Gene Model Identifier
TTHERM_00402050
Standard Name
COI12
Aliases
PreTt12749 | 43.m00267 | 3713.m00093
Description
A Hsp90 co-chaperone required for the loading of scnRNAs to Twi1p
Genome Browser (Macronucleus)
Genome Browser (Micronucleus)
No Data fetched for Gene Ontology Annotations
( PF07337 ) DC-EC Repeat
( PF00515 ) tetratricopeptide repeat
( PF07719 ) tetratricopeptide repeat
( PF08180 ) B melanoma antigen family
( PF02071 ) Aromatic-di-Alanine (AdAR) repeat
Tetrahymena Functional Genomics Database:
Signal Peptide Present?: No
TTHERM_00402050
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No Data fetched for StockID
(v.2006 protein sequences)
Source Identifier Score Description
Tetrahymena borealis EI9_13976.1 1.999872053281847e-142 hypothetical protein (544 aa)
Paragraph No Gene Name Paragraph Text 103 COI12 The Tetrahymena Hsp90 co-chaperone Coi12p promotes scnRNA loading into the Argonaute protein Twi1p in both ATP-dependent and ATP-independent manners. 105 GIW1 ,COI12 ,TWI1 ATP-dependent and ATP-independent activities of Coi12p facilitate scnRNA loading by counteracting the Twi1p-binding protein Giw1p, which is important for sorting scnRNAs to Twi1p (Woehrer et al. 2015).
Ref:29021213 : Noto T, Mochizuki K (2017) Whats, hows and whys of programmed DNA elimination in Tetrahymena. Open biology 7(10): Ref:25588944 : Woehrer SL, Aronica L, Suhren JH, Busch CJ, Noto T, Mochizuki K (2015) A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms. The EMBO journal 34(4):559-77Ref:26688337 : Kataoka K, Mochizuki K (2015) Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination. Developmental cell 35(6):775-88
>TTHERM_00402050(coding)ATG TAT TAC TTG CCT AAA AGA TAC TTT TCC AAA TAA ATC AAA TTT CAA ATC AAA CTC AAA TTT GGT AGG AAA TTA AAT TTT CAA GCT AAA TAA ACT GCC CTC CCC AAT AAC TTT AAT ATT TAC ATG TAA ATC TAT TTG ATT GAT TTT TAA TTA TTT CGT TCA ATA TAT ATA GCT AGC TAG CTA GAT AGA TTG CTT TAA AGT AAT TCA ATC AAT TTC AAC AAA AAG ATA ATT ACT TTA ATT AGC AAG GCT ATT TTA AAT ATT AAA ACA AAC ACT ATT ATA TTA AAA ATT AAA TAA ATT ATA ATT AAG CAT TAT TTC ATT AAA AAA TAA ATA AAA GAC ATT AAA ATG GAT TCA TCT AAT GAA AAC ACA AGG AGC TCT TCT TGT AAT GAG TAG GAA ACT AAT TCA GAA CTT TAG TAA AGT GTT AAT GAG AGT TGT ACC AGC CTA GAA GAG TAG TAA TTC AGC ACT CCT TTT TTA TCC AGC CAA GAA ACT GTA TAG GTA GAC TAA GCA TTC TAA GAA TCC ACT AAA TAG AAT GAA GGA ACT TCT TCT TTC TTA AAC GAG ACC TAA TGC TAT CAA GAT TGT AAG CCC AAT TTA ATT TCT AAA GGA GAG TCA AAT CAA CAG TAA TAC AAA GAG TAA ACT CAA GAA ATT AGT GAG ATT TTA GAA AAC CCT TTT GCT TAA AAT ACA CCA ACT GAT TAA TGG AGC ATT GTA GAA GAA AAA GAT GGT AAT AAA CAA GCA GAT AGT TTT GAT ATT TTA TAA GAC AAA TTG ATT AAA GAG GAA ACA TAT AAC ATC CCT AGT TGG AAT TAT GAG CCT TAA GAT TTT AAA GCA GAT ATT GAC TTT GAA AAA TAT GAC AAA GAA AAT CTA GAT CAC CTA AAG AAA GTC TAC AAG CCT CCA TAA ATT GAA GAC GTC GTC GAA AAA GTA GAA TAA GAT GAA AAT GGG CTT AAA ATC TAA ACT TTA TCT TAA TTC AAT ATA CCT AAA TGC AAT ATA CTG AAG CTT GAT ATG AGT TTT CTC TAA ACT TGG CAA TCA AAA GAA ATA GTA CCA TGC TTT ACT ATG TTT TCA GAA CCA AAA ACT AAC AAC GGG GAA AGT CTA AAT TGT GAT GAA GAA GAA ACT AAT CCT TAG ATT GAT AAG AAA TGG TGC AGA GAT GTT TAA GTT GTC TTT GAA GAA AGA GAT TAG AAT GGT GAG CTT ATT GAT AAA TAT AGA GTT GTC AAA GAA AAA AGA ACA GTT AAA TTA TAA GGA GAT ATA TCA GCA AAG TGG TAT ATT TGT CTA GAG CAG ATG AAG CCA AAT GAA ACT AAG TGG TTT AAA ATG GAA TAA AAA CTT CTT TGG CAG ATT GGA CAA AAA AAT TTA GCT TAA TAT GAG TGT ATT TAT CTA AAA ATA TAA ATT GTT GGA GTA AAG GCT CTT GCT CTT TCT GAA ATG AAA GAT AAA CTT GAA AAA AAT AAC TTA CAA CCC TAA CAG TAA AAT ATA ATC TAT GAG GAT TAT AGT TAA ATA GCT CAG AAA TCA GAA GAG TTT AAC AAT GAA GGA AAA ATT CTA TTC TCT ATT ATG AAT TAT GAA AAA GCT GCA AAA TGG TTT AAC AAA GCA TTT AGT ATT TGG AGA GGA ATG AGC AAA AAG CTT AGA AAA ACT TTA AAT TCT GAA TAG GAA TAG AAT TAT ATT GAT AAG AGT AAC TAG TTT GGT GCT AAT TAT GCA TAA TGC CTT ATT AAC CTC AAA AAA TAT TAA GAG TGT GTG GAT TTT TAC TAA AAA AAC AAG CTT TCT TCT AAT AAG AAC ATT TAT AAA CTT GTA AAA AGT TTA TAT GAA TTA CAT AAC TAT GAA AAA GCT ATT TAA GTA ATA GAT AAA CAG TTT CCT TAA AAT GAT GAA AAC TCA GTT GAT AAA TTT ATG AAC GGT AAT CAA GAA AGT TTA CTT CCA GCT GAA TTC TAA AAG CTT AAA AGT CAG TGT TAA GTA AAG CTA AAA ATG TTA GAA AAT CAA TCA ATA AAT ACA TTT TAT AGA AAA TTG TTT TAA TGA >TTHERM_00402050(protein)M Y Y L P K R Y F S K Q I K F Q I K L K F G R K L N F Q A K Q T A L P N N F N I Y M Q I Y L I D F Q L F R S I Y I A S Q L D R L L Q S N S I N F N K K I I T L I S K A I L N I K T N T I I L K I K Q I I I K H Y F I K K Q I K D I K M D S S N E N T R S S S C N E Q E T N S E L Q Q S V N E S C T S L E E Q Q F S T P F L S S Q E T V Q V D Q A F Q E S T K Q N E G T S S F L N E T Q C Y Q D C K P N L I S K G E S N Q Q Q Y K E Q T Q E I S E I L E N P F A Q N T P T D Q W S I V E E K D G N K Q A D S F D I L Q D K L I K E E T Y N I P S W N Y E P Q D F K A D I D F E K Y D K E N L D H L K K V Y K P P Q I E D V V E K V E Q D E N G L K I Q T L S Q F N I P K C N I L K L D M S F L Q T W Q S K E I V P C F T M F S E P K T N N G E S L N C D E E E T N P Q I D K K W C R D V Q V V F E E R D Q N G E L I D K Y R V V K E K R T V K L Q G D I S A K W Y I C L E Q M K P N E T K W F K M E Q K L L W Q I G Q K N L A Q Y E C I Y L K I Q I V G V K A L A L S E M K D K L E K N N L Q P Q Q Q N I I Y E D Y S Q I A Q K S E E F N N E G K I L F S I M N Y E K A A K W F N K A F S I W R G M S K K L R K T L N S E Q E Q N Y I D K S N Q F G A N Y A Q C L I N L K K Y Q E C V D F Y Q K N K L S S N K N I Y K L V K S L Y E L H N Y E K A I Q V I D K Q F P Q N D E N S V D K F M N G N Q E S L L P A E F Q K L K S Q C Q V K L K M L E N Q S I N T F Y R K L F Q >TTHERM_00402050(gene)ATG TAT TAC TTG CCT AAA AGA TAC TTT TCC AAA TAA ATC AAA TTT CAA ATC AAA CTC AAA TTT GGT AGG AAA TTA AAT TTT CAA GCT AAA TAA ACT GCC CTC CCC AAT AAC TTT AAT ATT TAC ATG TAA ATC TAT TTG ATT GAT TTT TAA TTA TTT CGT TCA ATA TAT ATA GCT AGC TAG CTA GAT AGA TTG CTT TAA AGT AAT TCA ATC AAT TTC AAC AAA AAG ATA ATT ACT TTA ATT AGC AAG GCT ATT TTA AAT ATT AAA ACA AAC ACT ATT ATA TTA AAA ATT AAA TAA ATT ATA ATT AAG CAT TAT TTC ATT AAA AAA TAA ATA AAA GAC ATT AAA ATG GAT TCA TCT AAT GAA AAC ACA AGG AGC TCT TCT TGT AAT GAG TAG GAA ACT AAT TCA GAA CTT TAG TAA AGT GTT AAT GAG AGT TGT ACC AGC CTA GAA GAG TAG TAA TTC AGC ACT CCT TTT TTA TCC AGC CAA GAA ACT GTA TAG GTA GAC TAA GCA TTC TAA GAA TCC ACT AAA TAG AAT GAA GGA ACT TCT TCT TTC TTA AAC GAG ACC TAA TGC TAT CAA GAT TGT AAG CCC AAT TTA ATT TCT AAA GGA GAG TCA AAT CAA CAG TAA TAC AAA GAG TAA ACT CAA GAA ATT AGT GAG ATT TTA GAA AAC CCT TTT GCT TAA AAT ACA CCA ACT GAT TAA TGG AGC ATT GTA GAA GAA AAA GAT GGT AAT AAA CAA GCA GAT AGT TTT GAT ATT TTA TAA GAC AAA TTG ATT AAA GAG GAA ACA TAT AAC ATC CCT AGT TGG AAT TAT GAG CCT TAA GAT TTT AAA GCA GAT ATT GAC TTT GAA AAA TAT GAC AAA GAA AAT CTA GAT CAC CTA AAG AAA GTC TAC AAG CCT CCA TAA ATT GAA GAC GTC GTC GAA AAA GTA GAA TAA GAT GAA AAT GGG CTT AAA ATC TAA ACT TTA TCT TAA TTC AAT ATA CCT AAA TGC AAT ATA CTG AAG CTT GAT ATG AGT TTT CTC TAA ACT TGG CAA TCA AAA GAA ATA GTA CCA TGC TTT ACT ATG TTT TCA GAA CCA AGT AAG ATT CAT TCC AGT TTT AAA CTA CTT CTA CTT ACT TAC TTA CTT ATT ATT ATT TTT AAT TAA TTA GAT TTA GTT TTA ATT TTG TAA TTT TTG AAT TTT CTG AAT CTT TTT TTT TCA GTT TTT AAA ATT TAA AAT GAA TAA ATT TAA TTA ATT TAC AAT AAA TTA AAA AAT TTT TAA ACA TTT TAT TTG AAA ATT GGC TAA AAT TTG TTA TAT AGA AAT AAA AAA TAT TCC AAA ATT GTT TAT TTC ATG AAA TAT TTT ATT TAA AAA TTA ATC TAG AAA CTA ACA ACG GGG AAA GTC TAA ATT GTG ATG AAG AAG AAA CTA ATC CTT AGA TTG ATA AGA AAT GGT GCA GAG ATG TTT AAG TTG TCT TTG AAG AAA GAG ATT AGA ATG GTG AGC TTA TTG ATA AAT ATA GAG TTG TCA AAG AAA AAA GAA CAG TTA AAT TAT AAG GAG ATA TAT CAG CAA AGT GGT ATA TTT GTC TAG AGC AGA TGA AGC CAA ATG AAA CTA AGT GGT TTA AAA TGG AAT AAA AAC TTC TTT GGC AGA TTG GAC AAA AAA ATT TAG CTT AAT ATG AGT GTA TTT ATC TAA AAA TAT AAA TTG TTG GAG TAA AGG CTC TTG CTC TTT CTG AAA TGA AAG ATA AAC TTG AAA AAA ATA ACT TAC AAC CCT AAC AGT AAA ATA TAA TCT ATG AGG ATT ATA GTT AAA TAG CTC AGA AAT CAG AAG AGT TTA ACA ATG AAG GAA AAA TTC TAT TCT CTA TTA TGA ATT ATG AAA AAG CTG CAA AAT GGT TTA ACA AAG CAT TTA GTA TTT GGA GAG GAA TGA GCA AAA AGC TTA GAA AAA CTT TAA ATT CTG AAT AGG AAT AGA ATT ATA TTG ATA AGA GTA ACT AGT TTG GTG CTA ATT ATG CAT AAT GCC TTA TTA ACC TCA AAA AAT ATT AAG AGT GTG TGG ATT TTT ACT AAA AAA ACA AGC TTT CTT CTA ATA AGA ACA TTT ATA AAC TTG TAA AAA GTT TAT ATG AAT TAC ATA ACT ATG AAA AAG CTA TTT AAG TAA TAG ATA AAC AGT TTC CTT AAA ATG ATG AAA ACT CAG TTG ATA AAT TTA TGA ACG GTA ATC AAG AAA GTT TAC TTC CAG CTG AAT TCT AAA AGC TTA AAA GTC AGT GTT AAG TAA AGC TAA AAA TGT TAG AAA ATC AAT CAA TAA ATA CAT TTT ATA GAA AAT TGT TTT AAT GA
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