGAATCAAACAATTTAAATTAGA
ATAATAACAATAGCAGCAGCAATGATTATTTGGACGCATAAGTTGGGGAGTTAATTGGAT
AAGGTAAAATAGTAAATCAGATTTATTTAATTTTGGACAAATAAATTATTCAAAAGGTGC
ATATGGTCGAGTTTATAAAGGATTTGTCAAGAGTACTGGAAAATTTATTGCAATAAAAGA
AATGAAAGAAGAAATGATGTTAGGAGAAGATGCTCACTCTTTATTAGAAAGCATTTGCAA
AGAGATTTAATTGCTGAAGTAGCTTTCTCATAAAAATATAGTAAACTACATTGGATCAAA
AAAGCAAGAAGGTAGTGTGTATATTTACATGGAATATATGCCAGGAGGATCAATATCTGA
AATGCTGAAAAAGTATGGAGGATTTGATGAAGAAGTTATTTAAAAATTTGTTAAACAGTT
ACTTGAAGGTTTAATTTATCTACATTCAAAAGGAGTTATTCATCGAGATTTAAAAGTAAA
TATTACATTTAAACTTAAACAAATTTCAAATATTTATCTATTTATTTTAGGGAGCAAATA
TTTTATCTGATGGTTAAGGCAATGTGAAGTTAGCAGATTTTGGAGCTGCTAGAAATATAG
AAAATATTTTGTAGCATTCTCTATCATAGTCAGAATTTTGCAATTCTATAAAAGGGTAAA
ATAAATTTTATAAATTATTCTTTATCTTCAATTTAAACTAAAAAACTAAGAAATAATCAT
TTTACTGTTCTGAATTAAGTTTAAAACAAAATAATAAATAAAAAATGAAATATGATGTTA
TGAATTATTTGATAAAATATATTTATAATTCAAATTTAATGATAATAAAATTTTTAATTT
AGATCCCTTTATTGGATGGCTCCAGAATTAATTAAAAATGAAAAACATGGAAGAAGAATA
GATGTTTGGAGCTTGGGCTGTACTGTAATTGAAATGGCATCTGCTTAGCATCCATGGTAA
ATAAATTAATGTTAATAACTTAAATTGAAAATACATTGTTTATTAAATTAAATAAAGGGA
AAACATTAAAAAATTCTCAGATTTAGCAAATGCTGTGATAGAATAATAACCCATACCAAT
ACCTTAGCATTTGAGTGAAGAATGCAAAGATTTTATCTCGAAATGCTGCACTTATGATAA
AAAAATGAGACCAAAATCTCAATAACTTTTTAATCACCCTTTTCTATAAAAAAAATACTC
CTGA