Identifiers and Description

Gene Model Identifier

TTHERM_00439250

Standard Name

GIP1 (Granule-biosynthesis Induced Protease 1)

Aliases

PreTt05482 | 49.m00254 | 3708.m00103

Description

Granule-biosynthesis induced protease; putative cysteine protease; transcription induced following exocytosis; putative cargo protein of dense core secretory granules

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• dense core granule (IDA) | GO:0031045 | Ref:12456006

Molecular Function

• cysteine-type peptidase activity (IEA) | GO:0008234

Biological Process

• proteolysis (IEA) | GO:0006508
• vesicle organization (IEP) | GO:0016050 | Ref:12456006

Domains

• ( PF02218 ) Repeat in HS1/Cortactin
• ( PF00112 ) Papain family cysteine protease
• ( PF08246 ) Cathepsin propeptide inhibitor domain (I29)

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 16%

TetraMine Data

TTHERM_00439250

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_06987.1	1.99972299831384e-147	papain family cysteine proteas e containing protein (344 aa)
Oxytricha	Contig1254.0.g80	8.003186242472315e-51	Papain family cysteine proteas e
DictyBase	DDB_G0290957	8.003782782428492e-46	cprA on chromosome: 5 position 4812963 to 4814596
WormBase	WBGene00000776	2.0005131442217614e-40	locus:cpl-1 status:Confirmed UniProt:O45734 protein_id :CAB07275.1
Stentor Coeruleus	SteCoe_27084	2.6102790696677047e-23

General Information

No Data fetched for General Information

Associated Literature

1. Ref:12456006: Haddad A, Bowman GR, Turkewitz AP (2002) New class of cargo protein in Tetrahymena thermophila dense core secretory granules. Eukaryotic cell 1(4):583-93

Sequences

>TTHERM_00439250(coding)
ATGATACTCAAACATATCATCAATTAAATAAAATATTTACTAGAACGAACGGTAAGCTTT
AAATCTTGGATATTTTAGTCATAAAATTTATAAAAATTATAAAACAAAAAAACTAATAAA
TAAAAAATGAATAAGCTACTTATCTCTGCTTTAATTTGCTTAATGATTGCTACTCCTAGT
GTGTTTTGCTAGGATGTTGAAAATAACATTTCTGAAGACATTAAAGTCTAAGACTTATTA
GCATACAATAAATGGAGATTCAACTATAAGAGAGTCTATCTTAATGAAGAAGAGCAGATC
TACAGATAGATTGTTTTCTTTGAAAATCTTGCTAGTGTTAACAAACACCCTTCTCATAAA
TCCTACAGTAAGGGTTTGAACCAGTTCTCTGATATGACTAAAGAAGAATTCAAACAAAGA
GTTTTGAATAAGAAGATTTCTAAAAAGGCTAGCAGTAATAAGGGTGGTAGAAATTTAGCT
GCTGATCCAGCTGTTTCCAACTTAGTCTTTCCCACCAATAATCTTCCTCTATCTGTTGAT
TGGAGAAAAAGAGGTGTCCTCAATCCTGTAAAAAATTAAGGTACTTGTGGTTCATGCTGG
ACTTTTGCAACTGCTGGCATCCTTGAGTCATTCAACTAAATTAAAAATAAATAGCTTCTT
AAGTTCTCTGAGCAACAACTTGTTGATTGTGTCAGCCTAGCTGGATATGATTCTGATGGT
TGTGATGGTGGTTTTTAAGAAGATGGTGTTAGATATGCAATTGAGTATGGTATTGTTTAA
TCTTACAAATACCCTTATGTTGGATATCAAGGTAGATGCAAAGTCACATCTCCCACTTCT
CGTTCTGTAGGTTTTTACCCTTAAAAGTTCCAACTTGTCAATAAAACTGAAGCTGACTTG
AAAGCTGCTTTAGTTTTCTCCCCTGTTTCAATCTCCGTCAATGCTGATACCTGGAAAGAA
TACTATGGTGGTGTTTTTGATGAATGTGGATATACTACCGAAGAAGATCTCAATCATGCT
GTCATCGCTGTAGGTTATGACCAAGAAGGTAACTGGATTGTTAGAAACAGTTGGTCTGCA
GCTTGGGGTGAAGATGGTTACATAAGATTAGCTCCTGGTAACACTTGTGGTATTTTGCTT
GATGGATTAATAGTTACTTAATGA

>TTHERM_00439250(protein)
MILKHIINQIKYLLERTVSFKSWIFQSQNLQKLQNKKTNKQKMNKLLISALICLMIATPS
VFCQDVENNISEDIKVQDLLAYNKWRFNYKRVYLNEEEQIYRQIVFFENLASVNKHPSHK
SYSKGLNQFSDMTKEEFKQRVLNKKISKKASSNKGGRNLAADPAVSNLVFPTNNLPLSVD
WRKRGVLNPVKNQGTCGSCWTFATAGILESFNQIKNKQLLKFSEQQLVDCVSLAGYDSDG
CDGGFQEDGVRYAIEYGIVQSYKYPYVGYQGRCKVTSPTSRSVGFYPQKFQLVNKTEADL
KAALVFSPVSISVNADTWKEYYGGVFDECGYTTEEDLNHAVIAVGYDQEGNWIVRNSWSA
AWGEDGYIRLAPGNTCGILLDGLIVTQ

>TTHERM_00439250(gene)
ATGATACTCAAACATATCATCAATTAAATAAAATATTTACTAGAACGAACGGTAAGCTTT
AAATCTTGGATATTTTAGTCATAAAATTTATAAAAATTATAAAACAAAAAAACTAATAAA
TAAAAAATGAATAAGCTACTTATCTCTGCTTTAATTTGCTTAATGATTGCTACTCCTAGT
GTGTTTTGCTAGGATGTTGAAAATAACATTTCTGAAGACATTAAAGTCTAAGACTTATTA
GCATACAATAAATGGAGATTCAACTATAAGAGAGTCTATCTTAATGAAGAAGAGCAGATC
TACAGATAGATTGTTTTCTTTGAAAATCTTGCTAGTGTTAACAAACACCCTTCTCATAAA
TCCTACAGTAAGGGTTTGAACCAGTTCTCTGATATGACTAAAGAAGAATTCAAACAAAGA
GTTTTGAATAAGAAGATTTCTAAAAAGGCTAGCAGTAATAAGGGTGGTAGAAATTTAGCT
GCTGATCCAGCTGTTTCCAACTTAGTCTTTCCCACCAATAATCTTCCTCTATCTGTTGAT
TGGAGAAAAAGAGGTGTCCTCAATCCTGTAAAAAATTAAGGTACTTGTGGTTCATGCTGG
ACTTTTGCAACTGCTGGCATCCTTGAGTCATTCAACTAAATTAAAAATAAATAGCTTCTT
AAGTTCTCTGAGCAACAACTTGTTGATTGTGTCAGCCTAGCTGGATATGATTCTGATGGT
TGTGATGGTGGTTTTTAAGAAGATGGTGTTAGATATGCAATTGAGTATGGTATTGTTTAA
TCTTACAAATACCCTTATGTTGGATATCAAGGTAGATGCAAAGTCACATCTCCCACTTCT
CGTTCTGTAGGTTTTTACCCTTAAAAGTTCCAACTTGTCAATAAAACTGAAGCTGACTTG
AAAGCTGCTTTAGTTTTCTCCCCTGTTTCAATCTCCGTCAATGCTGATACCTGGAAAGAA
TACTATGGTGGTGTTTTTGATGAATGTGGATATACTACCGAAGAAGATCTCAATCATGCT
GTCATCGCTGTAGGTTATGACCAAGAAGGTAACTGGATTGTTAGAAACAGTTGGTCTGCA
GCTTGGGGTGAAGATGGTTACATAAGATTAGCTCCTGGTAACACTTGTGGTATTTTGCTT
GATGGATTAATAGTTACTTAATGA