Identifiers and Description

Gene Model Identifier

TTHERM_00624720

Standard Name

GRL4 (GRanule Lattice)

Aliases

PreTt07460 | 87.m00240 | 3814.m00940

Description

Granule lattice protein; acidic, calcium-binding structural protein of dense core granules; translated as a pro-protein precursor; contains coiled-coil region

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• dense core granule (IDA) | GO:0031045 | Ref:16014006

Biological Process

• exocytosis (IMP) | GO:0006887 | Ref:15958493

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: Yes
Presense Probability: 89.2%

TetraMine Data

TTHERM_00624720

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_12046.1	9.997093137033517e-262	granule lattice protein 4 (377 aa)
Oxytricha	Contig761.1.g41	0.000005000363240844623	Tetratricopeptide repeat

General Information

No Data fetched for General Information

Associated Literature

1. Ref:15958493: Cowan AT, Bowman GR, Edwards KF, Emerson JJ, Turkewitz AP (2005) Genetic, genomic, and functional analysis of the granule lattice proteins in Tetrahymena secretory granules. Molecular biology of the cell 16(9):4046-60
2. Ref:14690495: Turkewitz AP (2004) Out with a bang! Tetrahymena as a model system to study secretory granule biogenesis. Traffic (Copenhagen, Denmark) 5(2):63-8
3. Ref:11438705: Chilcoat ND, Elde NC, Turkewitz AP (2001) An antisense approach to phenotype-based gene cloning in Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America 98(15):8709-13
4. Ref:9450970: Verbsky JW, Turkewitz AP (1998) Proteolytic processing and Ca2+-binding activity of dense-core vesicle polypeptides in Tetrahymena. Molecular biology of the cell 9(2):497-511
5. Ref:9380694: Haddad A, Turkewitz AP (1997) Analysis of exocytosis mutants indicates close coupling between regulated secretion and transcription activation in Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America 94(20):10675-80

Sequences

>TTHERM_00624720(coding)
ATGAGATACGCTGCTCTCTTCCTTCTTGCCTTAATCAGCTTCAACGCTGTTTATGCCGTC
TCTCTCAGAAAGAGCTCTGACGCCATGAAGACTTCTTTCGCTCTTGAAAGATTGAGATTC
ATCGGAAAGAAATCTCCTATTGCTAAACAAATTATCTCTGCTGTTGAATTACACTTAACC
ACTGGTGGTTTGGTTGATGATGTCATTGATTTAGTCAAGTAAGCCTAAGAAGATGTTGCC
AACAGAAACGTTGCTCTCCAAGCTGAATACACTGCCAAGAGAGGTGCTTTGGAAGATTAA
ATTAACACCACCACCTAATAACTCAATGAAGAAAACGACAGATTAGCTGTTGTTAACGAC
GCCATTGATGCCCTCAACGGTTAAATCGACAGTTTGAACACTCAAATTGCTAACCTCGTC
TAATAACTCTAAAACCTCTAAGCCAGAGAAGATGCTATCAACTAAGCCAGAGAAGTTGAT
GTCAAGACCTACGAAGTTAGAAAGTAAAGAGATGAAAACTCCCTCGCTGTCTTGGAATAA
ATCATCCAAAGATTACTTGCCTTATAACAAAGAGGTAACGCTTTCCTCCAAGTCTCCAAG
AAGGAAATCGAAAGAATCTTGAAGAGAATCCCCAAGTCCAACCCCATCCAAGCTTTGGTT
CAACTCTCCACCAAGTTCGACGAATAAAGATTAGCTGAAGTCATTAGCAAGCTCTAAACC
ATCTAAGCTGCCATCCAAGCTTCTTACATTGAAGATGCTAACGGTGAAGTTGCTGACAAG
TAAAGATACGATGCTCTCATTTAAGAAATCGCCACCATCAGAGCCCAAACTCAATAATAA
TTAGCTGATGCCTAATAAGCTTTGAGTGATGCTGAAGCTTCCTTAGCCTAATTCGTCCAA
GAATAAGGTAACTTACAACAACAAATCGCTGTCAACGAAGGTATCCTTGCTGATGCCCAA
GCTGCCTTAGCTCACACCATCGCTACCTACGAAGCTAGAATCCAAGAAGGTCAAGAAGCT
CTCGCCGCTATCAACCTTGCTCTCGATGTTTTACAACAAAACTAATCAGACTTATAAGGA
GTTGAAGATTTCTCTAATGCCTACAATGCCTACCAAGCTGGTAACAGTACTGATGCTGGT
GATGATGCTGGTGATGATTCTGGTGTTGAAGGTGAAGCTTTCTGA

>TTHERM_00624720(protein)
MRYAALFLLALISFNAVYAVSLRKSSDAMKTSFALERLRFIGKKSPIAKQIISAVELHLT
TGGLVDDVIDLVKQAQEDVANRNVALQAEYTAKRGALEDQINTTTQQLNEENDRLAVVND
AIDALNGQIDSLNTQIANLVQQLQNLQAREDAINQAREVDVKTYEVRKQRDENSLAVLEQ
IIQRLLALQQRGNAFLQVSKKEIERILKRIPKSNPIQALVQLSTKFDEQRLAEVISKLQT
IQAAIQASYIEDANGEVADKQRYDALIQEIATIRAQTQQQLADAQQALSDAEASLAQFVQ
EQGNLQQQIAVNEGILADAQAALAHTIATYEARIQEGQEALAAINLALDVLQQNQSDLQG
VEDFSNAYNAYQAGNSTDAGDDAGDDSGVEGEAF

>TTHERM_00624720(gene)
AAAAAACAAATAATATTAAATCAAAAAATAACAAAAAAAACAAAAATTAAAAGGAAAACA
ATAATGAGATACGCTGCTCTCTTCCTTCTTGCCTTAATCAGCTTCAACGCTGTTTATGCC
GTCTCTCTCAGAAAGAGCTCTGACGCCATGAAGACTTCTTTCGCTCTTGAAAGATTGAGA
TTCGTAATGACTCACTTTCATATTATCATTTTCATCAAGGAGTGAACCACTTTTTCACAA
AGTCTTCATTTTTTTTTCGAATGACTAATTACTTTGTAAACCATAAATCTTAAAGTCAGT
CGCTCCTTGAAATACTTTGCTCTCATTTTAGAATAAAATATAACTAAAAATGAAAGAAAA
AACAAATGCCCAAGCAATCTAACATAATTTCATATTATTTTCTACTTGATTGCTAATCTT
ATAATATCAAAATTTTTATTCAACCTGCCACAGTGCCTTTTTCCCCTTTTGATACATAAA
TACATACATTCAATAAGCCGTTTTATTCAATAAAATTAATTTTAATAAAATTATAATATT
ATTTATTTAAAATAAGATCGGAAAGAAATCTCCTATTGCTAAACAAATTATCTCTGCTGT
TGAATTACACTTAACCACTGGTGGTTTGGTTGATGATGTCATTGATTTAGTCAAGTAAGC
CTAAGAAGATGTTGCCAACAGAAACGTTGCTCTCCAAGCTGAATACACTGCCAAGAGAGG
TGCTTTGGAAGATTAAATTAACACCACCACCTAATAACTCAATGAAGAAAACGACAGATT
AGCTGTTGTTAACGACGCCATTGATGCCCTCAACGGTTAAATCGACAGTTTGAACACTCA
AATTGCTAACCTCGTCTAATAACTCTAAAACCTCTAAGCCAGAGAAGATGCTATCAACTA
AGCCAGAGAAGTTGATGTCAAGACCTACGAAGTTAGAAAGTAAAGAGATGAAAACTCCCT
CGCTGTCTTGGAATAAGTACTTGCTTGCTTTCTTTTTTGACTTTTTTTTTTAATAAAAAT
GAAAATAATTCTAATTCTAAACTTTTTAAATAATAAAATAGATCATCCAAAGATTACTTG
CCTTATAACAAAGAGGTAACGCTTTCCTCCAAGTCTCCAAGAAGGAAATCGAAAGAATCT
TGAAGAGAATCCCCAAGTCCAACCCCATCCAAGCTTTGGTTCAACTCTCCACCAAGTTCG
ACGAATAAAGATTAGCTGAAGTCATTAGCAAGCTCTAAACCATCTAAGCTGCCATCCAAG
CTTCTTACATTGAAGATGCTAACGGTGAAGTTGCTGACAAGTAAAGATACGATGCTCTCA
TTTAAGAAATCGCCACCATCAGAGCCCAAACTCAATAATAATTAGCTGATGCCTAATAAG
CTTTGAGTGATGCTGAAGCTTCCTTAGCCTAATTCGTCCAAGAATAAGGTAACTTACAAC
AACAAATCGCTGTCAACGAAGGTATCCTTGCTGATGCCCAAGCTGCCTTAGCTCACACCA
TCGCTACCTACGAAGCTAGAATCCAAGAAGGGTAATTAATTAATTGATTACATTTTTTAA
TATTAATTGTATTAACTTTTAATAACTTTCATATTTTTAAAAATTATAGTCAAGAAGCTC
TCGCCGCTATCAACCTTGCTCTCGATGTTTTACAACAAAACTAATCAGACTTATAAGGAG
TTGAAGATTTCTCTAATGCCTACAATGCCTACCAAGCTGGTAACAGTACTGATGCTGGTG
ATGATGCTGGTGATGATTCTGGTGTTGAAGGTGAAGCTTTCTGA