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Identifiers and Description
Gene Model Identifier
TTHERM_00691720Standard Name
ICT1 (Integral-membrane Cation Transporter 1)Aliases
PreTt03010 | 106.m00150 | 3674.m00063Description
ICT1 NRAMP (natural resistance-associated macrophage protein) metal ion transporter family protein; NRAMP family Mn2+/Fe2+ transporters containing proteinGenome Browser (Macronucleus)
Genome Browser (Micronucleus)
Gene Ontology Annotations
Cellular Component
- membrane (IEA) | GO:0016020
Molecular Function
- transporter activity (IEA) | GO:0005215
Biological Process
- transport (IEA) | GO:0006810
Domains
Gene Expression Profile
- Tetrahymena Functional Genomics Database:
Change in Gene Expression
TMHMM
TMHMM
Signal Peptide
Signal Peptide Present?: No
Presense Probability: 11.6%
TetraMine Data
TTHERM_00691720
WebApollo
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Tetrahymena Stock Center
No Data fetched for StockID
Homologs (v.2006 protein sequences)
Source Identifier Score Description Tetrahymena borealis EI9_17571.1 9.997093137033517e-262 NRAMP family Mn2+/Fe2+ transpo
rters containing protein (488
aa)
Oxytricha Contig20600.0.g69 3.999836123447869e-144 Natural resistance-associated
macrophage protein
DictyBase DDB_G0276973 2.0007666164339447e-112 nramp1 on chromosome: 2 positi
on 7564058 to 7565770
WormBase WBGene00004876 6.000988504514371e-99 locus:smf-1 NRAMP-like trans
porter smf-1 status:Confirme
d UniProt:Q21434 protein_i
d:CCD70800.1
SGD YOL122C 9.002663577881587e-59 SMF1 Divalent metal ion transp
orter with a broad specificity
for di-valent and tri-valent
metals; post-translationally r
egulated by levels of metal io
ns; member of the Nramp family
of metal transport proteins
General Information
Paragraph No Gene Name Paragraph Text 43 ICT1 Tetrahymena thermophila ICT1 is homologous to the natural resistance-associated macrophage protein (NRAMP) family, composed of membrane proteins that are divalent cation transporters. It contains one domain (E-value=3.7x10-108), which is located in the middle of the protein. Given the function of the homologous proteins, it is likely that ICT1 is an integral membrane protein and functions as a cation transporter. Paragraph by: Alec Koh and Katherine Tully (undergraduates), Keck Science Department, Claremont McKenna College and Scripps College.
Associated Literature
No Data fetched for Associated Literature
Sequences
>TTHERM_00691720(coding)
ATGGCTGAAGTAGGATAGAACAATATCAATTCTGGAACTGTTAACAGCAATGATCATTAA
GAGAAAATTAATGTAAAGTTTTCATTAAGGGAATTTTTCTAATATTTTGGACCAGGCTTA
CTCGTAGCTATCGCTTACATCGATCCTGGTAATTTGGCTGGTGATATGGATGCAGGTTTA
AATGGTAAATATCACTTGTTATGGGTACTTTTCTTATCAACACTCTTAGGTTTCTTCTTT
TAAAACCGTGCTATGATGATTGGTTTGGTTACTGGAAAAGATATGGCTAAATTATGTCGC
TACTATTATCCTAAAAAAATGTCTATCTTGTTATGGATTATGGCTGAAATCGCTATTATA
GGCAGTGATATTCAAGAAGTATTAGGATCTGCTATTGCATTATAAATTCTTTTTGGACTC
AAATTATGGATCGGAGTTATCTTAACTATTTCTTCTACTATTCTTATTTTATTAATAAAA
TATGTTGGTATGCGCTTTTTAGAATTAATCTTTGGTATTCTTATAGGAACTATGGCTATT
TGCTTCTTTATTGATCTTGGTTACATTGCTCCTAATTTCGGTGAATTAATGGAAGGAATG
TTTGTCCCTTACATCCCATCATCTGCACTCACTTCCATGGTTGGTTTAATAGGTGCTGTC
CTCATGCCTCACAATCTATATCTTCATTCATCTCTTGTTTATGAAAAGAAGATTTCCAGA
AATGACAGACCTCTTCTCCATAAATCCATTTTTTATTTCAAAATTGAAACAGGTATCTCT
CTCCTAATTTCTTTCTTCATAAACATGGCAGTCATTGGTACTTTTGCTAATTGGTACAAT
AGTGGAACAGATATTGATTTAAGCTCTGCTGCCACAGTCCTTGAAGAAAACTTTGGTGCA
GCTGCCAAGTACATTTGGGGTATCGGTTTATTGGCTGCTGGTTAATCATCAACTTTAACT
GGTACTCTTGCTGGTTAATTTGTCATGTCTGGATTTGTTAAAATGAGAGTAAGCAAGTTC
AAAAGAGCTTTTATTACTCGTGCTATTGCAATCGTTCCTGCTATTGTTATAGCTTTTATT
GCTGATGATGAAGACTTTAATAACTATTTAAATATTCTTCAAGCAATACAACTTCCCTTT
GCCGTTATTCCACTTCTTAAGCTTTCAATGGATAGAGAACTCATGGGTGAATTTACTATT
GGTAAAGTTCAATTAACTTTATTGAGTGTCCTTTCCGCTGCTATTGTAGGAGTAAACTAT
TACGCATCAGTACCTGATGAAGTAAACTGGTCTGAAGCTTGGATCTATATCATTCTCGTA
GTTATGGTTTTATACTTTATCTTTTTAGGAATCGTGCTTTTCACTAAAATTAAAGATACT
AAGGACGTCAAATAAAGTATGCTATCAAATCATAAGCAATCTTTAATTTAAGATGATGAA
TAATATCATGTTAAATAATGA>TTHERM_00691720(protein)
MAEVGQNNINSGTVNSNDHQEKINVKFSLREFFQYFGPGLLVAIAYIDPGNLAGDMDAGL
NGKYHLLWVLFLSTLLGFFFQNRAMMIGLVTGKDMAKLCRYYYPKKMSILLWIMAEIAII
GSDIQEVLGSAIALQILFGLKLWIGVILTISSTILILLIKYVGMRFLELIFGILIGTMAI
CFFIDLGYIAPNFGELMEGMFVPYIPSSALTSMVGLIGAVLMPHNLYLHSSLVYEKKISR
NDRPLLHKSIFYFKIETGISLLISFFINMAVIGTFANWYNSGTDIDLSSAATVLEENFGA
AAKYIWGIGLLAAGQSSTLTGTLAGQFVMSGFVKMRVSKFKRAFITRAIAIVPAIVIAFI
ADDEDFNNYLNILQAIQLPFAVIPLLKLSMDRELMGEFTIGKVQLTLLSVLSAAIVGVNY
YASVPDEVNWSEAWIYIILVVMVLYFIFLGIVLFTKIKDTKDVKQSMLSNHKQSLIQDDE
QYHVKQ>TTHERM_00691720(gene)
ATGGCTGAAGTAGGATAGAACAATATCAATTCTGGAACTGTTAACAGCAATGATCATTAA
GAGAAAATTAATGTAAAGTTTTCATTAAGGGAATTTTTCTAATATTTTGGACCAGGCTTA
CTCGTAGCTATCGCTTACATCGATCCTGGTAATTTGGCTGGTGATATGGATGCAGGTTTA
AATGGTAAATATCACTTGTTATGGGTACTTTTCTTATCAACACTCTTAGGTTTCTTCTTT
TAAAACCGTGCTATGATGATTGGTTTGGTTACTGGAAAAGATATGGCTAAATTATGTCGC
TACTATTATCCTAAAAAAATGTCTATCTTGTTATGGATTATGGCTGAAATCGCTATTATA
GGCAGTGATATTCAAGAAGTATTAGGATCTGCTATTGCATTATAAATTCTTTTTGGACTC
AAATTATGGATCGGAGTTATCTTAACTATTTCTTCTACTATTCTTATTTTATTAATAAAA
TATGTTGGTATGCGCTTTTTAGAATTAATCTTTGGTATTCTTATAGGAACTATGGCTATT
TGCTTCTTTATTGATCTTGGTTACATTGCTCCTAATTTCGGTGAATTAATGGAAGGAATG
TTTGTCCCTTACATCCCATCATCTGCACTCACTTCCATGGTTGGTTTAATAGGTGCTGTC
CTCATGCCTCACAATCTATATCTTCATTCATCTCTTGTTTATGAAAAGAAGATTTCCAGA
AATGACAGACCTCTTCTCCATAAATCCATTTTTTATTTCAAAATTGAAACAGGTATCTCT
CTCCTAATTTCTTTCTTCATAAACATGGCAGTCATTGGTACTTTTGCTAATTGGTACAAT
AGTGGAACAGATATTGATTTAAGCTCTGCTGCCACAGTCCTTGAAGAAAACTTTGGTGCA
GCTGCCAAGTACATTTGGGGTATCGGTTTATTGGCTGCTGGTTAATCATCAACTTTAACT
GGTACTCTTGCTGGTTAATTTGTCATGTCTGGATTTGTTAAAATGAGAGTAAGCAAGTTC
AAAAGAGCTTTTATTACTCGTGCTATTGCAATCGTTCCTGCTATTGTTATAGCTTTTATT
GCTGATGATGAAGACTTTAATAACTATTTAAATATTCTTCAAGCAATACAACTTCCCTTT
GCCGTTATTCCACTTCTTAAGCTTTCAATGGATAGAGAACTCATGGGTGAATTTACTATT
GGTAAAGTTCAATTAACTTTATTGAGTGTCCTTTCCGCTGCTATTGTAGGAGTAAACTAT
TACGCATCAGTACCTGATGAAGTAAACTGGTCTGAAGCTTGGATCTATATCATTCTCGTA
GTTATGGTTTTATACTTTATCTTTTTAGGAATCGTGCTTTTCACTAAAATTAAAGATACT
AAGGACGTCAAATAAAGTATGCTATCAAATCATAAGCAATCTTTAATTTAAGATGATGAA
TAATATCATGTTAAATAATGA
