Gene Model Identifier
TTHERM_00295700
Standard Name
FSF1
Aliases
PreTt15680 | 27.m00340 | 3692.m00143
Description
Formaldehyde dehydrogenase/S-formylglutathione hydrolase fusion protein; fusion protein containing two enzymes known to catalyze sequential steps in the formaldehyde detoxification pathway in yeast; this fusion unique to ciliates
Genome Browser (Macronucleus)
Genome Browser (Micronucleus)
Molecular Function Biological Process
( PF00756 ) putative esterase
( TIGR01751 ) crotonyl-CoA reductase
( TIGR00692 ) L-threonine 3-dehydrogenase
( TIGR02821 ) S-formylglutathione hydrolase
( TIGR01202 ) Chlorophyll synthesis pathway, bchC
( PF08240 ) Alcohol dehydrogenase GroES-like domain
( PF00326 ) peptidase, S9A/B/C familie, catalytic domain
( PF00107 ) oxidoreductase, zinc-binding dehydrogenase family
( TIGR02822 ) zinc-binding alcohol dehydrogenase family protein
( TIGR02819 ) formaldehyde dehydrogenase, glutathione-independent
( TIGR03201 ) 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
( TIGR03366 ) putative phosphonate catabolism associated alcohol
( TIGR02825 ) leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
( TIGR02818 ) S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase
Tetrahymena Functional Genomics Database:
Signal Peptide Present?: No
TTHERM_00295700
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No Data fetched for StockID
(v.2006 protein sequences)
Source Identifier Score Description
Tetrahymena borealis EI9_08836.1 9.997093137033517e-262 alcohol dehydrogenase (684 aa)
Oxytricha Contig9574.0.0.g63 9.997093137033517e-262 Putative esterase
WormBase WBGene00019240 1.000274544751666e-156 Alcohol dehydrogenase class-3
DictyBase DDB_G0281865 2.9986999840889833e-149 adh5 on chromosome: 3 position
SGD YDL168W 1.99904246446894e-143 SFA1 Bifunctional enzyme conta
Paragraph No Gene Name Paragraph Text 14 FSF1 A macronuclear chromosome containing a fusion gene was cloned from the spirotrichous ciliate Oxytricha trifallax. The gene encodes a single polypeptide containing homologs of two proteins that catalyze sequential steps in the formaldehyde detoxification pathway in Saccharomyces cerevisiae. These two proteins are formaldehyde dehydrogenase (FALDH) and S-formylglutathione hydrolase (SFGH); the fusion gene is called FSF1 (FALDH/SFGH Fusion 1). A similar gene was identified in the Tetrahymena thermophila genome sequence, and a T. thermophila EST sequenced from both ends showed that the fusion gene is expressed in this species in vivo. FSF1 has not yet been identified in other ciliates, but a fusion of these two genes has been identified in another group of protists, the diatoms. An EST from Phaeodactylum tricornutum and a gene from the genome sequence of Thalassiosira pseudonana both encode a fusion of these two genes, but in the opposite orientation of the ciliate genes. In diatoms, the SFGH domain is found N-terminal to the FALDH domain, suggesting that these two fusion genes evolved independently in ciliates and diatoms. The diatom genes were named SFF1 to highlight these differences.
Ref:15858209 : Stover NA, Cavalcanti AR, Li AJ, Richardson BC, Landweber LF (2005) Reciprocal fusions of two genes in the formaldehyde detoxification pathway in ciliates and diatoms. Molecular biology and evolution 22(7):1539-42Ref:SUPR000381
>TTHERM_00295700(coding)ATG GAC GCA TCT TTA CTC TCT GAA TTC CTT AAA ACT GCT GGC CAA ACC ATC ACT TGT AAG GCT GCT GTA GCT TGG GAA GCT AAC AAA CCT TTA GAT TAC ACT GAC ATT TAA GTT GCT CCT CCT AAG AAA GGA GAA GTT CGT ATT AAA GTT TTT GCA AAT GCT CTT TGC CAT ACT GAT ATT TAC ACC TTA GAA GGA CAC GAT CCT GAA GGT CTT TTC CCA AGC ATT CTT GGT CAT GAA GGT ACA GGT ATT GTT GAA AGT ATT GGT GAA GGA GTT ACT TCT GTT AAG CCT GGT GAT ATT GTT ATT CCT TGC TAC ACA CCT GAA TGC AGG GAA TTC TCT TGT ATT TAT TGT AAC AAT GAA AAC ACT AAC CTT TGT CCT AAG ATT AGA GCC TTC TAA GGA AAG GGT TTG ATG CCT GAT GGT ACA AGC AGA TTT TCT AAG GAT GGT AAA ACT ATC TAT CAC TTT ATG GGG TGT TCT AGT TTC TCT GAA TAC ACA GTT GTT GCT GAA ATT TCT TGT GCT AAA GTT AGC GAC AAG ATT GAT GTT AAC CAA ATG TGT CTT TTG GGT TGT GGT ATC AGC ACT GGT TGG GGT GCT GCA ATT AAT ACT TGC AAA GTA AGA CCT GGA TCA ACA GTT GTC GTA TTT GGT CTT GGT GCA GTT GGT TTA GCA GTA GTT CAA GCT GCT AAA ATT AAA GGA GCA AGA AAA ATT GTT GGT ATT GAT CTT AAC AGT GAA AAA TTC ACT TTA GCT AAA GAT TTC GGT TGC ACT GAA TGC TGG AAT CCT AAA GAG TTG GAC GGT AAG ACC ATT AAG GAA CAC CTT ATT TCC TTA GAA CCT TGG GGT TAT GAT TTC ACA TTT GAT TGC ACT GGT ATC ACT GCT GTT ATG AGA GAT GCT TTA GAA ATT GCT CAC AGA GGA TTT GGT GAA AGT TGC GTT ATT GGT GTT GCT GCT TCT GGT CAT GAA ATT TCT ACT AGA CCA TTC TAA TTA GTT ACT GGT AGA TAA TGG AAA GGA ACT GCC TTT GGT GGA TGG AAA AGC AGA ACT GAA GTT CCC TAA TTA GTT TAA CAA GTA TCT ACT GGG GAA TTG CCA ATT CAA AAA TAC ATT ACT CAT GAA ATT AAG GGC TTA CAA AAT GTC AAC TAA GCT ATT GAT GCT TTA CAC TCA GGA AAA TGC TTG CGT GCA GTT GTT CAT ATC AAC GAA AGA CCT GAT TTC AAC AAA GAA TAG GTA TCA AAG TTA GTC CCT CGT GTT TAT TCT AAT GCA AGA AGT CAT AAT GGA TGG GTA AAG AGA GTA AAG CAT TAT TCT GAA TCT CTT TAA TGC GAA ATG CAA TTT TCA ATT TAC ATC CCT GAT AAG AAG TCT CGT AAT GCT TAA CTT CCC CCT GTT CTT TAT TAT CTT AGT GGA CTT ACT TGC ACT GAT GAA AAC GCT TTG GTA AAA TCT GGC TTC TAA AGA TAT GCC TCT GAA CTC GGT ATT GCT GTT GTA TTC CCT GAC ACC TCA CCT CGT GTT GAT ATT GAA GGT GAT AAC GAA AGT TGG GAC TTT GGT AAA TCA GCT GGA TTC TAC TTA AAT GCT ACT TAA GAA AAA TGG AGA AAG AAC TAC AAT ATG TTC ACC TAT ATC TCT GAA GAA TTA CCA AAA TTG ATT GGA GAA TTC TTC CCT GTT GAT GTA AGC AGA GCT GGT ATT ACT GGT CAC TCT ATG GGT GGT ATG GGA GCT CTT AAC ATA TTC TTA AAG AAC CCA GGT AAA TAT TTG AGT GTC TCT GCC TTT GCT CCT ATT TGC AAT CCC ACT TAG TGC CCT TGG GGA GTT AAG GCT TTC ACT AAC TAT TTA GGC TCT GTA GAA GCT GGT AAA TAG TAT GAT CCA ACT GAA CTT ATT GTT TAA TAT AAT GGT CCC AAG GCT AAG ATT TTA ATT GAT CAA GGT ACT CAT GAC TCA TTC CTT TAC AAT TAA CTT CAT CCT TAA AAT TTC TTA AAG GCT GCA TCT TCA GTT AAT TAC CCT GTT GAA TTC AGA TAT CAA AAT AAC TAT GAT CAC CTC TAC TTC TTT GTA GAG ACC TTC ATG GGA GAT CAT TTC AAG CAC CAT GCT TAA TAT CTT CTT AGA TGA >TTHERM_00295700(protein)M D A S L L S E F L K T A G Q T I T C K A A V A W E A N K P L D Y T D I Q V A P P K K G E V R I K V F A N A L C H T D I Y T L E G H D P E G L F P S I L G H E G T G I V E S I G E G V T S V K P G D I V I P C Y T P E C R E F S C I Y C N N E N T N L C P K I R A F Q G K G L M P D G T S R F S K D G K T I Y H F M G C S S F S E Y T V V A E I S C A K V S D K I D V N Q M C L L G C G I S T G W G A A I N T C K V R P G S T V V V F G L G A V G L A V V Q A A K I K G A R K I V G I D L N S E K F T L A K D F G C T E C W N P K E L D G K T I K E H L I S L E P W G Y D F T F D C T G I T A V M R D A L E I A H R G F G E S C V I G V A A S G H E I S T R P F Q L V T G R Q W K G T A F G G W K S R T E V P Q L V Q Q V S T G E L P I Q K Y I T H E I K G L Q N V N Q A I D A L H S G K C L R A V V H I N E R P D F N K E Q V S K L V P R V Y S N A R S H N G W V K R V K H Y S E S L Q C E M Q F S I Y I P D K K S R N A Q L P P V L Y Y L S G L T C T D E N A L V K S G F Q R Y A S E L G I A V V F P D T S P R V D I E G D N E S W D F G K S A G F Y L N A T Q E K W R K N Y N M F T Y I S E E L P K L I G E F F P V D V S R A G I T G H S M G G M G A L N I F L K N P G K Y L S V S A F A P I C N P T Q C P W G V K A F T N Y L G S V E A G K Q Y D P T E L I V Q Y N G P K A K I L I D Q G T H D S F L Y N Q L H P Q N F L K A A S S V N Y P V E F R Y Q N N Y D H L Y F F V E T F M G D H F K H H A Q Y L L R >TTHERM_00295700(gene)ATG GAC GCA TCT TTA CTC TCT GAA TTC CTT AAA ACT GCT GGC CAA ACC ATC ACT TGT AAG GCT GCT GTA GCT TGG GAA GCT AAC AAA CCT TTA GAT TAC ACT GAC ATT TAA GTT GCT CCT CCT AAG AAA GGA GAA GTT CGT ATT AAA GTT TTT GCA AAT GCT CTT TGC CAT ACT GAT ATT TAC ACC TTA GAA GGA CAC GAT CCT GAA GGT CTT TTC CCA AGC ATT CTT GGT CAT GAA GGT ACA GGT ATT GTT GAA AGT ATT GGT GAA GGA GTT ACT TCT GTT AAG CCT GGT GAT ATT GTT ATT CCT TGC TAC ACA CCT GAA TGC AGG GAA TTC TCT TGT ATT TAT TGT AAC AAT GAA AAC ACT AAC CTT TGT CCT AAG ATT AGA GCC TTC TAA GGT AAA AAT TAC TTT TAT TTA TTA ATA ATT AAT ATA GCT TAG CTT TCT ATG AAG AAC TAC AAC AAT ACT ATG ACT TTT AAG GAA TTT TAT TAA AAG GAT AAA GGC ATA ATT TAT AAA TTC TAC TTA CCA TTA AAT GAT AAA GTG TAA TAT TAT TAA TTT TAA TTA AAG GAA AGG GTT TGA TGC CTG ATG GTA CAA GCA GAT TTT CTA AGG ATG GTA AAA CTA TCT ATC ACT TTA TGG GGT GTT CTA GTT TCT CTG AAT ACA CAG TTG TTG CTG AAA TTT CTT GTG CTA AAG TTA GCG ACA AGA TTG ATG TTA ACC AAA TGT GTC TTT TGG GTT GTG GTA TCA GCA CTG GTT GGG GTG CTG CAA TTA ATA CTT GCA AAG TAA GAC CTG GAT CAA CAG TTG TCG TAT TTG GTC TTG GTG CAG TTG GTT TAG CAG TAG TTC AAG CTG CTA AAA TTA AAG GAG CAA GAA AAA TTG TTG GTA TTG ATC TTA ACA GTG AAA AAT TCA CTT TAG CTA AAG ATT TCG GTT GCA CTG AAT GCT GGA ATC CTA AAG AGT TGG ACG GTA AGA CCA TTA AGG AAC ACC TTA TTT CCT TAG AAC CTT GGG GTT ATG ATT TCA CAT TTG ATT GCA CTG GTA TCA CTG CTG TTA TGA GAG ATG CTT TAG AAA TTG CTC ACA GAG GGT AAT TAG TTT TTA AAA GAT GTT TTA TAT AGA TAT TCA AAA TAG TTA ATC AGT AAC AAA AAA GAT TCT TTG TGA ATT GGT TAG GAA TAG GAA GAG AAA ATT CAC AAT TTA ATA AAA AAA ATT TTA TTG ATA ATT AAT TTT TTA GGG TTT CCA TCT AAT TTT GAA TAT TTT TAA TTA CTA TTG ATC TTT GAA TAA ACA AGC AAA TGT AGG ATT AAA TTT ATT AAA TAA ATT TTA TGA TTA TTA ATT ATA TAG ATT TGG TGA AAG TTG CGT TAT TGG TGT TGC TGC TTC TGG TCA TGA AAT TTC TAC TAG ACC ATT CTA ATT AGT TAC TGG TAG ATA ATG GAA AGG AAC TGC CTT TGG TGG ATG GAA AAG CAG AAC TGA AGT TCC CTA ATT AGT TTA ACA AGT ATC TAC TGG GGA ATT GCC AAT TCA AAA ATA CAT TAC TCA TGA AAT TAA GGG CTT ACA AAA TGT CAA CTA AGC TAT TGA TGC TTT ACA CTC AGG AAA ATG CTT GCG TGC AGT TGT TCA TAT CAA CGA AAG ACC TGA TTT CAA CAA AGA ATA GGT ATC AAA GTT AGT CCC TCG TGT TTA TTC TAA TGC AAG AAG TCA TAA TGG ATG GGT AAA GAG AGT AAA GCA TTA TTC TGA ATC TCT TTA ATG CGA AAT GCA ATT TTC AAT TTA CAT CCC TGA TAA GAA GTC TCG TAA TGC TTA ACT TCC CCC TGT TCT TTA TTA TCT TAG TGG ACT TAC TTG CAC TGA TGA AAA CGC TTT GGT AAA ATC TGG CTT CTA AAG ATA TGC CTC TGA ACT CGG TAT TGC TGT TGT ATT CCC TGA CAC CTC ACC TCG TGT TGA TAT TGA AGG TGA TAA CGA AAG TTG GGA CTT TGG TAA ATC AGC TGG ATT CTA CTT AAA TGC TAC TTA AGA AAA ATG GAG AAA GAA CTA CAA TAT GTT CAC CTA TAT CTC TGA AGA ATT ACC AAA ATT GAT TGG AGA ATT CTT CCC TGT TGA TGT AAG CAG AGC TGG TAT TAC TGG TCA CTC TAT GGG TGG TAT GGG AGC TCT TAA CAT ATT CTT AAA GAA CCC AGG TAA ATA TTT GAG TGT CTC TGC CTT TGC TCC TAT TTG CAA TCC CAC TTA GTG CCC TTG GGG AGT TAA GGC TTT CAC TAA CTA TTT AGG CTC TGT AGA AGC TGG TAA ATA GTA TGA TCC AAC TGA ACT TAT TGT TTA ATA TAA TGG TCC CAA GGC TAA GAT TTT AAT TGA TCA AGG TAC TCA TGA CTC ATT CCT TTA CAA TTA ACT TCA TCC TTA AAA TTT CTT AAA GGC TGC ATC TTC AGT TAA TTA CCC TGT TGA ATT CAG ATA TCA AAA TAA CTA TGA TCA CCT CTA CTT CTT TGT AGA GAC CTT CAT GGG AGA TCA TTT CAA GCA CCA TGC TTA ATA TCT TCT TAG ATG A
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