Identifiers and Description

Gene Model Identifier

TTHERM_00438800

Standard Name

DES24 (C-24 Sterol DeEthylase)

Aliases

PreTt05437 | 49.m00209 | 3708.m00058

Description

Sterol deethylase; catalyzes the removal of a C-24 ethyl group from C29 sterols

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• endoplasmic reticulum (IEA) | GO:0005783

Molecular Function

• oxidoreductase activity (IEA) | GO:0016491
• iron ion binding (IEA) | GO:0005506
• sterol binding (IMP) | GO:0032934 | Ref:21257793

Biological Process

• oxidation-reduction process (IEA) | GO:0055114
• fatty acid biosynthetic process (IEA) | GO:0006633

Domains

• ( PF01598 ) Sterol desaturase
• ( PF01506 ) hepatitis C virus non-structural 5a

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 15.8%

TetraMine Data

TTHERM_00438800

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_12442.1	9.997093137033517e-262	hypothetical protein (287 aa)
Oxytricha	Contig18492.0.g71	0.00000000030007160092483236	Fatty acid hydroxylase superfa mily
SGD	YGR060W	0.00000000039982266684865623	ERG25 C-4 methyl sterol oxidas e, catalyzes the first of thre e steps required to remove two C-4 methyl groups from an int ermediate in ergosterol biosyn thesis; mutants accumulate the sterol intermediate 4,4-dimet hylzymosterol
DictyBase	DDB_G0269788	0.000000030002053728821195	DDB_G0269788 on chromosome: 1 position 3558146 to 3559074
Stentor Coeruleus	SteCoe_22752	0.00001670170079024566

General Information

No Data fetched for General Information

Associated Literature

1. Ref:21257793: Tomazic ML, Najle SR, Nusblat AD, Uttaro AD, Nudel CB (2011) A novel sterol desaturase-like protein promoting dealkylation of phytosterols in Tetrahymena thermophila. Eukaryotic cell 10(3):423-34

Sequences

>TTHERM_00438800(coding)
ATGGGTTTTGTTATAACACCAAAAGTAGGTTTTATAATTGATCAATCTATAGTCTTTGGA
GGTTTCGCCTTAGGCTTAATATCTAAAAATCCTTTATAATGGTATGAAGTTTTCTTTAAA
CTCTATATAGGTCTCAACCTTGTGCTTATGCCATTTGCTGGATTAGTGACATTATTCTGT
AAAATATTTGGTAAGCGTATATAAGATCCTCCAAAACCCACTCAATATTTAAAAGAAATT
TTTGAAACTACTCGCTGCTATTGGGTAGTCTCTCTTTTGGCAGCATGGCCTGTCTAAAGA
TATCTTAATGGTGAATTGACAGCTTATACCATGGATTTAAAAGAGAGTTTTGTAGGAGAC
TCTATCATTTTAAACACTCTGTTTATGGTATTTTTCTTCTTATTAGTTGACTTCCACACT
TATTGGAAACATCGCCTTTTACATACTCGTACATTCTGGTATTTCCACAGAAATCACCAC
TCTTTCTTTGATCCTTCATGCTTTGCTTCTTTTGGAGTATCACCATTTGAATCTGTCCTT
ACTTTTGGTCCCTTATTATTTGATTAACTCGAAATAGCCAATCAATTTAAGCTCTGCACA
TGGCTTCATGGAAGTGTTATCCTTTTCTTTATAGTTTTAAATATTTACCTTCACTGTGGA
TACACATTTGACTTCATAGAAAATACTCTTCCAAAACTATTCATCAACACATCGGCCCAC
CATAACCTCCATCACTCAAAAACTAAAATTCACTTCAGTGAACTTTTGACTCTTTGGGAT
TACCTTATGAACACTGGAGCCACATTTTACAACAAACAAGAATTTTAATAAAAATTAGAA
AAAGAAAAATCTTGA

>TTHERM_00438800(protein)
MGFVITPKVGFIIDQSIVFGGFALGLISKNPLQWYEVFFKLYIGLNLVLMPFAGLVTLFC
KIFGKRIQDPPKPTQYLKEIFETTRCYWVVSLLAAWPVQRYLNGELTAYTMDLKESFVGD
SIILNTLFMVFFFLLVDFHTYWKHRLLHTRTFWYFHRNHHSFFDPSCFASFGVSPFESVL
TFGPLLFDQLEIANQFKLCTWLHGSVILFFIVLNIYLHCGYTFDFIENTLPKLFINTSAH
HNLHHSKTKIHFSELLTLWDYLMNTGATFYNKQEFQQKLEKEKS

>TTHERM_00438800(gene)
ATGGGTTTTGTTATAACACCAAAAGTAGGTTTTATAATTGATCAATCTATAGTCTTTGGA
GGTTTCGCCTTAGGCTTAATATCTAAAAATCCTTTATAATGGTATGAAGTTTTCTTTAAA
CTCTATATAGGTCTCAACCTTGTGCTTATGCCATTTGCTGGATTAGTGACATTATTCTGT
AAAATATTTGGTAAGCGTATATAAGATCCTCCAAAACCCACTCAATATTTAAAAGAAATT
TTTGAAACTACTCGCTGCTATTGGGTAGTCTCTCTTTTGGCAGCATGGCCTGTCTAAAGA
TATCTTAATGGTGAATTGACAGCTTATACCATGGATTTAAAAGAGAGTTTTGTAGGAGAC
TCTATCATTTTAAACACTCTGTTTATGGTATTTTTCTTCTTATTAGTTGACTTCCACACT
TATTGGAAACATCGCCTTTTACATACTCGTACATTCTGGTATTTCCACAGAAATCACCAC
TCTTTCTTTGATCCTTCATGCTTTGCTTCTTTTGGAGTATCACCATTTGAATCTGTCCTT
ACTTTTGGTCCCTTATTATTTGATTAACTCGAAATAGCCAATCAATTTAAGCTCTGCACA
TGGCTTCATGGAAGTGTTATCCTTTTCTTTATAGTTTTAAATATTTACCTTCACTGTGGA
TACACATTTGACTTCATAGAAAATACTCTTCCAAAACTATTCATCAACACATCGGCCCAC
CATAACCTCCATCACTCAAAAACTAAAATTCACTTCAGTGAACTTTTGACTCTTTGGGAT
TACCTTATGAACACTGGAGCCACATTTTACAACAAACAAGAATTTTAATAAAAATTAGAA
AAAGAAAAATCTTGA