Identifiers and Description

Gene Model Identifier

TTHERM_00551070

Standard Name

HPL7 (Heterochromatin Protein 1 Like 7)

Aliases

PreTt29211 | 72.m00134

Description

Heterochromatin protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• nucleus (IEA) | GO:0005634
• chromatin (IEA) | GO:0000785
• micronucleus (IDA) | GO:0031040 | Ref:28692189

Molecular Function

• chromatin binding (IEA) | GO:0003682

Biological Process

• chromatin assembly or disassembly (IEA) | GO:0006333

Domains

• ( PF06658 ) Protein of unknown function (DUF1168)
• ( PF00385 ) 'chromo' (CHRromatin Organization MOdifier) domain

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.2%

TetraMine Data

TTHERM_00551070

WebApollo

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Tetrahymena Stock Center

• ( SD02326 ) Macronucleus: Neo4 upstream and 2 HA tags inserted after the ATG of TCD2
• ( SD02327 ) Macronucleus: Neo4 upstream and 2 HAtags inserted after the ATG of TCD2
• ( SD02495 ) Macronucleus: Two HA tags after ATG of TCD2, neo4 in 5’ flank, inserted into MTT1 locus for over expression, need Cd
• ( SD02496 ) Macronucleus: Two HA tags after ATG of TCD2, neo4 in 5’ flank, inserted into MTT1 locus for over expression, need Cd
• ( SD02506 ) Macronucleus: TCD2 was knocked out with neo4, then the wt TCD2 gene with a bsr1cassette upstream was somatically reintroduced into the cell
• ( SD02507 ) Macronucleus: TCD2 was knocked out with neo4, then the wt TCD2 gene with a bsr1cassette upstream was somatically reintroduced into the cell

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_07338.1	2.0007019863683806e-141	heterochromatin protein (422 a a)
DictyBase	DDB_G0283023	0.0000009995106777214876	hcpA on chromosome: 4 position 170065 to 170742
WormBase	WBGene00001995	0.000005000363240844623	locus:hpl-1 status:Confirmed UniProt:G5EET5 protein_id :CAA94152.1
Oxytricha	Contig9832.0.g37	0.00003998524687536623	Chromo (CHRromatin Organisatio n MOdifier) domain

General Information

No Data fetched for General Information

Associated Literature

1. Ref:28692189: Wiley EA, Horrell S, Yoshino A, C Schornak C, Bagnani C, L Chalker D (2017) Diversification of HP1-like Chromo Domain Proteins in Tetrahymena thermophila. The Journal of eukaryotic microbiology ( ):

Sequences

>TTHERM_00551070(coding)
ATGAAAAAGAGAAGACAATCAACAAATAATGAAAAGCAGGAAGATCTTTATGAACCTGAA
AAGATATTAGATAAAAAAGTTAATTAAAGTGGTACTTCCTATTTGGTTAAATGGAAAGGT
TTTAGGGCTTCACAAGCAACATGGGAATTTTATAAAAACATATCTCATTGCAATTGGCTT
TTTGAAGATTGGGAAGAGTAGTAAAATAGAAAGGAATTACAAAAAATCAAGAATATGGAT
AGGATAATAGACAAAAAATATGTAAATAGTAAAGTTTTTTATTTGGTTTCTCTAAAAAAT
GGCGGAGAAGATGTATGGATTAGAAGAAAGGCTTTGATGCTTGACCATGCCGATAAAATT
TCTGAATATGAAAAGAGTGATTAATTGGTTGGGGCTAAAAGAAAATATTAATAGAAAAGA
TTTAGCAAAAGCTAAGATAGATTTCTTAGCAGTGATGAAGATTTGAGCGATTCTTAAAGT
GATAAAAATTCAGATAATAGCTAAAATAATTCAAGCAATAGCGATAATAGTTAAAGTAGA
AGCGGAAGCAGTTCAGATTCATGCAGTAGAAGCTCTTCAGAAGATAATTAAGATGAAAAT
ACAAATTAAAGAGGAAAAAGTAATGGTAGAAGAAAGGGTAGAATTTATAACAATAAAAAA
AAACCGAAGAGAGGAGGAAATAGAAAAAATTAAAAAGGATAGAATATTAATGATTCAAAT
AGTAGCTCAGATGAGAATAGTGAGCAAGAAGTCTCTGAATCAAGAAGAATAGTTAAAACA
AAAAGAAAAATTCCAAAAAAATGCAAAATTTTATATGATAAGCTTCCTTTTTATGGTATA
CTTGGTATAGATGAACCAAAATCTATAAAAAATATGGTCATAGACAAAAGAGTAGGGACG
AAGGATGATGGATATTTTGCTTGTGATATTATTTGGAAAATTAGACCTAATAAACAATAG
CCTGTCGATAGTAGAGTCAGCAGAAAAGATATAAAAGAGTTCTATCCTCTTATTTTAATA
GAATTTTATGAGTATAATATGACATATAATGGTGAAGTAGTCAATGCTGATGATGAAGAT
GACTTAGAATATTACAATGGTGATGATGAAGAAGATGCTGATCATGATGATGAGTATTAT
TAAAAATTATAAAGAAAAGCTGGTAAAAAACCTCTTGAAAACGAAAACTCAGAAGCTGAT
AATTAGGATGAAAAATCTGAAGATTCATTTAGCTTTTAGAATTAGATTTACTATGGGTAT
GCTAAAACTAATGAATAGAAAAAGTATGTTAAATTTGATGAAAAATTCTTCAACAACAAT
CAAATGGAAGAAATGTGA

>TTHERM_00551070(protein)
MKKRRQSTNNEKQEDLYEPEKILDKKVNQSGTSYLVKWKGFRASQATWEFYKNISHCNWL
FEDWEEQQNRKELQKIKNMDRIIDKKYVNSKVFYLVSLKNGGEDVWIRRKALMLDHADKI
SEYEKSDQLVGAKRKYQQKRFSKSQDRFLSSDEDLSDSQSDKNSDNSQNNSSNSDNSQSR
SGSSSDSCSRSSSEDNQDENTNQRGKSNGRRKGRIYNNKKKPKRGGNRKNQKGQNINDSN
SSSDENSEQEVSESRRIVKTKRKIPKKCKILYDKLPFYGILGIDEPKSIKNMVIDKRVGT
KDDGYFACDIIWKIRPNKQQPVDSRVSRKDIKEFYPLILIEFYEYNMTYNGEVVNADDED
DLEYYNGDDEEDADHDDEYYQKLQRKAGKKPLENENSEADNQDEKSEDSFSFQNQIYYGY
AKTNEQKKYVKFDEKFFNNNQMEEM

>TTHERM_00551070(gene)
ATGAAAAAGAGAAGACAATCAACAAATAATGAAAAGCAGGAAGATCTTTATGAACCTGAA
AAGATATTAGATAAAAAAGTTAATTAAAGTGGTACTTCCTATTTGGTTAAATGGAAAGGT
TTTAGGGCTTCACAAGCAACATGGGTAAATACATAAATTTATTTCCATAATTAGAGCTCA
ATAAAAAATGTGTTATTATAAACCAGGAATTTTATAAAAACATATCTCATTGCAATTGGC
TTTTTGAAGATTGGGAAGAGTAGTAAAATAGAAAGGAATTACAAAAAATCAAGAATATGG
ATAGGATAATAGACAAAAAATATGTAAATAGTAAAGTTTTTTATTTGGTTTCTCTAAAAA
ATGGCGGAGAAGATGTATGGATTAGAAGAAAGGCTTTGATGCTTGACCATGCCGATAAAA
TTTCTGAATATGAAAGTAATTATTTTGAAGATTTAAATTTCTTTTACATTTATTTATATT
TGATTTATATAAAGAGAGTGATTAATTGGTTGGGGCTAAAAGAAAATATTAATAGAAAAG
ATTTAGCAAAAGCTAAGATAGATTTCTTAGCAGTGATGAAGATTTGAGCGATTCTTAAAG
TGATAAAAATTCAGATAATAGCTAAAATAATTCAAGCAATAGCGATAATAGTTAAAGTAG
AAGCGGAAGCAGTTCAGATTCATGCAGTAGAAGCTCTTCAGAAGATAATTAAGATGAAAA
TACAAATTAAAGAGGAAAAAGTAATGGTAGAAGAAAGGGTAGAATTTATAACAATAAAAA
AAAACCGAAGAGAGGAGGAAATAGAAAAAATTAAAAAGGATAGAATATTAATGATTCAAA
TAGTAGCTCAGATGAGAATAGTGAGCAAGAAGTCTCTGAATCAAGAAGAATAGTTAAAAC
AAAAAGAAAAATTCCAAAAAAATGCAAAATTTTATATGATAAGCTTCCTTTTTATGGTAT
ACTTGGTATAGATGAACCAAAATCTATAAAAAATATGGTCATAGACAAAAGAGTAGGGAC
GAAGGATGATGGATATTTTGCTTGTGATATTATTTGGAAAATTAGACCTAATAAACAATA
GCCTGTCGATAGTAGAGTCAGCAGAAAAGATATAAAAGAGTTCTATCCTCTTATTTTAAT
AGAATTTTATGAGTATAATATGACATATAATGGTGAAGTAGTCAATGCTGATGATGAAGA
TGACTTAGAATATTACAATGGTGATGATGAAGAAGATGCTGATCATGATGATGAGTATTA
TTAAAAATTATAAAGAAAAGCTGGTAAAAAACCTCTTGAAAACGAAAACTCAGAAGCTGA
TAATTAGGATGAAAAATCTGAAGATTCATTTAGCTTTTAGAATTAGATTTACTATGGGTA
TGCTAAAACTAATGAATAGAAAAAGTATGTTAAATTTGATGAAAAATTCTTCAACAACAA
TCAAATGGAAGAAATGTGA