Identifiers and Description

Gene Model Identifier

TTHERM_00459230

Standard Name

DMC1 (Disrupted Meiotic CDNA 1)

Aliases

PreTt20354 | 53.m00256 | 3712.m00114

Description

Meiosis-specific RecA; homolog of S. cerevisiae DMC1

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• micronucleus (IDA) | GO:0031040 | Ref:21483758

Biological Process

• meiotic nuclear division (IMP) | GO:0007126 | Ref:21483758
• double-strand break repair (IMP) | GO:0006302 | Ref:21483758

Domains

• ( PF08423 ) Rad51
• ( PF00154 ) recA protein
• ( TIGR02238 ) meiotic recombinase Dmc1
• ( TIGR02239 ) DNA repair protein RAD51
• ( TIGR02236 ) DNA repair and recombination protein
• ( TIGR02237 ) DNA repair and recombination protein

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.6%

TetraMine Data

TTHERM_00459230

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_13810.1	5.999773492405769e-126	hypothetical protein (252 aa)
Oxytricha	Contig4225.0.0.g49	7.000620174165717e-94	Rad51
DictyBase	DDB_G0273611	8.003693242657371e-87	rad51-2 on chromosome: 2 posit ion 3169189 to 3170422
SGD	YER179W	9.99562814099401e-84	DMC1 Meiosis-specific protein required for repair of double- strand breaks and pairing betw een homologous chromosomes; ho molog of Rad51p and the bacter ial RecA protein
WormBase	WBGene00004297	1.0002223712504345e-79	locus:rad-51 status:Confirme d UniProt:G5EGG8 protein_i d:CAE47473.1
Stentor Coeruleus	SteCoe_17466	7.47197233734299e-43

General Information

No Data fetched for General Information

Associated Literature

1. Ref:21483758: Howard-Till RA, Lukaszewicz A, Loidl J (2011) The recombinases Rad51 and Dmc1 play distinct roles in DNA break repair and recombination partner choice in the meiosis of Tetrahymena. PLoS genetics 7(3):e1001359
2. Ref:SUPR000124

Sequences

>TTHERM_00459230(coding)
ATGAACGATTGTTACTCTGATAAAGAAGATAATGAAGAATAAAACTAAATTGCTCAAGAA
GAGATCTTTTTAGTAGAAATGCTTGCAACTGAGGGAGTTAACAATAATGAAATACAAAAG
CTTAAAAAGAATGGAATCCTTTCACTCAAATCTTTAGTTATGAACACAAAGAGGGATCTT
GTTAATATCTATGGAATTCCTGATAATAAAGCTGATTCATATGTCAAAAAAGCTTCAGAA
ATATTAGCTCGATCTGAAAACAGCAGGTTATTCAGCAGTGAGTTTGTTCTCGGTACTACT
GTACTATAAAGAAGGAGTTAAATAAGAAGAATATCAACAGGATCCAAGGCTTTAGATGAT
ATATTGAATGGGGGAATAGAGTCTCAAAGCATAACAGAATTTTATGGAGAATATCGTTCA
GGCAAAACATAAATAGCTCATACTGCATGCGTTCTGGCTCAATCTTAAGATCATTGCTAA
AGTCCAGGAAAAGTTTTATACATTGATACTGAAGGAACCTTCAGACCTGAAAGAATATGC
TAAATAGCTTCGCACTACGGAATGGAGGGTGAATATGCCCTAAGTAATATAATTTATGGG
AGAGCCTATAACGTAGATTAATAAAACACATTGCTTATTAAAGGAGCCCAATTAATGGTA
GAGGAAAATTGTTTTGCTCTACTAGTTGTTGATTCAATAATGGCTAATTTTAGATGCGAT
TTTTCTGGAAGAGGAGATCTCTCTGAAAGACAATAAGCACTTGGCAAGTTTATGAGCAGA
TTATAAAGAATGGCTGCTGAATTTAATATCGCAGTGATTATAACAAACTAAGTTATGGCT
GATCCAAGTGGAGCCATGACTGGAGGCGCTATACCCTAGCCCAAGCCAATTGGAGGCCAT
ATTTTAGCCCATGCATCGACATAGCGCTTATTCATGAAGAAGAAAACTGATAACATCCGT
AAAGTAAAGCTGGTTGATTCACCTTATTTGTAAGATAAAGAAGTTGATATTATGGTTAGC
GACAGAGGAGTAGGAGATGTTGAATGTGATAAAAAGCCTTCTACTGGTTGA

>TTHERM_00459230(protein)
MNDCYSDKEDNEEQNQIAQEEIFLVEMLATEGVNNNEIQKLKKNGILSLKSLVMNTKRDL
VNIYGIPDNKADSYVKKASEILARSENSRLFSSEFVLGTTVLQRRSQIRRISTGSKALDD
ILNGGIESQSITEFYGEYRSGKTQIAHTACVLAQSQDHCQSPGKVLYIDTEGTFRPERIC
QIASHYGMEGEYALSNIIYGRAYNVDQQNTLLIKGAQLMVEENCFALLVVDSIMANFRCD
FSGRGDLSERQQALGKFMSRLQRMAAEFNIAVIITNQVMADPSGAMTGGAIPQPKPIGGH
ILAHASTQRLFMKKKTDNIRKVKLVDSPYLQDKEVDIMVSDRGVGDVECDKKPSTG

>TTHERM_00459230(gene)
ATGAACGATTGTTACTCTGATAAAGAAGATAATGAAGAATAAAACTAAATTGCTCAAGAA
GAGATCTTTTTAGTAGAAATGCTTGCAACTGAGGGAGTTAACAATAATGAAATACAAAAG
CTTAAAAAGGTATGTAGTTGTTATATTAATTCACAATAAGACAATATCATTGATTATATA
AAAATAAATATAAAGAATGGAATCCTTTCACTCAAATCTTTAGTTATGAACACAAAGAGG
GATCTTGTTAATATCTATGGAATTCCTGATAATAAAGCTGATTCATATGTCAAAAAAGCT
TCAGAAATATTAGCTCGATCTGAAAACAGCAGGTTATTCAGCAGTGAGTTTGTTCTCGGT
ACTACTGTACTATAAAGAAGGAGTTAAATAAGAAGAATATCAACAGGATCCAAGGCTTTA
GATGATATATTGAATGGGGGAATAGAGTCTCAAAGCATAACAGAATTTTATGGAGAATAT
CGTTCAGGCAAAACATAAATAGCTCATACTGCATGCGTTCTGGCTCAATCTTAAGATCAT
TGCTAAAGTAAAACAAGCATAAGAAATTTTAACTGGTTTTAAATAAATTATTCTGCTTAA
ATATAGCCATTTAAATAAAAAAATAGGTCCAGGAAAAGTTTTATACATTGATACTGAAGG
AACCTTCAGACCTGAAAGAATATGCTAAATAGCTTCGCACTACGGAATGGAGGGTGAATA
TGCCCTAAGTAATATAATTTATGGGAGAGCCTATAACGTAGATTAATAAAACACATTGCT
TATTAAAGGAGCCCAATTAATGGTAGAGGAAAATTGTTTTGCTCTACTAGTTGTTGATTC
AATAATGGCTAATTTTAGATGCGATTTTTCTGGAAGAGGAGATCTCTCTGAAAGACAATA
AGCACTTGGCAAGTTTATGAGCAGATTATAAAGAATGGCTGCTGAATTTAATATCGCAGT
GGTAAATAAATACATTCTTTATTTTATCAACACCTTTCTGCTTTTATACGATTCTTATTC
TTAAAATTAACAAACAGATTATAACAAACTAAGTTATGGCTGATCCAAGTGGAGCCATGA
CTGGAGGCGCTATACCCTAGCCCAAGCCAATTGGAGGCCATATTTTAGCCCATGCATCGA
CATAGCGCTTATTCATGAAGAAGAAAACTGATAACATCCGTAAAGTAAAGTAAAACAAAA
CAAAACTTCTTAAATCACAAATAAAAAATTTTTCTTTCACTTAATTAAAGGCTGGTTGAT
TCACCTTATTTGTAAGATAAAGAAGTTGATATTATGGTTAGCGACAGAGGAGTAGGAGAT
GTTGAATGTGATAAAAAGCCTTCTACTGGTTGA