Identifiers and Description

Gene Model Identifier

TTHERM_00138080

Standard Name

FIB1 (FIBrillarin 1)

Aliases

PreTt24434 | PreTt24435 | 10.m00484 | FIB | 3698.m00201

Description

Fibrillarin; essential protein localized to nucleoli in the macronucleus of vegetative cells; involved in rRNA processing; associates with U3 snoRNA

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• nucleolus (IDA) | GO:0005730 | Ref:9201715
• macronucleus (IDA) | GO:0031039 | Ref:9201715

Molecular Function

• RNA binding (IEA) | GO:0003723
• snoRNA binding (IPI) | GO:0030515 | Ref:9201715
• methyltransferase activity (IEA) | GO:0008168

Biological Process

• tRNA processing (IEA) | GO:0008033
• rRNA processing (IEA) | GO:0006364
• rRNA processing (ISS) | GO:0006364 | Ref:9201715

Domains

• ( PF01269 ) Fibrillarin
• ( PF08241 ) methyltransferase domain
• ( PF01391 ) Collagen triple helix repeat (20
• ( PF08704 ) tRNA methyltransferase complex GCD14 subunit
• ( TIGR00080 ) protein-L-isoaspartate O-methyltransferase
• ( TIGR00438 ) ribosomal RNA large subunit methyltransferase
• ( PF01135 ) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 9.9%

TetraMine Data

TTHERM_00138080

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_05872.1	1.9994249217050915e-157	fibrillarin (1203 aa)
WormBase	WBGene00001423	3.999284652801983e-113	locus:fib-1 rRNA 2-O-methylt ransferase fibrillarin statu s:Confirmed UniProt:Q22053 protein_id:CAB01657.1
Oxytricha	Contig11749.0.g117	6.001115222296727e-111	Fibrillarin
DictyBase	DDB_G0269878	2.998733531465523e-108	fbl on chromosome: 1 position 3783828 to 3785196
SGD	YDL014W	1.999745369828301e-106	NOP1 Nucleolar protein, compon ent of the small subunit proce ssome complex, which is requir ed for processing of pre-18S r RNA; has similarity to mammali an fibrillarin
Stentor Coeruleus	SteCoe_34908	3.392270193026015e-47

General Information

No Data fetched for General Information

Associated Literature

1. Ref:9201715: David E, McNeil JB, Basile V, Pearlman RE (1997) An unusual fibrillarin gene and protein: structure and functional implications. Molecular biology of the cell 8(6):1051-61

Sequences

>TTHERM_00138080(protein)
MGKDFKSGGGNAGGKPFNKGPGGPGGRPFNKGPGGPGGPGGKFGGGRPGGPGGKFGAKGP
RGPKTIIVKHRLEGVFICKGQQEALVTKNFFPGESVYNEKRMSVEENGEKIEYRVWNPYR
SKIAAAVVGGISDIHIKPGSKVLYLGGASGTTVSHVADIVGPTGVVYAVEFSHRSGRDLV
NMAKKRTNVVPIIGDARKPQEYRFLVGMVDVVFADVAQPDQARIMGMNCQYFLKNGGHFL
ISIKACCIDSTNEPAVVFAAEVQKLKEEGLKPEQQLTLEPYERDHAMVLGSYRA

>TTHERM_00138080(coding)
ATGGGTAAAGATTTCAAGTCAGGTGGTGGCAATGCTGGTGGAAAGCCCTTCAATAAAGGT
CCTGGAGGTCCTGGTGGAAGACCCTTCAATAAGGGTCCTGGTGGTCCCGGTGGTCCTGGT
GGCAAATTCGGTGGTGGCAGACCCGGTGGCCCTGGTGGCAAATTTGGTGCCAAGGGTCCT
AGAGGTCCCAAGACTATTATTGTTAAGCATAGATTAGAAGGTGTTTTCATCTGCAAAGGT
CAATAAGAAGCTTTGGTAACTAAAAATTTCTTCCCTGGTGAATCTGTTTACAATGAAAAA
CGTATGTCCGTTGAAGAAAACGGTGAAAAGATTGAATATCGTGTCTGGAATCCCTACAGA
TCTAAAATTGCTGCTGCTGTTGTTGGTGGTATTTCTGATATTCATATTAAACCTGGCTCC
AAGGTTCTCTATTTGGGTGGTGCCTCTGGTACAACTGTCTCTCACGTTGCTGATATTGTT
GGACCCACTGGTGTTGTCTATGCTGTCGAATTCTCTCACAGAAGTGGTAGAGATTTGGTA
AATATGGCTAAGAAGAGAACCAATGTTGTTCCCATTATCGGTGATGCTAGAAAGCCCCAA
GAATACAGATTCTTAGTCGGTATGGTCGATGTCGTCTTCGCTGATGTTGCCCAACCTGAT
CAAGCTAGAATTATGGGTATGAACTGTTAATACTTCTTAAAGAATGGTGGTCACTTCCTT
ATCTCCATTAAGGCTTGCTGTATTGATTCAACCAACGAACCTGCAGTCGTTTTCGCTGCT
GAAGTACAAAAATTAAAAGAAGAAGGTCTCAAGCCTGAATAATAACTTACTCTTGAACCT
TATGAAAGAGATCACGCTATGGTCCTCGGTTCTTACAGAGCTTGA

>TTHERM_00138080(gene)
ATGGGTAAAGATTTCAAGTCAGGTGGTGGCAATGCTGGTGGAAAGCCCTTCAATAAAGGT
CCTGGAGGTCCTGGTGGAAGACCCTTCAATAAGGGTCCTGGTGGTCCCGGTGGTCCTGGT
GGCAAATTCGGTGGTGGCAGACCCGGTGGCCCTGGTGGCAAATTTGGTGCCAAGGGTCCT
AGAGGTCCCAAGACTATTATTGTTAAGCATAGATTAGAAGGTGTTTTCATCTGCAAAGGT
CAATAAGAAGCTTTGGTAACTAAAAATTTCTTCCCTGGTGAATCTGTTTACAATGAAAAA
CGTATGTCCGTTGAAGAAAACGGTGAAAAGATTGAATATCGTGTCTGGAATCCCTACAGA
TCTAAAATTGCTGCTGCTGTTGTTGGTGGTATTTCTGATATTCATATTAAACCTGGCTCC
AAGGTTCTCTATTTGGGTATATATTTTAATTCTTTTCAATTAATTGATACAGCTTTGAAT
AGTTTGCATACAGCAAGGCTGTTTAAAAACAAAAATGCTAGATACTAATCAGATGGTTGA
CTTTAAAATATAATCAACTCAATCAATTATTGCAAAATATTAAAAAAGATTGATAGATAG
AAAGTATGTATGTATGTATGGGATACTCTACTTAAAATAAAATAAGTATTTGTTATACAA
ATATAAAGTAGGATTAATTCAATGCAGATAGATAGTTAGCATTTGCAAAAATATAAAATC
CCATAATGAAAATTGTAGCTGATTGTATTGAATAAATAAATACATTTCTATCTACAATAA
AAAGCATTTGAAAGATATATTTATCTTACAACATATACTACTAATATATAAATCGATAAA
TGAATGAATAAATAAATAGAATTTTTAAATTTTGCTTTAATCAATAATCCATATAAAATT
TACGCTGCTATTCTAAATAAATAAGTCAATAGCAATTAATTTTACTAAAATAAAATTTAT
TTTAGGATATTTTTATAACAAACAAACAAAGAAAGAATGATGGTTAAATTCATAGAGATT
TATATCTGAATTTATTTAACATCGATTATATCATTTAATTTCAATCAATTGAGTTAAAAA
TCTCTCATGAATAATGATATATTTTATAAACTTACTTATTTCTTTATTTTTAAGATGTAG
AAATAATTAATTCCCATCGATAATATAATAGAATCATCTAGCAAAATTTTTATTTAAACA
CATATTAAATTAAATTAATTATAAATAGGTGGTGCCTCTGGTACAACTGTCTCTCACGTT
GCTGATATTGTTGGACCCACTGGTGTTGTCTATGCTGTCGAATTCTCTCACAGAAGTGGT
AGAGATTTGGTAAATATGGCTAAGAAGAGAACCAATGTTGTTCCCATTATCGGTGATGCT
AGAAAGCCCCAAGAATACAGATTCTTAGTCGGTATGGTCGATGTCGTCTTCGCTGATGTT
GCCCAACCTGATCAAGCTAGAATTATGGGTATGAACTGTTAATACTTCTTAAAGAATGGT
GGTCACTTCCTTATCTCCATTAAGGCTTGCTGTATTGATTCAACCAACGAACCTGCAGTC
GTTTTCGCTGCTGAAGTACAAAAATTAAAAGAAGAAGGTCTCAAGCCTGAATAATAACTT
ACTCTTGAACCTTATGAAAGAGATCACGCTATGGTCCTCGGTTCTTACAGAGCTTGA