Identifiers and Description

Gene Model Identifier

TTHERM_00312120

Standard Name

DTS1 (Dihydrofolate reductase-Thymidylate Synthase 1)

Aliases

PreTt03400 | 30.m00209 | 3810.m01825

Description

Bifunctional dihydrofolate reductase-thymidylate synthase

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• thymidylate synthase activity (IEA) | GO:0004799
• dihydrofolate reductase activity (IEA) | GO:0004146

Biological Process

• nucleotide biosynthetic process (IEA) | GO:0009165
• glycine biosynthetic process (IEA) | GO:0006545
• dTMP biosynthetic process (IEA) | GO:0006231

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.1%

TetraMine Data

TTHERM_00312120

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_03227.1	9.997093137033517e-262	bifunctional dihydrofolate red uctase-thymidylate synthase (4 86 aa)
Oxytricha	Contig20294.0.g9	6.000727524697947e-169	Thymidylate synthase
WormBase	WBGene00022455	9.998919090800975e-129	Thymidylate synthase status: Confirmed UniProt:Q9N588 p rotein_id:CCD66193.1
SGD	YOR074C	2.9990837046884738e-127	CDC21 Thymidylate synthase, re quired for de novo biosynthesi s of pyrimidine deoxyribonucle otides; expression is induced at G1/S
Stentor Coeruleus	SteCoe_17804	3.665820411179563e-77

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00312120(coding)
ATGAAAACAAGACATTTTGATATAGTTTTAGCTTAGACTTTAAAAAAATAGGGTATAGGT
TATAAGAACAGTTTACCATGGAGACTACCTAATGAGCTTAAAAACTTTAAAAAAATAACT
ACAGAAACTAAGAACAAAGGCCTATAAAACGCTGTTATCATGGGTAAAAATACTTGGGAA
GCACTACCTAAAAAGCAATAACCATTGAAAGATCGCTTAAATATTGTTATTTCCACTACT
ATGCAAGAGGGGTAAATTGCAGATCATTCCTACGCCTGTAAAAGCTTAGATTCTGCTTTA
AACTTTTTAGAATAGTAAAATTAAATATAAGATGCCCTTGTAATTGGAGGAGCTAAACTT
TGCCAATAAGCATTAAGCGATCAGAGACTTAGATAGATTCATCTAACAAGAGTAGGTGTC
GAAGTTGAGTGCGATGTTTTTATGCAAAAGGACTACTTAAAAAACTTTGATATGATTGAG
GTGTCTGAAACTTAAAGCGAAAATAATTTAAATTATGATTTTACTAGGTATTTTAATAAG
AATTATAAAGGATAAGTTGACCCTTCTCTCTTTAAGAAAATGTACAAGCCTCATCAAGAA
TATTAATACTTAGAACTTATCGATGAAATTATAAAGAATGGACATGTTAAAACAGACAGA
ACTGGAACTGGTACAATTTCTCAGTTTGGCAAGTTGATGAGATTTGACTTATCAAAGAGT
TTTCCTCTGCTTACTACCAAAAATGTTTTTTGGAGAGGTGTAGTAGAAGAACTTATTTGG
TTTATCAAAGGCAGTACAAACAGCAAAATACTTTCAGAAAAAGGAGTTAAAATATGGGAC
GGTAATGGCAGCAGAGAATTTTTAGATTAATTAGGCTTTAAAAACAGAGAAGAAGGAGAT
TTAGGTCCTGTTTATGGTTTCTAATGGAGACACTTCGGTGCTGAATATAAAGATATGCAT
ACAAATTATAAAGGTAAAGGTGTCGACCAGCTTCAAGATTTAATTAACACAATAAAGAAA
AATCCTGACAGCAGAAGGATGATTATGAATGCCTGGAATGTTAAAGATCTACCATTGATG
GCTTTACCTCCTTGTCATGTCATGAGCTAGTTTTATGTAAATGATAATAAACTAAGCTGT
ATGATGTACTAAAGATCTTGTGATATGGGTTTAGGAATACCATTTAATATAGCCAGTTAT
GCTTTATTGACTCATATGATAGCTTAAGTCACTAATATGTAAGTTGGAGAGTTTATACAT
GTTCTAGGTGATGCTCATGTTTACTCTAATCACGTAGATTAACTAAAAATTTAATTAGAA
AGAGCTCCATACCCCTTCCCTCTTTTAAAAATTAATAACAACAAGTAATATAACTCTATT
GAAGACTTCACTCTTGAAGATTTCGAATTAATTGGATACAACTATCACCCTAAAATATAA
ATGAAAATGGCTGTCTGA

>TTHERM_00312120(protein)
MKTRHFDIVLAQTLKKQGIGYKNSLPWRLPNELKNFKKITTETKNKGLQNAVIMGKNTWE
ALPKKQQPLKDRLNIVISTTMQEGQIADHSYACKSLDSALNFLEQQNQIQDALVIGGAKL
CQQALSDQRLRQIHLTRVGVEVECDVFMQKDYLKNFDMIEVSETQSENNLNYDFTRYFNK
NYKGQVDPSLFKKMYKPHQEYQYLELIDEIIKNGHVKTDRTGTGTISQFGKLMRFDLSKS
FPLLTTKNVFWRGVVEELIWFIKGSTNSKILSEKGVKIWDGNGSREFLDQLGFKNREEGD
LGPVYGFQWRHFGAEYKDMHTNYKGKGVDQLQDLINTIKKNPDSRRMIMNAWNVKDLPLM
ALPPCHVMSQFYVNDNKLSCMMYQRSCDMGLGIPFNIASYALLTHMIAQVTNMQVGEFIH
VLGDAHVYSNHVDQLKIQLERAPYPFPLLKINNNKQYNSIEDFTLEDFELIGYNYHPKIQ
MKMAV

>TTHERM_00312120(gene)
ATGAAAACAAGACATTTTGATATAGTTTTAGCTTAGACTTTAAAAAAATAGGGTATAGGT
TATAAGAACAGTTTACCATGGAGACTACCTAATGAGCTTAAAAACTTTAAAAAAATAACT
ACAGAAACTAAGAACAAAGGCCTATAAAACGCTGTTATCATGGGTAAAAATACTTGGGAA
GCACTACCTAAAAAGCAATAACCATTGAAAGATCGCTTAAATATTGTTATTTCCACTACT
ATGCAAGAGGGGTAAATTGCAGATCATTCCTACGCCTGTAAAAGCTTAGATTCTGCTTTA
AACTTTTTAGAATAGTAAAATTAAATATAAGATGCCCTTGTAATTGGAGGAGCTAAACTT
TGCCAATAAGCATTAAGCGATCAGAGACTTAGATAGATTCATCTAACAAGAGTAGGTCAG
TAGAATTAAATTTATTAAATACTTTCTTTTTATGAACAAAAGAGATAATTAAATAACTTT
TCAAAAATATTTAGGTGTCGAAGTTGAGTGCGATGTTTTTATGCAAAAGGACTACTTAAA
AAACTTTGATATGATTGAGGTGTCTGAAACTTAAAGCGAAAATAATTTAAATTATGATTT
TACTAGGTATTTTAATAAGAATTATAAAGGATAAGTTGACCCTTCTCTCTTTAAGAAAAT
GTACAAGCCTCATCAAGAATATTAATACTTAGAACTTATCGATGAAATTATAAAGAATGG
ACATGTTAAAACAGACAGAACTGGAACTGGTACAATTTCTCAGTTTGGCAAGTTGATGAG
ATTTGACTTATCAAAGAGTTTTCCTCTGCTTACTACCAAAAATGTTTTTTGGAGAGGTGT
AGTAGAAGTAATAAATATATTTATTTATTTATTAATTTATAGTTTGATAGATTTAAAAAT
GAAATTTAGTCTGATTTTTAGTAGAATAAATAAAATAATCTAAATATATAAATTAATAGG
AACTTATTTGGTTTATCAAAGGCAGTACAAACAGCAAAATACTTTCAGAAAAAGGAGTTA
AAATATGGGACGGTAATGGCAGCAGAGAATTTTTAGATTAATTAGGCTTTAAAAACAGAG
AAGAAGGAGATTTAGGTCCTGTTTATGGTTTCTAATGGAGACACTTCGGTGCTGAATATA
AAGATATGCATACAAATTATAAAGGTAAAGGTGTCGACCAGCTTCAAGATTTAATTAACA
CAATAAAGAAAAATCCTGACAGCAGAAGGATGATTATGAATGCCTGGAATGTTAAAGATC
TACCATTGATGGCTTTACCTCCTTGTCATGTCATGAGCTAGTTTTATGTAAATGATAATA
AACTAAGCTGTATGATGTACTAAAGATCTTGTGATATGGGTTTAGGAATACCATTTAATA
TAGCCAGTTATGCTTTATTGACTCATATGATAGCTTAAGTCACTAATATGTAAGTTGGAG
AGTTTATACATGTTCTAGGTGATGCTCATGTTTACTCTAATCACGTAGATTAACTAAAAA
TTTAATTAGAAAGAGCTCCATACCCCTTCCCTCTTTTAAAAATTAATAACAACAAGTAAT
ATAACTCTATTGAAGACTTCACTCTTGAAGATTTCGAATTAATTGGATACAACTATCACC
CTAAAATATAAATGAAAATGGCTGTCTGA