Identifiers and Description

Gene Model Identifier

TTHERM_00558100

Standard Name

AMT3 (Adenine MethylTransferase (AMT) 3 targeting position N-six of Adenine)

Aliases

PreTt07908 | 73.m00152 | 3735.m00046 | MTA5

Description

MT-a70 family protein; MT-A70 RNA methyltransferase family protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039 | Ref:SUPR000146
• cytoplasm (IDA) | GO:0005737 | Ref:SUPR000146

Molecular Function

• methyltransferase activity (IEA) | GO:0008168

Biological Process

• nucleobase-containing compound metabolic process (IEA) | GO:0006139

Domains

• ( PF05063 ) MT-A70

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.3%

TetraMine Data

TTHERM_00558100

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_14374.1	9.997093137033517e-262	MT-A70 family protein (758 aa)
SGD	YGL192W	9.997975313387782e-28	IME4 Probable mRNA N6-adenosin e methyltransferase required f or entry into meiosis; transcr ibed in diploid cells; haploid s repress IME4 transcription v ia production of antisense IME 4 transcripts; antisense trans cription is repressed in diplo ids
Oxytricha	Contig17486.0.g100	1.0000422327488734e-24	MT-A70
Stentor Coeruleus	SteCoe_23497	0.0000000000018795288165390832

General Information

No Data fetched for General Information

Associated Literature

1. Ref:31722409: Wang Y, Sheng Y, Liu Y, Zhang W, Cheng T, Duan L, Pan B, Qiao Y, Liu Y, Gao S (2019) A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N6-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription. Nucleic acids research 47(22):11771-11789
2. Ref:SUPR000146

Sequences

>TTHERM_00558100(coding)
ATGTAACCTCAACAGAATTAAAATTAGTAGCAATAATAATAGCAGCAATCATAGCAACAG
CAGTAATAAAATTAGCAACTGCCACAGCTTCAATAATCTATGTCTTCATAGCAGTAACAA
AATTAATAGTAAGAAAAATAAATTATAATAAAAAGAGGTACAACTTCAAAAAGAAACGAC
TACTGCTAGAATTTTGTTAATACTCATGAGCGTCCATAGAATTTTATTATGAATATCCGT
CCAGAAGAGCGTTTTATAGAATACCCAAAATTGCAAGATTTGATAAAATTTAAGGATGAT
TTAATTAAAAAGCGTAACCATCCTCCTGTATATTTAAAGGCTGATTTAAAATATTATGAT
TTGTCTAAGCTTGGTAAGTTTGATGTCATTATGATGGATCCACCTTGGAAGGAATATGAA
GAGAGAGTACAAGGTCTTCCCATATATAGCCAGTATCCTGAGAAATTTAATTCATGGGAT
CTAAATGAAATTGCTGCATTACCTATTGATGAAATTTCAGATAAACCTAGCTTTTTGTTT
TTATGGGTAGGCTCCGATCATTTAGATTAGGGAAGAGAACTGTTTAGAAAGTGGGGATAT
AAAAGATGTGAAGATATAGTTTGGGTAAAAACTAATAAAGATAAAACCAAAGAATATATA
GAATTACCTCATTCAAACCTTCTTGTGAGAGTTAAAGAACACTGTCTAGTAGGTTTACGT
GGAGATGTAAAAAGGGCTTCTGATTCTCATTTTATTCATGCAAATATAGATACTGATGTC
ATAGTAGCTGAGGAGCCTCCTCTTGGAAGTACTTAGAAACCTGCAGAAATATATGATATT
ATAGAGAGATTTTGCCTTGGAAGAAAGAGGTTAGAGTTATTTGGAGAAGTTCACAATGTC
AGATAAGGTTGGTTAACTATTGGAAAATTATTGGATGAAAGCAACTTTAATTAAGATGAG
TATAATAGTTGGTTTGATGGAGACAAAACTTATCCCTAAATATAAACCTATAGAGGTGGT
AGATATGTAGGAACAACACCTGATATAGAATAACTCAGGCCAAAATCTCCAACCAAAAAT
AATTAAATGAATTCAAACTAAAATATGTCTGGTTCTTAGGTTTCTGAATTTGACTTGGGA
ATACAATAGAAATAGCAAAAATTAAATCAGCAGTTTTGA

>TTHERM_00558100(protein)
MQPQQNQNQQQQQQQQSQQQQQQNQQLPQLQQSMSSQQQQNQQQEKQIIIKRGTTSKRND
YCQNFVNTHERPQNFIMNIRPEERFIEYPKLQDLIKFKDDLIKKRNHPPVYLKADLKYYD
LSKLGKFDVIMMDPPWKEYEERVQGLPIYSQYPEKFNSWDLNEIAALPIDEISDKPSFLF
LWVGSDHLDQGRELFRKWGYKRCEDIVWVKTNKDKTKEYIELPHSNLLVRVKEHCLVGLR
GDVKRASDSHFIHANIDTDVIVAEEPPLGSTQKPAEIYDIIERFCLGRKRLELFGEVHNV
RQGWLTIGKLLDESNFNQDEYNSWFDGDKTYPQIQTYRGGRYVGTTPDIEQLRPKSPTKN
NQMNSNQNMSGSQVSEFDLGIQQKQQKLNQQF

>TTHERM_00558100(gene)
ATGTAACCTCAACAGAATTAAAATTAGTAGCAATAATAATAGCAGCAATCATAGCAACAG
CAGTAATAAAATTAGCAACTGCCACAGCTTCAATAATCTATGTCTTCATAGCAGTAACAA
AATTAATAGTAAGAAAAATAAATTATAATAAAAAGAGGTACAACTTCAAAAAGAAACGAC
TACTGCTAGAATTTTGTTAATACTCATGAGCGTCCATAGAATTTTATTATGAATATCCGT
CCAGAAGAGCGTTTTATAGGTAATATTTTCAAAAATGAATTTATTTTTTAAGTGTTAAAT
TCAAATTCTAAAAAATTAATTGATTATTGAGCAGAATGAATGTCTATTGAAAACAAATTT
AAGAAATAAATGTGAATCAATCAAAATAAACTTTTCTTTTATTAAAATAGAATACCCAAA
ATTGCAAGATTTGATAAAATTTAAGGATGATTTAATTAAAAAGCGTAACCATCCTCCTGT
ATATTTAAAGGCTGATTTAAAATATTATGATTTGTCTAAGCTTGGTAAGTTTGATGTCAT
TATGATGGATCCACCTTGGAAGGAATATGAAGAGAGAGTACAAGGTCTTCCCATATATAG
CCAGTATCCTGAGAAATTTAATTCATGGGATCTAAATGAAATTGCTGCATTACCTATTGA
TGAAATTTCAGATAAACCTAGCTTTTTGTTTTTATGGGTAGGCTCCGATCATTTAGATTA
GGTATTTAAAAGAATTTATTAATGCATTTATTTACTTAGTAGACAGCTTAAACAATAAAA
ATATTAATAATTATGGGTGTTTTAATAATTAATTTTACATTTATTTTAATGTAGGGAAGA
GAACTGTTTAGAAAGTGGGGATATAAAAGATGTGAAGATATAGTTTGGGTAAAAACTAAT
AAAGATAAAACCAAAGAATATATAGAATTACCTCATTCAAACCTTCTTGTGAGAGTTAAA
GAACACTGTCTAGTAGGTTTACGTGGAGATGTAAAAAGGGCTTCTGATTCTCATTTTATT
CATGCAAATATAGATACTGATGTCATAGTAGCTGAGGAGCCTCCTCTTGGAAGTAAAAAA
TATAGCTTTTCCTTTAATCATTTTAAGATTTCATTTATATATTTTAATTGATATTTAAAA
AGGTACTTAGAAACCTGCAGAAATATATGATATTATAGAGAGATTTTGCCTTGGAAGAAA
GAGGTTAGAGTTATTTGGAGAAGTTCACAATGTCAGATAAGGTTGGTTAACTATTGGAAA
ATTATTGGATGAAAGCAACTTTAATTAAGATGAGTATAATAGTTGGTTTGATGGAGACAA
AACTTATCCCTAAATATAAACCTATAGAGGTGGTAGATATGTAGGAACAACACCTGATAT
AGAATAACTCAGGCCAAAATCTCCAACCAAAAATAATTAAATGAATTCAAACTAAAATAT
GTCTGGTTCTTAGGTTTCTGTAAATTTTTTTCATATTCATTCATAATATCAAAATAATTT
ATTTATTTTTTTAAGGAATTTGACTTGGGAATACAATAGAAATAGCAAAAATTAAATCAG
CAGTTTTGA