Tian M, Agreiter C, Loidl J (2020) Spatial constraints on chromosomes are instrumental to meiotic pairing. Journal of cell science 133(22): PUBMED:33172984
Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert JP, Pearlman RE, Fillingham J (2020) Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila. Scientific reports 10(1):168 PUBMED:31932604
Akematsu T, Sánchez-Fernández R, Kosta F, Holzer E, Loidl J (2019) The Transmembrane Protein Semi1 Positions Gamete Nuclei for Reciprocal Fertilization in Tetrahymena. iScience 23(1):100749 PUBMED:31884169
Identifiers and Description
Gene Model Identifier
TTHERM_00300320
Standard Name
EZL2 (Enhancer of Zeste-Like 2)
Aliases
PreTt19327 | 28.m00286 | 3691.m00104
Description
EZL2 SET domain protein; Enhancer of zeste homolog; putative H3K27 HKMT
SET1 Histone methyltransferase
, subunit of the COMPASS (Set1
C) complex; COMPASS methylates
histone H3K4; Set1p-dependent
H3K4 trimethylation recruits
Nrd1p, allowing efficient term
ination of snoRNAs and cryptic
unstable transcripts (CUTs) b
y Nrd1p-Nab3p-Sen1p pathway; m
odulates histone acetylation l
evels in promoter proximal reg
ions to ensure efficient Nrd1p
-dependent termination; requir
ed in transcriptional silencin
g near telomeres and at silent
mating type loci; has a SET d
omain
General Information
No Data fetched for General Information
Associated Literature
Ref:24382802: Zhang C, Gao S, Molascon AJ, Liu Y, Andrews PC (2014) Quantitative proteomics reveals histone modifications in crosstalk with H3 lysine 27 methylation. Molecular & cellular proteomics : MCP 13(3):749-59
Ref:25161194: Papazyan R, Voronina E, Chapman JR, Luperchio TR, Gilbert TM, Meier E, Mackintosh SG, Shabanowitz J, Tackett AJ, Reddy KL, Coyne RS, Hunt DF, Liu Y, Taverna SD (2014) Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis. eLife 3( ):e02996
Ref:23884606: Gao S, Xiong J, Zhang C, Berquist BR, Yang R, Zhao M, Molascon AJ, Kwiatkowski SY, Yuan D, Qin Z, Wen J, Kapler GM, Andrews PC, Miao W, Liu Y (2013) Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes & development 27(15):1662-79
Ref:23150054: Zhang C, Molascon AJ, Gao S, Liu Y, Andrews PC (2013) Quantitative proteomics reveals that the specific methyltransferases Txr1p and Ezl2p differentially affect the mono-, di- and trimethylation states of histone H3 lysine 27 (H3K27). Molecular & cellular proteomics : MCP 12(6):1678-88
Ref:22427430: Chung PH, Yao MC (2012) Tetrahymena thermophila JMJD3 homolog regulates H3K27 methylation and nuclear differentiation. Eukaryotic cell 11(5):601-14
Ref:17575054: Liu Y, Taverna SD, Muratore TL, Shabanowitz J, Hunt DF, Allis CD (2007) RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes & development 21(12):1530-45