Identifiers and Description

Gene Model Identifier

TTHERM_00196590

Standard Name

CYC1 (CYClin 1)

Aliases

PreTt06844 | 16.m00500

Description

Cyclin; N-terminal domain containing protein; putative mitotic cyclin; similar to paramecium CYC1 and CYC2; involved in DNA replication and/or spindle assembly; expressed during conjugation

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• cellular_component (ND) | GO:0005575 | Ref:10568031

Molecular Function

• cyclin-dependent protein serine/threonine kinase regulator activity (ISS) | GO:0016538 | Ref:10568031
• protein binding (ISS) | GO:0005515 | Ref:10568031

Biological Process

• regulation of cyclin-dependent protein serine/threonine kinase activity (ISS) | GO:0000079 | Ref:10568031

Domains

• ( PF08613 ) Cyclin
• ( PF00134 ) cyclin, N-terminal domain
• ( PF02984 ) Cyclin, C-terminal domain
• ( PF04947 ) Poxvirus Late Transcription Factor VLTF3
• ( TIGR01215 ) cell division topological specificity factor
• ( PF05867 ) Caenorhabditis elegans repeat of unknown

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.2%

TetraMine Data

TTHERM_00196590

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_03829.1	9.997093137033517e-262	cyclin domain-containing prote in (435 aa)
Oxytricha	Contig19213.0.g10	1.999469658314961e-75	Cyclin, N-terminal domain
DictyBase	DDB_G0275493	4.000904604388404e-59	cycB on chromosome: 2 position 6000211 to 6001649
SGD	YPR119W	9.997441244797434e-45	CLB2 B-type cyclin involved in cell cycle progression; activ ates Cdc28p to promote the tra nsition from G2 to M phase; ac cumulates during G2 and M, the n targeted via a destruction b ox motif for ubiquitin-mediate d degradation by the proteasom e
WormBase	WBGene00000868	2.9986404383886433e-43	locus:cyb-3 G2/mitotic-speci fic cyclin-B3 status:Confirm ed UniProt:Q10654 protein_ id:CAB03311.2
Stentor Coeruleus	SteCoe_32735	3.6251409191435593e-34

General Information

No Data fetched for General Information

Associated Literature

1. Ref:27192402: Yan GX, Dang H, Tian M, Zhang J, Shodhan A, Ning YZ, Xiong J, Miao W (2016) Cyc17, a meiosis-specific cyclin, is essential for anaphase initiation and chromosome segregation in Tetrahymena thermophila. Cell cycle (Georgetown, Tex.) 15(14):1855-64
2. Ref:12736907: Kovács P, Pállinger E (2003) Effects of indomethacin on the divisional morphogenesis and cytoskeleton-dependent processes of Tetrahymena. Cell biochemistry and function 21(2):169-75
3. Ref:12183062: Zhang H, Huang X, Tang L, Zhang QJ, Frankel J, Berger JD (2002) A cyclin-dependent protein kinase homologue associated with the basal body domains in the ciliate Tetrahymena thermophila. Biochimica et biophysica acta 1591(1-3):119-128
4. Ref:11596915: Berger JD (2001) Riding the ciliate cell cycle--a thirty-five-year prospective. The Journal of eukaryotic microbiology 48(5):505-18
5. Ref:10568031: Zhang H, Adl SM, Berger JD (2000) Two distinct classes of mitotic cyclin homologues, Cyc1 and Cyc2, are involved in cell cycle regulation in the ciliate Paramecium tetraurelia. The Journal of eukaryotic microbiology 46(6):585-96
6. Ref:SUPR000103

Sequences

>TTHERM_00196590(coding)
ATGGCTTGCCTACAAATGAGAAATGGTGAATAATCCATGTTTGGAGACTCAAACAAATTA
TAAAGCAATCAACTTCGTGCTTTCGGGCGTGAGATTCAAAATATCCCTGACAGTCGCTTT
AATACAAGATCTTAATCAATAAAAGCAAACATGTAGCCTCACCACGCCTAAAAGCTTAGC
ATGGAATTAGATACAAATATAAATGAATAAGAGAACGGAATGAAAAGAAGTTCTCCTAGA
AAATTTTCAATGCATGTGAAGCATTCCTCCGAAGTTCCATAAAACCATTAAAAGAGAATG
TCAAGCTAAATTGACACTGTAAGCAATAATGGAACAGAGCGCTCATATTAAACCAATTAA
ACTGGCCTTTAAAATAAAAATATTGACATGAAAAATATAGAATTTGAATTGAATAGGATT
TCTAAGGAAGACTCTGAAAAACCAACTTTAGTTGCTTAATACTCAAAGCAAATATTCGAT
TATATGCGCTAAAGAGAGATTGCCTTCAAAGTCGGTGAATACATGGAAAAATAAACTTAA
ATCAATGACAGAATGAGAGCCATTTTGGTTGACTGGATTGTGGAAATACATAGAAAGTGT
AAATTGTTACCTGAAACTTTATTTATTACTGTCAATTTAATTGACCGCTTCTTGGATAGA
GCCACATGCACTAGAGATAATTTATAGCTTGTAGGTGTAACTGCTTTGTTCATAGCTTCT
AAATACGAAGAAATATATCCTCCTAATCTTAATGATTTTGTTGAAGCCACCTAGAAAGCT
TACAGAAAAAATGATGTTTTATAAATGGAAGGAAGCATTATTTGTGCCCTAAATTTCAAC
TTAACAGTTCCCACATCTCTCCGTTTCCTTGAAAGATACGGACGCGTTGATAAACTTGAT
AAAAAATCTTTTGACATGAGCTTATATATTCTTTAACTCTGCTTAGTCGAATATAAATTT
GTTAAATACTCAGAATCATTAAAAGCTTGCGCTGCTATCTATCTCACAAATAAGCTATTT
AAAAAGAATATTTGCTGGAGTGATGTCCTCACTGGTCACACTTAACATACCGAGCAATAA
ATTAGACCTTGTGCTCTCGAAATGTGCCTTTTACTTCAATCAGCATCAACTAACTAAACC
CAAGCCGTTCGCAGAAAATTCCTTAGTTCAGAGTATAGCGAAGTAGCAACCATACAAATT
GAAAAAATGAATCCTTCATAATAAAACACACAATAGCATTCATATTAAAATAATTAAAAT
TACCCTCCCAACATTCCTAAATACAACTACAGAGAATAATATTGA

>TTHERM_00196590(protein)
MACLQMRNGEQSMFGDSNKLQSNQLRAFGREIQNIPDSRFNTRSQSIKANMQPHHAQKLS
MELDTNINEQENGMKRSSPRKFSMHVKHSSEVPQNHQKRMSSQIDTVSNNGTERSYQTNQ
TGLQNKNIDMKNIEFELNRISKEDSEKPTLVAQYSKQIFDYMRQREIAFKVGEYMEKQTQ
INDRMRAILVDWIVEIHRKCKLLPETLFITVNLIDRFLDRATCTRDNLQLVGVTALFIAS
KYEEIYPPNLNDFVEATQKAYRKNDVLQMEGSIICALNFNLTVPTSLRFLERYGRVDKLD
KKSFDMSLYILQLCLVEYKFVKYSESLKACAAIYLTNKLFKKNICWSDVLTGHTQHTEQQ
IRPCALEMCLLLQSASTNQTQAVRRKFLSSEYSEVATIQIEKMNPSQQNTQQHSYQNNQN
YPPNIPKYNYREQY

>TTHERM_00196590(gene)
ATGGCTTGCCTACAAATGAGAAATGGTGAATAATCCATGTTTGGAGACTCAAACAAATTA
TAAAGCAATCAACTTCGTGCTTTCGGGCGTGAGATTCAAAATATCCCTGACAGTCGCTTT
GTAAAAATTTTTTTCATTTTTCAAATTAATTTCAAATATCCATCTCTCTTATTTTGATGC
TTTTAAGCTTTTTTTTAAGCTGCTTCAACTAAAAGAGTTTGATGAAAGCTAAAGGGAAAA
GAAGGATATTGTTTCAAATGAAGCCATAGCATAGCTATCTCTCTTTAAAATTTTCTAACA
ATTATTTAATTTATAATAGAATACAAGATCTTAATCAATAAAAGCAAACATGTAGCCTCA
CCACGCCTAAAAGCTTAGCATGGAATTAGATACAAATATAAATGAATAAGAGAACGGAAT
GAAAAGAAGTTCTCCTAGAAAATTTTCAATGCATGTGAAGCATTCCTCCGAAGTTCCATA
AAACCATTAAAAGAGAATGTCAAGCTAAATTGACACTGTAAGCAATAATGGAACAGAGCG
CTCATATTAAACCAATTAAACTGGCCTTTAAAATAAAAATATTGACATGAAAAATATAGA
ATTTGAATTGAATAGGATTTCTAAGGAAGACTCTGAAAAACCAACTTTAGTTGCTTAATA
CTCAAAGCAAATATTCGATTATATGCGCTAAAGAGAGGTAAAAAAATACTTTCAAGCTCA
TTTATTTTATAATGACTCAAAATACCAAAAATGTTTGCCAACTAAAAATCATTTCCTCAG
CAAAGCAATTCATTTTAATTTTGTTAAGCATTCATTTTAAAATAAACATTTTTGTTTTTA
ATTTCCATCAAAGAAGTTGCTATTAAAAATTAAAAGTGATATTTTTGCTTTACGCAATTT
GAAATGTAAATTGAAATATCAAATAAGCAAGCAAGCAAATAAATAAACAAAATCCTTTTA
AATTAATAGAAAAATTTAAAATTAAATTGTAATAAGTATTATCCTAACTAATATTTTCTT
GCAAAATAATTCAAATAGTTTTATTTTTCGAGAGCCAAGTATTTTTTAGTATAATTATTC
GACTACTAATCTCCTGATTTAATTAAATTTGCAAATTAAAAATTGATCACTTTAAAATTC
AATTATTCAAAAATTAAATATCTAATAGAGTTTGTATCTAAATGTTTTTTAATCGAATTT
AAATTATTAACGATTAAACAAACATCTTTTTTAAAAAAGCGGCATGCTTAATTTATATTT
TCTAATTGAGAAATTTCAAATAAAAGGAAAATTATAAAATATTTTAAAATCACTCAATTT
CTAAAATTTATTTTATTCGTAAAATAAACTAGATTGCCTTCAAAGTCGGTGAATACATGG
AAAAATAAACTTAAATCAATGACAGAATGAGAGCCATTTTGGTTGACTGGATTGTGGAAA
TACATAGAAAGTGTAAATTGTTACCTGAAACTTTATTTATTACTGTCAATTTAATTGACC
GCTTCTTGGATAGAGCCACATGCACTAGAGATAATTTATAGCTTGTAGGTGTAACTGCTT
TGTTCATAGCTTCTAAATACGAAGAAATATATCCTCCTAATCTTAATGATTTTGTTGAAG
CCACCTAGAAAGCTTACAGAAAAAATGATGTTTTATAAATGGAAGGAAGCATTATTTGTG
CCCTAAATTTCAACTTAACAGTTCCCACATCTCTCCGTTTCCTTGAAAGATACGGACGCG
TTGATAAACTTGATAAAAAATCTTTTGACATGAGCTTATATATTCTTTAACTCTGCTTAG
TCGAATATAAATTTGTTAAATACTCAGAATCATTAAAAGCTTGCGCTGCTATCTATCTCA
CAAATAAGCTATTTAAAAAGAATATTTGCTGGAGTGATGTCCTCACTGGTCACACTTAAC
ATACCGAGCAATAAATTAGACCTTGTGCTCTCGAAATGTGCCTTTTACTTCAATCAGCAT
CAACTAACTAAACCCAAGCCGTTCGCAGAAAATTCCTTAGTTCAGAGTATAGCGAAGTAG
CAACCATACAAATTGAAAAAATGAATCCTTCATAATAAAACACACAATAGCATTCATATT
AAAATAATTAAAATTACCCTCCCAACATTCCTAAATACAACTACAGAGAATAATATTGA