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Identifiers and Description
Gene Model Identifier
LIA4 (Localize In macronuclear Anlagen)
PreTt16408 | 6.m00482 | 3836.m02076
Localize In macronuclear Anlagen 4 protein - involved in macronuclear differentiation.
LIA4 is expressed exclusively during conjugation and Lia4p localizes to developing macronuclei. It is required for completion of conjugation, DNA rearrangement, chromosome breakage, and Pdd1 foci (dumposome) formation (Horrell SA and Chalker DL, unpublished data).
Ref:25084866: Horrell SA, Chalker DL (2014) LIA4 encodes a chromoshadow domain protein required for genomewide DNA rearrangements in Tetrahymena thermophila. Eukaryotic cell 13(10):1300-11
Ref:17519286: Yao MC, Yao CH, Halasz LM, Fuller P, Rexer CH, Wang SH, Jain R, Coyne RS, Chalker DL (2007) Identification of novel chromatin-associated proteins involved in programmed genome rearrangements in Tetrahymena. Journal of cell science 120(Pt 12):1978-89
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