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Identifiers and Description
Gene Model Identifier
HOP2 (Meiosis-specific homolog of budding yeast HOmologous Pairing 2)
PreTt21461 | 134.m00141 | HOP2A
HOP2 has a role in chiasmata and meiotic bivalent formation. There exists a ubiquitously expressed paralog, TTHERM_01190440 (HOPP2), which is essential for vegetative growth.
HOP2 Meiosis-specific protein
that localizes to chromosomes,
preventing synapsis between n
onhomologous chromosomes and e
nsuring synapsis between homol
ogs; complexes with Mnd1p to p
romote homolog pairing and mei
otic double-strand break repai
Hop2 and Mnd1 are meiosis-specific proteins that function in a complex in budding yeast. Their general architecture is strikingly similar, and therefore they are potentially homologous protein families. The Hop2-Mnd1 system seems to have undergone duplication in the evolutionary history of Tetrahymena, because both protein families are represented by two homologs with distinct expression patterns in this species. Just as for HOP2 (meiotic) and HOPP2 (ubiquitous), there is a meiotic (MND1)and a ubiquitously expressed (MNDP1) version, which raises the possibility that a meiotic and a ubiquitous Mnd1p-Hop2p complex exists.
Ref:18522989: Mochizuki K, Novatchkova M, Loidl J (2008) DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Journal of cell science 121(Pt 13):2148-58
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