Identifiers and Description

Gene Model Identifier

TTHERM_00691720

Standard Name

ICT1 (Integral-membrane Cation Transporter 1)

Aliases

PreTt03010 | 106.m00150 | 3674.m00063

Description

NRAMP family Mn2+/Fe2+ transporters containing protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• membrane (IEA) | GO:0016020

Molecular Function

• transporter activity (IEA) | GO:0005215

Biological Process

• transport (IEA) | GO:0006810

Domains

• ( PF01461 ) 7TM chemoreceptor
• ( PF07695 ) 7TM diverse intracellular signalling
• ( PF07690 ) transporter, major facilitator family
• ( PF01566 ) Natural resistance-associated macrophage protein
• ( TIGR01197 ) metal ion transporter, metal ion

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.6%

TetraMine Data

TTHERM_00691720

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_17571.1	9.997093137033517e-262	NRAMP family Mn2+/Fe2+ transpo rters containing protein (488 aa)
Oxytricha	Contig20600.0.g69	3.999836123447869e-144	Natural resistance-associated macrophage protein
DictyBase	DDB_G0276973	2.0007666164339447e-112	nramp1 on chromosome: 2 positi on 7564058 to 7565770
WormBase	WBGene00004876	6.000988504514371e-99	locus:smf-1 NRAMP-like trans porter smf-1 status:Confirme d UniProt:Q21434 protein_i d:CCD70800.1
SGD	YOL122C	9.002663577881587e-59	SMF1 Divalent metal ion transp orter with a broad specificity for di-valent and tri-valent metals; post-translationally r egulated by levels of metal io ns; member of the Nramp family of metal transport proteins

General Information

Paragraph No	Gene Name	Paragraph Text
43	ICT1	Tetrahymena thermophila ICT1 is homologous to the natural resistance-associated macrophage protein (NRAMP) family, composed of membrane proteins that are divalent cation transporters. It contains one domain (E-value=3.7x10-108), which is located in the middle of the protein. Given the function of the homologous proteins, it is likely that ICT1 is an integral membrane protein and functions as a cation transporter. Paragraph by: Alec Koh and Katherine Tully (undergraduates), Keck Science Department, Claremont McKenna College and Scripps College.

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00691720(coding)
ATGGCTGAAGTAGGATAGAACAATATCAATTCTGGAACTGTTAACAGCAATGATCATTAA
GAGAAAATTAATGTAAAGTTTTCATTAAGGGAATTTTTCTAATATTTTGGACCAGGCTTA
CTCGTAGCTATCGCTTACATCGATCCTGGTAATTTGGCTGGTGATATGGATGCAGGTTTA
AATGGTAAATATCACTTGTTATGGGTACTTTTCTTATCAACACTCTTAGGTTTCTTCTTT
TAAAACCGTGCTATGATGATTGGTTTGGTTACTGGAAAAGATATGGCTAAATTATGTCGC
TACTATTATCCTAAAAAAATGTCTATCTTGTTATGGATTATGGCTGAAATCGCTATTATA
GGCAGTGATATTCAAGAAGTATTAGGATCTGCTATTGCATTATAAATTCTTTTTGGACTC
AAATTATGGATCGGAGTTATCTTAACTATTTCTTCTACTATTCTTATTTTATTAATAAAA
TATGTTGGTATGCGCTTTTTAGAATTAATCTTTGGTATTCTTATAGGAACTATGGCTATT
TGCTTCTTTATTGATCTTGGTTACATTGCTCCTAATTTCGGTGAATTAATGGAAGGAATG
TTTGTCCCTTACATCCCATCATCTGCACTCACTTCCATGGTTGGTTTAATAGGTGCTGTC
CTCATGCCTCACAATCTATATCTTCATTCATCTCTTGTTTATGAAAAGAAGATTTCCAGA
AATGACAGACCTCTTCTCCATAAATCCATTTTTTATTTCAAAATTGAAACAGGTATCTCT
CTCCTAATTTCTTTCTTCATAAACATGGCAGTCATTGGTACTTTTGCTAATTGGTACAAT
AGTGGAACAGATATTGATTTAAGCTCTGCTGCCACAGTCCTTGAAGAAAACTTTGGTGCA
GCTGCCAAGTACATTTGGGGTATCGGTTTATTGGCTGCTGGTTAATCATCAACTTTAACT
GGTACTCTTGCTGGTTAATTTGTCATGTCTGGATTTGTTAAAATGAGAGTAAGCAAGTTC
AAAAGAGCTTTTATTACTCGTGCTATTGCAATCGTTCCTGCTATTGTTATAGCTTTTATT
GCTGATGATGAAGACTTTAATAACTATTTAAATATTCTTCAAGCAATACAACTTCCCTTT
GCCGTTATTCCACTTCTTAAGCTTTCAATGGATAGAGAACTCATGGGTGAATTTACTATT
GGTAAAGTTCAATTAACTTTATTGAGTGTCCTTTCCGCTGCTATTGTAGGAGTAAACTAT
TACGCATCAGTACCTGATGAAGTAAACTGGTCTGAAGCTTGGATCTATATCATTCTCGTA
GTTATGGTTTTATACTTTATCTTTTTAGGAATCGTGCTTTTCACTAAAATTAAAGATACT
AAGGACGTCAAATAAAGTATGCTATCAAATCATAAGCAATCTTTAATTTAAGATGATGAA
TAATATCATGTTAAATAATGA

>TTHERM_00691720(protein)
MAEVGQNNINSGTVNSNDHQEKINVKFSLREFFQYFGPGLLVAIAYIDPGNLAGDMDAGL
NGKYHLLWVLFLSTLLGFFFQNRAMMIGLVTGKDMAKLCRYYYPKKMSILLWIMAEIAII
GSDIQEVLGSAIALQILFGLKLWIGVILTISSTILILLIKYVGMRFLELIFGILIGTMAI
CFFIDLGYIAPNFGELMEGMFVPYIPSSALTSMVGLIGAVLMPHNLYLHSSLVYEKKISR
NDRPLLHKSIFYFKIETGISLLISFFINMAVIGTFANWYNSGTDIDLSSAATVLEENFGA
AAKYIWGIGLLAAGQSSTLTGTLAGQFVMSGFVKMRVSKFKRAFITRAIAIVPAIVIAFI
ADDEDFNNYLNILQAIQLPFAVIPLLKLSMDRELMGEFTIGKVQLTLLSVLSAAIVGVNY
YASVPDEVNWSEAWIYIILVVMVLYFIFLGIVLFTKIKDTKDVKQSMLSNHKQSLIQDDE
QYHVKQ

>TTHERM_00691720(gene)
ATGGCTGAAGTAGGATAGAACAATATCAATTCTGGAACTGTTAACAGCAATGATCATTAA
GAGAAAATTAATGTAAAGTTTTCATTAAGGGAATTTTTCTAATATTTTGGACCAGGCTTA
CTCGTAGCTATCGCTTACATCGATCCTGGTAATTTGGCTGGTGATATGGATGCAGGTTTA
AATGGTAAATATCACTTGTTATGGGTACTTTTCTTATCAACACTCTTAGGTTTCTTCTTT
TAAAACCGTGCTATGATGATTGGTTTGGTTACTGGAAAAGATATGGCTAAATTATGTCGC
TACTATTATCCTAAAAAAATGTCTATCTTGTTATGGATTATGGCTGAAATCGCTATTATA
GGCAGTGATATTCAAGAAGTATTAGGATCTGCTATTGCATTATAAATTCTTTTTGGACTC
AAATTATGGATCGGAGTTATCTTAACTATTTCTTCTACTATTCTTATTTTATTAATAAAA
TATGTTGGTATGCGCTTTTTAGAATTAATCTTTGGTATTCTTATAGGAACTATGGCTATT
TGCTTCTTTATTGATCTTGGTTACATTGCTCCTAATTTCGGTGAATTAATGGAAGGAATG
TTTGTCCCTTACATCCCATCATCTGCACTCACTTCCATGGTTGGTTTAATAGGTGCTGTC
CTCATGCCTCACAATCTATATCTTCATTCATCTCTTGTTTATGAAAAGAAGATTTCCAGA
AATGACAGACCTCTTCTCCATAAATCCATTTTTTATTTCAAAATTGAAACAGGTATCTCT
CTCCTAATTTCTTTCTTCATAAACATGGCAGTCATTGGTACTTTTGCTAATTGGTACAAT
AGTGGAACAGATATTGATTTAAGCTCTGCTGCCACAGTCCTTGAAGAAAACTTTGGTGCA
GCTGCCAAGTACATTTGGGGTATCGGTTTATTGGCTGCTGGTTAATCATCAACTTTAACT
GGTACTCTTGCTGGTTAATTTGTCATGTCTGGATTTGTTAAAATGAGAGTAAGCAAGTTC
AAAAGAGCTTTTATTACTCGTGCTATTGCAATCGTTCCTGCTATTGTTATAGCTTTTATT
GCTGATGATGAAGACTTTAATAACTATTTAAATATTCTTCAAGCAATACAACTTCCCTTT
GCCGTTATTCCACTTCTTAAGCTTTCAATGGATAGAGAACTCATGGGTGAATTTACTATT
GGTAAAGTTCAATTAACTTTATTGAGTGTCCTTTCCGCTGCTATTGTAGGAGTAAACTAT
TACGCATCAGTACCTGATGAAGTAAACTGGTCTGAAGCTTGGATCTATATCATTCTCGTA
GTTATGGTTTTATACTTTATCTTTTTAGGAATCGTGCTTTTCACTAAAATTAAAGATACT
AAGGACGTCAAATAAAGTATGCTATCAAATCATAAGCAATCTTTAATTTAAGATGATGAA
TAATATCATGTTAAATAATGA