Identifiers and Description

Gene Model Identifier

TTHERM_00442300

Standard Name

ASF1 (Anti-Silencing Factor 1)

Aliases

PreTt05630 | 50.m00199 | 3681.m00058

Description

Anti-silencing protein, ASF1-like containing protein; mediates nuclear transport of newly synthesized histones H3 and H4

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• nucleus (IEA) | GO:0005634

Molecular Function

• histone binding (IDA) | GO:0042393 | Ref:24120531

Biological Process

• chromatin assembly or disassembly (IEA) | GO:0006333

Domains

• ( PF04729 ) Anti-silencing protein, ASF1-like

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.2%

TetraMine Data

TTHERM_00442300

WebApollo

Fullscreen View

Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_12563.1	6.002196208547375e-166	anti-silencing protein, ASF1-l ike containing protein (251 aa )
Oxytricha	Contig22786.0.g13	4.000820122464668e-47	ASF1 like histone chaperone
DictyBase	DDB_G0285513	3.0009061039838537e-46	asf1 on chromosome: 4 position 3334165 to 3335058
SGD	YJL115W	5.998886722426197e-42	ASF1 Nucleosome assembly facto r, involved in chromatin assem bly and disassembly, anti-sile ncing protein that causes dere pression of silent loci when o verexpressed; plays a role in regulating Ty1 transposition
WormBase	WBGene00006817	2.00017271388466e-38	locus:unc-85 Probable histon e chaperone asf-1 status:Con firmed UniProt:Q19326 prot ein_id:CCD69205.1
Stentor Coeruleus	SteCoe_15840	3.532628572200807e-24

General Information

No Data fetched for General Information

Associated Literature

1. Ref:28621664: Akematsu T, Fukuda Y, Garg J, Fillingham JS, Pearlman RE, Loidl J (2017) Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11. eLife 6( ):
2. Ref:24120531: Garg J, Lambert JP, Karsou A, Marquez S, Nabeel-Shah S, Bertucci V, Retnasothie DV, Radovani E, Pawson T, Gingras AC, Pearlman RE, Fillingham JS (2013) Conserved Asf1-importin ? physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila. Journal of proteomics 94( ):311-26

Sequences

>TTHERM_00442300(coding)
ATGGCCTTAGTCAACATCTAAAACATCCAATTTCATAACAACCCTTGCCCTTTTTTGAGT
CCCTTTAAACTTGACGTAACCTTCGAATGTATCAAACCTATACCTGATGACATTGAATGG
TAATTAATTTATATTGGTTCTGCTAAAGATGAGAAATACGATTAAGTCCTTGATAAATTC
AGTATTGGGTCATTAGATTAAGGAGTGCTTTAATTTACCATTGAAACAAATCCACCTGAT
CACACTAAGATTCCAAACAAAGATGATTTACTTGGTGTAACTGCTATAATTCTAACTGTT
TCATACCACAATCAGGAGTTTTTCCGTGTTGGATACTATGTCTACAATCAATACAATGAT
CAGGAACTTATTATTAATGATCCTCCTTAAATTCTAATTGATAAGGTTGAGCGTAGTATC
CTTGATAAATAGCCTCGTATCACTCATTTCAACATAAAATGGGGTACTGAGGATGAAAAT
AAAGAAACTGACCCTAATACTTTAGCTATCCTCTAACAGTAATTAGCTTAAAATGGAACC
ATTCCTAATTAACTCATGCAAGAAATGCAATAAGTGAATAGCTAAATGCAATCTTTCTTA
CCTGATCCTTTTTCTAAGTCATCAGGAATACTCTAAGAGTTAACAACATAAGGATAGACT
AACAGCACAAATAGTTTCATGTTTGGTTAAGGGCTAGACATACCTTAAAATAATGCATTC
CAACCTACAAATGTATTCAGTTCTAATCCTTACTGA

>TTHERM_00442300(protein)
MALVNIQNIQFHNNPCPFLSPFKLDVTFECIKPIPDDIEWQLIYIGSAKDEKYDQVLDKF
SIGSLDQGVLQFTIETNPPDHTKIPNKDDLLGVTAIILTVSYHNQEFFRVGYYVYNQYND
QELIINDPPQILIDKVERSILDKQPRITHFNIKWGTEDENKETDPNTLAILQQQLAQNGT
IPNQLMQEMQQVNSQMQSFLPDPFSKSSGILQELTTQGQTNSTNSFMFGQGLDIPQNNAF
QPTNVFSSNPY

>TTHERM_00442300(gene)
AAAAAAAATTAAAAAAACAAATTTTAATAATTCAAGAAAAAGTAAGAAAAAAATCTTGCT
CATTTTCAGAAAGAAAAAAGGTTAGAAAAAGTTTATCTTCACACAAAGCTTCACAGCTCA
TCAAAGAACTCTATTTTTATTAATTTATAGGAAGCAACTTCGTTTCGCGTTAGAATAAAA
TAAATATTAAACAAGAAAAAAATCCAAAAAGTACGCATTTATCTACCTCAAATAAGCAAA
ATGGCCTTAGTCAACATCTAAAACATCCAATTTCATAACAACCCTTGCCCTTTTTTGAGT
CCCTTTAAACTTGACGTAACCTTCGAATGTATCAAACCTATACCTGATGACATTGAATGG
TAATTAATTTATATTGGTTCTGCTAAAGATGAGAAATACGATTAAGTCCTTGATAAATTC
AGTATTGGGTCATTAGATTAAGGAGTGCTTTAATTTACCATTGAAACAAATCCACCTGAT
CACACTAAGATTCCAAACAAAGATGATTTACTTGGTGTAACTGCTATAATTCTAACTGTT
TCATACCACAATCAGGAGTTTTTCCGTGTTGGATACTATGTCTACAATCAATACAATGAT
CAGGAACTTATTATTAATGATCCTCCTTAAATTCTAATTGATAAGGTTGAGCGTAGTATC
CTTGATAAATAGCCTCGTATCACTCATTTCAACATAAAATGGGGTACTGAGGATGAAAAT
AAAGAAACTGACCCTAATACTTTAGCTATCCTCTAACAGTAATTAGCTTAAAATGGAACC
ATTCCTAATTAACTCATGCAAGAAATGCAATAAGTGAATAGCTAAATGCAATCTTTCTTA
CCTGATCCTTTTTCTAAGTCATCAGGAATACTCTAAGAGTTAACAACATAAGGATAGACT
AACAGCACAAATAGTTTCATGTTTGGTTAAGGGCTAGACATACCTTAAAATAATGCATTC
CAACCTACAAATGTATTCAGTTCTAATCCTTACTGA