Identifiers and Description

Gene Model Identifier

TTHERM_00215960

Standard Name

AOS2 (Activation Of Smt3p 2 )

Aliases

PreTt22220 | 18.m00246 | 3701.m00009

Description

ThiF family protein; Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

• ( PF00899 ) ThiF family
• ( TIGR02354 ) thiamine biosynthesis protein ThiF
• ( TIGR02355 ) molybdopterin synthase sulfurylase MoeB
• ( TIGR00055 ) di-trans,poly-cis-decaprenylcistransferase
• ( TIGR02356 ) thiazole biosynthesis adenylyltransferase ThiF

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 24.6%

TetraMine Data

TTHERM_00215960

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_06564.1	9.997093137033517e-262	ThiF family protein (520 aa)
DictyBase	DDB_G0287965	7.996627236682682e-106	nae1 on chromosome: 5 position 887341 to 889297
Oxytricha	Contig9991.0.g10	1.999022616705709e-90	ThiF family
WormBase	WBGene00006735	1.0004460510701209e-64	locus:ula-1 NEDD8-activating enzyme E1 regulatory subunit status:Confirmed UniProt:Q 18217 protein_id:CCD65733.1
Stentor Coeruleus	SteCoe_30113	1.1089390193121365e-40
SGD	YPR180W	4.9988726541653934e-26	AOS1 Subunit of a heterodimeri c nuclear SUMO activating enzy me (E1) with Uba2p; activates Smt3p (SUMO) before its conjug ation to proteins (sumoylation ), which may play a role in pr otein targeting; essential for viability

General Information

No Data fetched for General Information

Associated Literature

1. Ref:SUPR000186
2. Ref:SUPR000154

Sequences

>TTHERM_00215960(coding)
ATGTCATCTAAAGATAAATACGATAGATAGCTTCGTCTTTGGGGTCCTCAAGGCTAAAGA
AAGTTGGCCAATTCTAAGATTTTGCTCTTAGGAGCAGCACCTGCAGGAGTTGAAGCTCTT
AAAAATTTAGTTTTACCAGGATGCGGTCACATTACTATTGTAGACCACCAACTCATTACT
GAGAGAGATTTAGGAAACAATTTTTTCTGCTCTCCTGAAGATTTAGGTCAACCCCGTGCT
AAGAGTGTCTGTGATAATCTTACAGAAATGAATCCTGAAGATGTTCATGGTAAGTGGCTT
AATGAAAATGTAGATGAATTAGCTGCTAAGGAAGATTTTATTAAAGAGTTTACTTGCGTT
ATAGCAAATGAGTTGCTTGATGAAGAACTTCATAAGCTATCTGTTATTTGTGATAAATAT
AATATTAAATTACTGGCAATCTAAACAAATGGATTTTATGCTTAGTTGCGTCTCTAAGCA
GGTCGTCATTGCATTATAGAAAGCAAACCAGACAGAGACTTCTATGACTGGACTCTTCGT
ATCCGCCAACCTTTCTAACATCTTCAAGATTTTTGTGATAAATTTGATTTGTAGGATTTA
TCAACTCATGAAGATAAGAATCCTCTAGCTCACGTACCTTTTGTAGTTATTTTAGTAAAG
GCTATGAATGCATGGAAGCAATCTCATAATGGTAATGCTCCTTCATCAATCCAAGAAAAG
AATGAATTTAAAAAAACCATCGAGACTCAAATGCACTGGCTTGAAGCTAAGGATCGTGAA
AATTTCGAAGAAGCTCTTGCCAAGATTTACTGGGCTCATAAAGATGCTACCTAAATTCCA
GATAATTTATAAGTTCTTTTTGATCATGATTATTGTAAAAATTTGGATCACTCTAGCTCT
GATGACTTAAAGTTCTGGACTCTTGTAGCTGCTCTTAAGAAATTCCGTGATGAAAATAAC
CACTTCCTGCCTGTTGATCGTCGTATCCCAGATATGAAATCTACTACTGAATGGTATATC
TAATTAAAGGAGGTTTATCAAACCTAACACAATGCCGACCGTGAAGCTTTTGTAAAAATT
CTAAATTAAATAAATACCAAAAATCTTGTTTTTGATCAAAATGAGGATATTTAAGTATTC
CTTGATAATATTAACTGCTTAGAATTTATCGATTTCCACTCTATTGATAACGAGTTAACC
AAGCCAATTGAAACAGAAAACTATGATAACCAAAACCACCTTTGGTTTGTTGGATAAAGA
GCTGTTAATTAATTCTATTAAAAGCATAGAAGATTCCCCAATCCTTCTGATTAAGCAGAG
TTGTCTTAAATAGCAGCTTAAATAAGAGAAACTAAATATCCTAATTATGTTGCTATTGAA
GAAGGTATTATCTAGGAATTCTGTAGATACGAAGATTCCCGTCTTCATAATATTGCTGCT
ATTATTGGTGGAGTTGCATCTCAAGAAGCTATTAAGCTTATAACTAACTAGTTTGTCCCT
TTAAATAACACTTACATTTTTAATGGTATTACTTGTGAAGGTGTCACTTTAGAATACTGA

>TTHERM_00215960(protein)
MSSKDKYDRQLRLWGPQGQRKLANSKILLLGAAPAGVEALKNLVLPGCGHITIVDHQLIT
ERDLGNNFFCSPEDLGQPRAKSVCDNLTEMNPEDVHGKWLNENVDELAAKEDFIKEFTCV
IANELLDEELHKLSVICDKYNIKLLAIQTNGFYAQLRLQAGRHCIIESKPDRDFYDWTLR
IRQPFQHLQDFCDKFDLQDLSTHEDKNPLAHVPFVVILVKAMNAWKQSHNGNAPSSIQEK
NEFKKTIETQMHWLEAKDRENFEEALAKIYWAHKDATQIPDNLQVLFDHDYCKNLDHSSS
DDLKFWTLVAALKKFRDENNHFLPVDRRIPDMKSTTEWYIQLKEVYQTQHNADREAFVKI
LNQINTKNLVFDQNEDIQVFLDNINCLEFIDFHSIDNELTKPIETENYDNQNHLWFVGQR
AVNQFYQKHRRFPNPSDQAELSQIAAQIRETKYPNYVAIEEGIIQEFCRYEDSRLHNIAA
IIGGVASQEAIKLITNQFVPLNNTYIFNGITCEGVTLEY

>TTHERM_00215960(gene)
ATGTCATCTAAAGATAAATACGATAGATAGCTTCGTCTTTGGGGTCCTCAAGGCTAAAGA
AAGTTGGCCAATTCTAAGATTTTGCTCTTAGGAGCAGCACCTGCAGGAGTTGAAGCTCTT
AAAAATTTAGTTTTACCAGGATGCGGTCACATTACTATTGTAGACCACCAACTCATTACT
GAGAGAGATTTAGGAAACAATTTTTTCTGCTCTCCTGAAGATTTAGGTCAACCCCGTGCT
AAGAGTGTCTGTGATAATCTTACAGAAATGAATCCTGAAGATGTTCATGGTAAGTGGCTT
AATGAAAATGTAGATGAATTAGCTGCTAAGGAAGATTTTATTAAAGAGTTTACTTGCGTT
ATAGCAAATGAGTTGCTTGATGAAGAACTTCATAAGCTATCTGTTATTTGTGATAAATAT
AATATTAAATTACTGGCAATCTAAACAAATGGATTTTATGCTTAGTTGCGTCTCTAAGCA
GGTCGTCATTGCATTATAGAAAGCAAACCAGACAGAGACTTCTATGACTGGACTCTTCGT
ATCCGCCAACCTTTCTAACATCTTCAAGATTTTTGTGATAAATTTGATTTGTAGGATTTA
TCAACTCATGAAGATAAGAATCCTCTAGCTCACGTACCTTTTGTAGTTATTTTAGTAAAG
GCTATGAATGCATGGAAGCAATCTCATAATGGTAATGCTCCTTCATCAATCCAAGAAAAG
AATGAATTTAAAAAAACCATCGAGACTCAAATGCACTGGCTTGAAGCTAAGGATCGTGAA
AATTTCGAAGAAGCTCTTGCCAAGATTTACTGGGCTCATAAAGATGCTACCTAAATTCCA
GATAATTTATAAGTTCTTTTTGATCATGATTATTGTAAAAATTTGGATCACTCTAGCTCT
GATGACTTAAAGTTCTGGACTCTTGTAGCTGCTCTTAAGAAATTCCGTGATGAAAATAAC
CACTTCCTGCCTGTTGATCGTCGTATCCCAGATATGAAATCTACTACTGAATGGTATATC
TAATTAAAGGAGGTTTATCAAACCTAACACAATGCCGACCGTGAAGCTTTTGTAAAAATT
CTAAATTAAATAAATACCAAAAATCTTGTTTTTGATCAAAATGAGGATATTTAAGTATTC
CTTGATAATATTAACTGCTTAGAATTTATCGATTTCCACTCTATTGATAACGAGTTAACC
AAGCCAATTGAAACAGAAAACTATGATAACCAAAACCACCTTTGGTTTGTTGGATAAAGA
GCTGTTAATTAATTCTATTAAAAGCATAGAAGATTCCCCAATCCTTCTGATTAAGCAGAG
TTGTCTTAAATAGCAGCTTAAATAAGAGAAACTAAATATCCTAATTATGTTGCTATTGAA
GAAGGTATTATCTAGGAATTCTGTAGATACGAAGATTCCCGTCTTCATAATATTGCTGCT
ATTATTGGTGGAGTTGCATCTCAAGAAGCTATTAAGCTTATAACTAACTAGTTTGTCCCT
TTAAATAACACTTACATTTTTAATGGTATTACTTGTGAAGGTGTCACTTTAGAATACTGA