Identifiers and Description

Gene Model Identifier

TTHERM_00497960

Standard Name

CCT7 (Chaperonin Containing TCP-1 ortholog 7 )

Aliases

PreTt06961 | 62.m00245 | TtCCTeta | 3715.m00106

Description

CCT-eta chaperonin subunit; expressed during cilia biogenesis and conjugation

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• chaperonin-containing T-complex (ISS) | GO:0005832 | Ref:8925913

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein binding (IEA) | GO:0005515
• protein binding (ISS) | GO:0005515 | Ref:8925913

Biological Process

• cilium assembly (IEP) | GO:0042384 | Ref:8925913
• cellular protein metabolic process (IEA) | GO:0044267

Domains

• ( TIGR02348 ) chaperonin GroL
• ( PF00118 ) TCP-1/cpn60 chaperonin family
• ( TIGR02345 ) T-complex protein 1, eta subunit
• ( TIGR02341 ) T-complex protein 1, beta subunit
• ( TIGR02347 ) T-complex protein 1, zeta subunit
• ( TIGR02340 ) T-complex protein 1, alpha subunit
• ( TIGR02342 ) T-complex protein 1, delta subunit
• ( TIGR02344 ) T-complex protein 1, gamma subunit
• ( TIGR02346 ) T-complex protein 1, theta subunit
• ( TIGR02343 ) T-complex protein 1, epsilon subunit
• ( TIGR02339 ) thermosome, various subunits, archaeal

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 17.2%

TetraMine Data

TTHERM_00497960

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Stentor Coeruleus	SteCoe_6384	0
WormBase	WBGene00020391	9.997093137033517e-262	locus:cct-7 status:Confirmed UniProt:Q9TZS5 protein_id :CCD74224.1
Tetrahymena borealis	EI9_20972.1	9.997093137033517e-262	TCP-1/cpn60 chaperonin family protein (562 aa)
DictyBase	DDB_G0291225	9.997093137033517e-262	cct7 on chromosome: 6 position 201367 to 203505
Oxytricha	Contig22245.0.g37	9.997093137033517e-262	TCP-1/cpn60 chaperonin family
SGD	YJL111W	9.997093137033517e-262	CCT7 Subunit of the cytosolic chaperonin Cct ring complex, r elated to Tcp1p, required for the assembly of actin and tubu lins in vivo; mutant has incre ased aneuploidy tolerance

General Information

No Data fetched for General Information

Associated Literature

1. Ref:14567989: Seixas C, Casalou C, Melo LV, Nolasco S, Brogueira P, Soares H (2003) Subunits of the chaperonin CCT are associated with Tetrahymena microtubule structures and are involved in cilia biogenesis. Experimental cell research 290(2):303-21
2. Ref:11718895: Casalou C, Cyrne L, Rosa MR, Soares H (2001) Microtubule cytoskeleton perturbation induced by taxol and colchicine affects chaperonin containing TCP-1 (CCT) subunit gene expression in Tetrahymena cells. Biochimica et biophysica acta 1522(1):9-21
3. Ref:10524223: Domingues C, Soares H, Rodrigues-Pousada C, Cyrne L (1999) Structure of Tetrahymena CCT theta gene and its expression under colchicine treatment. Biochimica et biophysica acta 1446(3):443-9
4. Ref:9819444: Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (1998) Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. Molecular and cellular biology 18(12):7584-9
5. Ref:9337846: Soares H, Cyrne L, Casalou C, Ehmann B, Rodrigues-Pousada C (1997) The third member of the Tetrahymena CCT subunit gene family, TpCCT alpha, encodes a component of the hetero-oligomeric chaperonin complex. The Biochemical journal 326 ( Pt 1)( ):21-9
6. Ref:8925913: Cyrne L, Guerreiro P, Cardoso AC, Rodrigues-Pousada C, Soares H (1996) The Tetrahymena chaperonin subunit CCT eta gene is coexpressed with CCT gamma gene during cilia biogenesis and cell sexual reproduction. FEBS letters 383(3):277-83
7. Ref:8573069: Walkley NA, Demaine AG, Malik AN (1996) Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. The Biochemical journal 313 ( Pt 2)( ):381-9
8. Ref:7961900: Soares H, Penque D, Mouta C, Rodrigues-Pousada C (1994) A Tetrahymena orthologue of the mouse chaperonin subunit CCT gamma and its coexpression with tubulin during cilia recovery. The Journal of biological chemistry 269(46):29299-307

Sequences

>TTHERM_00497960(coding)
ATGAGTTATCTTTTGCAACCTACCATTTTGCTCTTGAAGGACGGTACTGATACTTCCTAA
GGAAAGGCTTAAATTGTTTCCAACATTAATGCTGTCTAATCTATTGTAGAAATCGTTAAG
ACCACTTTAGGTCCCCGTGGTATGGATAAATTGATTGAAGGTGGAATGAAGGGAGCCACT
ATTTCCAATGATGGTGCTACTATTTTAAACTTATTAGATATTGTTCACCCTGCTGCTAAG
ACTCTTGTTGATATTGCTAAGGCTTAAGACGATGAAGTTGGTGATGGTACCACTTCTGTC
TGCCTTTTGGCTGGTGAATTATTGAAGGAATCTAAGTACTTCATCGAAGAAGGTATGCAC
CCATAAATTATCACTAAGGGTTACAAGGAAGCCCTCAAGTTAGCTCTTTAATTCTTACAC
GAAAATGCTCACTCTGTAGCTGATAAGAACGAAACTGAAAAGAGAGAAATGCTCATTAAG
TGCGCTTAAACCTCTTTAAACTCCAAATTATTAGCTCATTACAAGGAATTCTTCTCTGAG
TTAGTTGTTTAAGCCGTTGAAACTCTTGAAACTAATCTCCTCGACAAAGACCTTATCGGT
ATCAAGATGGTCACCGGTGGTTCAGTCACTGATTCTTTCTTGGTTAGTGGTGTCGCTTTC
AAGAAAACCTTCTCTTATGCAGGTTTTGAACAACAACCCAAAAAGTTCAATAACCCTAAG
ATTTGCTTACTTAACATCGAATTAGAATTAAAGGCTGAAAAGGAAAATGCTGAAATTAGA
ATTGAAAATCCTGATGATTACAAGTCAATTGTTGATGCTGAATGGGAGTTGATTTATGAA
AAGTTAAGAAAGATTGTTGAATCTGGTGCTAACATTGTTCTCTCCAAGCTTCCTATTGGT
GATTTGGCCACTCAATACTTCGCTGATCGTAACATTTTCTGTGCTGGTCGTGTTGATGCT
GAAGATATGAAGAGAGTCCAAAAATCTACTGGTGCCATCGTTCAAACCACTGTCAATGGT
TTGACTGAAGATGTCTTAGGTACTTGCAACCAATTCGAAGAAGTTTAAATCGGTGCTGAA
AGATATAACCTCTTCAAGGATTGCCCTCACTCTAAGAGTGCTACCATCATTTTAAGAGGT
GGTGCTGAATAATTCATTGCTGAAGCTGAACGTTCTCTTAATGATGCAATCATGATCGTC
AGAAGATGCATGAAGGCCAATAAAATCGTTCCTGGTGGTGGTGCCATCGAATTAGAAATC
TCTCGTCTTCTCCGTTTACACTCCAGAAAGACTGAAGGAAAGATCTAATTAGTTATTAAT
GCTTTTGCTAAGGCTCTTGAAGTCATTCCCAGAACTATTGCTGATAATGCTGGTCACGAC
TCCATTCAAGTTCTTAATAAACTCCGTCAAAAGCATGCTATTGAAACCGAACAATCTAGA
AACTTCGGTGTTGATATTAATGCTGCTGATGGTATTGGCAATAACTACGAAAATTTTGTT
TGGGAACCTATCGTTGTCAGAAAAAATGCTTTGTCTGCTGCCACTGAAGCTGCTTGCACT
ATTTTAAGTATTGATGAAACTGTTAGAAATCCCAAGAGTGAACAACCTAAGGCTCCCCCT
GGTGGACTCAGAAGAGGTGGTCCTCAAGGAATGGCTGGTTTGGCTAAAAATGCTAAGCTC
GGAAAGTGA

>TTHERM_00497960(protein)
MSYLLQPTILLLKDGTDTSQGKAQIVSNINAVQSIVEIVKTTLGPRGMDKLIEGGMKGAT
ISNDGATILNLLDIVHPAAKTLVDIAKAQDDEVGDGTTSVCLLAGELLKESKYFIEEGMH
PQIITKGYKEALKLALQFLHENAHSVADKNETEKREMLIKCAQTSLNSKLLAHYKEFFSE
LVVQAVETLETNLLDKDLIGIKMVTGGSVTDSFLVSGVAFKKTFSYAGFEQQPKKFNNPK
ICLLNIELELKAEKENAEIRIENPDDYKSIVDAEWELIYEKLRKIVESGANIVLSKLPIG
DLATQYFADRNIFCAGRVDAEDMKRVQKSTGAIVQTTVNGLTEDVLGTCNQFEEVQIGAE
RYNLFKDCPHSKSATIILRGGAEQFIAEAERSLNDAIMIVRRCMKANKIVPGGGAIELEI
SRLLRLHSRKTEGKIQLVINAFAKALEVIPRTIADNAGHDSIQVLNKLRQKHAIETEQSR
NFGVDINAADGIGNNYENFVWEPIVVRKNALSAATEAACTILSIDETVRNPKSEQPKAPP
GGLRRGGPQGMAGLAKNAKLGK

>TTHERM_00497960(gene)
ATATAAAATATACATAAAAAAAATCTTTAAAAAAATCAAAAACAAAAAGCACTCAAAATT
ATACAACCACATAATAAAGCTATGAGTTATCTTTTGGTATTTATTTTTTCTTTTTACTTA
ATTCTTAACAGCAGAAATATTTTACTACAAACCAATGCGCTTACTTTTGTCCAATATTTT
GCCTTAGTTAATTTGAAATCCCATAAAATGCTTCTCCTTGCGCCCATAAACAGCAAATTT
TACATGACCTTCAAATAGATTATTATTATTATTACCATTTAATACATTCGATTATAAGAT
TGTATTAACATATAGACTGTTTATGGCACTTATAGTAGCAAATAGTTTAAATATTGAAGC
TTATATCATGATGATTTCATATGATTTATTTGCTATTATCTGCACAAATAATGCTTTGCT
TTGATTTTAATTAACACTTTTTAACTTTTATACTATAGCAACCTACCATTTTGCTCTTGA
AGGACGGTACTGATACTTCCTAAGGAAAGGCTTAAATTGTTTCCAACATTAATGCTGTCT
AATCTATTGTAGAAATCGTTAAGACCACTTTAGGTAAATAAATTTAGAATTTTAAAAAAC
AATTTATACAAAAGCTTAGCAAATCTCAGCAATATAATCTTATTCAAGCAACTTATGAAA
AAGGATATAAAAAAAGCAATTGTTTGCTTAAATTGTTATTGTTATTAAGCAATATTCAAA
TAGGATACTTAAACCTAAATAAAATTTTTTTATTTTAAAGAAATAGAAATGTTATAAAGC
AATTTTACTTTAATTTTAAAATGTTTGAATAAAATTTGAAAAATAAACGATCAACCCACC
AAGCATCGAACAAAATATATCTTCTTCATTGATTATAAACAAAAGCACATAAAATAAAGA
TTATTAGATTTGTTAAATTTCATTCGACTCAAATTATATTCTAACCATCATTTTAATTTT
TATAGGTCCCCGTGGTATGGATAAATTGATTGAAGGTGGAATGAAGGGAGCCACTATTTC
CAATGATGGTGCTACTATTTTAAACTTATTAGATATTGTTCACCCTGCTGCTAAGACTCT
TGTTGATATTGCTAAGGCTTAAGACGATGAAGTTGGTGATGGTACCACTTCTGTCTGCCT
TTTGGCTGGTGAATTATTGAAGGAATCTAAGTACTTCATCGAAGAAGGTATGCACCCATA
AATTATCACTAAGGGTTACAAGGAAGCCCTCAAGTTAGCTCTTTAATTCTTACACGAAAA
TGCTCACTCTGTAGCTGATAAGAACGAAACGTAATTATTTATAAAGATATACTGTTATAT
AATCTAAATTATTATAATTTTACATTAGTGAAAAGAGAGAAATGCTCATTAAGTGCGCTT
AAACCTCTTTAAACTCCAAATTATTAGCTCATTACAAGGAATTCTTCTCTGAGTTAGTTG
TTTAAGCCGTTGAAACTCTTGAAACTAATCTCCTCGACAAAGACCTTATCGGTATCAAGA
TGGTCACCGGTGGTTCAGTCACTGTAAGATTTTATTTTTTAAAATTCAAAATATTCAAAA
AGGAAATTATCTAAATATGTGCCCAGCTAGCTAGCTAGCTACCTAAATTATTAACATTTT
TTAAAATTTTATTTTCATTAATAAATAGGATTCTTTCTTGGTTAGTGGTGTCGCTTTCAA
GAAAACCTTCTCTTATGCAGGTTTTGAACAACAACCCAAAAAGTTCAATAACCCTAAGAT
TTGCTTACTTAACATCGAATTAGAATTAAAGGCTGAAAAGGAAAATGCTGAAATTAGAAT
TGAAAATCCTGATGATTACAAGTCAATTGTTGATGCTGAATGGGAGTTGATTTATGAAAA
GTTAAGAAAGATTGTTGAATCTGGTGCTAACATTGTTCTCTCCAAGCTTCCTATTGGTGA
TTTGGCCACTCAATACTTCGCTGATCGTAACATTTTCTGTGCTGGTCGTGTTGATGCTGA
AGATATGAAGAGAGTCCAAAAATCTACTGGTGCCATCGTTCAAACCACTGTCAATGGTTT
GACTGAAGATGTCTTAGGTACTTGCAACCAATTCGAAGAAGTTTAAATCGGTGCTGAAAG
ATATAACCTCTTCAAGGATTGCCCTCACTCTAAGAGTGCTACCATCATTTTAAGAGGTGG
TGCTGAATAATTCATTGCTGAAGCTGAACGTTCTCTTAATGATGCAATCATGATCGTCAG
AAGATGCATGAAGGCCAATAAAATCGTTCCTGGTGGTGGTGCCATCGAATTAGAAATCTC
TCGTCTTCTCCGTTTACACTCCAGAAAGACTGAAGGAAAGATCTAATTAGTTATTAATGC
TTTTGCTAAGGCTCTTGAAGTCATTCCCAGAACTATTGCTGATAATGCTGGTCACGACTC
CATTCAAGTTCTTAATAAACTCCGTCAAAAGCATGCTATTGAAACCGAACAATCTAGAAA
CTTCGGTGTTGATATTAATGCTGCTGATGGTATTGGCAATAACTACGAAAATTTTGTTTG
GGAACCTATCGTTGTCAGAAAAAATGCTTTGTCTGCTGCCACTGAAGTAAACATTTATTT
ACAAAGTTCAATCATATTTATTAAATTTATAATTTTACAAATTAGGCTGCTTGCACTATT
TTAAGTATTGATGAAACTGTTAGAAATCCCAAGAGTGAACAACCTAAGGCTCCCCCTGGT
GGACTCAGAAGAGGTGGTCCTCAAGGAATGGCTGGTTTGGCTAAAAATGCTAAGCTCGGA
AAGTGAGTTTTAAATAATTAAGCAAAGAAACAATAAAATTAAATCAATATTATTCTTAAT
TATCATTTATAATGTAATTATAGGTCATTTTTTGTATATTTATTTTTATTAAGTGTTTTA
AATAAATTAGAAAAAATGACTAATTCAAAATACTTTCA