Identifiers and Description

Gene Model Identifier

TTHERM_00401980

Standard Name

HRS1 (histidyl-tRNA synthetase 1)

Aliases

PreTt12743 | 43.m00261 | 3713.m00087

Description

HRS1 histidine-tRNA ligase; histidyl-tRNA synthetase family protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• cytoplasm (IEA) | GO:0005737

Molecular Function

• ATP binding (IEA) | GO:0005524
• aminoacyl-tRNA ligase activity (IEA) | GO:0004812
• nucleotide binding (IEA) | GO:0000166

Biological Process

• tRNA aminoacylation for protein translation (IEA) | GO:0006418
• translation (IEA) | GO:0006412

Domains

• ( TIGR00442 ) histidyl-tRNA synthetase
• ( TIGR00443 ) ATP phosphoribosyltransferase, regulatory subunit
• ( PF00587 ) tRNA synthetase class II core

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.1%

TetraMine Data

TTHERM_00401980

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_13986.1	9.997093137033517e-262	histidyl-tRNA synthetase (464 aa)
DictyBase	DDB_G0269822	3.0008725323024365e-87	mhisS on chromosome: 1 positio n 3669575 to 3671080
Stentor Coeruleus	SteCoe_24979	7.984904245686979e-30
Oxytricha	Contig9747.0.g58	7.996806159126539e-24	Histidyl-tRNA synthetase
SGD	YPR033C	3.998609120989657e-17	HTS1 Cytoplasmic and mitochond rial histidine tRNA synthetase ; efficient mitochondrial loca lization requires both a prese quence and an amino-terminal s equence; mutations in human or tholog HARS2 are associated wi th Perrault syndrome
WormBase	WBGene00002001	0.000000000000004001928599951003	locus:hars-1 Histidine--tRNA ligase status:Confirmed U niProt:P34183 protein_id:CAD 89746.1

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00401980(coding)
ATGTAGAGATTTAGCTCTTTGCAATCTGTTAAGGGAATGAAGGATTTAGTTGGAAATTAG
CTTTTGAAGCATCGATTTATATTTGATTGCGGTGCTAAGGTAATGGAAAAGCATGGGTAC
TAGATGATTGTTTAAAATATTTTAGAGCATAAATAAGTTTTCTCGAGAACTTTAGGAGAT
ACATCTGAAATTATTAATAAAGAAATGTATGGATTTACTGATTAGTCAGGTAAAGAACTT
GTACTTAGACCAGAAGGTACTGCAAGTGTTGTACGTCATATTTTAGAAAATTCAAAGCAC
TTCGAATAGTAGCAGAAATATTATTATTACGGTCCTATGTATAGATATGAGCGCCCTCAA
CTAGGAAGGCAAAGATAATTTTACTAGCTAGGATGTGAATTTTTACATAAAGAGAATCCT
AAAAATAGCTACTTAATAGATGCTGAGATCATTATAGTAGCTCATAAGTTTTTACAAAGG
GTATTGGGCAAACATTCCGAATTTTAAATGGAGATCAATACAATAGGAGATGTTGAAGAC
AGAGTAAAATACAATTCAATTTTAAAAGAATACTATGAAAAAAATATACACAAACTTTCT
GAATTAAGTAAAATGCGCTTAGAAAGAAATAATCCTTTAAGAATATTTGATTCTAAGGAG
GCATAAGATTAAGATTTAATAGCTAATGCTCCTTAATTTTCAGAAAGTATGAAATAAGAA
AGCAAAGAATACTTTAGAAATCTTTTAGAAGTACTAGATTCTCTTAATATTTCTTACAAG
ATAAATCCTTTACTAGTAAGAGGATTAGATTATTACTCACACACTTGCTTTGAAATCAAA
AATGTTGCTCAATAGGGTAAATCTTAAGACACAATCCTGGCAGGTGGCAGATACGATCAT
CTAGCATCAGTTCTTAACTCAAAAGCTACCAACTTAAACGGAGTAGGCTTTGCATGTGGT
ATCGAAAGAATTGGCTTGCTCTTGCAAGACGATGATCCCAAGTTAAAAGAGTTTGAGAAG
AAAAAGATTAAAATAGGAATTGTTCCTGTCCTAGGAAAATAAAATTTAAGTGATGAATTT
GAAAGAAATCTCAAGCTATATTGCGTCAATTTAATGAATTCAATCTCTGATGATTAAATT
GAAGTCTAACTTGTCCTTCATACATCTAAAATGGATAAGTAAATGGAATATTTATTGAAG
AATGAATTCAAATGGGGTATTTTCATTGGCGAAAATGAGGTGAAAGAAAAAAAAGTGAGC
ATAAAAAATTTATTAGATCGCGAAAGTTTTACTATTGAACGTGAGTAGATAAATAATTAC
CAATTTTGA

>TTHERM_00401980(protein)
MQRFSSLQSVKGMKDLVGNQLLKHRFIFDCGAKVMEKHGYQMIVQNILEHKQVFSRTLGD
TSEIINKEMYGFTDQSGKELVLRPEGTASVVRHILENSKHFEQQQKYYYYGPMYRYERPQ
LGRQRQFYQLGCEFLHKENPKNSYLIDAEIIIVAHKFLQRVLGKHSEFQMEINTIGDVED
RVKYNSILKEYYEKNIHKLSELSKMRLERNNPLRIFDSKEAQDQDLIANAPQFSESMKQE
SKEYFRNLLEVLDSLNISYKINPLLVRGLDYYSHTCFEIKNVAQQGKSQDTILAGGRYDH
LASVLNSKATNLNGVGFACGIERIGLLLQDDDPKLKEFEKKKIKIGIVPVLGKQNLSDEF
ERNLKLYCVNLMNSISDDQIEVQLVLHTSKMDKQMEYLLKNEFKWGIFIGENEVKEKKVS
IKNLLDRESFTIEREQINNYQF

>TTHERM_00401980(gene)
ATGTAGAGATTTAGCTCTTTGCAATCTGTTAAGGGAATGAAGGATTTAGTTGGAAAGTAA
TAAATATTTATTACTTTTTCCATTTAAAAATTAAACTATTATAAAACTATAAAGTTAGCT
TTTGAAGCATCGATTTATATTTGATTGCGGTGCTAAGGTAATGGAAAAGCATGGGTACTA
GATGATTGTTTAAAATATTTTAGAGCATAAATAAGTTTTCTCGAGAACTTTAGGAGATAC
ATCTGAAATTATTAATAAAGTAAAAAAAACTTATGCTCTCTTATTTTAATTTAGTCAACT
TTAAATATTCATTTTAAGATTTTTATGAGTATTTTCCTTTTTTTTATATTGTTTCTTAAA
GTTGATAAATTTTGGTTGATTTAATAGATAATTCTAGTTAATTTTTTTGAAATCCATTAA
GATTTTATGTTTTTTTATCTAACCAATTTATGATTCATTTTATAAAAGGAAATGTATGGA
TTTACTGATTAGTCAGGTAAAGAACTTGTACTTAGACCAGAAGGTACTGCAAGTGTTGTA
CGTCATATTTTAGAAAATTCAAAGCACTTCGAATAGTAGCAGAAATATTATTATTACGGT
CCTATGTATAGATATGAGCGCCCTCAACTAGGAAGGCAAAGATAATTTTACTAGCTAGGA
TGTGAATTTTTACATAAAGAGAATCCTAAAAATAGCTACTTAATAGATGCTGAGATCATT
ATAGTAGCTCATAAGTTTTTACAAAGGGTATTGGGCAAACATTCCGAATTTTAAATGGAG
ATCAATACAATAGGAGATGTTGAAGACAGAGTAAAATACAATTCAATTTTAAAAGAATAC
TATGAAAAAAATATACACAAACTTTCTGAATTAAGTAAAATGCGCTTAGAAAGAAATAAT
CCTTTAAGAATATTTGATTCTAAGGAGGCATAAGATTAAGATTTAATAGCTAATGCTCCT
TAATTTTCAGAAAGTATGAAATAAGAAAGCAAAGAATACTTTAGAAATCTTTTAGAAGTA
CTAGATTCTCTTAATATTTCTTACAAGATAAATCCTTTACTAGTAAGAGGATTAGATTAT
TACTCACACACTTGCTTTGAAATCAAAAATGTTGCTCAATAGGGTAAATCTTAAGACACA
ATCCTGGCAGGTGGCAGATACGATCATCTAGCATCAGTTCTTAACTCAAAGTATAATTAA
ATAAAATATTTTTAAATTTTAAATACATTTAATAAAAACCCAAATAAAATCATAGTAGAA
AAAAAATTTAATTTGAAACAATTTAAGTAAATTTGTAAAAAATAATTAGAATTTATGATC
AAAGTTATAAATAACATAAGATTTATTTTTTTAATATTTGCTACAAATACATAATAAATA
AATGGTTGAAATAGCATTTCATTTATATATCAAATTTTTTAAAAATACAAACAGTTATTT
TATTTACTATTAAATAAAATTTTATAAATTAGAAACATTAAATAATATTTCAAATAATTT
TAAATGATTTAATCTAATTTAAATATTCATATTTTATTGTTAATGATTTTGGCTTTTATA
TGGTTTAAGATAAAAAAGATATGAAGATTTTATTTATCTATCTACATTAATTTTATTTAG
GATGTTTTTTATTCTTCTACTAGCACTTTTTTTAGCTATAAGTTGAAATTATATAGAATT
TATTTGGATTAACTATATATTCATTTTCTCCATCATTGCATATGTTGGATTCACCAACAC
TAGAGTATTTTTCCATCTATAGCATTATTTCGGTTTGCTATTAGATTTCTATTTATTACG
ACTATTTTAATACAAGATAGAGGAAAAATAGAACAAGTAGCAAATTCTCCTTCTTTATAT
AAGATATTTTGTTCAATATATAATTGTTTTATGTTCACTTTGTTAAACCACATTTATACA
TTTTAAATTTTATTTTAAATTATAGAGCTACCAACTTAAACGGAGTAGGCTTTGCATGTG
GTATCGAAAGAATTGGCTTGCTCTTGCAAGACGATGATCCCAAGTTAAAAGAGTTTGAGA
AGAAAAAGATTAAAATAGGAATTGTTCCTGTCCTAGGAAAATAAAATTTAAGTGATGAAT
TTGAAAGAAATCTCAAGCTATATTGCGTCAATTTAATGAATTCAATCTCTGATGATTAAA
TTGAAGTCTAACTTGTCCTTCATACATCTAAAATGGATAAGTAAATGGAATATTTATTGA
AGGTAATTACTATTGATATATTATTGAAACTAATTATTGAAAGCAAAAATAGGTTTTAGT
TTTTAAGATGAAGCTTATTTGAAATAGAATGATTTTAAATTTAACATTTTTTGTTTAAAA
TAGAATGAATTCAAATGGGGTATTTTCATTGGCGAAAATGAGGTGAAAGAAAAAAAAGTG
AGCATAAAAAATTTATTAGATCGCGAAAGTTTTACTATTGAACGTGAGTAGATAAATAAT
TACCAATTTTGA