Identifiers and Description

Gene Model Identifier

TTHERM_01190440

Standard Name

HOP3 (HOP2 (HOmologous Pairing 2) paralog 3)

Aliases

PreTt14763 | 268.m00039 | HOP2B | HOPP2

Description

HOPP2 TBP1 interacting protein; Ubiquitously expressed paralog of meiotically expressed gene HOP2 (TTHERM_00794620); essential for vegetative growth; Ubiquitously expressed paralog of meiotically expressed gene HOP2 (TTHERM_00794620); essential for vegetative growth

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

• ( TIGR00019 ) peptide chain release factor 1
• ( PF07106 ) Tat binding protein 1(TBP-1)-interacting protein

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.9%

TetraMine Data

TTHERM_01190440

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_16778.1	5.00227046936594e-128	tat binding protein 1(TBP-1)-i nteracting protein (TBPIP) (41 6 aa)
Oxytricha	Contig9892.0.g55	9.997975313387782e-28	Tat binding protein 1(TBP-1)-i nteracting protein (TBPIP)
DictyBase	DDB_G0280989	0.0000000000000700196834671948	hop2 on chromosome: 3 position 3917295 to 3918133
Stentor Coeruleus	SteCoe_18286	0.0000000000002543665647376923
SGD	YGL033W	0.0000000029989608248573072	HOP2 Meiosis-specific protein that localizes to chromosomes, preventing synapsis between n onhomologous chromosomes and e nsuring synapsis between homol ogs; complexes with Mnd1p to p romote homolog pairing and mei otic double-strand break repai r

General Information

Paragraph No	Gene Name	Paragraph Text
16	HOP3	HOP2B is a homolog of budding yeast HOmologous Pairing 2. It is essential for vegetative growth. HOP2B has a meiosis-specific paralog in Tetrahymena (HOP2, HOP2A, TTHERM_00794620) which is the yeast HOP2 ortholog.
55	HOP3	Hop2 and Mnd1 are meiosis-specific proteins that function in a complex in budding yeast. Their general architecture is strikingly similar, and therefore they are potentially homologous protein families. The Hop2-Mnd1 system seems to have undergone duplication in the evolutionary history of Tetrahymena, because both protein families are represented by two homologs with distinct expression patterns in this species. Just as for HOP2 (meiotic) and HOPP2 (ubiquitous), there is a meiotic (MND1)and a ubiquitously expressed (MNDP1) version, which raises the possibility that a meiotic and a ubiquitous Mnd1p-Hop2p complex exists.

Associated Literature

1. Ref:18522989: Mochizuki K, Novatchkova M, Loidl J (2008) DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Journal of cell science 121(Pt 13):2148-58

Sequences

>TTHERM_01190440(coding)
ATGAGTTAAGTTGAAGAAAAAGTTGATGTTGAAGAGGGTGCTCAAGAAAACGATCAAGCT
GAAGATACAGGAAGAAGAAGATCTACAAGAGCAAGAGCTCCTCCTGCACCTACTGCTCCT
GCTGCTAAGAAAGATCCTAAGGCAGCAAAGGGAGCTAAGAAGGGCGCAGCTAAAAAAGAT
CCTAAATAGAAAAAAGGAGCAAAAAAGAAAGGATCTGATGATGAAGATTCAGACATTGAA
ATTATTGAAGACAAGCCAGAAAATATGGATGACGAAGAAGAAGAAATTAAAGAAAAAAAA
GAAACAAAAGAAAAAAAAGATGATGAATTAGATGAAGAAGATGAAATTGAAGAAGAACCT
TCTGAAGATGACGATGATGAGGAAGATGAATTTGATGAAAAGCCAAAAAAGAAAGGAAAA
GGTGCTGCTAAATCTGCACCCGCTGCTAAAAAAGGTAAGGCAGCTGAAAAGCCTGAAAAG
AAGGCTCCTGCTACTAAAGCTCCTGCAGCCAAAGGCAAAAAGAAATCTAAAGAAAGCGAT
GATGAAGACGACTTTAATGATGATAGTGAAGAGGCTAAACCAAAGGGAAAAGGTGGAGCT
GCTAAAAAGGGTGCTCCTGCTAAGAAGGGAAAAAAAGATGAAGATGATGGAGGCACTGTT
GATGATGATACTGTACTTGAATATATGAAGAAAGCTAATAGACCATATTCTTTGATTAAT
ATTTGTGATAATTTACATGGAAAAATTAAGAAGACCGCTTTATAGAAAATGCTCGATGGG
TTGGTCAGTAAGAATAAATTGACTTGCAAAGAGTTTGGTAAAGCTAAAATTTATCTCATG
AATTAAGATTTGTTGCCATAGGTTGATAAATCAGAGCTAGAATAAATGCAAAATGATTTG
AATGAAAAAAGAGTTTACTTGAGAGAAATTGGTGAAGAAATCAAAGAACTTACTAAAAAA
ATAGCCACTTATAATAAATAATTAACCAATGCTTAAATTTAAGAAGAAATTGTAAAGAAC
GAAAAAATGATTAAGTAACTAGAAGATAAAATGCATTTCTATTAAAGTGATAAATTCGTT
TAAGCATCAGAATCCGATGTTAAGAAGCACGAAGAAGCATATCAAAAAATGGAGAAAGAA
TACAAGAGACGTAGAAGAATGTGTAAGGATGGTATTGGTCAAATAGCTGAAGGTATGAAT
AAAAAGCTATCAGAAGTATAAGAATTGATTGGAATAGAAGAGGAAGATGAGTGA

>TTHERM_01190440(protein)
MSQVEEKVDVEEGAQENDQAEDTGRRRSTRARAPPAPTAPAAKKDPKAAKGAKKGAAKKD
PKQKKGAKKKGSDDEDSDIEIIEDKPENMDDEEEEIKEKKETKEKKDDELDEEDEIEEEP
SEDDDDEEDEFDEKPKKKGKGAAKSAPAAKKGKAAEKPEKKAPATKAPAAKGKKKSKESD
DEDDFNDDSEEAKPKGKGGAAKKGAPAKKGKKDEDDGGTVDDDTVLEYMKKANRPYSLIN
ICDNLHGKIKKTALQKMLDGLVSKNKLTCKEFGKAKIYLMNQDLLPQVDKSELEQMQNDL
NEKRVYLREIGEEIKELTKKIATYNKQLTNAQIQEEIVKNEKMIKQLEDKMHFYQSDKFV
QASESDVKKHEEAYQKMEKEYKRRRRMCKDGIGQIAEGMNKKLSEVQELIGIEEEDE

>TTHERM_01190440(gene)
ATGAGTTAAGTTGAAGAAAAAGTTGATGTTGAAGAGGGTGCTCAAGAAAACGATCAAGCT
GAAGATACAGGAAGAAGAAGATCTACAAGAGCAAGAGCTCCTCCTGCACCTACTGCTCCT
GCTGCTAAGAAAGATCCTAAGGCAGCAAAGGGAGCTAAGAAGGGCGCAGCTAAAAAAGAT
CCTAAATAGAAAAAAGGAGCAAAAAAGAAAGGATCTGATGATGAAGATTCAGACATTGTA
ATCAAAATTTTGAGAAATCAATCATTTTTGAATTGAAATTAATTATCAAATTTCAAATAA
TTAATTGGTAGGAAATTATTGAAGACAAGCCAGAAAATATGGATGACGAAGAAGAAGAAA
TTAAAGAAAAAAAAGAAACAAAAGAAAAAAAAGATGATGAATTAGATGAAGAAGATGAAA
TTGAAGAAGAACCTTCTGAAGATGACGATGATGAGGAAGATGAATTTGATGAAAAGCCAA
AAAAGAAAGGAAAAGGTGCTGCTAAATCTGCACCCGCTGCTAAAAAAGTAGAAATACTCC
ATTTTTAGAAATATTTATTTATTTCAATTTATCTTTTTATTAGGGTAAGGCAGCTGAAAA
GCCTGAAAAGAAGGCTCCTGCTACTAAAGCTCCTGCAGCCAAAGGCAAAAAGAAATCTAA
AGAAAGCGATGATGAAGACGACTTTAATGATGATAGTGAAGAGGCTAAACCAAAGGGAAA
AGGTGGAGCTGCTAAAAAGGGTGCTCCTGCTAAGAAGGGAAAAAAAGATGAAGATGATGG
AGGCACTGTTGATGGTAATTTAACTTCAAGTGAAATTTAAAGCTAATAAATTTGATTGAT
TTTTATATTAGATGATACTGTACTTGAATATATGAAGAAAGCTAATAGACCATATTCTTT
GATTAATATTTGTGATAATTTACATGGAAAAATTAAGAAGACCGCTTTATAGAAAATGCT
CGATGGGTTGGTCAGTAAGGTAAGCTATTTAATTTTGTAATAAAAATAACATAGATCATT
TTACTTAAACCATTAAAATAGAATAAATTGACTTGCAAAGAGTTTGGTAAAGCTAAAATT
TATCTCATGAATTAAGATTTGTTGCCATAGGTTGATAAATCAGAGCTAGAATAAATGCAA
AATGATTTGAATGAAAAAAGAGTTTACTTGAGAGAAATTGGTGAAGAAATCAAAGAACTT
ACTAAAAAAATAGCCACTTATAATAAATAATTAACCAATGCTTAAATTTAAGAAGAAATT
GTAAAGAACGAAAAAATGGTAAAATATTTTATTATTTATTTATTTATTTACTCTCTTCTT
TTTATTCTTTTCTAAATATTCTTTAAATTAAATATCAGATTAAGTAACTAGAAGATAAAA
TGCATTTCTATTAAAGTGATAAATTCGTTTAAGCATCAGAATCCGATGTTAAGAAGCACG
AAGAAGCATATCAAAAAATGGAGGTAAATTAATTTAATTTAAACTTTTTAATTCAAATTT
TTTATTTATTTATTTATTTATTTATTTATTTATTTATAATTAAATTACAGAAAGAATACA
AGAGACGTAGAAGAATGTGTAAGGATGGTATTGGTCAAATAGCTGAAGGTATGAATAAAA
AGCTATCAGAAGTATAAGAATTGATTGGAATAGAAGAGGAAGATGAGTGA