Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert JP, Pearlman RE, Fillingham J (2020) Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila. Scientific reports 10(1):168 PUBMED:31932604
Akematsu T, Sánchez-Fernández R, Kosta F, Holzer E, Loidl J (2019) The Transmembrane Protein Semi1 Positions Gamete Nuclei for Reciprocal Fertilization in Tetrahymena. iScience 23(1):100749 PUBMED:31884169
Tian M, Loidl J (2019) An MCM family protein promotes interhomolog recombination by preventing precocious intersister repair of meiotic DSBs. PLoS genetics 15(12):e1008514 PUBMED:31815942
Identifiers and Description
Gene Model Identifier
TTHERM_00836580
Standard Name
BTU2 (Beta-Tubulin 2
)
Aliases
146.m00071 | PreTt17770 | 3743.m00003
Description
Beta-tubulin; ciliary form is phosphorylated by CaMK; multiple polyglycation sites are required for survival and partial removal affects growth, motility, and cytokinesis; transcript destabilized by heat shock; protein identical to Btu1p
TUB2 Beta-tubulin; associates
with alpha-tubulin (Tub1p and
Tub3p) to form tubulin dimer,
which polymerizes to form micr
otubules
General Information
No Data fetched for General Information
Associated Literature
Ref:15470250: Smith JJ, Yakisich JS, Kapler GM, Cole ES, Romero DP (2004) A beta-tubulin mutation selectively uncouples nuclear division and cytokinesis in Tetrahymena thermophila. Eukaryotic cell 3(5):1217-26
Ref:11864572: Duan J, Gorovsky MA (2002) Both carboxy-terminal tails of alpha- and beta-tubulin are essential, but either one will suffice. Current biology : CB 12(4):313-6
Ref:11862218: Thazhath R, Liu C, Gaertig J (2002) Polyglycylation domain of beta-tubulin maintains axonemal architecture and affects cytokinesis in Tetrahymena. Nature cell biology 4(3):256-9
Ref:10847334: Gaertig J (2000) Molecular mechanisms of microtubular organelle assembly in Tetrahymena. The Journal of eukaryotic microbiology 47(3):185-90
Ref:10403369: Nakazawa M, Moreira D, Laurent J, Le Guyader H, Fukami Y, Ito K (1999) Biochemical analysis of the interaction between elongation factor 1alpha and alpha/beta-tubulins from a ciliate, Tetrahymena pyriformis. FEBS letters 453(1-2):29-34
Ref:10331805: Gaertig J, Gao Y, Tishgarten T, Clark TG, Dickerson HW (1999) Surface display of a parasite antigen in the ciliate Tetrahymena thermophila. Nature biotechnology 17(5):462-5
Ref:7651434: Gu L, Gaertig J, Stargell LA, Gorovsky MA (1995) Gene-specific signal transduction between microtubules and tubulin genes in Tetrahymena thermophila. Molecular and cellular biology 15(9):5173-9
Ref:9072048: Nakamura K, Shigaki Y, Takaya C (1995) Proteolysis of tubulin isotypes within Tetrahymena axonemes. Biological chemistry Hoppe-Seyler 376(12):729-32
Ref:7775576: Gaertig J, Cruz MA, Bowen J, Gu L, Pennock DG, Gorovsky MA (1995) Acetylation of lysine 40 in alpha-tubulin is not essential in Tetrahymena thermophila. The Journal of cell biology 129(5):1301-10
Ref:7804247: Levasseur PJ, Meng Q, Bouck GB (1995) Tubulin genes in the algal protist Euglena gracilis. The Journal of eukaryotic microbiology 41(5):468-77
Ref:7910408: Gaertig J, Thatcher TH, Gu L, Gorovsky MA (1994) Electroporation-mediated replacement of a positively and negatively selectable beta-tubulin gene in Tetrahymena thermophila. Proceedings of the National Academy of Sciences of the United States of America 91(10):4549-53
Ref:7816630: Gaertig J, Gu L, Hai B, Gorovsky MA (1994) High frequency vector-mediated transformation and gene replacement in Tetrahymena. Nucleic acids research 22(24):5391-8
Ref:8102139: Soares H, Galego L, Cóias R, Rodrigues-Pousada C (1993) The mechanisms of tubulin messenger regulation during Tetrahymena pyriformis reciliation. The Journal of biological chemistry 268(22):16623-30
Ref:8221902: Gaertig J, Thatcher TH, McGrath KE, Callahan RC, Gorovsky MA (1993) Perspectives on tubulin isotype function and evolution based on the observation that Tetrahymena thermophila microtubules contain a single alpha- and beta-tubulin. Cell motility and the cytoskeleton 25(3):243-53
Ref:8102497: Mitchison TJ (1993) Localization of an exchangeable GTP binding site at the plus end of microtubules. Science (New York, N.Y.) 261(5124):1044-7
Ref:1640053: Nakamura K, Okuya Y, Katahira M, Yoshida S, Wada S, Okuno M (1992) Analysis of tubulin isoforms by two-dimensional gel electrophoresis using SDS-polyacrylamide gel electrophoresis in the first dimension. Journal of biochemical and biophysical methods 24(3-4):195-203
Ref:1339345: Dupuis P (1992) The beta-tubulin genes of Paramecium are interrupted by two 27 bp introns. The EMBO journal 11(10):3713-9
Ref:1902785: Soares H, Cyrne L, Barahona I, Rodrigues-Pousada C (1991) Different patterns of expression of beta-tubulin genes in Tetrahymena pyriformis during reciliation. European journal of biochemistry 197(2):291-9
Ref:1900051: Penque D, Galego L, Rodrigues-Pousada C (1991) Multiple alpha-tubulin isoforms in cilia and cytoskeleton of Tetrahymena pyriformis generated by post-translational modifications. Studies during reciliation. European journal of biochemistry 195(2):487-94
Ref:1689806: Krawczyńska W, Kludkiewicz B (1990) Polyadenylated RNA during DAPI-arrested regeneration of Tetrahymena cilia. Molecular and cellular biochemistry 92(1):53-60
Ref:2470096: Harper DS, Jahn CL (1989) Differential use of termination codons in ciliated protozoa. Proceedings of the National Academy of Sciences of the United States of America 86(9):3252-6
Ref:2768213: Hirano-Ohnishi J, Watanabe Y (1989) Ca2+/calmodulin-dependent phosphorylation of ciliary beta-tubulin in Tetrahymena. Journal of biochemistry 105(6):858-60
Ref:3139885: Barahona I, Soares H, Cyrne L, Penque D, Denoulet P, Rodrigues-Pousada C (1988) Sequence of one alpha- and two beta-tubulin genes of Tetrahymena pyriformis. Structural and functional relationships with other eukaryotic tubulin genes. Journal of molecular biology 202(3):365-82
Ref:3137027: Cóias R, Galego L, Barahona I, Rodrigues-Pousada C (1988) Destabilization of tubulin mRNA during heat shock in Tetrahymena pyriformis. European journal of biochemistry 175(3):467-74
Ref:3901010: Suprenant KA, Hays E, LeCluyse E, Dentler WL (1985) Multiple forms of tubulin in the cilia and cytoplasm of Tetrahymena thermophila. Proceedings of the National Academy of Sciences of the United States of America 82(20):6908-12
Ref:6413210: Little M, Quinlan RA, Hoffman EJ, Ludueña RF (1983) Identification and characterization of axopodial tubulins from Echinosphaerium nucleofilum. European journal of cell biology 31(1):55-61
Ref:6192014: Barahona I, Rodrigues-Pousada C (1983) Site of tubulin synthesis in Tetrahymena pyriformis. FEBS letters 158(2):271-5
Ref:7440655: Gavin RH (1980) The oral apparatus of Tetrahymena. V. Oral apparatus polypeptides and their distribution. Journal of cell science 44( ):317-33
Ref:7458914: Roobol A, Pogson CI, Gull K (1980) Identification and characterization of microtubule proteins from myxamoebae of Physarum polycephalum. The Biochemical journal 189(2):305-12
Ref:111932: Marcaud L, Hayes D (1979) RNA synthesis in starved deciliated Tetrahymena pyriformis. European journal of biochemistry 98(1):267-73
Ref:119852: Fliss ER, Suyama Y (1979) Tetrahymena tubulins and in vitro translation of Tetrahymena RNA. The Journal of protozoology 26(3):505-9
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Signal Peptide
Homologs (v.2006 protein sequences)
General Information 
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