Identifiers and Description

Gene Model Identifier

TTHERM_00348580

Standard Name

COI7 (COnjugation-Induced 7)

Aliases

PreTt05270 | 36.m00234 | 3703.m00096

Description

hypothetical protein; Specifically expressed during conjugation

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.2%

TetraMine Data

TTHERM_00348580

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_09767.1	9.999242092827953e-100	hypothetical protein (259 aa)
Stentor Coeruleus	SteCoe_12080	0.00000004139937718785167
Oxytricha	Contig16339.0.g84	0.00000005001214305021125	Leucine Rich repeats (2 copies )
WormBase	WBGene00009367	0.0000009995106777214876	Acidic leucine-rich nuclear ph osphoprotein 32-related protei n 1 status:Confirmed UniPr ot:O62220 protein_id:CAB0426 5.1
DictyBase	DDB_G0290421	0.000005998506718272351	DDB_G0290421 on chromosome: 5 position 4063431 to 4065691

General Information

Paragraph No	Gene Name	Paragraph Text
115	COI6, JMJ1, LIA5, COI7	Coi6p, its interaction partners Coi7p and Lia5p, and the histone demethylase Jmj1p are crucial for confining the production of small RNAs and the formation of heterochromatin to the eliminated sequences. The loss of Coi6p, Coi7p or Jmj1p causes ectopic DNA elimination.
114	COI7, COI6	Coi7p directly interacts with Coi6p and is required for the stable accumulation of Coi6p.

Associated Literature

1. Ref:29021213: Noto T, Mochizuki K (2017) Whats, hows and whys of programmed DNA elimination in Tetrahymena. Open biology 7(10):
2. Ref:28273462: Suhren JH, Noto T, Kataoka K, Gao S, Liu Y, Mochizuki K (2017) Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena. Cell reports 18(10):2494-2507
3. Ref:25588944: Woehrer SL, Aronica L, Suhren JH, Busch CJ, Noto T, Mochizuki K (2015) A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms. The EMBO journal 34(4):559-77

Sequences

>TTHERM_00348580(coding)
ATGGAATTACTAGATTCAGATATAGGCTCTCAAATAAATTAGTAGGTTGAAGGAAAAAAT
TTTAAAGAAGTGGAGGATATCTATTTACAAAATATACAATCTGCTAAATTCACCTCGGAA
TACAGAGAAAAAATTTAATCTTTCCCAAATTTAATATGCTTTAGCCTCACTAACATGAAT
TTCAGCAAAATATAAGATCTTCCTATTTTAAAGAGACTGCTAAGATTAGAGATATGTTAT
TGCACCTTCGATATCAGTAGTCTCAATTAAATTTACATTTAATTTCCAAGGCTTGTGAGT
TTAAGGCTAGTTGGATGTAATATTAGCTCATATTCATAAATTGAATGTTTAACAAGCTTG
CCAGACTTGGCCTAATTAGATCTATTTAATAATCCTATTTACAAATTTAATTACGAATAT
CAGAGCTTTCATTAAAAAATGTTCGAATTATTTCCTAAATTGATGTATTTGGACAATCTT
AAAAAAGATTTCTCAAGAGCTTGTACCATTCCTATAAATTAGATTGATCCAAAATAACTT
ATTCAAGAAGTTGAAATCCCTAAATTTGTAGATAAACTCAACAGATCAAACATAAACTCT
TAGAATAATAGTTTTAATTCTAATAAATTGACACGTAAAAATAATATTAACAATCCAAAC
AAAAGAAGGGCTGACAATTCAGACGAAGAGGATGATGACCTTGATGAAGATTACCAAGAA
GATAGTGATGAACCATCAAATCAAAGACATGGCTATCAAACTAGAAAATAATAGAAATTA
GCTGCATACAAATGA

>TTHERM_00348580(protein)
MELLDSDIGSQINQQVEGKNFKEVEDIYLQNIQSAKFTSEYREKIQSFPNLICFSLTNMN
FSKIQDLPILKRLLRLEICYCTFDISSLNQIYIQFPRLVSLRLVGCNISSYSQIECLTSL
PDLAQLDLFNNPIYKFNYEYQSFHQKMFELFPKLMYLDNLKKDFSRACTIPINQIDPKQL
IQEVEIPKFVDKLNRSNINSQNNSFNSNKLTRKNNINNPNKRRADNSDEEDDDLDEDYQE
DSDEPSNQRHGYQTRKQQKLAAYK

>TTHERM_00348580(gene)
ATGGAATTACTAGATTCAGATATAGGCTCTCAAATAAATTAGTAGGTTGAAGGAAAAAAT
TTTAAAGAAGTGGAGGATATCTATTTACAAAATATACAATCTGCTAAATTCACCTCGGAA
TACAGAGAAAAAATTTAATCTTTCCCAAATTTAATATGCTTTAGCCTCACTAACATGAAT
TTCAGCAAAATATAAGATCTTCCTATTTTAAAGAGACTGCTAAGATTAGAGATATGTTAT
TGCACCTTCGATATCAGTAGTCTCAATTAAATTTACATTTAATTTCCAAGGCTTGTGAGT
TTAAGGCTAGTTGGATGTAATATTAGCTCATATTCATAAATTGAATGTTTAACAAGCTTG
CCAGACTTGGCCTAATTAGATCTATTTAATAATCCTATTTACAAATTTAATTACGAATAT
CAGAGCTTTCATTAAAAAATGTTCGAATTATTTCCTAAATTGATGTATTTGGACAATCTT
AAAAAAGATTTCTCAAGAGCTTGTACCATTCCTATAAATTAGATTGATCCAAAATAACTT
ATTCAAGAAGTTGAAATCCCTAAATTTGTAGATAAACTCAACAGATCAAACATAAACTCT
TAGAATAATAGTTTTAATTCTAATAAATTGACACGTAAAAATAATATTAACAATCCAAAC
AAAAGAAGGGCTGACAATTCAGACGAAGAGGATGATGACCTTGATGAAGATTACCAAGAA
GATAGTGATGAACCATCAAATCAAAGACATGGCTATCAAACTAGAAAATAATAGAAATTA
GCTGCATACAAATGA