Identifiers and Description

Gene Model Identifier

TTHERM_00961880

Standard Name

EFR2 (Elongation Factor 2 Related 2)

Aliases

PreTt23676 | 178.m00057

Description

EFR2 translation elongation factor EF-2 subunit; Elongation factor 2 related protein; expressed only during conjugation- significant amino acid identity to EF-2 ifrom other eukaryotes but with differences at some residues that are typically post-translational regulation sites

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• GTP binding (IEA) | GO:0005525
• GTPase activity (IEA) | GO:0003924

Biological Process

• translation (ISS) | GO:0006412 | Ref:14729267

Domains

• ( PF04644 ) Motilin/ghrelin
• ( PF08477 ) Miro-like protein
• ( PF00167 ) Fibroblast growth factor
• ( PF01926 ) GTPase of unknown function
• ( TIGR01393 ) GTP-binding protein LepA
• ( PF03144 ) Elongation factor Tu domain 2
• ( PF00679 ) Elongation factor G C-terminus
• ( PF03764 ) Elongation factor G, domain IV
• ( TIGR01394 ) GTP-binding protein TypA/BipA
• ( TIGR00503 ) peptide chain release factor 3
• ( TIGR00484 ) translation elongation factor G
• ( TIGR00231 ) small GTP-binding protein domain
• ( TIGR00485 ) translation elongation factor Tu
• ( TIGR00490 ) translation elongation factor aEF-2
• ( PF00009 ) Elongation factor Tu GTP binding
• ( PF05705 ) Eukaryotic protein of unknown function
• ( TIGR00483 ) translation elongation factor EF-1, subunit
• ( TIGR00475 ) selenocysteine-specific translation elongation factor

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.4%

TetraMine Data

TTHERM_00961880

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Stentor Coeruleus	SteCoe_7852	0
WormBase	WBGene00001167	9.997093137033517e-262	locus:eef-2 Elongation facto r 2 status:Confirmed UniPr ot:P29691 protein_id:CAB0298 5.1
Tetrahymena borealis	EI9_08465.1	9.997093137033517e-262	elongation factor G, domain IV family protein (842 aa)
DictyBase	DDB_G0287685	9.997093137033517e-262	cinC on chromosome: 5 position 689907 to 692602
Oxytricha	Contig22552.0.g51	9.997093137033517e-262	Elongation factor Tu GTP bindi ng domain
SGD	YOR133W	9.997093137033517e-262	EFT1 Elongation factor 2 (EF-2 ), also encoded by EFT2; catal yzes ribosomal translocation d uring protein synthesis; conta ins diphthamide, the unique po sttranslationally modified his tidine residue specifically AD P-ribosylated by diphtheria to xin

General Information

No Data fetched for General Information

Associated Literature

1. Ref:14729267: Malavé TM, Forney JD (2004) Identification of a developmentally regulated translation elongation factor 2 in Tetrahymena thermophila. Gene 326( ):97-105
2. Ref:12673598: Ueno H, Gonda K, Takeda T, Numata O (2003) Identification of elongation factor-1alpha as a Ca2+/calmodulin-binding protein in Tetrahymena cilia. Cell motility and the cytoskeleton 55(1):51-60

Sequences

>TTHERM_00961880(coding)
ATGAAGACTCTCCAGATTGAGAAGATAAGAGAACTCATGATGAACCCCAATCAAATCAGA
AATATGTCTGTCATAGCCCACGTTGATCATGGTAAGACTACTTTAACTGATTCTTTGTTA
GCTAGAGCTGGTATCATCTCAGAAAGCAACGCTGGTAAAGCCTGCATGATGGATACTGAC
CCAAAAGAACAAAAAATGGGAATCACCATTAAGTCAACTGGAGTTTCCTTATACTATCAA
AATACTGTGACCAAGTAGGAGAGTATCATTAATTTGATTGATTCTCCAGGTCATATTGAC
TTTTCTGGTGAAGTTACTGCTGCATTAAGAGTTACTGATGGAGCTCTTGTTGTGGTAGAT
GCTGTTGAAGGTGTTGCTGTTCAAACAGAAACAGTTCTAAGGCAGGCTTGCCAAGAACGA
ATACGACCCGTTCTTGTAATTAATAAGCTAGACAGACTATTTAGTGAGCTTAAGGATGAT
TATGAAAATATTTATCAAAGATTAGTAGAGATCATAGCAAGGATTAATTCTATCTTGGAA
ATGAACGAAAATGAATCTATTAAAGGCTACACTTTAGATCCCTCACTTGGAAATGTTGCT
TTCTCTTCTGGTAAACAGTGCTGGGGATTCACTTTAAAGACTTTTGCTAGAATTTATAGT
CAAAAATTCTCAACAAAGGAAGAAACTTTAATGACTAAATTATGGGGAGACAACTATTTT
AATCCTCAAACAAAGTAATTCACCTCAGAATTAATCAGTAATAATACCTAAAACAAGTAA
GCTAGTCGTTCATTCATTGAATTCGTTTTAGTTCCTTTAGATAAGTACTATTCAGCCTCT
TCAAATGCAGAAATTGAAACTCTTTCCAAGATGGTTGAAAAGCTCAACCTTTCTTCCATT
CTAACTTCAGCTGAATTAGAAAGACTCAAATAGGTTGATGTTCAAGAGAGAATCAAGAGG
TCTATGAGGGCTTGGTTACCCTTAGCCGATGCCATACTTGAAATGGTCTAAGATCATTTA
CCTTCACCAAAAGAGGCTATGAAATATCGTAGTTTGTATCTTTACGAAGGACCTGCTGGT
GATGAGGCTTGTGCAGCAATGAGAGAATGTAATTCTGAGGGACCTCTCATGGTTTACATT
TCAAAAATGGTTTAAACTGAAGATCTTGGTAGATTTTATGCTTTTGGTAGAGTATTCAGT
GGCACAATATCTCAAGGCATGAAAGTCAGAGTCTAAGGTCCTGACTATAAACCTGGAAGC
AAAGAAGATCTCTTTATCAAAACAATCTAGCATACATTTTTGATGATGGGTAAACAGCAT
GAGCCTATCGAATCAGTACCAGCTGGAGGTACCGTCCTCATCTTAGGTGTTGATAACGCT
CTTACTAAAACAGGAACTCTTACAACTTCAGAAACAGCACATAATATCAGAAACATGAAG
TACACGATTTCACCTATATTGAGAGTTGCTGTCAATACTCCTAACTAACAAGATCTTACA
CGTCTACTTGAAGGTCTTAAGATGCTTCAAAAATATGATCCTCTTGTTCAAGTAGAAGTT
GAAGAAAATACAGGATCCTATGTTGTTGCTGGTAGTGGTGAATTGCATATTAAAATTTGC
TTAGAAAAACTGAATGATTTCACCCACAACTCTATTAATATTGTTGCTTCTCAACCCACT
GTATCTTACAGAGAAACAATAGCTGAAAAGAGCTCTTAAACTTGCCTAGCTAAGACTGAA
AATAAGCTTAATCATCTGTATGGTACTTGCGAACCACTTGATGAAGAATTAGGATCAGCA
ATAGTGAGCAAAAAAATAAATATTAAAGACATTAACAACTAAAAAATGATTAACAGTTTG
GTGAATGATTATTCTTGGGAAAGAGAAGATGCAAAGCGTATATGGTGCTTCGGTCCTCTA
GAAAAGGAGTCCACTAATTGCATCGTAAACCAAACAGTTGGTATATAAGGTATGCCTGCA
ATTCAGCCTTCTATAATAACCGCCTTCGAATGGTGTACTAAGGAAGGTCTTTTGTGTGAT
GAGCCTCTTAGAAATATTCGCTTTAACATAATGGATGTAATAATACACGATGAACCTGCT
CATCACAGAAGCAATCAAATAACCCCAGCAGCTAGAAGGCTATTTAAGGCTTGCTAATAT
GTGAGTGAACCTAAAATTTTGGAACCATTTTATTTATGCAACATTAAAACTCCAGATGAA
AGGAAAGGACCTATATATGCATTCCTCAATAAATTCCTAGATAAGAGAAGAGGTTTAGTT
TTAGGAGAAGAATATGATGATATATTTACCGTGATTCAAGCCTACATCCCTGTATCTGAA
AGCTTTGGATTCGACCAAGCTATAAAGTCAGTCTCCTAAGGTATGGCAATGCCAGCTCTC
TCATTCAGTCACTGGCAAGCAGTCTAGGGTAATCCACTCGACCCAGAATCAGAATCAGGT
AAGATTGTTAATGAAATAAGAATAAGAAAAGGTTTGAATGCTAAAATACCAGAACTCAAC
TATTATCTTGATAAACTTTGA

>TTHERM_00961880(protein)
MKTLQIEKIRELMMNPNQIRNMSVIAHVDHGKTTLTDSLLARAGIISESNAGKACMMDTD
PKEQKMGITIKSTGVSLYYQNTVTKQESIINLIDSPGHIDFSGEVTAALRVTDGALVVVD
AVEGVAVQTETVLRQACQERIRPVLVINKLDRLFSELKDDYENIYQRLVEIIARINSILE
MNENESIKGYTLDPSLGNVAFSSGKQCWGFTLKTFARIYSQKFSTKEETLMTKLWGDNYF
NPQTKQFTSELISNNTQNKQASRSFIEFVLVPLDKYYSASSNAEIETLSKMVEKLNLSSI
LTSAELERLKQVDVQERIKRSMRAWLPLADAILEMVQDHLPSPKEAMKYRSLYLYEGPAG
DEACAAMRECNSEGPLMVYISKMVQTEDLGRFYAFGRVFSGTISQGMKVRVQGPDYKPGS
KEDLFIKTIQHTFLMMGKQHEPIESVPAGGTVLILGVDNALTKTGTLTTSETAHNIRNMK
YTISPILRVAVNTPNQQDLTRLLEGLKMLQKYDPLVQVEVEENTGSYVVAGSGELHIKIC
LEKLNDFTHNSINIVASQPTVSYRETIAEKSSQTCLAKTENKLNHLYGTCEPLDEELGSA
IVSKKINIKDINNQKMINSLVNDYSWEREDAKRIWCFGPLEKESTNCIVNQTVGIQGMPA
IQPSIITAFEWCTKEGLLCDEPLRNIRFNIMDVIIHDEPAHHRSNQITPAARRLFKACQY
VSEPKILEPFYLCNIKTPDERKGPIYAFLNKFLDKRRGLVLGEEYDDIFTVIQAYIPVSE
SFGFDQAIKSVSQGMAMPALSFSHWQAVQGNPLDPESESGKIVNEIRIRKGLNAKIPELN
YYLDKL

>TTHERM_00961880(gene)
ATGAAGACTCTCCAGATTGAGAAGATAAGAGAACTCATGATGAACCCCAATCAAATCAGA
AATATGTCTGTCATAGCCCACGTTGATCATGGTAAGACTACTTTAACTGATTCTTTGTTA
GCTAGAGCTGGTATCATCTCAGAAAGCAACGCTGGTAAAGCCTGCATGATGGATACTGAC
CCAAAAGAACAAAAAATGGGAATCACCATTAAGTCAACTGGAGTTTCCTTATACTATCAA
AATACTGTGACCAAGTAGGAGAGTATCATTAATTTGATTGATTCTCCAGGTCATATTGAC
TTTTCTGGTGAAGTTACTGCTGCATTAAGAGTTACTGATGGAGCTCTTGTTGTGGTAGAT
GCTGTTGAAGGTGTTGCTGTTCAAACAGAAACAGTTCTAAGGCAGGCTTGCCAAGAACGA
ATACGACCCGTTCTTGTAATTAATAAGCTAGACAGACTATTTAGTGAGCTTAAGGATGAT
TATGAAAATATTTATCAAAGATTAGTAGAGATCATAGCAAGGATTAATTCTATCTTGGAA
ATGAACGAAAATGAATCTATTAAAGGCTACACTTTAGATCCCTCACTTGGAAATGTTGCT
TTCTCTTCTGGTAAACAGTGCTGGGGATTCACTTTAAAGACTTTTGCTAGAATTTATAGT
CAAAAATTCTCAACAAAGGAAGAAACTTTAATGACTAAATTATGGGGAGACAACTATTTT
AATCCTCAAACAAAGTAATTCACCTCAGAATTAATCAGTAATAATACCTAAAACAAGTAA
GCTAGTCGTTCATTCATTGAATTCGTTTTAGTTCCTTTAGATAAGTACTATTCAGCCTCT
TCAAATGCAGAAATTGAAACTCTTTCCAAGATGGTTGAAAAGCTCAACCTTTCTTCCATT
CTAACTTCAGCTGAATTAGAAAGACTCAAATAGGTTGATGTTCAAGAGAGAATCAAGAGG
TCTATGAGGGCTTGGTTACCCTTAGCCGATGCCATACTTGAAATGGTCTAAGATCATTTA
CCTTCACCAAAAGAGGCTATGAAATATCGTAGTTTGTATCTTTACGAAGGACCTGCTGGT
GATGAGGCTTGTGCAGCAATGAGAGAATGTAATTCTGAGGGACCTCTCATGGTTTACATT
TCAAAAATGGTTTAAACTGAAGATCTTGGTAGATTTTATGCTTTTGGTAGAGTATTCAGT
GGCACAATATCTCAAGGCATGAAAGTCAGAGTCTAAGGTCCTGACTATAAACCTGGAAGC
AAAGAAGATCTCTTTATCAAAACAATCTAGCATACATTTTTGATGATGGGTAAACAGCAT
GAGCCTATCGAATCAGTACCAGCTGGAGGTACCGTCCTCATCTTAGGTGTTGATAACGCT
CTTACTAAAACAGGAACTCTTACAACTTCAGAAACAGCACATAATATCAGAAACATGAAG
TACACGATTTCACCTATATTGAGAGTTGCTGTCAATACTCCTAACTAACAAGATCTTACA
CGTCTACTTGAAGGTCTTAAGATGCTTCAAAAATATGATCCTCTTGTTCAAGTAGAAGTT
GAAGAAAATACAGGATCCTATGTTGTTGCTGGTAGTGGTGAATTGCATATTAAAATTTGC
TTAGAAAAACTGAATGATTTCACCCACAACTCTATTAATATTGTTGCTTCTCAACCCACT
GTATCTTACAGAGAAACAATAGCTGAAAAGAGCTCTTAAACTTGCCTAGCTAAGACTGAA
AATAAGCTTAATCATCTGTATGGTACTTGCGAACCACTTGATGAAGAATTAGGATCAGCA
ATAGTGAGCAAAAAAATAAATATTAAAGACATTAACAACTAAAAAATGATTAACAGTTTG
GTGAATGATTATTCTTGGGAAAGAGAAGATGCAAAGCGTATATGGTGCTTCGGTCCTCTA
GAAAAGGAGTCCACTAATTGCATCGTAAACCAAACAGTTGGTATATAAGGTATGCCTGCA
ATTCAGCCTTCTATAATAACCGCCTTCGAATGGTGTACTAAGGAAGGTCTTTTGTGTGAT
GAGCCTCTTAGAAATATTCGCTTTAACATAATGGATGTAATAATACACGATGAACCTGCT
CATCACAGAAGCAATCAAATAACCCCAGCAGCTAGAAGGCTATTTAAGGCTTGCTAATAT
GTGAGTGAACCTAAAATTTTGGAACCATTTTATTTATGCAACATTAAAACTCCAGATGAA
AGGAAAGGACCTATATATGCATTCCTCAATAAATTCCTAGATAAGAGAAGAGGTTTAGTT
TTAGGAGAAGAATATGATGATATATTTACCGTGATTCAAGCCTACATCCCTGTATCTGAA
AGCTTTGGATTCGACCAAGCTATAAAGTCAGTCTCCTAAGGTATGGCAATGCCAGCTCTC
TCATTCAGTCACTGGCAAGCAGTCTAGGGTAATCCACTCGACCCAGAATCAGAATCAGGT
AAGATTGTTAATGAAATAAGAATAAGAAAAGGTTTGAATGCTAAAATACCAGAACTCAAC
TATTATCTTGATAAACTTTGA