Identifiers and Description

Gene Model Identifier

TTHERM_00486070

Standard Name

CPD1 (CAP-D2 homolog 1)

Aliases

PreTt19539 | 59.m00177 | 3680.m00034 | CPDT1

Description

Condensin subunit, HEAT repeat

Genome Browser (Macronucleus)

GBrowse

Genome Browser (Micronucleus)

GBrowse

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

Gene Expression Profile

  • Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 13.3%

TetraMine Data

TTHERM_00486070

WebApollo

Fullscreen View

Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

SourceIdentifierScoreDescription
Tetrahymena borealisEI9_12109.19.997093137033517e-262hypothetical protein (1399 aa)
OxytrichaContig17170.0.g397.000315720897034e-164non-SMC mitotic condensation c
omplex subunit 1
DictyBaseDDB_G02939841.0001478224244938e-84ncapD2 on chromosome: 6 positi
on 3563765 to 3568484
SGDYLR272C2.0002571866765887e-62YCS4 Subunit of the condensin
complex; required for establis
hment and maintenance of chrom
osome condensation, chromosome
segregation, chromatin bindin
g of condensin, tRNA gene clus
tering at the nucleolus, and s
ilencing at the mating type lo
cus
Stentor CoeruleusSteCoe_99692.4426007377405277e-36
WormBaseWBGene000010870.00000000000001000191320216021locus:dpy-28 Condensin compl
ex subunit 1 status:Confirme
d UniProt:Q9U2M1 protein_i
d:CAA16340.3

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:29237819: Howard-Till R, Loidl J (2018) Condensins promote chromosome individualization and segregation during mitosis, meiosis, and amitosis in Tetrahymena thermophila. Molecular biology of the cell 29(4):466-478

Sequences

>TTHERM_00486070(coding)
ATGACTGAGTTTTTCATATTCCCATTCAGCTTCTCTGAGATCAGAGAACAGTCATCAGAC
AGTAGATATACTGTCGTTGGTGGAAATTTCGTAAAAGGTTAGGAAGAGAAGTAAATAAAA
AGGACCCTTAATGAACTAGATAGAGCAATTTACGAAGATATTCATATTATAAATGAAAGC
GACAGATTTGATTATTTATATTGGATTATTACTATGATGGAAGAAAGTAAAGAGAAGATG
AATGTAGAAATCCTAGTAAAAGTTGGAGATATAATACACACTCATTTCTAGCGCATTATT
AAAATGCTTGACGATGTTGATGGAGAAGATTAAATCAACTAACATAGAATCTCATTTAAA
ATGCTGGCATTCTTAGCTTTTTACTATCTGAATGCAAGTTGTGTTAAAAAGCCAAAAAAG
GCTTTAATTTCAAATGAAATAAGAGGAAAAAAAGAGGTTTCTAATGAGTATATTGAGAAA
ATAGCTGAAAAGCAAGCTATTTTATTAAGGTTATTTGAAGAATCTCTTTTAATTAATTTT
AAAACGCTTTGGTAAAGAAGAGAAATTGATTCACAGTTTTTCAAATACTATTATGAGACA
TCCTTGAAAATGCTTGAAAGCAAGCAATTATTAAAATAGCAAAATATTAAAGAAACCATA
TTTAACATTTTGAAGAAGGTTATTTTTATAAACTCTGATAGCTTGAGCACTATATAATTT
AAATTGATCAATTTAATTTATGAAGAAGAAAACATAGTTGAATATATTTGCGATTTTTTA
TTATCAACATAAAATTAAAACAGTGGCAATACCAACCAAGATGAATTTTTAATTCTTTTG
AATATTAGTGAAGATTAAAGGGATAATAGCGAGAAGAACTATTCTCAACTTTGCACAGAT
ACTCTCATTCGTTTAGTAAATTATGCAAATTAAACTAATGTAAATACTGAATCATAAGCA
GTCAAGAATGTCAAAGAATTCTTATTAAAAATGTCTGAAAAGATTCCTAAAATATTTTAC
AACAATTTATCTTGCTTTGTCTAACTCCTAGATAATGAAGCTTACCATTTAAGAAATGCA
GTAGTAGAAATAATGGGTAACATTATTAAAAATGTTCTGTCAACTCGTTAAAATCTTCCT
TAGGATGAGTAAAGTCTCTAAGAAGAAGAGAGTGAAAACCATGAAAAAGCAAAAGAAAAG
ATACTTGATGCGTTGATTTAAAGAATATATGACAAGCATGCTTTTTCAAGATCACATGTT
TTATAAGTTTTTATAGATTTATGCACTTAAAATCTTATTCCTCAAAATTACCTTTTCCCA
TTATTAGGATGTGCTTGTGATAGAATAAAAGATACATCTGCTAATGTTCGTAAGAAAGCC
ATCATCCTATTGCTTAAAATTATGGAATTTTACTTCATCATATTTGCAGCTTCTTAAAAT
AGAGTTAAATTCCATACTATAGAAGAGCTTGAAAGAGAACAAAGTTTCAATGAAACTGAA
AAATCAGAACTCATTTCAGAATAAAAATAAATAGAAGAAAAATTATAAGACAGAGAAAAC
GTAGAATAATTTCACGAATTTTAGCACGACTTAAATTAAGTTAAGAGAAAAATAGAATTA
TGCATGAAGTTAAAGCATAATTTGGATGAATATACAAAAATGATTAACTAAATTGAATTG
ATTATGCCAAATCTCTTATAATTACTGGGTTCCAAAAATAACTCAGATGTTACAGAAACC
ATTAAATTAATGATTTATTTATATTAAACAAATATTCAATGTGCTAATCAAGGAATTAGA
AAGATGCTCGTCTTAATATGGTCAAGAGAAAAGCTAGTAAAAGAAGAGCTCATTAAAGCT
TATTGGATTCTATATTTAGATGAAAAGGCATTCAAGCCAGAAGGAGTAGCTAAAAATTTA
GTTTATTTGTTTAAAAAAGCAAATCTAACAGATTTAACCTCATTAGAAGAATTGCTGGTT
GCAATACAAAAATGGAATCAAACAATCGAAGAGAAAGAAAGAGAAAAGAAACAAGATATG
TTTTACATAAGCAATAAAACATTCGATAAAATTTGGGATATATTCACAACTTCTGTCATT
TAAAACGATGCTAATTCTAAATATTCTATGAGAGCTGCTCTAACTATCCTCCGTATAAGT
TCTTAAAATAACAAGGTTATATTCACATAAAATAGAATGATTTCTCTAATTGAAGTTTTG
AAAAAATTCTTAAGGTTAAATTAACCTGATTGGATAGTAGTCAAAGAGATAGGCATTTTA
CTTGAAAATAAAGAGGATTGCAATTATTTAAATAGCTTCATAAAGCTCATGATTTTTATA
CTTATCAAATTTTAAGGTACTGTTGATAATGAGTGGTATTGTGCTTGTGAACAAATATTA
AATACAATCTTTTCAATAGAATAAAATCCTGAGAGTCTTATCAAGTATCTCATTCTTAGA
TGTACAAAAACTCTATTGGAAGGATAAGATACAAACAGCGATATCAATAAAAATATTGAA
ATTCCTTAAACTCCTCCAAGAAATATTGTTGAAGCTGTAAGTCCTTTAAAAGTTACACCC
TTTTAAAGTCCTAAGTAAACTTTTGAAACAGAAGAAAATGAAGAAAGCAAGCAGCTGTTA
TTCGAAAGAAGACTTGGTCATTTGTTGTTCCTTGTTGGACATTGCGCACTTAAATTGCTT
ATTCATATTGATAATATTGAAAACGAACTCAAAAAGCTAAAAATTGAAGGAGAAAAAAAA
TAAGAGGAACAACAGCACAAAGATGGAGCTGAAGCTGCTGAATTAGATAAGATTTATGGT
GGTTTAGAAGCTGAATACGAAAAGAGATTAGAGTATCTTCATAAAATAGCTGAAGAAAAT
ATTATAAATGGAGATAATTTGATAGCACAATATAAACCTTGGGTAGACAAGATTGTCAAA
GATATTATTGAAAACTAAGAAGGTGCAGACTACAGAAATGTTGATTTAGACAGAGTTGCT
GTTCTTACTTTATGTAAATTCATGTGCGTATCAAAAGTATACTGTGAATAGAATCTCCCT
ATCTTATTTAAATTACTGGAATCCTCTTTTTCAGACCATCTGCTAAAGATCAATATTATA
GTATCAATTGGAGATTTGCTTCACAAATATCCTAATCTTGTTGAACCTTATAATTCAAAG
ATTTTTGCAAAATTGCATGATCCAGATGTTTAAGTTAGAAAAACAACTATGATGGTATTG
ACTCATCTTATTTTAAATGATATGATGAAAATTAGAGGTGAAATATGTGAAGTAGCTCTC
CTTTTAGAAGATGAAGAGCCTAAGATTTAAAACATTGTCAAATTATTCTTGCATGAACTC
CACAAGAAAGATTAAAAAATTATTTATAATCTTTTACCTGAAGCTATTGGCAGAATGTCT
CGTTAAGATAAAACAGAACTAGGAGCTCCTATACATGAAAAAACTTTTGAAAATTTTGCA
AAAAATATTATGCAATATTTAGAAAAAGATAAATATTCAGAAACCCTTGTTGAAAAGCTT
TGTGTCCGTTTCCAAAATTCATAAAACTAAAGAGAATGGAGAAATTGTAGCTTCTGTCTT
AGTTAGCTTAGTTATAACGAGAAAGGTTTAAGAAAATTAATTGAATTCTATGAAAATTAC
AGAGAAAAGCTTCATGACCAAGAAATTATGGAAAATTTCTAAAATATTCTCATCAAGTTA
AAGAGATTACCAAAGCAAGAAATGAAACCTTTAATTGAAGAATTTGAAGCAAAGCTTTAA
GCTTATAAGGTTGAATCATTTGAACCTGTTAAGAAAAAAGAAACTGCTTTAGCAGCTAAG
GCTAAGCGTGTTGCTGACAAAAAGAAAAAAGATGAGAGCAATAAAGAAAATTAATAAAAT
TAAATAAATACTAGAACAAAAAGCAAAAAATAAACTAAGAAAAACTAAGAAGAAAGTGAT
GAAGATGAGCTCGAAGGAGAAGATAAAAATGAAGACTTCGAAGAGGAGGAAGAAGAAATC
GAAGAAAAACCTTAAACAAATAAAAGATTTTAGAAAAAAGAGCAACCTAAAAAGAGAGTC
TTAAGAAAGACTAATTTAAATAAAAAGAGATCAATGGTAGAAGAAGATGAAGATGATGAA
TAAATGGATAGTGAAGGAGATTATGATGAAGATGATGAAGATTATAACTGA


>TTHERM_00486070(protein)
MTEFFIFPFSFSEIREQSSDSRYTVVGGNFVKGQEEKQIKRTLNELDRAIYEDIHIINES
DRFDYLYWIITMMEESKEKMNVEILVKVGDIIHTHFQRIIKMLDDVDGEDQINQHRISFK
MLAFLAFYYLNASCVKKPKKALISNEIRGKKEVSNEYIEKIAEKQAILLRLFEESLLINF
KTLWQRREIDSQFFKYYYETSLKMLESKQLLKQQNIKETIFNILKKVIFINSDSLSTIQF
KLINLIYEEENIVEYICDFLLSTQNQNSGNTNQDEFLILLNISEDQRDNSEKNYSQLCTD
TLIRLVNYANQTNVNTESQAVKNVKEFLLKMSEKIPKIFYNNLSCFVQLLDNEAYHLRNA
VVEIMGNIIKNVLSTRQNLPQDEQSLQEEESENHEKAKEKILDALIQRIYDKHAFSRSHV
LQVFIDLCTQNLIPQNYLFPLLGCACDRIKDTSANVRKKAIILLLKIMEFYFIIFAASQN
RVKFHTIEELEREQSFNETEKSELISEQKQIEEKLQDRENVEQFHEFQHDLNQVKRKIEL
CMKLKHNLDEYTKMINQIELIMPNLLQLLGSKNNSDVTETIKLMIYLYQTNIQCANQGIR
KMLVLIWSREKLVKEELIKAYWILYLDEKAFKPEGVAKNLVYLFKKANLTDLTSLEELLV
AIQKWNQTIEEKEREKKQDMFYISNKTFDKIWDIFTTSVIQNDANSKYSMRAALTILRIS
SQNNKVIFTQNRMISLIEVLKKFLRLNQPDWIVVKEIGILLENKEDCNYLNSFIKLMIFI
LIKFQGTVDNEWYCACEQILNTIFSIEQNPESLIKYLILRCTKTLLEGQDTNSDINKNIE
IPQTPPRNIVEAVSPLKVTPFQSPKQTFETEENEESKQLLFERRLGHLLFLVGHCALKLL
IHIDNIENELKKLKIEGEKKQEEQQHKDGAEAAELDKIYGGLEAEYEKRLEYLHKIAEEN
IINGDNLIAQYKPWVDKIVKDIIENQEGADYRNVDLDRVAVLTLCKFMCVSKVYCEQNLP
ILFKLLESSFSDHLLKINIIVSIGDLLHKYPNLVEPYNSKIFAKLHDPDVQVRKTTMMVL
THLILNDMMKIRGEICEVALLLEDEEPKIQNIVKLFLHELHKKDQKIIYNLLPEAIGRMS
RQDKTELGAPIHEKTFENFAKNIMQYLEKDKYSETLVEKLCVRFQNSQNQREWRNCSFCL
SQLSYNEKGLRKLIEFYENYREKLHDQEIMENFQNILIKLKRLPKQEMKPLIEEFEAKLQ
AYKVESFEPVKKKETALAAKAKRVADKKKKDESNKENQQNQINTRTKSKKQTKKNQEESD
EDELEGEDKNEDFEEEEEEIEEKPQTNKRFQKKEQPKKRVLRKTNLNKKRSMVEEDEDDE
QMDSEGDYDEDDEDYN


>TTHERM_00486070(gene)
ATGACTGAGTTTTTCATATTCCCATTCAGCTTCTCTGAGATCAGAGAACAGTCATCAGAC
AGTAGATATACTGTAAATTATTTTAAACTTCAATTCCAATTATAGATTTTTAATAAATTC
ATTTTATAGATCTTGTATGAGATTATTAAAATTTTGAATATTTCTGATAGGTCGTTGGTG
GAAATTTCGTAAAAGGTTAGGAAGAGAAGTAAATAAAAAGGACCCTTAATGAACTAGATA
GAGCAATTTACGAAGATATTCATATTATAAATGAAAGCGACAGATTTGATTATTTATATT
GGATTATTACGTAATTATTCTACTAATTTTATATTTAAAAAATGAACTTTAGAGCATTCA
TTAACGTTTTTATGATGATCTAATAGTATGATGGAAGAAAGTAAAGAGAAGATGAATGTA
GAAATCCTAGTAAAAGTTGGAGATATAATACACACTCATTTCTAGCGCATTATTAAAATG
CTTGACGATGTTGATGGAGAAGATTAAATCAACTAACATAGAATCTCATTTAAAATGCTG
GCATTCTTAGCTTTTTACTATCTGAATGCAAGTTGTGTTAAAAAGCCAAAAAAGGCTTTA
ATTTCAAATGAAATAAGAGGAAAAAAAGAGGTTTCTAATGAGTATATTGAGAAAATAGCT
GAAAAGCAAGCTATTTTATTAAGGTTATTTGAAGAATCTCTTTTAATTAATTTTAAAACG
CTTTGGTAAAGAGTAAATAAAATCTTTTTTAACTTTTTCTTTTTATGATGATAATTTATG
TATATATCAATCATTTATTTAAAATATTTTTATTCTAGTTTTTTATGTTTCAAGAATATC
TTTTCATTAATCATAAATTTAAAATAGAGAGAAATTGATTCACAGTTTTTCAAATACTAT
TATGAGACATCCTTGAAAATGCTTGAAAGCAAGCAATTATTAAAATAGCAAAATATTAAA
GAAACCATATTTAACATTTTGAAGAAGGTTATTTTTATAAACTCTGATAGCTTGAGCACT
ATATAATTTAAATTGATCAATTTAATTTATGAAGAAGAAAACATAGTTGAATATATTTGC
GATTTTTTATTATCAACATAAAATTAAAACAGTGGCAATACCAACCAAGATGAATTTTTA
ATTCTTTTGAATATTAGTGAAGATTAAAGGGATAATAGCGAGAAGAACTATTCTCAACTT
TGCACAGATACTCTCATTCGTTTAGTAAATTATGCAAATTAAACTAATGTAAATACTGAA
TCATAAGCAGTCAAGAATGTCAAAGAATTCTTATTAAAAATGTCTGAAAAGATTCCTAAA
ATATTTTACAACAATTTATCTTGCTTTGTCTAACTCCTAGATAATGAAGCTTACCATTTA
AGAAATGCAGTAGTAGAAATAATGGGTAACATTATTAAAAATGTTCTGTCAACTCGTTAA
AATCTTCCTTAGGATGAGTAAAGTCTCTAAGAAGAAGAGAGTGAAAACCATGAAAAAGCA
AAAGAAAAGATACTTGATGCGTTGATTTAAAGAATATATGACAAGCATGCTTTTTCAAGA
TCACATGTTTTATAAGTTTTTATAGATTTATGCACTTAAAATCTTATTCCTCAAAATTAC
CTTTTCCCATTATTAGGATGTGCTTGTGATAGAATAAAAGATACATCTGCTAATGTTCGT
AAGAAAGCCATCATCCTATTGCTTAAAATTATGGAATTTTACTTCATCATATTTGCAGCT
TCTTAAAATAGAGTTAAATTCCATACTATAGAAGAGCTTGAAAGAGAACAAAGTTTCAAT
GAAACTGAAAAATCAGAACTCATTTCAGAATAAAAATAAATAGAAGAAAAATTATAAGAC
AGGTAAAATATTTTTATTAAGTTAAAATTCAAGTTTGCATTCATTTTTTAATAAAAATTA
ATAAATTTTTATTATTTTAAATAGAGAAAACGTAGAATAATTTCACGAATTTTAGCACGA
CTTAAATTAAGTTAAGAGAAAAATAGAATTATGCATGAAGTTAAAGCATAATTTGGATGA
ATATACAAAAATGATTAACTAAATTGAATTGATTATGCCAAATCTCTTATAATTACTGGG
TTCCAAAAATAACTCAGATGTTACAGAAACCATTAAATTAATGATTTATTTATATTAAAC
AAATATTCAATGTGCTAATCAAGGAATTAGAAAGATGCTCGTCTTAATATGGTCAAGAGA
AAAGCTAGTAAAAGAAGAGCTCATTAAAGCTTATTGGGTAAAATAAACAATTTATTATCA
ATAAAAAAATATATTTAATTTATTTATTTATAATAAAAAATTAGATTCTATATTTAGATG
AAAAGGCATTCAAGCCAGAAGGAGTAGCTAAAAATTTAGTTTATTTGTTTAAAAAAGCAA
ATCTAACAGATTTAACCTCATTAGAAGAATTGCTGGTTGCAATACAAAAATGGAATCAAA
CAATCGAAGAGAAAGAAAGAGAAAAGAAACAAGATATGTTTTACATAAGCAATAAAACAT
TCGATAAAATTTGGGATATATTCACAACTTCTGTCATTTAAAACGATGCTAATTCTAAAT
ATTCTATGAGAGCTGCTCTAACTATCCTCCGTATAAGTTCTTAAAATAACAAGGTTATAT
TCACATAAAATAGAATGATTTCTCTAATTGAAGTTTTGAAAAAATTCTTAAGGTTAAATT
AACCTGATTGGATAGTAGTCAAAGAGATAGGTACAATTTAATTTTGAAATGCATTCATTT
ATTTTAATATTTTTTCATTATATAGGCATTTTACTTGAAAATAAAGAGGATTGCAATTAT
TTAAATAGCTTCATAAAGCTCATGATTTTTATACTTATCAAATTTTAAGGTACTGTTGAT
AATGAGTGGTATTGTGCTTGTGAACAAATATTAAATACAATCTTTTCAATAGAATAAAAT
CCTGAGAGTCTTATCAAGTATCTCATTCTTAGATGTACAAAAACTCTATTGGAAGGATAA
GATACAAACAGCGATATCAATAAAAATATTGAAATTCCTTAAACTCCTCCAAGAAGTAAG
TATATCCTTTAATTACTTAAAATTCAAAATTTAAAATAATTTTAAAAGATATTGTTGAAG
CTGTAAGTCCTTTAAAAGTTACACCCTTTTAAAGTCCTAAGTAAACTTTTGAAACAGAAG
AAAATGAAGAAAGCAAGCAGCTGTTATTCGAAAGAAGACTTGGTCATTTGTTGTTCCTTG
TATACAATTTATATAATAAAATTAATAAAAAATTAAAAAAATATAATTTTATCTAAATAA
TAGGTTGGACATTGCGCACTTAAATTGCTTATTCATATTGATAATATTGAAAACGAACTC
AAAAAGCTAAAAATTGAAGGAGAAAAAAAATAAGAGGAACAACAGCACAAAGATGGAGCT
GAAGCTGCTGAATTAGATAAGATTTATGGTGGTTTAGAAGCTGAATACGAAAAGAGATTA
GAGTATCTTCATAAAATAGCTGAAGAAAATATTATAAATGGAGATAATTTGATAGCACAA
TATAAACCTTGGGTAGACAAGATTGTCAAAGATATTATTGAAAACTAAGAAGGTGCAGAC
TACAGAAATGTTGATTTAGACAGAGTTGCTGTTCTTACTTTATGTAAATTCATGTGCGTA
TCAAAAGTATACTGTGAATAGAATCTCCCTATCTTATTTAAATTACTGGAATCCTCTTTT
TCAGACCATCTGCTAAAGATCAATATTATAGTATCAATTGGAGATTTGCTTCACAAATAT
CCTAATCTTGTTGAACCTTATAATTCAAAGATTTTTGCAAAGTAAATTTCCTTTTATTTT
GATTAAATTTAATATTTATCTTAAATAATAGATTGCATGATCCAGATGTTTAAGTTAGAA
AAACAACTATGATGGTATTGACTCATCTTATTTTAAATGATATGATGAAAATTAGAGGTG
AAATATGTGAAGTAGCTCTCCTTTTAGAAGATGAAGAGCCTAAGATTTAAAACATTGTCA
AATTATTCTTGCATGAACTCCACAAGAAAGATTAAAAAATTATTTATAATCTTTTACCTG
AAGCTATTGGCAGAATGTCTCGTTAAGATAAAACAGAACTAGGAGCTCCTATACATGAAA
AAACTTTTGAAAATTTTGCAAAAAATATTATGCAATATTTAGAAAAAGATAAATATTCAG
AAACCCTTGTTGAAAAGCTTTGTGTCCGTTTCCAAAATTCATAAAGTAATTAATTTATTT
ATTGATTTTTAACTATAATAAATAACTTACGTTAATAAAGACTAAAGAGAATGGAGAAAT
TGTAGCTTCTGTCTTAGTTAGCTTAGTTATAACGAGAAAGGTTTAAGAAAATTAATTGAA
TTCTATGAAAATTACAGAGAAAAGCTTCATGACCAAGAAATTATGGAAAATTTCTAAAAT
ATTCTCATCAAGTTAAAGAGATTACCAAAGCAAGAAATGAAACCTTTAATTGAAGAATTT
GAAGCAAAGCTTTAAGCTTATAAGGTTGAATCATTTGAACCTGTTAAGAAAAAAGAAACT
GCTTTAGCAGCTAAGGCTAAGCGTGTTGCTGACAAAAAGAAAAAAGATGAGAGCAATAAA
GAAAATTAATAAAATTAAATAAATACTAGAACAAAAAGCAAAAAATAAACTAAGAAAGTA
AAAATTATTTACAAAAAATATATTATTTAAATAAATAAATTTTAAATAAGAACTAAGAAG
AAAGTGATGAAGATGAGCTCGAAGGAGAAGATAAAAATGAAGACTTCGAAGAGGAGGAAG
AAGAAATCGAAGAAAAACCTTAAACAAATAAAAGATTTTAGAAAAAAGAGCAACCTAAAA
AGAGAGTCTTAAGAAAGACTAATTTAAATAAAAAGAGATCAATGGTAGAAGAAGATGAAG
ATGATGAATAAATGGATAGTGAAGGAGATTATGATGAAGATGATGAAGATTATAACTGA