Identifiers and Description

Gene Model Identifier

TTHERM_00263330

Standard Name

KIN2 (KINesin)

Aliases

PreTt29398 | 23.m00294

Description

Kinesin-II heavy chain homolog; implicated in intraciliary transport; shares essential functions with KIN1 in ciliary assembly and maintenance, rotokinesis and phagocytosis

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• kinesin II complex (ISS) | GO:0016939 | Ref:10512852

Molecular Function

• ATP binding (IEA) | GO:0005524
• microtubule motor activity (IEA) | GO:0003777

Biological Process

• cilium assembly (IGI) | GO:0042384 | Ref:10512852
• movement of cell or subcellular component (IGI) | GO:0006928 | Ref:10512852
• phagocytosis (IGI) | GO:0006909 | Ref:10512852
• cell separation after cytokinesis (IGI) | GO:0000920 | Ref:10512852
• microtubule-based movement (IEA) | GO:0007018

Domains

• ( PF03789 ) ELK domain
• ( PF00225 ) Kinesin motor domain

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.7%

TetraMine Data

TTHERM_00263330

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Stentor Coeruleus	SteCoe_29748	0
Tetrahymena borealis	EI9_14207.1	9.997093137033517e-262	kinesin motor domain-containin g protein (734 aa)
Oxytricha	Contig740.0.g101	3.000294738490095e-167	Kinesin motor domain
WormBase	WBGene00002222	9.995938456217754e-149	locus:klp-11 status:Partiall y_confirmed UniProt:Q19633 protein_id:CAA92295.2
DictyBase	DDB_G0280967	9.996584278131743e-91	kif3 on chromosome: 3 position 4109358 to 4113107
SGD	YBL063W	6.997420649987812e-71	KIP1 Kinesin-related motor pro tein required for mitotic spin dle assembly, chromosome segre gation, and 2 micron plasmid p artitioning; functionally redu ndant with Cin8p for chromosom al but not plasmid functions

General Information

No Data fetched for General Information

Associated Literature

1. Ref:14983519: Awan A, Bernstein M, Hamasaki T, Satir P (2004) Cloning and characterization of Kin5, a novel Tetrahymena ciliary kinesin II. Cell motility and the cytoskeleton 58(1):1-9
2. Ref:12925756: Brown JM, Fine NA, Pandiyan G, Thazhath R, Gaertig J (2003) Hypoxia regulates assembly of cilia in suppressors of Tetrahymena lacking an intraflagellar transport subunit gene. Molecular biology of the cell 14(8):3192-207
3. Ref:10512852: Brown JM, Marsala C, Kosoy R, Gaertig J (1999) Kinesin-II is preferentially targeted to assembling cilia and is required for ciliogenesis and normal cytokinesis in Tetrahymena. Molecular biology of the cell 10(10):3081-96
4. Ref:10772758: Brown JM, Hardin C, Gaertig J (1999) Rotokinesis, a novel phenomenon of cell locomotion-assisted cytokinesis in the ciliate Tetrahymena thermophila. Cell biology international 23(12):841-8
5. Ref:11212349: Cole DG (1999) Kinesin-II, the heteromeric kinesin. Cell Mol Life Sci 56(3-4):217-26

Sequences

>TTHERM_00263330(coding)
ATGACTACAAGTAAAAACAACAGCGAATGCTTTAAGGTAGCTGTAAGATGCAGACCCCTA
AATAATGATGAAATATAAAATGAAAGAAGTTCAGTTGTTTCTGTAAACCCTCAAAGAGGA
GAAATATAAATCAAACAAAAGCATGATTAAGCTGAACAACATAGGATTTTTGCATTTGAC
TAAGTTTTCGAACCTGATATTTAATAAGAGGTTGTGTATAAATGTATTGCCTACCCTATT
GTTGAGAGCGTTTTAGAAGGCTACAATGGAACAATTTTCGCTTATGGCTAAACTGGTACT
GGAAAAACGCATACTATTTAAGGGAGAAATGAGCCAATTAATGAAAGAGGTATCATTCCT
AGGGCTTTTGAACATATTTTCCACTCTATTAAAGGCTCGCCAAACACTTAATTTTTAGTA
CATGTTAGTTTTCTTGAATTATATAATGAAGAGATTTAAGACTTGCTTTCCACCAAGAAT
AAAAAATTAGAATTAAGAGAAAAAGCAGAGACTGGCGTCTTTGTGAAAGATTTAACTAGT
TTTTTAGTTTAAAATGAATAGGAATTAAATGATAAATTTTAGCAAGGTATTTTGAATCGT
AAAGTTGGTTAAACTAAAATGAGTTCATGTTCATCTCGTTCTCACTCTATCCTTTCTGTA
ACTATTGAGAGGTGCGATGTTGTGAATGGGGAAAACCATATTAAAGTAGGTAAGTTAAAT
TTAGTTGACCTCGCTGGATCTGAACGTTAAAGTAAAACTCAAGCAACAGGCTCTCGTTTT
AAAGAAGGAGTATATATTAACTTAAGTTTAACTACTTTAGGTAATGTTATTTCCTCTCTC
ATCGATCCTAAAGCTTCTCATATTCCATATAGAGATTCTAAATTGACTAGAATTCTTTAA
GACTCTCTAGGTGGCAACACCAAAACTGTGATGATCGCTAATATTGGTCCTGCTGATTAT
AACTAAGATGAAACAATATCTACTTTAAGATATGCTCACAGAGCGAAATCAATATAAAAT
CATGCTTAAATTAACGAGGATCCCAAATAAGCAATGATAAGAAAATTTTAAGAGGAAATA
TCTAGCTTAAAATAGTAGTTATCAGGTTTACTTGAAACTGGAGGAGATTTTAATATGAAT
GCTGAAGTTAAAAAGATAGAAAAAATTGTTTTTAAATATGATGACGAAGAAATTATAAAA
TTGAAACAAAAACTTGAATAACAAAAATCTGATATTGAAAATAACTATGAAAATGAAGTA
AAGAAAATAGAAGAAGATAAGTAGTTACAGGAAAAAGAAAAGTAGCAGCTTATTTATTAG
CTTCAGGAAAAAGAACAAAAGTAGCAATAATAAAAATAGCAATAATAAAAACTACTTGGT
AAACTTTAGAAAATGTAACATAAAGTAATACAAGGAGAAGAAACTATGTAGAGAGTTCTT
GAAAACGAAAGATAACTGAATAAAGAATTGCAATAAGCAAATGAAAGAGATCGCTAAGCA
GCTTTACAAATCTAATAAAATGAAGATTTTATATTAGAGATAAACATGAAATTTAAGAAC
CAAGTTGAAGAAAAATAAGAAAAATAGAAAAGAATAAATCTTTTATTTGATAGATTGTGC
TAAATTTAATAATAAAATAAAGATATTGATGAATTTTATGTTTCTGAAATAGACTAGCTA
TAAGAAAGTTACAGAGACTTACAGAAAGAATTAAAATTAAAAAGATTTATCTTAGATTAT
TTCATTCCTTAAAAAGAATTAAAAAGATTATCAGAGAAAGCTATGTATAGTGAAGAATAA
CAAAATTGGGTATATCCTATTCAAAATTTGACTGGTAAATATATGAGAAGATCTGATGAA
AGTTAAGTTTCCCTTAAAGAAATTTAATCTGAAGATCTAGAACAAGATTCAAAAGTTTAT
TTTGTATACACAGAGCAAGGACCTATTAGAGAATAGTTTTTTTACACAACTGAAATAAAA
AAGCAAGAATATGCTTAACGAAAAAATGATCCTCTTAAACAAAATTTTGAATAATCAAAT
ACTTAATTTGTAAAAACTAAAAAGAGATCTAAAAGTTAAATAAATTAAATCTGA

>TTHERM_00263330(protein)
MTTSKNNSECFKVAVRCRPLNNDEIQNERSSVVSVNPQRGEIQIKQKHDQAEQHRIFAFD
QVFEPDIQQEVVYKCIAYPIVESVLEGYNGTIFAYGQTGTGKTHTIQGRNEPINERGIIP
RAFEHIFHSIKGSPNTQFLVHVSFLELYNEEIQDLLSTKNKKLELREKAETGVFVKDLTS
FLVQNEQELNDKFQQGILNRKVGQTKMSSCSSRSHSILSVTIERCDVVNGENHIKVGKLN
LVDLAGSERQSKTQATGSRFKEGVYINLSLTTLGNVISSLIDPKASHIPYRDSKLTRILQ
DSLGGNTKTVMIANIGPADYNQDETISTLRYAHRAKSIQNHAQINEDPKQAMIRKFQEEI
SSLKQQLSGLLETGGDFNMNAEVKKIEKIVFKYDDEEIIKLKQKLEQQKSDIENNYENEV
KKIEEDKQLQEKEKQQLIYQLQEKEQKQQQQKQQQQKLLGKLQKMQHKVIQGEETMQRVL
ENERQLNKELQQANERDRQAALQIQQNEDFILEINMKFKNQVEEKQEKQKRINLLFDRLC
QIQQQNKDIDEFYVSEIDQLQESYRDLQKELKLKRFILDYFIPQKELKRLSEKAMYSEEQ
QNWVYPIQNLTGKYMRRSDESQVSLKEIQSEDLEQDSKVYFVYTEQGPIREQFFYTTEIK
KQEYAQRKNDPLKQNFEQSNTQFVKTKKRSKSQINQI

>TTHERM_00263330(gene)
AGAATAAAAAAAAGAGATAAAATCATGACTACAAGTAAAAACAACAGCGAATGCTTTAAG
GTAGCTGTAAGATGCAGACCCCTAAATAATGATGAAATATAAAATGAAAGAAGTTCAGTT
GTTTCTGTAAACCCTCAAAGAGGAGAAATATAAATCAAACAAAAGCATGATTAAGCTGAA
CAACATAGGATTTTTGCATTTGACTAAGTTTTCGAACCTGATATTTAATAAGAGGTTGTG
TATAAATGTATTGCCTACCCTATTGTTGAGAGCGTTTTAGAAGGCTACAATGGAACAATT
TTCGCTTATGGCTAAACTGGTACTGGAAAAACGCATACTATTTAAGGGAGAAATGAGCCA
ATTAATGAAAGAGGTATCATTCCTAGGGCTTTTGAACATATTTTCCACTCTATTAAAGGC
TCGCCAAACACTTAATTTTTAGTACATGTTAGTTTTCTTGAATTATATAATGAAGAGATT
TAAGACTTGCTTTCCACCAAGAATAAAAAATTAGAATTAAGAGAAAAAGCAGAGACTGGC
GTCTTTGTGAAAGATTTAACTAGTTTTTTAGTTTAAAATGAATAGGAATTAAATGATAAA
TTTTAGCAAGGTATTTTGAATCGTAAAGTTGGTTAAACTAAAATGAGTTCATGTTCATCT
CGTTCTCACTCTATCCTTTCTGTAACTATTGAGAGGTGCGATGTTGTGAATGGGGAAAAC
CATATTAAAGTAGGTAAGTTAAATTTAGTTGACCTCGCTGGATCTGAACGTTAAAGTAAA
ACTCAAGCAACAGGCTCTCGTTTTAAAGAAGGAGTATATATTAACTTAAGTTTAACTACT
TTAGGTAATGTTATTTCCTCTCTCATCGATCCTAAAGCTTCTCATATTCCATATAGAGAT
TCTAAATTGACTAGAATTCTTTAAGACTCTCTAGGTGGCAACACCAAAACTGTGATGATC
GCTAATATTGGTAACAAGCGATTTAAAATAAAACATAACAAATTAAAATTTATTATTAAA
ATTCTTAATATAATCTTTAATTTTACAAAAATAATTTCTTTCTGAAATAGCGAAAGTTTA
ATCAAACCATTTATTTTATAAATTTTCCTTTAAAAGAATTTTTATTAACTTTTTAATATT
TTTTATAAATTGTGTGTACTTTTTTTTTTAACAGGTCCTGCTGATTATAACTAAGATGAA
ACAATATCTACTTTAAGATATGCTCACAGAGCGAAATCAATATAAAATCATGCTTAAATT
AACGAGGATCCCAAATAAGCAATGATAAGAAAATTTTAAGAGGAAATATCTAGCTTAAAA
TAGTAGTTATCAGGTTTACTTGAAACTGGAGGAGATTTTAATATGAATGCTGAAGTTAAA
AAGGTAATTCAGATATTTTTTTATTAAAAAGAAAATAGTTTTAAGATTTAATAAACTTAA
TATTTATTAGATAGAAAAAATTGTTTTTAAATATGATGACGAAGAAATTATAAAATTGAA
ACAAAAACTTGAATAACAAAAATCTGATATTGAAAATAACTATGAAAATGAAGTAAAGAA
AATAGAAGAAGATAAGTAGTTACAGGAAAAAGAAAAGTAGCAGCTTATTTATTAGCTTCA
GGAAAAAGAACAAAAGTAGCAATAATAAAAATAGCAATAATAAAAACTACTTGGTAAACT
TTAGAAAATGTAACATAAAGTAATACAAGGAGAAGAAACTATGTAGAGAGTTCTTGAAAA
CGAAAGATAACTGAATAAAGAATTGCAATAAGCAAATGAAAGAGATCGCTAAGCAGCTTT
ACAAATCTAATAAAATGAAGATTTTATATTAGAGATAAACATGAAATTTAAGAACCAAGT
TGAAGAAAAATAAGAAAAATAGAAAAGAATAAATCTTTTATTTGATAGATTGTGCTAAAT
TTAATAATAAAATAAAGATATTGATGAATTTTATGTTTCTGAAATAGACTAGCTATAAGA
AAGTTACAGAGACTTACAGAAAGAATTAAAATTAAAAAGATTTATCTTAGATTATTTCAT
TCCTTAAAAAGAATTAAAAAGATTATCAGTAAATATTTTTTTTTAATATTAGTCTTATTT
TCATCATTAAATAAAATTAGGAGAAAGCTATGTATAGTGAAGAATAACAAAATTGGGTAT
ATCCTATTCAAAATTTGACTGGTAAATATATGAGAAGATCTGATGAAAGTTAAGTTTCCC
TTAAAGAAATTTAATCTGAAGATCTAGAACAAGATTCAAAAGTTTATTTTGTATACACAG
AGCAAGGACCTATTAGAGAATAGTTTTTTTACACAACTGAAATAAAAAAGCAAGAATATG
CTTAACGAAAAAATGATCCTCTTAAACAAAATTTTGAATAATCAAATACTTAATTTGTAA
AAACTAAAAAGAGATCTAAAAGTTAAATAAATTAAATCTGA