Identifiers and Description

Gene Model Identifier

TTHERM_00633360

Standard Name

HTB1 (Histone h Two B )

Aliases

PreTt28005 | 90.m00169 | histone H2B-1

Description

Histone H2B; one of the four histones (H2A, H2B, H3 and H4) that comprise the protein core of the eukaryotic nucleosome; differs from Htb2p by three amino acids

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• micronucleus (TAS) | GO:0031040 | Ref:8760889
• macronucleus (TAS) | GO:0031039 | Ref:8760889

Domains

• ( PF00125 ) Core histone H2A/H2B/H3/H4
• ( PF00808 ) Histone-like transcription factor (CBF/NF-Y) and

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.8%

TetraMine Data

TTHERM_00633360

WebApollo

Fullscreen View

Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_15821.1	9.998074580622396e-81	core histone H2A/H2B/H3/H4 fam ily protein (122 aa)
Oxytricha	Contig678.1.g53	2.000065869309806e-55	Core histone H2A/H2B/H3/H4
SGD	YDR224C	5.00115835552873e-49	HTB1 Histone H2B, core histone protein required for chromati n assembly and chromosome func tion; nearly identical to HTB2 ; Rad6p-Bre1p-Lge1p mediated u biquitination regulates transc riptional activation, meiotic DSB formation and H3 methylati on
WormBase	WBGene00001915	6.998316056150599e-49	locus:his-41 Probable histon e H2B 3 status:Confirmed U niProt:Q27484 protein_id:CAA 94740.1
DictyBase	DDB_G0286509	6.998020510507768e-25	H2Bv3 on chromosome: 4 positio n 4575107 to 4575571
Stentor Coeruleus	SteCoe_2198	1.2995814250075031e-24

General Information

No Data fetched for General Information

Associated Literature

1. Ref:19822522: Wang Z, Cui B, Gorovsky MA (2009) Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena. The Journal of biological chemistry 284(50):34870-9
2. Ref:15199121: Medzihradszky KF, Zhang X, Chalkley RJ, Guan S, McFarland MA, Chalmers MJ, Marshall AG, Diaz RL, Allis CD, Burlingame AL (2004) Characterization of Tetrahymena histone H2B variants and posttranslational populations by electron capture dissociation (ECD) Fourier transform ion cyclotron mass spectrometry (FT-ICR MS). Molecular & cellular proteomics : MCP 3(9):872-86
3. Ref:8760889: Liu X, Gorovsky MA (1996) Cloning and characterization of the major histone H2A genes completes the cloning and sequencing of known histone genes of Tetrahymena thermophila. Nucleic acids research 24(15):3023-30
4. Ref:2713375: Nickel BE, Allis CD, Davie JR (1989) Ubiquitinated histone H2B is preferentially located in transcriptionally active chromatin. Biochemistry 28(3):958-63
5. Ref:3039463: Nomoto M, Imai N, Saiga H, Matsui T, Mita T (1987) Characterization of two types of histone H2B genes from macronuclei of Tetrahymena thermophila. Nucleic acids research 15(14):5681-97
6. Ref:6818230: Nomoto M, Kyogoku Y, Iwai K (1982) N-Trimethylalanine, a novel blocked N-terminal residue of Tetrahymena histone H2B. Journal of biochemistry 92(5):1675-8
7. Ref:6804458: Nomoto M, Hayashi H, Iwai K (1982) Tetrahymena histone H2B. Complete amino acid sequence. Journal of biochemistry 91(3):897-904

Sequences

>TTHERM_00633360(coding)
ATGGCTCCCAAGAAAGCTCCCGCTGCCGCTGCTGAAAAGAAGGTCAAGAAGGCCCCCACA
ACCGAAAAGAAGAACAAGAAGAAGAGATCAGAAACCTTCGCCATCTACATCTTCAAGGTC
TTAAAGCAAGTCCACCCTGATGTCGGTATTTCCAAGAAGGCTATGAACATTATGAACTCC
TTCATTAACGACTCCTTCGAAAGAATCGCCTTAGAATCCTCTAAGTTGGTCAGATTCAAC
AAGAGAAGAACCCTCTCATCCAGGGAAGTCTAAACCGCTGTCAAGCTCTTATTACCCGGT
GAACTCGCTAGACACGCCATCTCCGAAGGTACCAAGGCCGTCACCAAGTTCTCTTCTTCT
ACCAACTGA

>TTHERM_00633360(protein)
MAPKKAPAAAAEKKVKKAPTTEKKNKKKRSETFAIYIFKVLKQVHPDVGISKKAMNIMNS
FINDSFERIALESSKLVRFNKRRTLSSREVQTAVKLLLPGELARHAISEGTKAVTKFSSS
TN

>TTHERM_00633360(gene)
ATGGCTCCCAAGAAAGCTCCCGCTGCCGCTGCTGAAAAGAAGGTCAAGAAGGCCCCCACA
ACCGAAAAGAAGAACAAGAAGAAGAGATCAGAAACCTTCGCCATCTACATCTTCAAGGTC
TTAAAGCAAGTCCACCCTGATGTCGGTATTTCCAAGAAGGCTATGAACATTATGAACTCC
TTCATTAACGACTCCTTCGAAAGAATCGCCTTAGAATCCTCTAAGTTGGTCAGATTCAAC
AAGAGAAGAACCCTCTCATCCAGGGAAGTCTAAACCGCTGTCAAGCTCTTATTACCCGGT
GAACTCGCTAGACACGCCATCTCCGAAGGTACCAAGGCCGTCACCAAGTTCTCTTCTTCT
ACCAACTGA