Identifiers and Description

Gene Model Identifier

TTHERM_00577030

Standard Name

APM2 (Adaptor Protein complex Medium (Mu) subunit )

Aliases

PreTt28990 | 77.m00202 | 3812.m02678

Description

homolog of adaptor protein complex (AP-2) medium (mu) subunit; localized near coated pits and the contractile vacuole pores

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• plasma membrane (IDA) | GO:0005886 | Ref:16276403
• clathrin adaptor complex (IEA) | GO:0030131
• contractile vacuole pore (IDA) | GO:0031913 | Ref:16276403
• AP-2 adaptor complex (ISS) | GO:0030122 | Ref:16276403

Molecular Function

• protein binding (IEA) | GO:0005515

Biological Process

• vesicle-mediated transport (ISS) | GO:0016192 | Ref:16276403
• vesicle-mediated transport (IEA) | GO:0016192
• intracellular protein transport (IEA) | GO:0006886

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.8%

TetraMine Data

TTHERM_00577030

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Stentor Coeruleus	SteCoe_9626	0
Tetrahymena borealis	EI9_04058.1	9.997093137033517e-262	adaptor complexes medium subun it protein (433 aa)
Oxytricha	Contig21325.0.g90	9.997316819378982e-180	Adaptor complexes medium subun it family
DictyBase	DDB_G0277139	8.001983224960958e-155	apm2 on chromosome: 2 position 7788092 to 7789756
WormBase	WBGene00001082	8.00283818813536e-121	locus:dpy-23 AP-2 complex su bunit mu status:Confirmed UniProt:P35603 protein_id:CC D68419.1
SGD	YPL259C	8.002331242114626e-85	APM1 Mu1-like medium subunit o f the clathrin-associated prot ein complex (AP-1); binds clat hrin; involved in clathrin-dep endent Golgi protein sorting

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16276403: Elde NC, Morgan G, Winey M, Sperling L, Turkewitz AP (2005) Elucidation of clathrin-mediated endocytosis in tetrahymena reveals an evolutionarily convergent recruitment of dynamin. PLoS genetics 1(5):e52

Sequences

>TTHERM_00577030(coding)
ATGATTAGCTCTATTGTTTTTATTAACTCTAAAGGTGAAATCTTAATTTATAGAATTTAT
AAGGATGATATTAGCAGAGCAGAGACTATGTAATTCTGCACAAATGTAGTAGCTCGTAAG
GAAAGCAAAGAATCCCCTATTGTAAACATAGATGGTACTTCATTTATCCACGTCAGCTAC
AAAGATATAATATTATTAGCCACAACTAAATGTAATATAAATGCTGCTATGACAATTTAG
TTTCTTTATTAGTTGATAAATGTTTGCAAGTCCTATTTTGGTGATTTCGATGAAAACAAT
ATTCGTAAATAGTTTGTTCTCATCTATGAATTGCTCGATGAAATTATGGATTATGGTCTT
CCTTAAATTCTAGACCCCGATCTTTTAAAGTAATCAATTCAAGAAGGAGGCAAGCAAGAT
GGCATGACTGATATAGAAAAATTAAAATAATTTACTTAATAAGCTACTAATGCTTAATCG
TGGAGAGCACCAAACATTTTCTACAAAAAGAATGAAGTCTACATTGATATTATAGAAAGC
GTAAATGTAAGTATGTCAGTTAAGGGATCTATCCTTAAAGCTGATGTCTCAGGAAAAGTT
ATGGTAAAAGCTCTACTCAGTGGTGTCCCTGATTGTAAATTTGGTATGAATGACAAGGTC
TTAATGGAAAAAGAACCTCCTAAACCAGGTTCAAATCCTTAATAAGGTGGCTAAAACAAT
AAGGGTATTACAATCGATGACTTAAAGTTCCATCCTTGTGTAGTCCTTCCCAAGTTTGAC
AAAGAAAGAGCTATCACATTCACTCCTCCTGATGGTGAGTTCTAGCTAATGAGCTACAGA
ATTACTGAGAATGTCAATTTACCTTTCAAAATAATGCCCGTAATTAACGAAGATGGAAAT
AATATTGAAGTAAGAGTAAAGCTAAAATCTATTTTTGATAAAACTCAATATGCAACTAAT
GTTGCTTTAAAGGTTCCTTGCCCTAAAAATACTGCAAACACATCAAACACTGCTAGTATA
GGAAGAGCTAAATATGAACCAGAATAAGGAGGTATCGTTTGGAGAATAAAGAAGTTCTAG
GGAGAAACTGAAGCTCTTCTTAGATGTGAAATCGTGTTGAGTAATACTGCTCTTGATAAA
AATTGGGTAAAACCTCCTATATCTCTTGAATTCTAAGTTCCATCATTTACAGCAAGTGGC
TTGAGAGTAAGATTCTTGCGTATTCATGAAAAAAGTGGTTATCACCCTACAAAATGGATT
CGTTATATAACTAAGGGTGGTGAATATCTTCATCGTATATGA

>TTHERM_00577030(protein)
MISSIVFINSKGEILIYRIYKDDISRAETMQFCTNVVARKESKESPIVNIDGTSFIHVSY
KDIILLATTKCNINAAMTIQFLYQLINVCKSYFGDFDENNIRKQFVLIYELLDEIMDYGL
PQILDPDLLKQSIQEGGKQDGMTDIEKLKQFTQQATNAQSWRAPNIFYKKNEVYIDIIES
VNVSMSVKGSILKADVSGKVMVKALLSGVPDCKFGMNDKVLMEKEPPKPGSNPQQGGQNN
KGITIDDLKFHPCVVLPKFDKERAITFTPPDGEFQLMSYRITENVNLPFKIMPVINEDGN
NIEVRVKLKSIFDKTQYATNVALKVPCPKNTANTSNTASIGRAKYEPEQGGIVWRIKKFQ
GETEALLRCEIVLSNTALDKNWVKPPISLEFQVPSFTASGLRVRFLRIHEKSGYHPTKWI
RYITKGGEYLHRI

>TTHERM_00577030(gene)
ATGATTAGCTCTATTGTTTTTATTAACTCTAAAGGTGAAATCTTAATTTATAGAATTTAT
AAGGATGATATTAGCAGAGCAGAGACTATGTAATTCTGCACAAATGTAGTAGCTCGTAAG
GAAAGCAAAGAATCCCCTATTGTAAACATAGATGGTACTTCATTTATCCACGTCAGCTAC
AAAGATATAATATTATTAGCCACAACTAAATGTAATATAAATGCTGCTATGACAATTTAG
TTTCTTTATTAGTTGATAAATGTTTGCAAGTCCTATTTTGGTGATTTCGATGAAAACAAT
ATTCGTAAATAGTTTGTTCTCATCTATGAATTGCTCGATGAAGTAAATATTTAAAATTTA
ACATTTAGAAATAGATTAATATGATAAACCAATCTTTATTAGTTCCCAAAAATCTAAAAA
AAAACGAAAAATAAAGTTAGTTATGTTATTTAAATAACATTTATAATCAAAGTGTAATTG
ACTATTGAAAAGGTTAATAAAATATCCTTTTAATACAATCGAATAATGGATTTATGAAGA
TATTTCTTTCTAAATAAAAATGAAATATTTGAAATCTTTAATTTATCAAAAAAAAAAATT
TTTTTTTCTTTCTATAAAAAAAGATTATGGATTATGGTCTTCCTTAAATTCTAGACCCCG
ATCTTTTAAAGTAATCAATTCAAGAAGGAGGCAAGCAAGATGGCATGACTGATATAGAAA
AATTAAAATAATTTACTTAATAAGCTACTAATGCTTAATCGTGGAGAGCACCAAACATTT
TCTACAAAAAGAATGAAGTCTACATTGATATTATAGAAAGCGTAAATGTAAGTATGTCAG
TTAAGGGATCTATCCTTAAAGCTGATGTCTCAGGAAAAGTTATGGTAAAAGCTCTACTCA
GTGGTGTCCCTGATTGTAAATTTGGTATGAATGACAAGGTCTTAATGGAAAAAGAACCTC
CTAAACCAGGTTCAAATCCTTAATAAGGTGGCTAAAACAATAAGGGTATTACAATCGATG
ACTTAAAGTTCCATCCTTGTGTAGTCCTTCCCAAGTTTGACAAAGGTAATTATTTATTTA
TTTAGTTTTTTAAATGAAAAAGGTTTGATCTCCTTTATGAAATTTCATTATTAAGTTAAA
AAAATATAGTAAAATTAAGAAATAGATAGATATGTTTGATTTCTGTCAAAAATTTGAATT
ATTTAAAAAAATAATATAAAACAGAAAGAAGGATTAAAAAAAACATAAATGTTGCAAAAT
AAAATTTCAAATAATTCAATTTTATTATAGGATTTTCACTTTAGTGCAAATTTAAATCCT
TTCAAAATAATTTTTATTTCTATTTATATATAGAAAGAGCTATCACATTCACTCCTCCTG
ATGGTGAGTTCTAGCTAATGAGCTACAGAATTACTGAGAATGTCAATTTACCTTTCAAAA
TAATGCCCGTAATTAACGAAGATGGAAATAATATTGAAGTAAGAGTAAAGCTAAAATCTA
TTTTTGATAAAACTCAATATGCAACTAATGTTGCTTTAAAGGTTCCTTGCCCTAAAAATA
CTGCAAACACATCAAACACTGCTAGTATAGGAAGAGCTAAATATGAACCAGAATAAGGAG
GTATCGTTTGGAGAATAAAGAAGTTCTAGGGAGAAACTGAAGCTCTTCTTAGATGTGAAA
TCGTGTTGAGTAATACTGCTCTTGATAAAAATTGGGTAAAACCTCCTATATCTCTTGAAT
TCTAAGTTCCATCATTTACAGCAAGTGGCTTGAGAGTAAGATTCTTGCGTATTCATGAAA
AAAGTGGTTATCACCCTACAAAATGGATTCGTTATATAACTAAGGGTGGTGAATATCTTC
ATCGTATATGA