Identifiers and Description

Gene Model Identifier

TTHERM_00794600

Standard Name

APN2 (APurinic Nuclease 2)

Aliases

PreTt21459 | 134.m00139 | APE1

Description

APN2 ExoIII family purinic/apyrimidinic (AP) endonuclease family animal Ape2 subfamily protein; Exodeoxyribonuclease III family protein; AP endonuclease; involved in base excision repair pathway

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• nuclease activity (IEA) | GO:0004518
• endonuclease activity (IEA) | GO:0004519

Biological Process

• DNA repair (IEA) | GO:0006281

Domains

• ( TIGR00195 ) exodeoxyribonuclease III
• ( TIGR00633 ) exodeoxyribonuclease III (xth)
• ( TIGR03395 ) sphingomyelin phosphodiesterase
• ( PF03372 ) endonuclease/exonuclease/phosphatase family

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 16%

TetraMine Data

TTHERM_00794600

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_13338.1	9.997093137033517e-262	exodeoxyribonuclease III famil y protein (419 aa)
Oxytricha	Contig20170.0.g42	1.0004137340105782e-93	Endonuclease/Exonuclease/phosp hatase family
DictyBase	DDB_G0277701	4.000392704867155e-81	apeA on chromosome: 2 position 8367690 to 8368775
WormBase	WBGene00001372	9.996907204735647e-62	locus:exo-3 status:Confirmed UniProt:G5EBR7 protein_id :CAB03235.1
Stentor Coeruleus	SteCoe_20039	1.3336148155022614e-34
SGD	YBL019W	0.000000005997038937208364	APN2 Class II abasic (AP) endo nuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII

General Information

No Data fetched for General Information

Associated Literature

1. Ref:SUPR000163

Sequences

>TTHERM_00794600(coding)
ATGATTAAATCTTTTAGATTTTCAGCTTCTAGTCTTTTAAATTTTAGAAACCAATGCTTT
AATACTTAACGTGTAGGTAAGGTATTTTATGCGCCAAAGTTATTAACTTTCCCACTGTTG
AAGTAAAATTTTACTCAGCTCGAAAAAGGCTCAGACTTGCAATAATCAGTAGAAAAATAA
ACTAAAAAGAAAAAAGGTATGAGTAAAATAATTAAAAAATCAAGCTCTATTTCAGAGCCT
GAATAGTCGTAGTCCAGTACTACTACTTAAAAGACTAAAAAGCAGGCTCAATTAGGTGAT
TTCTTTGCTGGAATAAAAAAAAAACCTGAGACCTAAGTTGAAGATAAAGTAGAAATAAAT
ACAGAATTAGGAGATGGAATTTGGAAAGATCGTTAAAATATTAAAATAGCATGTTGGAAT
GTGAATGGATTAAGAGCTGTTTTGAAAAGAGAAGACTTATAAAAGTATATAAAGTAAGAA
AATCCTGATATTCTATGCCTAAATGAAACTAAAATAGATGAATCGAATTTTATAAAAGAA
AAAGTATACAAAGATATTCCTTCAGGCTATTACTAATATTGGAATTTCTGTATACCACCA
ATTAAGGGTTACTCTGGCGTTTCTATTTTCTCTAAAGAAAAAGTCATTAGCATTAAAAAA
GGTATAGATATTGCAGAGCACGAGAACGAAGGAAGGGTTCTTACAGCTGAATTCGATAAA
TTTTATTTAGTTGTAGTTTATGTCCCTAATGCAGGATCGGAATTAGTTAGACTAGATTAT
AGAGTTAATTCGTTTGATAAAGACTTTCAAAATTATTTAAACTAACTAAAATTGAAAAAA
AATGTGATTCTTTGTGGTGATTTAAATGTAGCTCACTAAGAAATAGATATAGCTAATCCC
AAATCTAATAGAAACTCTCCAGGATTTACAATTGAAGAAAGGAATAGCTTTAGTAAATTT
TTAGAAAGTGGATGGATAGATACATTTAGATTTTTATATCCAGAAACTATAAAATATTCT
TGGTGGAGTGTTAGAACTAAAGCTAGAGAATCAAATATAGGATGGAGAATAGATTATTTC
GTTGTAAATAAAGAATTTAAGTCCTCTATTAAAGACTCTATGATAAATAATAATATCTAT
GGAAGTGACCATTGTCCAGTTGAATTTATTTTAAATTTAGATGCTATTTAATAAAATGAA
ACTTCTTCAAACGAAAATACATAAACAAATAAATCTAATTGA

>TTHERM_00794600(protein)
MIKSFRFSASSLLNFRNQCFNTQRVGKVFYAPKLLTFPLLKQNFTQLEKGSDLQQSVEKQ
TKKKKGMSKIIKKSSSISEPEQSQSSTTTQKTKKQAQLGDFFAGIKKKPETQVEDKVEIN
TELGDGIWKDRQNIKIACWNVNGLRAVLKREDLQKYIKQENPDILCLNETKIDESNFIKE
KVYKDIPSGYYQYWNFCIPPIKGYSGVSIFSKEKVISIKKGIDIAEHENEGRVLTAEFDK
FYLVVVYVPNAGSELVRLDYRVNSFDKDFQNYLNQLKLKKNVILCGDLNVAHQEIDIANP
KSNRNSPGFTIEERNSFSKFLESGWIDTFRFLYPETIKYSWWSVRTKARESNIGWRIDYF
VVNKEFKSSIKDSMINNNIYGSDHCPVEFILNLDAIQQNETSSNENTQTNKSN

>TTHERM_00794600(gene)
ATGATTAAATCTTTTAGATTTTCAGCTTCTAGTCTTTTAAATTTTAGAAACCAATGCTTT
AATACTTAACGTGTAGGTAAGGTATTTTATGCGCCAAAGTTATTAACTTTCCCACTGTTG
AAGTAAAGTAATAATAATTATAGTATTACCGCCTAAAGATATTAAATAATATATTGAATT
TTTAAAATTTAGATTTTACTCAGCTCGAAAAAGGCTCAGACTTGCAATAATCAGTAGAAA
AATAAACTAAAAAGAAAAAAGGTATGAGTAAAATAATTAAAAAATCAAGCTCTATTTCAG
AGCCTGAATAGTCGTAGTCCAGTACTACTACTTAAAAGACTAAAAAGCAGGCTCAATTAG
GTGATTTCTTTGCTGGAATAAAAAAAAAACCTGAGACCTAAGTTGAAGATAAAGTAGAAA
TAAATACAGAATTAGGAGATGGAATTTGGAAAGATCGTTAAAATATTAAAATAGCATGTT
GGAATGTGAATGGATTAAGAGCTGTTTTGAAAAGAGAAGACTTATAAAAGTATATAAAGT
AAGAAAATCCTGATATTCTATGCCTAAATGAAACTAAAATAGATGAATCGAATTTTATAA
AAGAAAAAGTATACAAAGATATTCCTTCAGGCTATTACTAATATTGGTAATTTTATCAAA
AAACTATAATTTTTAGTTTTACATTTCTAAAAATATTAAAAAACAAATAAATAATTTTAT
AAATAATTAACATAATAATAGATTAATGAATTAAATTAATTTAGCTTTAATATTGTTATA
AGAATTTATTAAATACATAAATTAATAAACTAAAAAGGAATTTCTGTATACCACCAATTA
AGGGTTACTCTGGCGTTTCTATTTTCTCTAAAGAAAAAGTCATTAGCATTAAAAAAGGTA
TAGATATTGCAGAGCACGAGAACGAAGGAAGGGTTCTTACAGCTGAATTCGATAAATTTT
ATTTAGTTGTAGTTTATGTCCCTAATGCAGGATCGGAATTAGTTAGACTAGATTATAGAG
TTAATTCGTTTGATAAAGACTTTCAAAATTATTTAAACTAACTAAAATTGAAAAAAAATG
TGATTCTTTGTGGTGATTTAAATGTAGCTCACTAAGAAATAGATATAGCTAATCCCAAAT
CTAATAGAAACTCTCCAGGATTTACAATTGAAGAAAGGAATAGCTTTAGTAAATTTTTAG
AAAGTGGATGGATAGATACATTTAGATTTTTATATCCAGAAACTATAAAATATTCTTGGT
GGAGTGTTAGAACTAAAGCTAGAGAATCAAATATAGGATGGAGAATAGATTATTTCGTTG
TAAATAAAGAATTTAAGTCCTCTATTAAAGACTCTATGATAAATAATAATATCTATGGAA
GTGACCATTGTCCAGTTGAATTTATTTTAAATTTAGATGCTATTTAATAAAATGAAACTT
CTTCAAACGAAAATACATAAACAAATAAATCTAATTGA