Identifiers and Description

Gene Model Identifier

TTHERM_01123840

Standard Name

HIB1 (HydroxyIsoButyrate dehydrogenase 1)

Aliases

PreTt03038 | 244.m00024 | 3834.m00386

Description

HIB1 3-hydroxyisobutyrate dehydrogenase

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• phosphogluconate dehydrogenase (decarboxylating) activity (IEA) | GO:0004616

Biological Process

• oxidation-reduction process (IEA) | GO:0055114
• pentose-phosphate shunt (IEA) | GO:0006098

Domains

• ( PF02254 ) TrkA-N domain
• ( TIGR00745 ) 2-dehydropantoate 2-reductase
• ( TIGR03026 ) nucleotide sugar dehydrogenase
• ( TIGR00112 ) pyrroline-5-carboxylate reductase
• ( TIGR01692 ) 3-hydroxyisobutyrate dehydrogenase
• ( TIGR01505 ) 2-hydroxy-3-oxopropionate reductase
• ( PF03807 ) NADP oxidoreductase coenzyme F420-dependent
• ( PF00107 ) oxidoreductase, zinc-binding dehydrogenase family
• ( TIGR00872 ) 6-phosphogluconate dehydrogenase (decarboxylating)
• ( PF03446 ) NAD binding domain of 6-phosphogluconate

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 13.6%

TetraMine Data

TTHERM_01123840

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_15858.1	9.997093137033517e-262	3-hydroxyisobutyrate dehydroge nase (317 aa)
DictyBase	DDB_G0292566	2.0005330067840427e-93	hibA on chromosome: 6 position 1891263 to 1892228
Oxytricha	Contig18515.0.g30	9.996584278131743e-91	NAD binding domain of 6-phosph ogluconate dehydrogenase
WormBase	WBGene00007122	9.999030951775615e-88	Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial status:Confirmed UniProt:Q9 XTI0 protein_id:CAB03798.1
Stentor Coeruleus	SteCoe_386	0.0000000000002543665647376923
SGD	YGR256W	0.000030009396760408108	GND2 6-phosphogluconate dehydr ogenase (decarboxylating), cat alyzes an NADPH regenerating r eaction in the pentose phospha te pathway; required for growt h on D-glucono-delta-lactone

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_01123840(coding)
ATGAGAAGAATCGCTCGTTCCTTAAATAACTCCTAATATCTCAGAGCAGAAACTGTTGGT
TTCATCGGTTTGGGAAATATGGGTGGCCCTATGGCTCTTAATTTAGCTAGAAAAGGTGGC
TTTGAAGTTATTGCTTTTGATGTAAATAAAGATTCTTTGAAGAAATATGCTAAAGAAGGT
TTAGCTGTTTGTGAAGATGTTACAGTATTGGCACGTAAAGCTAACAAGTTCGTTACAATG
CTTCCTAACTCTTCCCATGTTAGCAGTGTCTTAGAAGGGGAAAATGGATTATTCTAAAAG
AGTGCAAAAAATAGTTTGTTTATTGATTCATCTACAATTTCTTATCATGCTGCTATAAAG
ATCTACGAAAATGCTAAGAAGGTCAATCAACGTTACATTGATGCTCCTGTTAGTGGTGGT
GTTGGTGCTGCAACAGCTGGTACTCTCACTTTTATGGTTGGTGCTGAAAATAAGGAACTC
TTCTAAGAATGCAAAAATCTTCTTTAACACATGGGTAAAAATATCGCCAACTGTGAAAAA
CCTGGTGCTGGATCTATTGCTAAAATTTGCAATAACATGGCTCTTGGTATTGAAATGATA
GCCGTTGCAGAAGCTATCTCCTTGGGCAAAAAGCTTGGTATCGACCCTAAAGTTCTTTCA
TCAATCATGAATACTGCATCTGGTAGATGCTGGAGTAGTGAAGTCTATAACCCTTGCCCT
GGCGTATTAGAAAATGTTCCTGCTTCTAAGGGTTATGAAGGAGGTTTTGCTTGTGAACTT
ATGCTTAAGGATTTAGGATTAGCTGCTGATGCTGCAAAACAAGCTTCTGCTGATGTTCCT
CTTGGTAACCATGCAAAAGATATTTACTAAAAATTGGTTGAATTGGGACTTAATCGTAAA
GATTTTGCTATCGTTTATGATGTCCTCTTAAATAATAAACTTAAATAATGA

>TTHERM_01123840(protein)
MRRIARSLNNSQYLRAETVGFIGLGNMGGPMALNLARKGGFEVIAFDVNKDSLKKYAKEG
LAVCEDVTVLARKANKFVTMLPNSSHVSSVLEGENGLFQKSAKNSLFIDSSTISYHAAIK
IYENAKKVNQRYIDAPVSGGVGAATAGTLTFMVGAENKELFQECKNLLQHMGKNIANCEK
PGAGSIAKICNNMALGIEMIAVAEAISLGKKLGIDPKVLSSIMNTASGRCWSSEVYNPCP
GVLENVPASKGYEGGFACELMLKDLGLAADAAKQASADVPLGNHAKDIYQKLVELGLNRK
DFAIVYDVLLNNKLKQ

>TTHERM_01123840(gene)
ATGAGAAGAATCGCTCGTTCCTTAAATAACTCCTAATATCTCAGAGCAGAAACTGTTGGT
TTCATCGGTTTGGGAAATATGGGTGGCCCTATGGCTCTTAATTTAGCTAGAAAAGGTGGC
TTTGAAGTTATTGCTTTTGATGTAAATAAAGATTCTTTGAAGAAATATGCTAAAGAAGGT
TTAGCTGTTTGTGAAGATGTTACAGTATTGGCACGTAAAGCTAACAAGTTCGTTACAATG
CTTCCTAACTCTTCCCATGTTAGCAGTGTCTTAGAAGGGGAAAATGGATTATTCTAAAAG
AGTGCAAAAAATAGTTTGTTTATTGATTCATCTACAATTTCTTATCATGCTGCTATAAAG
ATCTACGAAAATGCTAAGAAGGTCAATCAACGTTACATTGATGCTCCTGTTAGTGGTGGT
GTTGGTGCTGCAACAGCTGGTACTCTCACTTTTATGGTTGGTGCTGAAAATAAGGAACTC
TTCTAAGAATGCAAAAATCTTCTTTAACACATGGGTAAAAATATCGCCAACTGTGAAAAA
CCTGGTGCTGGATCTATTGCTAAAATTTGCAATAACATGGCTCTTGGTATTGAAATGATA
GCCGTTGCAGAAGCTATCTCCTTGGGCAAAAAGCTTGGTATCGACCCTAAAGTAAACAAT
TTTATATTTATATTAGTCATTAAAATATTCTAAAAGACATAAATAAAATTATTAGTAGAA
CAAATATTATGAGAATTAAATTATGCTATCATTTTCAATCAAAAAAATTATTTTTTTTAA
AAAACTGTTATAAATAAATATATTTTTTGTCTTTTTATTTATTTATTTATTAATTTCCAT
TTTTAAAATAAATAAACTAATAAATAATAAAATAGGTTCTTTCATCAATCATGAATACTG
CATCTGGTAGATGCTGGAGTAGTGAAGTCTATAACCCTTGCCCTGGCGTATTAGAAAATG
TTCCTGCTTCTAAGGGTTATGAAGGAGGTTTTGCTTGTGAACTTATGCTTAAGGATTTAG
GATTAGCTGCTGATGCTGCAAAACAAGCTTCTGCTGATGTTCCTCTTGGTAACCATGCAA
AAGATATTTACTAAAAATTGGTTGAATTGGGACTTAATCGTAAAGATTTTGCTATCGTTT
ATGATGTCCTCTTAAATAATAAACTTAAATAATGA