Tian M, Agreiter C, Loidl J (2020) Spatial constraints on chromosomes are instrumental to meiotic pairing. Journal of cell science 133(22): PUBMED:33172984
Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert JP, Pearlman RE, Fillingham J (2020) Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila. Scientific reports 10(1):168 PUBMED:31932604
Akematsu T, Sánchez-Fernández R, Kosta F, Holzer E, Loidl J (2019) The Transmembrane Protein Semi1 Positions Gamete Nuclei for Reciprocal Fertilization in Tetrahymena. iScience 23(1):100749 PUBMED:31884169
Identifiers and Description
Gene Model Identifier
TTHERM_01190440
Standard Name
HOP3 (HOP2 (HOmologous Pairing 2) paralog 3)
Aliases
PreTt14763 | 268.m00039 | HOP2B | HOPP2
Description
HOPP2 TBP1 interacting protein; Ubiquitously expressed paralog of meiotically expressed gene HOP2 (TTHERM_00794620); essential for vegetative growth; Ubiquitously expressed paralog of meiotically expressed gene HOP2 (TTHERM_00794620); essential for vegetative growth
HOP2 Meiosis-specific protein
that localizes to chromosomes,
preventing synapsis between n
onhomologous chromosomes and e
nsuring synapsis between homol
ogs; complexes with Mnd1p to p
romote homolog pairing and mei
otic double-strand break repai
r
HOP2B is a homolog of budding yeast HOmologous Pairing 2. It is essential for vegetative growth. HOP2B has a meiosis-specific paralog in Tetrahymena (HOP2, HOP2A, TTHERM_00794620) which is the yeast HOP2 ortholog.
Hop2 and Mnd1 are meiosis-specific proteins that function in a complex in budding yeast. Their general architecture is strikingly similar, and therefore they are potentially homologous protein families. The Hop2-Mnd1 system seems to have undergone duplication in the evolutionary history of Tetrahymena, because both protein families are represented by two homologs with distinct expression patterns in this species. Just as for HOP2 (meiotic) and HOPP2 (ubiquitous), there is a meiotic (MND1)and a ubiquitously expressed (MNDP1) version, which raises the possibility that a meiotic and a ubiquitous Mnd1p-Hop2p complex exists.
Associated Literature
Ref:18522989: Mochizuki K, Novatchkova M, Loidl J (2008) DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Journal of cell science 121(Pt 13):2148-58