Identifiers and Description

Gene Model Identifier

TTHERM_00585180

Standard Name

HPL4 (Heterochromatin Protein 1 Like 4)

Aliases

PreTt04124 | 80.m00170 | 3675.m00068 | HPC

Description

HPL4 heterochromatin protein; Heterochromatin protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• nucleus (IEA) | GO:0005634
• chromatin (IEA) | GO:0000785

Molecular Function

• chromatin binding (IEA) | GO:0003682

Biological Process

• chromatin assembly or disassembly (IEA) | GO:0006333

Domains

• ( PF09311 ) Rab5 binding
• ( TIGR00288 ) conserved hypothetical protein TIGR00288
• ( PF00385 ) 'chromo' (CHRromatin Organization MOdifier) domain

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.4%

TetraMine Data

TTHERM_00585180

WebApollo

Fullscreen View

Tetrahymena Stock Center

• ( SD02497 ) Macronucleus: Two HA tags after ATG of TCD3, neo2 in 5’ flank, inserted into MTT1 locus for over expression, need Cd
• ( SD02498 ) Macronucleus: Two HA tags after ATG of TCD3, neo2 in 5’ flank, inserted into MTT1 locus for over expression, need Cd
• ( SD02499 ) Macronucleus: Two HA tags after ATG of TCD4, neo2 in 5’ flank, inserted into MTT1 locus for over expression, need Cd
• ( SD02500 ) Macronucleus: Two HA tags after ATG of TCD4, neo2 in 5’ flank, inserted into MTT1 locus for over expression, need Cd
• ( SD02532 ) Macronucleus: Used one neo4 construct to KO both adjacent TCD3 and TCD4
• ( SD02533 ) Macronucleus: Used one neo4 construct to KO both adjacent TCD3 and TCD4

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_15193.1	4.997860539111522e-53	hypothetical protein (347 aa)
WormBase	WBGene00001996	0.000005998506718272351	locus:hpl-2 status:Confirmed UniProt:G5EDE2 protein_id :CAB07241.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:28692189: Wiley EA, Horrell S, Yoshino A, C Schornak C, Bagnani C, L Chalker D (2017) Diversification of HP1-like Chromo Domain Proteins in Tetrahymena thermophila. The Journal of eukaryotic microbiology ( ):

Sequences

>TTHERM_00585180(coding)
ATGGAACAATAATAAACAAATTTAGAATACTCTCCTTATATTTTTGAGATTGAGAGCATT
TTGGAAAAGAGAATTCATCCTAAAACAGGAAAAACAGAATTTTTAGTTTAATGGAAATAA
TGGCCAGATGATCCAACATGGGAGCCAGCTTAAAATATCTAAAGCTTTTTAAATAACAAT
AATTAAAAGAAAAAGGAAGATGATTCACATTCTAACTTGAAGCAAAGAAAATTGTAAAAA
ATTGAAGACAAAGTGAAGAGGTCTGAACAAGCAAATAATCAAACTTAGAAGCTAAATGAT
AGCTTGCAATATTTAGATGAATAAATTTAATTTCTTTAAAATAAATACGAGCTTTTTATT
TCAGATTCAGAGACAGAGTAAAAAAAATTAATTCCTGATAAAATAAGCGAAATTGAACCA
GAGTAAATTGAAAATGAAGAAAATACCAATATGATGAATAACGTTTAAATTGAGCCAATC
TATAAAATATTAGACAAATAAGAAGTTGAAAATACTATTTATTATCTTATTCTCTTTTAT
GATGAAAAATTACCTTAATGGGTGAAGTAAGAAAAGCTGATTGGCTATGAAGATGAAATT
TTAGAATATGAAAAACAAATAATTTAAGAGAGCACTGAACTAAACTCTAAATAGTTATTA
GAAACCAGTATATAAAGTATACAAAATGAAAATTTATAAATAGAAAAAGATCAAAAATAA
GAAGAAAATTAATTTAAAAAGGTAATGGATCAAGAAAATCTTGAAAAAAGTAAAAATAAT
TTTAATAGGAATCAACAATTTTAAAATGATATAGATGAAGGTGATTTTTTAACAGATTAA
ATATAAGATATAGAAGCAAACTTTATGTTTACTTATAGTATTAATTGGAAACCGAGAAAA
GATGGAAACATTCCTCTAAATAAATAAGTCTAATTTGTAAAAAAAATTACAATAACGCCA
TAAGAATTCATTGATTAAATCCTATAAAATAAATTTCTTAATTGA

>TTHERM_00585180(protein)
MEQQQTNLEYSPYIFEIESILEKRIHPKTGKTEFLVQWKQWPDDPTWEPAQNIQSFLNNN
NQKKKEDDSHSNLKQRKLQKIEDKVKRSEQANNQTQKLNDSLQYLDEQIQFLQNKYELFI
SDSETEQKKLIPDKISEIEPEQIENEENTNMMNNVQIEPIYKILDKQEVENTIYYLILFY
DEKLPQWVKQEKLIGYEDEILEYEKQIIQESTELNSKQLLETSIQSIQNENLQIEKDQKQ
EENQFKKVMDQENLEKSKNNFNRNQQFQNDIDEGDFLTDQIQDIEANFMFTYSINWKPRK
DGNIPLNKQVQFVKKITITPQEFIDQILQNKFLN

>TTHERM_00585180(gene)
ATGGAACAATAATAAACAAATTTAGAATACTCTCCTTATATTTTTGAGATTGAGAGCATT
TTGGAAAAGAGAATTCATCCTAAAACAGGAAAAACAGAATTTTTAGTTTAATGGAAATGT
ATATTTTATATTAAAAATTCAAGTATTTATTATTTAAAATAAATTTAATTTAGAATGGCC
AGATGATCCAACATGGGAGCCAGCTTAAAATATCTAAAGCTTTTTAAATAACAATAATTA
AAAGAAAAAGGAAGATGATTCACATTCTAACTTGAAGCAAAGAAAATTGTAAAAAATTGA
AGACAAAGTGAAGAGGTCTGAACAAGCAAATAATCAAACTTAGAAGCTAAATGATAGCTT
GCAATATTTAGATGAATAAATTTAATTTCTTTAAAATAAATACGAGCTTTTTATTTCAGA
TTCAGAGACAGAGTAAAAAAAATTAATTCCTGATAAAATAAGCGAAATTGAACCAGAGTA
AATTGAAAATGAAGAAAATACCAATATGATGAATAACGTTTAAATTGAGCCAATCTATAA
AATATTAGACAAATAAGAAGTTGAAAATACTATTTATTATCTTATTCTCTTTTATGGTAA
TATTTATTTTTGAATTATTTATTGAATTTATTGTTTAATAATTTTAGATGAAAAATTACC
TTAATGGGTGAAGTAAGAAAAGCTGATTGGCTATGAAGATGAAATTTTAGAATATGAAAA
ACAAATAATTTAAGAGAGCACTGAACTAAACTCTAAATAGTTATTAGAAACCAGTATATA
AAGTATACAAAATGAAAATTTATAAATAGAAAAAGATCAAAAATAAGAAGAAAATTAATT
TAAAAAGGTAATGGATCAAGAAAATCTTGAAAAAAGTAAAAATAATTTTAATAGGAATCA
ACAATTTTAAAATGATATAGATGAAGGTGATTTTTTAACAGATTAAATATAAGATATAGA
AGCAAACTTTATGTTTACTTATAGTATTAATTGGAAACCGAGAAAAGATGGAAACATTCC
TCTAAATAAATAAGTCTAATTTGTAAAAAAAATTACAATAACGCCATAAGAATTCATTGA
TTAAATCCTATAAAATAAATTTCTTAATTGA