Zhao X, Xiong J, Mao F, Sheng Y, Chen X, Feng L, Dui W, Yang W, Kapusta A, Feschotte C, Coyne RS, Miao W, Gao S, Liu Y (2019) RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena. Genes & development 33(5-6):348-364 PUBMED:30808657
Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J (2019) Proteomic analysis of histones H2A/H2B and variant Hv1 in Tetrahymena thermophila reveals an ancient network of chaperones. Molecular biology and evolution ( ): PUBMED:30796450
Tian M, Loidl J (2018) A chromatin-associated protein required for inducing and limiting meiotic DNA double-strand break formation. Nucleic acids research ( ): PUBMED:30357385
Identifiers and Description
Gene Model Identifier
TTHERM_00498190
Standard Name
HHF1 (Histone H Four 1)
Aliases
PreTt06984 | 62.m00268 | 3715.m00129
Description
Histone H4; one of the four histones (H2A, H2B, H3 and H4) that comprise the protein core of the eukaryotic nucleosome; adjacent to HHT2; encoded protein identical to Hhf2p; expressed during macronuclear S-phase
HHF2 Histone H4, core histone
protein required for chromatin
assembly and chromosome funct
ion; one of two identical hist
one proteins (see also HHF1);
contributes to telomeric silen
cing; N-terminal domain involv
ed in maintaining genomic inte
grity
Ref:14755052: Liu Y, Mochizuki K, Gorovsky MA (2004) Histone H3 lysine 9 methylation is required for DNA elimination in developing macronuclei in Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America 101(6):1679-84
Ref:12522258: Zilberman D, Cao X, Jacobsen SE (2003) ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science (New York, N.Y.) 299(5607):716-9
Ref:12665578: Ren Q, Gorovsky MA (2003) The nonessential H2A N-terminal tail can function as an essential charge patch on the H2A.Z variant N-terminal tail. Molecular and cellular biology 23(8):2778-89
Ref:14661947: Poux AN, Marmorstein R (2003) Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates. Biochemistry 42(49):14366-74
Ref:14536085: Clements A, Poux AN, Lo WS, Pillus L, Berger SL, Marmorstein R (2003) Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. Molecular cell 12(2):461-73
Ref:12455963: Duharcourt S, Yao MC (2002) Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila. Eukaryotic cell 1(2):293-303
Ref:11972045: Dou Y, Gorovsky MA (2002) Regulation of transcription by H1 phosphorylation in Tetrahymena is position independent and requires clustered sites. Proceedings of the National Academy of Sciences of the United States of America 99(9):6142-6
Ref:12123289: Waterborg JH (2002) Dynamics of histone acetylation in vivo. A function for acetylation turnover? Biochemistry and cell biology = Biochimie et biologie cellulaire 80(3):363-78
Ref:12297044: Taverna SD, Coyne RS, Allis CD (2002) Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell 110(6):701-11
Ref:11891286: Shang Y, Song X, Bowen J, Corstanje R, Gao Y, Gaertig J, Gorovsky MA (2002) A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. Proceedings of the National Academy of Sciences of the United States of America 99(6):3734-9
Ref:12351775: Jenuwein T (2002) Molecular biology. An RNA-guided pathway for the epigenome. Science (New York, N.Y.) 297(5590):2215-8
Ref:11784863: Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P (2002) Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Molecular and cellular biology 22(3):874-85
Ref:11751634: Briggs SD, Bryk M, Strahl BD, Cheung WL, Davie JK, Dent SY, Winston F, Allis CD (2001) Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes & development 15(24):3286-95
Ref:11135657: Tan S (2001) One HAT size fits all? Nature structural biology 8(1):8-10
Ref:11467741: Green GR (2001) Phosphorylation of histone variant regions in chromatin: unlocking the linker? Biochemistry and cell biology = Biochimie et biologie cellulaire 79(3):275-87
Ref:11112280: Trievel RC, Li FY, Marmorstein R (2000) Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor. Analytical biochemistry 287(2):319-28
Ref:9396628: Fogel GB, Brunk CF (1997) Expression of Tetrahymena histone H4 in yeast. Biochimica et biophysica acta 1354(2):116-26
Ref:8760889: Liu X, Gorovsky MA (1996) Cloning and characterization of the major histone H2A genes completes the cloning and sequencing of known histone genes of Tetrahymena thermophila. Nucleic acids research 24(15):3023-30
Ref:8415695: Kahn RW, Andersen BH, Brunk CF (1993) Transformation of Tetrahymena thermophila by microinjection of a foreign gene. Proceedings of the National Academy of Sciences of the United States of America 90(20):9295-9
Ref:1885002: Lin R, Cook RG, Allis CD (1991) Proteolytic removal of core histone amino termini and dephosphorylation of histone H1 correlate with the formation of condensed chromatin and transcriptional silencing during Tetrahymena macronuclear development. Genes & development 5(9):1601-10
Ref:3360847: Richman R, Chicoine LG, Collini MP, Cook RG, Allis CD (1988) Micronuclei and the cytoplasm of growing Tetrahymena contain a histone acetylase activity which is highly specific for free histone H4. The Journal of cell biology 106(4):1017-26
Ref:3822803: Horowitz S, Bowen JK, Bannon GA, Gorovsky MA (1987) Unusual features of transcribed and translated regions of the histone H4 gene family of Tetrahymena thermophila. Nucleic acids research 15(1):141-60
Ref:3785221: Pederson DS, Shupe K, Bannon GA, Gorovsky MA (1986) Formation of stable chromatin structures on the histone H4 gene during differentiation in Tetrahymena thermophila. Molecular and cellular biology 6(8):3014-7
Ref:3023930: Harrison GS, Findly RC, Karrer KM (1986) Site-specific methylation of adenine in the nuclear genome of a eucaryote, Tetrahymena thermophila. Molecular and cellular biology 6(7):2364-70
Ref:6322129: Bannon GA, Bowen JK, Yao MC, Gorovsky MA (1984) Tetrahymena H4 genes: structure, evolution and organization in macro- and micronuclei. Nucleic acids research 12(4):1961-75
Login
Recent Activity
Recent Papers
Identifiers and Description
Gene Ontology Annotations 
Domains
Gene Expression Profile
Signal Peptide
Homologs (v.2006 protein sequences)
General Information 
Associated Literature 
Sequences
