Identifiers and Description

Gene Model Identifier

TTHERM_00486790

Standard Name

DRP1 (Dynamin Related Protein 1)

Aliases

PreTt19610 | 59.m00248 | 3680.m00105

Description

DRP1 dynamin central region family protein; Dynamin-related protein (DRP); localized to endocytic sites; essential for growth; DRP1 expression required for clathrin-mediated endocytosis; one of 8 DRP genes in Tetrahymena

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• ciliary basal body (IDA) | GO:0036064 | Ref:16276403
• clathrin-coated pit (IDA) | GO:0005905 | Ref:16276403

Molecular Function

• GTP binding (IEA) | GO:0005525
• GTPase activity (IEA) | GO:0003924

Biological Process

• clathrin-dependent endocytosis (IMP) | GO:0072583 | Ref:16276403

Domains

• ( PF03789 ) ELK domain
• ( PF00350 ) Dynamin family
• ( PF01031 ) Dynamin central region
• ( PF01926 ) GTPase of unknown function
• ( PF02212 ) Dynamin GTPase effector domain
• ( PF08256 ) Aurein-like antibiotic peptide

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.3%

TetraMine Data

TTHERM_00486790

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Stentor Coeruleus	SteCoe_5951	0
Tetrahymena borealis	EI9_12179.1	9.997093137033517e-262	dynamin central region family protein (643 aa)
Oxytricha	Contig22482.0.g88	9.997093137033517e-262	Dynamin central region
SGD	YKR001C	9.999242092827953e-100	VPS1 Dynamin-like GTPase requi red for vacuolar sorting; also involved in actin cytoskeleto n organization, endocytosis, l ate Golgi-retention of some pr oteins, regulation of peroxiso me biogenesis
DictyBase	DDB_G0277849	3.9985196551577655e-99	dymA on chromosome: 3 position 252381 to 255025
WormBase	WBGene00001093	7.998415523157811e-91	locus:drp-1 status:Confirmed UniProt:Q8WQC9 protein_id :CCD70526.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16276403: Elde NC, Morgan G, Winey M, Sperling L, Turkewitz AP (2005) Elucidation of clathrin-mediated endocytosis in tetrahymena reveals an evolutionarily convergent recruitment of dynamin. PLoS genetics 1(5):e52

Sequences

>TTHERM_00486790(coding)
ATGGCTGAGCAAGAAAGTTCATTTTAGGGATCAGGTCTTTTTGATAACCTTAGAAAGTTA
ATTAACGTCATCGATGAATTAAGAGATGTCGGTTTACAACAATATATTAGATTGCCTAGA
ATCGCAGTTATTGGTTCTTAATCATCTGGTAAATCATCTCTTCTCGAAAGTATCGTTGGT
ATCGATTTCTTGCCAAGAGGTTCTGGTGTAGTTACTCGTAGACCTTTAGAACTCAGATTA
GTTCATGTGCCTCCCAATGAAAGATAAATCAAGCCATATGCTATTTTCGATGTTGATAAA
TCAAAGAAGTGGGAAAACTTTGATTAGGTTAGATAACAAATCGATTTCTTAACTGACCAA
GTTGCAGGTAAGAGAAAGAAAATTATCAATGACCCTATCGTATTGACTATTTACTCAAAT
GATGTTATCGATTTGACAATTATTGATTTGCCTGGTATTACAAGAATTCCCTTAAAAGAT
TCAGACCAATAAGAAGATATCGAAAAAGTTACTAAAGATATGGCTTACTCATACATAAAA
GATGAAAGAACAATTATTTTGTGTGTTGTTCCTGGTAACTAGGATATTTCTAACTCCGAT
GGTCTCTAATTAGCTAGAGAAGTAGACAGAGAAGGCAATAGAACAATTGGTGTTGTTACA
AAACTTGATATCATGGATGCTGATACTGATGCAAGAAAAATGATCATGGGTCTTGAAATT
CCTTTGAAATTAGGATATGTTGGTGTCAAGGGTAGATCTCAAAAGGATATTAATGACAAT
AAGAGAGTTTCTAAAGCTCTTGACGAAGAAAGACTTTTCTTTGCTTAGCATAAAGTATAC
TCAACTATGGATCCTAAGTTCTTAGGTACTAAAGCTTTGACTAATAAGTTATCAAGTGTG
CTTTTCTATCACATTAGAAATATTTTACCTGCTATCGTCAAGGAAATTAAAGATAAATTG
AAAGAATGTGAAGATAGACTTAAAGACTTGGGTCCCTCTCTTCCAAGAGAACAAAAAGAT
AAAATGCAACTTATCTGGACCATGATTACTGATTTTACTGAAAACTTTAAAAATACAATT
AAGGGTAAATACGATCAAAGACGTTCTAATATTAATACAGAATTATCTGGTGGTGCAGTT
ATTAAGATGATGTTCAATGAGCTTTATGAAGATTTCATTTAAAAAACCTTTAGAGCAACT
AGAGAATATAGCGATAAAGATATTTAAACAGCTATTTAATTGCATTAAGGTGATTCTATT
CCAGGTTTCCCCTCAATAGATGCTTTCTTATATTTAATTAATCCTCAATTAGAAAAGCTA
AAAGACCCTGCCTTTGAATGCTTAACTTAATGCTACAATTATTTGGAAGGTTTAGCTAAT
AAGATTTTGAAGAAAATATTCTCAAGATTCCCCACTGTTATGGACGAAATTGCAGATATT
ACAAGCAGAGTGCTTCAAGCTTAAAGAGATTAAGCAAAAGAAGTTGTTAACAATATTATT
GAATCTGAATAAGGTTACCTTTTCACTAATGATTTAGGCTATCTTGCTCACAGAACTCAT
TTGATTCCAGCTCAAGAATCTGGTAAAGAAGGTTAACAATAGATAGATGCTGAAAAAGCT
TTTATTAATGAATTGAGATCTAGAGTAGACGTTTACTTCAATATCGTTGTCAGAAATGTA
AGAGACTCTATTCCTAAGGCTATTGGTTTCTTCTTAGTTAAGGCTGCTTAAGAATAATTG
TAATATTAATTATATAATGAAATTATGAGAAGTGAAGATTCTCTTGGTAGCATTGCAGAA
CCTGCCAACATCGCAGAAGAAAGAGATACACTCAATAAAACTATCGAAGTTCTTCAAAAG
GCTCATAGAGTTATTAAGAGAGATCCTGATCTTCAACCCAGATATGATGGATAGAATCCT
TAAAAGCAAGTTGTTTGA

>TTHERM_00486790(protein)
MAEQESSFQGSGLFDNLRKLINVIDELRDVGLQQYIRLPRIAVIGSQSSGKSSLLESIVG
IDFLPRGSGVVTRRPLELRLVHVPPNERQIKPYAIFDVDKSKKWENFDQVRQQIDFLTDQ
VAGKRKKIINDPIVLTIYSNDVIDLTIIDLPGITRIPLKDSDQQEDIEKVTKDMAYSYIK
DERTIILCVVPGNQDISNSDGLQLAREVDREGNRTIGVVTKLDIMDADTDARKMIMGLEI
PLKLGYVGVKGRSQKDINDNKRVSKALDEERLFFAQHKVYSTMDPKFLGTKALTNKLSSV
LFYHIRNILPAIVKEIKDKLKECEDRLKDLGPSLPREQKDKMQLIWTMITDFTENFKNTI
KGKYDQRRSNINTELSGGAVIKMMFNELYEDFIQKTFRATREYSDKDIQTAIQLHQGDSI
PGFPSIDAFLYLINPQLEKLKDPAFECLTQCYNYLEGLANKILKKIFSRFPTVMDEIADI
TSRVLQAQRDQAKEVVNNIIESEQGYLFTNDLGYLAHRTHLIPAQESGKEGQQQIDAEKA
FINELRSRVDVYFNIVVRNVRDSIPKAIGFFLVKAAQEQLQYQLYNEIMRSEDSLGSIAE
PANIAEERDTLNKTIEVLQKAHRVIKRDPDLQPRYDGQNPQKQVV

>TTHERM_00486790(gene)
ATGGCTGAGCAAGAAAGTTCATTTTAGGGATCAGGTCTTTTTGATAACCTTAGAAAGTTA
ATTAACGTCATCGATGAATTAAGAGATGTCGGTTTACAACAATATATTAGATTGCCTAGA
ATCGCAGTTATTGGTTCTTAATCATCTGGTAAATCATCTCTTCTCGAAAGTATCGTTGGT
ATCGATTTCTTGCCAAGAGGTTCTGTAAGCTTTAAAATTAAAATACTCTTAATAAGTTAT
TTAAATTTAATCTACCTATAACAAAATAGGGTGTAGTTACTCGTAGACCTTTAGAACTCA
GATTAGTTCATGTGCCTCCCAGTAATAAAAAAGCATTTTTGTTTTTACATATTTTTATGA
ATATTTGAAAACAGTGAACATAAAACAATCTTTTTCTAACTTAAATGAAAAAAAATTTAC
TGATTAGATAGAATTTGATTGCGCTAGAATAGAATATCAAAATAAATTGAATCTAAAATA
TGAAACATTTTATTAATTTCAAACTATAAAAATTAGATGAAAGATAAATCAAGCCATATG
CTATTTTCGATGTTGATAAATCAAAGAAGTGGGAAAACTTTGATTAGGTTAGATAACAAA
TCGATTTCTTAACTGACCAAGTTGCAGGTAAGAGAAAGAAAATTATCAATGACCCTATCG
TATTGACTATTTACTCAAATGATGTTATCGATTTGACAATTATTGATTTGCCTGGTATTA
CAAGAATTCCCTTAAAAGATTCAGACCAATAAGAAGATATCGAAAAAGTTACTAAAGATA
TGGCTTACTCGTAACTTATTTTTTATATAATTACAAATGTTTTAATAGTAAATTATAGCC
AAAAGCTTCCATCAAAGCAACCTTCTTTGAAAAAAATTAAAGGAGTTTTTTAACTTAAGT
TATGAGGCGATTTTGTTAAAATTATCCAAATTAAAAGCAATACATCAATAAAAAATACTT
AATCATGCACACATTTTAAACAAAAATTATTATAAAAATAGATACATAAAAGATGAAAGA
ACAATTATTTTGTGTGTTGTTCCTGGTAACTAGGATATTTCTAACTCCGATGGTCTCTAA
TTAGCTAGAGAAGTAGACAGAGAAGGCAATAGAACAATTGGTGTTGTTACAAAAGTATGC
AGCATTTATTTCTTAAATATAAAAAATAAATAAATATTTTAGAGGCTATTTATTCTAAAT
TTGCTTTATTTAATTAAAAAAGCTTGATATCATGGATGCTGATACTGATGCAAGAAAAAT
GATCATGGGTCTTGAAATTCCTTTGAAATTAGGATATGTTGGTGTCAAGGGTAGATCTCA
AAAGGATATTAATGACAATAAGAGAGTTTCTAAAGCTCTTGACGAAGAAAGACTTTTCTT
TGCTTAGCATAAAGTATACTCAACTATGGATCCTAAGTTCTTAGGTACTAAAGCTTTGAC
TAATAAGTTATCAAGTGTGCTTTTCTATCACATTAGAAATATTTTACCTGCTATCGTCAA
GGAAATTAAAGATAAATTGAAAGAATGTGAAGATAGACTTAAAGACTTGGGTCCCTCTCT
TCCAAGAGAACAAAAAGATAAAATGCAACTTATCTGGACCATGATTACTGATTTTACTGA
AAACTTTAAAAATACAATTAAGGGTAAATACGATCAAAGACGTTCTAATATTAATACAGA
ATTATCTGGTGGTGCAGTTATTAAGATGATGGTAAATAAATTTACCTTATCATTAATTAT
TAATCATACATTTTTATATAATTAATTAAATAGTTCAATGAGCTTTATGAAGATTTCATT
TAAAAAACCTTTAGAGCAACTAGAGAATATAGCGATAAAGATATTTAAACAGCTATTTAA
TTGCATTAAGGTGATTCTATTCCAGGTTTCCCCTCAATAGATGCTTTCTTATATTTAATT
AATCCTCAATTAGAAAAGCTAAAAGACCCTGCCTTTGAATGCTTAACTTAATGCTACAAT
TATTTGGAAGGTTTAGCTAATAAGATTTTGAAGAAAATATTCTCAAGATTCCCCACTGTT
ATGGACGAAATTGCAGATATTACAAGCAGAGTGCTTCAAGCTGTAAATTTACTTTAATTT
TTATTTAAAAAGATATTTAGCTCAATATTTAAAATTAAAATAGTAAAGAGATTAAGCAAA
AGAAGTTGTTAACAATATTATTGAATCTGAATAAGGTTACCTTTTCACTAATGATTTAGG
CTATCTTGCTCACAGAACTCATTTGATTCCAGTATATTTTAATATTCTCAAACTTTTTAT
AAATAATTTTAATTAAAAAAAAAGGCTCAAGAATCTGGTAAAGAAGGTTAACAATAGATA
GATGCTGAAAAAGCTTTTATTAATGAATTGAGATCTAGAGTAGACGTTTACTTCAATATC
GTTGTCAGAAATGTAAGAGACTCTATTCCTAAGGCTATTGGTTTCTTCTTAGTTAAGGCT
GCTTAAGAATAATTGTAATATTAATTATATAATGAAATTATGAGAAGTGAAGATTCTCTT
GGTAGCATTGCAGAAGTATGTTTTTTTTTTCAAATAGTTAAAACCAAATTTAATCTTATT
TTTTTCTTCAATCTAGCCTGCCAACATCGCAGAAGAAAGAGATACACTCAATAAAACTAT
CGAAGTTCTTCAAAAGGCTCATAGAGTTATTAAGAGAGATCCTGAGTAATTTTATTTCAA
AAATGTAATTGTTTAAATAAATATTTTTTTTTAAATAGTCTTCAACCCAGATATGATGGA
TAGAATCCTTAAAAGCAAGTTGTTTGA