Tian M, Mochizuki K, Loidl J (2019) Non-coding RNA Transcription in Tetrahymena Meiotic Nuclei Requires Dedicated Mediator Complex-Associated Proteins. Current biology : CB ( ): PUBMED:31280995
Garg J, Saettone A, Nabeel-Shah S, Cadorin M, Ponce M, Marquez S, Pu S, Greenblatt J, Lambert JP, Pearlman RE, Fillingham J (2019) The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation. Current biology : CB ( ): PUBMED:31280994
Mutazono M, Noto T, Mochizuki K (2019) Diversification of small RNA amplification mechanisms for targeting transposon-related sequences in ciliates. Proceedings of the National Academy of Sciences of the United States of America ( ): PUBMED:31262823
Identifiers and Description
Gene Model Identifier
TTHERM_01190440
Standard Name
HOP3 (HOP2 (HOmologous Pairing 2) paralog 3)
Aliases
PreTt14763 | 268.m00039 | HOP2B | HOPP2
Description
Ubiquitously expressed paralog of meiotically expressed gene HOP2 (TTHERM_00794620); essential for vegetative growth;
Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
HOP2 Meiosis-specific protein
that localizes to chromosomes,
preventing synapsis between n
onhomologous chromosomes and e
nsuring synapsis between homol
ogs; complexes with Mnd1p to p
romote homolog pairing and mei
otic double-strand break repai
r
HOP2B is a homolog of budding yeast HOmologous Pairing 2. It is essential for vegetative growth. HOP2B has a meiosis-specific paralog in Tetrahymena (HOP2, HOP2A, TTHERM_00794620) which is the yeast HOP2 ortholog.
Hop2 and Mnd1 are meiosis-specific proteins that function in a complex in budding yeast. Their general architecture is strikingly similar, and therefore they are potentially homologous protein families. The Hop2-Mnd1 system seems to have undergone duplication in the evolutionary history of Tetrahymena, because both protein families are represented by two homologs with distinct expression patterns in this species. Just as for HOP2 (meiotic) and HOPP2 (ubiquitous), there is a meiotic (MND1)and a ubiquitously expressed (MNDP1) version, which raises the possibility that a meiotic and a ubiquitous Mnd1p-Hop2p complex exists.
Associated Literature
Ref:18522989: Mochizuki K, Novatchkova M, Loidl J (2008) DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Journal of cell science 121(Pt 13):2148-58
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Identifiers and Description
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Gene Expression Profile
Signal Peptide
Homologs (v.2006 protein sequences)
General Information 
Associated Literature 
Sequences
