Identifiers and Description

Gene Model Identifier

TTHERM_00655560

Standard Name

GND1 (6-phosphoGlucoNate Dehydrogenase 1)

Aliases

PreTt03654 | 96.m00123

Description

6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH-regenerating reaction in the pentose phosphate pathway

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• phosphogluconate dehydrogenase (decarboxylating) activity (IEA) | GO:0004616

Biological Process

• oxidation-reduction process (IEA) | GO:0055114
• pentose-phosphate shunt (IEA) | GO:0006098

Domains

• ( PF02153 ) prephenate dehydrogenase
• ( TIGR03026 ) nucleotide sugar dehydrogenase
• ( PF01488 ) Shikimate / quinate 5-dehydrogenase
• ( TIGR00112 ) pyrroline-5-carboxylate reductase
• ( TIGR01692 ) 3-hydroxyisobutyrate dehydrogenase
• ( PF02826 ) erythronate-4-phosphate dehydrogenase
• ( TIGR01505 ) 2-hydroxy-3-oxopropionate reductase
• ( PF03807 ) NADP oxidoreductase coenzyme F420-dependent
• ( PF02737 ) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
• ( TIGR00873 ) 6-phosphogluconate dehydrogenase, decarboxylating
• ( PF07991 ) Acetohydroxy acid isomeroreductase, catalytic domain
• ( TIGR00872 ) 6-phosphogluconate dehydrogenase (decarboxylating)
• ( PF03446 ) NAD binding domain of 6-phosphogluconate

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 31.7%

TetraMine Data

TTHERM_00655560

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_18003.1	9.997093137033517e-262	NAD binding domain-6-phosphogl uconate dehydrogenase (302 aa)
Oxytricha	Contig10468.0.g95	6.000220702367707e-121	NAD binding domain of 6-phosph ogluconate dehydrogenase
Stentor Coeruleus	SteCoe_386	2.572209372642415e-56
DictyBase	DDB_G0292566	4.00073564232477e-35	hibA on chromosome: 6 position 1891263 to 1892228
WormBase	WBGene00007122	1.999790113608142e-24	Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial status:Confirmed UniProt:Q9 XTI0 protein_id:CAB03798.1
SGD	YGR256W	0.000000000006001570085597868	GND2 6-phosphogluconate dehydr ogenase (decarboxylating), cat alyzes an NADPH regenerating r eaction in the pentose phospha te pathway; required for growt h on D-glucono-delta-lactone

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00655560(coding)
ATGGCTTAGTCTGCAATTAAAACTATCGGTTGGATTGGAACTGGTGTTATGGGTAAGTCT
ATGTGCTTACATTTGTTAAACGCTGGTTTCTAGCTAAATGTTTACAATAGAACTGCTAGT
AAGGCTGACGAATTAGTCAGTAAAGGAGCCAAGTTTTTAGCTCCTGAAGATTTAGCTAAA
AATTCTGATGTAGTATTTTTGATGCTTGGTTATCCTCATGATGTCTAATAAATGGTATTA
GGTGAATAAGGAATTTTAAAGCACATGAAAAAAGGTTCCTTATTGATTGACCACACTACA
TCCGCTCCTTCTCTTGCTGTAGAAATTGCAGCCGAAGCATAAAAGTATGGAATCGAAAGT
ATTGATGCCCCAGTTAGTGGAGGTGATATCGGAGCTAGAGAAGCTAGATTAGCAATTATG
TGTGGCGGTTCCCAAGCTGCTTTTGATCTTGCTCTTCCTATTTTATAAAAGTATGGTGCA
AATATCTAATTATTAGGTGGCGCAGGAGCAGGATAACACACCAAAATGACTAATTAAATT
TTATTAGCTAGCAATATGTTAGGTGTTGTTGAAGGCTTACTCTATGCTCATAAGGCTGGA
TTAGATTTAGATTAAGTAATTAATCTTATTAAGACTGGTGCTGCCTCATCTACTGCATGG
CACGTTCTTGGCTCAAGAATGGTTAAGCGTGACTTTGAACCTGGCTTCTATGTAGAGCAT
TTTATTAAGGATATGGATATTGCCTTAGAAGAGGCCAAAAGAGCTAACTTATGTCTCCCT
GGATTAGGCTTAGTAAAGTAATTTTATCATGCCTTAGTTGCATAAGGAGGTGCTCGTAAT
GGAACTTAAGCTATCATTAAAGTTTTAGAATAAATGAACAATGTTTAAATCGGAAAGAAA
TAATGA

>TTHERM_00655560(protein)
MAQSAIKTIGWIGTGVMGKSMCLHLLNAGFQLNVYNRTASKADELVSKGAKFLAPEDLAK
NSDVVFLMLGYPHDVQQMVLGEQGILKHMKKGSLLIDHTTSAPSLAVEIAAEAQKYGIES
IDAPVSGGDIGAREARLAIMCGGSQAAFDLALPILQKYGANIQLLGGAGAGQHTKMTNQI
LLASNMLGVVEGLLYAHKAGLDLDQVINLIKTGAASSTAWHVLGSRMVKRDFEPGFYVEH
FIKDMDIALEEAKRANLCLPGLGLVKQFYHALVAQGGARNGTQAIIKVLEQMNNVQIGKK
Q

>TTHERM_00655560(gene)
ATGGCTTAGTCTGCAATTAAAACTATCGGTTGGATTGGAACTGGTGTTATGGGTAAGTCT
ATGTGCTTACATTTGTTAAACGCTGGTTTCTAGCTAAATGTTTACAATAGAACTGCTAGT
AAGGCTGACGAATTAGTCAGTAAAGGAGCCAAGTTTTTAGCTCCTGAAGATTTAGCTAAA
AATTCTGATGTAGTATTTTTGATGCTTGGTTATCCTCATGATGTCTAATAAATGGTATTA
GGTGAATAAGGAATTTTAAAGCACATGAAAAAAGGTTCCTTATTGATTGACCACACTACA
TCCGCTCCTTCTCTTGCTGTAGAAATTGCAGCCGAAGCATAAAAGTATGGAATCGAAAGT
ATTGATGCCCCAGTTAGTGGAGGTGATATCGGAGCTAGAGAAGCTAGATTAGCAATTATG
TGTGGCGGTTCCCAAGCTGCTTTTGATCTTGCTCTTCCTATTTTATAAAAGTATGGTGCA
AATATCTAATTATTAGGTGGCGCAGGAGCAGGATAACACACCAAAATGACTAATTAAATT
TTATTAGCTAGCAATATGTTAGGTGTTGTTGAAGGCTTACTCTATGCTCATAAGGCTGGA
TTAGATTTAGATTAAGTAATTAATCTTATTAAGACTGGTGCTGCCTCATCTACTGCATGG
CACGTTCTTGGCTCAAGAATGGTTAAGCGTGACTTTGAAGTAAATTCTTTAATAATAAAC
ATTCTAAAATTCTATTAAAATACAAAAAAAATAAGATATATTTTAACAAAGCTATAATTT
ATAAAATATCTTTTTTGATGATAAAAATTTTGTTTTTTAAATCTTTGTTTTTCTTAGTTT
AATTATTTTTATTAAATAATAGCCTGGCTTCTATGTAGAGCATTTTATTAAGGATATGGA
TATTGCCTTAGAAGAGGCCAAAAGAGCTAACTTATGTCTCCCTGGATTAGGCTTAGTAAA
GTAATTTTATCATGCCTTAGTTGCATAAGGAGGTGCTCGTAATGGAACTTAAGCTATCAT
TAAAGTTTTAGAATAAATGAACAATGTTTAAATCGGAAAGAAATAATGA